Incidental Mutation 'R1937:Dhx29'
ID 213585
Institutional Source Beutler Lab
Gene Symbol Dhx29
Ensembl Gene ENSMUSG00000042426
Gene Name DExH-box helicase 29
Synonyms E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
MMRRC Submission 039955-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1937 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 113063988-113105966 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 113101864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 1311 (G1311D)
Ref Sequence ENSEMBL: ENSMUSP00000035244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038574]
AlphaFold Q6PGC1
Predicted Effect probably benign
Transcript: ENSMUST00000038574
AA Change: G1311D

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000035244
Gene: ENSMUSG00000042426
AA Change: G1311D

DomainStartEndE-ValueType
low complexity region 10 36 N/A INTRINSIC
low complexity region 41 54 N/A INTRINSIC
low complexity region 209 225 N/A INTRINSIC
low complexity region 240 255 N/A INTRINSIC
coiled coil region 279 308 N/A INTRINSIC
low complexity region 343 358 N/A INTRINSIC
Blast:DEXDc 411 450 2e-14 BLAST
DEXDc 569 763 1.09e-27 SMART
low complexity region 846 856 N/A INTRINSIC
HELICc 880 985 6.1e-17 SMART
HA2 1047 1138 8.9e-26 SMART
Pfam:OB_NTP_bind 1178 1298 3.8e-19 PFAM
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.7%
  • 20x: 93.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 106 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730480H06Rik C A 5: 48,531,777 (GRCm39) T35K probably benign Het
Abhd14a A G 9: 106,317,446 (GRCm39) probably benign Het
Abhd8 A G 8: 71,914,506 (GRCm39) F41L possibly damaging Het
Ace2 A T X: 162,939,524 (GRCm39) M123L possibly damaging Het
Actr5 T C 2: 158,477,949 (GRCm39) Y440H possibly damaging Het
Akr1c6 T A 13: 4,496,383 (GRCm39) N81K probably benign Het
Aqp11 T A 7: 97,386,725 (GRCm39) N157I possibly damaging Het
Arhgap10 T C 8: 78,071,282 (GRCm39) E568G probably damaging Het
Asb7 T A 7: 66,329,001 (GRCm39) Q13L probably benign Het
Atf7ip C A 6: 136,537,778 (GRCm39) A345E probably benign Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Bpifb4 A T 2: 153,785,996 (GRCm39) I259F probably damaging Het
Cand1 A T 10: 119,038,925 (GRCm39) D1218E probably damaging Het
Capg A G 6: 72,535,236 (GRCm39) probably null Het
Cep290 C T 10: 100,333,815 (GRCm39) T289M possibly damaging Het
Cfap69 T C 5: 5,643,818 (GRCm39) Y548C probably damaging Het
Cfap97d1 A T 11: 101,877,989 (GRCm39) H17L probably damaging Het
Cimip2b T A 4: 43,427,586 (GRCm39) K220N probably damaging Het
Clock A G 5: 76,377,340 (GRCm39) L652P probably damaging Het
Col3a1 C T 1: 45,373,453 (GRCm39) probably benign Het
Coro7 T C 16: 4,446,596 (GRCm39) E843G probably benign Het
Crebrf T C 17: 26,961,442 (GRCm39) S188P probably damaging Het
Crppa G A 12: 36,440,367 (GRCm39) V92I probably benign Het
Cul1 T C 6: 47,485,289 (GRCm39) F307L probably benign Het
Cyb561d2 G A 9: 107,417,515 (GRCm39) R79W probably damaging Het
Cyp3a59 T C 5: 146,031,187 (GRCm39) S117P possibly damaging Het
Ddias A G 7: 92,507,830 (GRCm39) I695T probably benign Het
Dync2h1 A G 9: 7,139,159 (GRCm39) probably null Het
