Incidental Mutation 'R1940:Duox1'
| ID |
213889 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
039958-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1940 (G1)
|
| Quality Score |
216 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 122156465 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 464
(V464A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099461
AA Change: V464A
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: V464A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Meta Mutation Damage Score |
0.3527 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.8%
- 20x: 93.7%
|
| Validation Efficiency |
98% (108/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
T |
C |
7: 120,032,832 (GRCm39) |
|
probably benign |
Het |
| Ace2 |
A |
T |
X: 162,939,524 (GRCm39) |
M123L |
possibly damaging |
Het |
| Acvr1c |
A |
T |
2: 58,173,517 (GRCm39) |
N248K |
probably damaging |
Het |
| Adam24 |
A |
T |
8: 41,134,400 (GRCm39) |
R623* |
probably null |
Het |
| Agbl2 |
T |
A |
2: 90,641,626 (GRCm39) |
L752Q |
probably damaging |
Het |
| Ankrd26 |
A |
T |
6: 118,488,654 (GRCm39) |
F1335Y |
probably damaging |
Het |
| Ankrd34a |
A |
G |
3: 96,505,992 (GRCm39) |
S399G |
probably benign |
Het |
| Aoc1l3 |
A |
T |
6: 48,967,007 (GRCm39) |
K652* |
probably null |
Het |
| Ap3d1 |
G |
A |
10: 80,545,607 (GRCm39) |
P1041S |
probably benign |
Het |
| Arid3b |
A |
T |
9: 57,703,431 (GRCm39) |
M466K |
possibly damaging |
Het |
| Arsj |
T |
C |
3: 126,231,995 (GRCm39) |
I247T |
probably damaging |
Het |
| AU016765 |
G |
A |
17: 64,826,873 (GRCm39) |
|
noncoding transcript |
Het |
| Azin2 |
C |
T |
4: 128,844,577 (GRCm39) |
|
probably null |
Het |
| Bcat2 |
T |
C |
7: 45,237,792 (GRCm39) |
Y313H |
possibly damaging |
Het |
| Cables2 |
A |
G |
2: 179,901,873 (GRCm39) |
V465A |
probably damaging |
Het |
| Ccdc60 |
G |
A |
5: 116,264,224 (GRCm39) |
H517Y |
probably damaging |
Het |
| Cd55b |
A |
T |
1: 130,345,843 (GRCm39) |
|
probably null |
Het |
| Cdc40 |
G |
A |
10: 40,759,067 (GRCm39) |
|
probably benign |
Het |
| Cdh20 |
G |
A |
1: 109,976,754 (GRCm39) |
V140I |
probably benign |
Het |
| Cdhr18 |
A |
T |
14: 13,828,582 (GRCm38) |
M726K |
probably null |
Het |
| Cfi |
T |
C |
3: 129,652,477 (GRCm39) |
|
probably benign |
Het |
| Chit1 |
G |
A |
1: 134,073,156 (GRCm39) |
|
probably null |
Het |
| Chn1 |
A |
G |
2: 73,455,245 (GRCm39) |
C39R |
probably damaging |
Het |
| Ciao1 |
A |
G |
2: 127,088,380 (GRCm39) |
S148P |
possibly damaging |
Het |
| Clmn |
G |
A |
12: 104,756,361 (GRCm39) |
T163I |
probably damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,320 (GRCm39) |
G154W |
probably damaging |
Het |
| Col19a1 |
A |
T |
1: 24,303,831 (GRCm39) |
C1117* |
probably null |
Het |
| Cplane1 |
T |
A |
15: 8,263,336 (GRCm39) |
S2496R |
probably damaging |
Het |
| Cyp2d10 |
T |
A |
15: 82,289,495 (GRCm39) |
I206F |
probably benign |
Het |
| Ddrgk1 |
G |
T |
2: 130,505,480 (GRCm39) |
|
probably benign |
Het |
| Ddx18 |
A |
T |
1: 121,482,953 (GRCm39) |
V611D |
probably damaging |
Het |
| Dnah8 |
A |
T |
17: 30,950,181 (GRCm39) |
H2000L |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Eif4enif1 |
A |
G |
11: 3,193,279 (GRCm39) |
H857R |
probably damaging |
Het |
| Elmo2 |
A |
G |
2: 165,133,970 (GRCm39) |
|
probably benign |
Het |
| Fam171b |
CCAGCAGCAGCAGCAGCAGCAGC |
CCAGCAGCAGCAGCAGCAGC |
2: 83,643,218 (GRCm39) |
|
probably benign |
Het |
| Glrx |
A |
G |
13: 75,988,256 (GRCm39) |
I57V |
probably benign |
Het |
| Golm1 |
A |
T |
13: 59,790,051 (GRCm39) |
|
probably benign |
Het |
| Grm3 |
G |
A |
5: 9,561,682 (GRCm39) |
R723W |
probably damaging |
Het |
| Gsta3 |
G |
A |
1: 21,327,601 (GRCm39) |
R45Q |
probably benign |
Het |
| Gtf3c3 |
A |
C |
1: 54,468,117 (GRCm39) |
|
probably benign |
Het |
| Hk3 |
C |
T |
13: 55,159,204 (GRCm39) |
V451I |
probably damaging |
Het |
| Hoxa10 |
C |
A |
6: 52,211,350 (GRCm39) |
G189C |
possibly damaging |
Het |
| Hs3st3b1 |
T |
C |
11: 63,780,569 (GRCm39) |
D186G |
probably benign |
Het |
| Hscb |
G