Ece2 T A 16: 20,436,616 (GRCm39) V146E probably damaging Het
Eml2 A G 7: 18,937,889 (GRCm39) K586E possibly damaging Het
Eps8l3 A G 3: 107,791,708 (GRCm39) E316G probably benign Het
Fam135b A T 15: 71,493,863 (GRCm39) L22H probably damaging Het
Focad T A 4: 88,319,318 (GRCm39) M1K probably null Het
Fryl A G 5: 73,290,710 (GRCm39) S65P probably damaging Het
Gm14190 C T 11: 99,581,556 (GRCm39) C4Y unknown Het
H2-T5 T A 17: 36,478,899 (GRCm39) T117S probably damaging Het
Ift74 T A 4: 94,550,883 (GRCm39) M345K probably benign Het
Jag1 C G 2: 136,925,393 (GRCm39) V1070L possibly damaging Het
Kcng1 T C 2: 168,104,941 (GRCm39) T302A probably benign Het
Kif20b T C 19: 34,930,278 (GRCm39) V1221A possibly damaging Het
Kif23 A T 9: 61,853,892 (GRCm39) probably null Het
Lpxn T G 19: 12,802,274 (GRCm39) S200A probably benign Het
Meiob A G 17: 25,037,305 (GRCm39) H61R probably benign Het
Mfhas1 C T 8: 36,056,799 (GRCm39) L425F probably damaging Het
Myo3a A T 2: 22,401,126 (GRCm39) S632C probably damaging Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Nbeal1 T A 1: 60,307,100 (GRCm39) Y374* probably null Het
Notch3 T C 17: 32,372,826 (GRCm39) S582G probably benign Het
Nphs1 A T 7: 30,173,798 (GRCm39) Q985L probably damaging Het
Oas1c T A 5: 120,941,049 (GRCm39) H248L probably benign Het
Or5c1 A T 2: 37,221,896 (GRCm39) N46Y probably damaging Het
Or5g26 T C 2: 85,494,341 (GRCm39) I146V probably benign Het
Or5h25 A T 16: 58,930,157 (GRCm39) M272K probably benign Het
Or8g35 A G 9: 39,381,333 (GRCm39) S230P possibly damaging Het
Pamr1 A T 2: 102,472,617 (GRCm39) I639F possibly damaging Het
Panx1 G T 9: 14,918,980 (GRCm39) T293K possibly damaging Het
Papss1 G T 3: 131,305,632 (GRCm39) V226F probably benign Het
Pax1 G T 2: 147,209,809 (GRCm39) G301V possibly damaging Het
Pdlim5 C A 3: 141,950,742 (GRCm39) R557L possibly damaging Het
Pdyn C A 2: 129,531,729 (GRCm39) M20I probably benign Het
Pelp1 G A 11: 70,284,541 (GRCm39) probably null Het
Pkd2 T C 5: 104,626,790 (GRCm39) V324A probably damaging Het
Pkdrej A G 15: 85,703,368 (GRCm39) I856T probably benign Het
Polr1a T C 6: 71,913,536 (GRCm39) probably null Het
Pot1a A T 6: 25,753,323 (GRCm39) D404E probably benign Het
Ppp2r2a A T 14: 67,253,878 (GRCm39) I430N possibly damaging Het
Prob1 C T 18: 35,787,279 (GRCm39) R325Q possibly damaging Het
Prrc2a T C 17: 35,376,884 (GRCm39) D742G probably damaging Het
Psmc1 C T 12: 100,081,102 (GRCm39) P54S probably benign Het
Rab22a A G 2: 173,530,004 (GRCm39) T61A probably damaging Het
Rims1 T A 1: 22,358,754 (GRCm39) K184N probably damaging Het
Rnf213 G A 11: 119,322,511 (GRCm39) R1376H probably damaging Het
Ryr2 T C 13: 11,683,848 (GRCm39) E3072G probably damaging Het
Serpina1b T C 12: 103,698,420 (GRCm39) K143R probably benign Het
Slc22a15 T G 3: 101,787,505 (GRCm39) probably null Het
Slc25a14 G A X: 47,740,840 (GRCm39) V210I probably benign Het
Slc25a48 A C 13: 56,596,811 (GRCm39) T31P probably damaging Het
Slc9a3 C T 13: 74,314,175 (GRCm39) probably null Het
Slx4 T C 16: 3,805,030 (GRCm39) *105W probably null Het
Smc6 A G 12: 11,349,399 (GRCm39) N794S probably benign Het
Spata18 G A 5: 73,834,307 (GRCm39) R387Q probably damaging Het
Sphkap C A 1: 83,245,162 (GRCm39) E1486* probably null Het
Srsf6 C T 2: 162,776,403 (GRCm39) probably benign Het
St8sia1 C T 6: 142,909,398 (GRCm39) A33T probably damaging Het
Tet2 T C 3: 133,194,399 (GRCm39) T12A possibly damaging Het
Tmem144 G T 3: 79,732,611 (GRCm39) S222R probably damaging Het
Tnrc6c A G 11: 117,646,849 (GRCm39) D1450G possibly damaging Het
Top1 A T 2: 160,512,042 (GRCm39) K27N unknown Het
Tox2 A G 2: 163,067,476 (GRCm39) H30R probably benign Het
Tra2b T C 16: 22,065,993 (GRCm39) probably benign Het
Trio A T 15: 27,833,142 (GRCm39) V1165E probably damaging Het
Troap T A 15: 98,975,269 (GRCm39) S145R probably damaging Het
Ttc34 G A 4: 154,950,139 (GRCm39) A1031T possibly damaging Het
Ttc6 C T 12: 57,663,109 (GRCm39) P302S probably benign Het
Ubiad1 A G 4: 148,528,468 (GRCm39) L147P probably damaging Het
Ugt2b35 G T 5: 87,149,141 (GRCm39) V131F probably damaging Het
Utp25 A T 1: 192,804,401 (GRCm39) D200E probably damaging Het
Vmn1r167 G A 7: 23,204,452 (GRCm39) T188I probably benign Het
Vmn1r46 G T 6: 89,953,716 (GRCm39) M188I probably benign Het
Vmn2r115 T A 17: 23,578,388 (GRCm39) N620K probably damaging Het
Vmn2r66 A G 7: 84,644,344 (GRCm39) S689P probably damaging Het
Wipf2 C T 11: 98,783,236 (GRCm39) R221* probably null Het
Zbtb16 T C 9: 48,571,078 (GRCm39) S563G probably benign Het
Zfp319 T C 8: 96,055,199 (GRCm39) T335A probably damaging Het
Zfp418 A G 7: 7,185,401 (GRCm39) R455G possibly damaging Het
Other mutations in Dhx29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Dhx29 APN 13 113,101,137 (GRCm39) missense probably benign 0.15
IGL00434:Dhx29 APN 13 113,091,759 (GRCm39) missense probably benign 0.00
IGL00659:Dhx29 APN 13 113,103,169 (GRCm39) splice site probably benign
IGL01618:Dhx29 APN 13 113,101,756 (GRCm39) missense probably damaging 1.00
IGL01777:Dhx29 APN 13 113,067,406 (GRCm39) missense probably benign 0.42
IGL02010:Dhx29 APN 13 113,103,168 (GRCm39) critical splice donor site probably null
IGL02125:Dhx29 APN 13 113,091,834 (GRCm39) splice site probably benign
IGL02324:Dhx29 APN 13 113,064,342 (GRCm39) missense probably damaging 1.00
IGL02801:Dhx29 APN 13 113,101,180 (GRCm39) missense probably damaging 1.00
R0001:Dhx29 UTSW 13 113,101,090 (GRCm39) missense probably damaging 0.99
R0362:Dhx29 UTSW 13 113,099,393 (GRCm39) missense probably benign
R0468:Dhx29 UTSW 13 113,099,811 (GRCm39) missense probably benign
R0569:Dhx29 UTSW 13 113,084,748 (GRCm39) missense probably benign 0.01
R0714:Dhx29 UTSW 13 113,064,499 (GRCm39) missense possibly damaging 0.55
R1460:Dhx29 UTSW 13 113,101,744 (GRCm39) splice site probably benign
R1579:Dhx29 UTSW 13 113,072,132 (GRCm39) critical splice donor site probably null
R1657:Dhx29 UTSW 13 113,089,377 (GRCm39) missense probably damaging 1.00
R1735:Dhx29 UTSW 13 113,081,620 (GRCm39) missense probably benign 0.00
R1768:Dhx29 UTSW 13 113,084,774 (GRCm39) missense probably damaging 1.00
R1851:Dhx29 UTSW 13 113,084,815 (GRCm39) missense probably damaging 1.00
R2180:Dhx29 UTSW 13 113,099,406 (GRCm39) critical splice donor site probably null
R2219:Dhx29 UTSW 13 113,089,338 (GRCm39) missense probably damaging 1.00
R2442:Dhx29 UTSW 13 113,083,508 (GRCm39) missense possibly damaging 0.94
R2679:Dhx29 UTSW 13 113,083,910 (GRCm39) critical splice donor site probably null
R2908:Dhx29 UTSW 13 113,064,385 (GRCm39) missense possibly damaging 0.78
R2912:Dhx29 UTSW 13 113,072,109 (GRCm39) missense probably damaging 1.00
R3414:Dhx29 UTSW 13 113,083,807 (GRCm39) missense probably damaging 0.99
R3931:Dhx29 UTSW 13 113,095,499 (GRCm39) missense probably damaging 1.00
R3957:Dhx29 UTSW 13 113,067,455 (GRCm39) missense probably benign
R4065:Dhx29 UTSW 13 113,101,276 (GRCm39) critical splice donor site probably null
R4207:Dhx29 UTSW 13 113,064,483 (GRCm39) missense probably benign 0.01
R4422:Dhx29 UTSW 13 113,083,781 (GRCm39) missense probably damaging 1.00
R4717:Dhx29 UTSW 13 113,083,469 (GRCm39) missense unknown
R4718:Dhx29 UTSW 13 113,083,469 (GRCm39) missense unknown
R5125:Dhx29 UTSW 13 113,069,134 (GRCm39) missense possibly damaging 0.81
R5178:Dhx29 UTSW 13 113,069,134 (GRCm39) missense possibly damaging 0.81
R5263:Dhx29 UTSW 13 113,084,755 (GRCm39) missense probably damaging 1.00
R5458:Dhx29 UTSW 13 113,103,155 (GRCm39) missense probably benign 0.00
R5469:Dhx29 UTSW 13 113,081,073 (GRCm39) missense possibly damaging 0.94
R5541:Dhx29 UTSW 13 113,076,908 (GRCm39) missense possibly damaging 0.47
R5573:Dhx29 UTSW 13 113,069,749 (GRCm39) missense probably benign 0.07
R5664:Dhx29 UTSW 13 113,083,413 (GRCm39) missense probably damaging 1.00
R5682:Dhx29 UTSW 13 113,067,383 (GRCm39) missense probably damaging 1.00
R5769:Dhx29 UTSW 13 113,090,251 (GRCm39) missense probably damaging 0.99
R5917:Dhx29 UTSW 13 113,099,377 (GRCm39) missense probably damaging 1.00
R5928:Dhx29 UTSW 13 113,101,002 (GRCm39) missense probably benign 0.00
R6115:Dhx29 UTSW 13 113,089,335 (GRCm39) critical splice acceptor site probably null
R6144:Dhx29 UTSW 13 113,101,105 (GRCm39) missense probably damaging 1.00
R6195:Dhx29 UTSW 13 113,101,071 (GRCm39) missense probably benign 0.08
R6233:Dhx29 UTSW 13 113,101,071 (GRCm39) missense probably benign 0.08
R6430:Dhx29 UTSW 13 113,081,153 (GRCm39) missense possibly damaging 0.77
R6480:Dhx29 UTSW 13 113,090,322 (GRCm39) nonsense probably null
R6527:Dhx29 UTSW 13 113,069,076 (GRCm39) missense probably damaging 1.00
R6856:Dhx29 UTSW 13 113,089,395 (GRCm39) missense probably benign 0.43
R7391:Dhx29 UTSW 13 113,099,393 (GRCm39) missense probably benign
R7555:Dhx29 UTSW 13 113,064,176 (GRCm39) start gained probably benign
R7602:Dhx29 UTSW 13 113,081,093 (GRCm39) missense possibly damaging 0.95
R8744:Dhx29 UTSW 13 113,089,418 (GRCm39) missense possibly damaging 0.54
R9281:Dhx29 UTSW 13 113,078,240 (GRCm39) missense possibly damaging 0.82
R9450:Dhx29 UTSW 13 113,083,862 (GRCm39) missense possibly damaging 0.78
R9496:Dhx29 UTSW 13 113,089,460 (GRCm39) missense probably damaging 1.00
R9716:Dhx29 UTSW 13 113,081,612 (GRCm39) missense possibly damaging 0.83
Z1177:Dhx29 UTSW 13 113,092,051 (GRCm39) missense probably null 1.00
Predicted Primers PCR Primer
(F):5'- GCAATGTGGTTGTGTAAACATACG -3'
(R):5'- TACGTTCTGTGACAGCAACATG -3'

Sequencing Primer
(F):5'- TCTACCTGAGAGAGACGA -3'
(R):5'- CTGTGACAGCAACATGATCTTC -3'
Posted On 2014-07-14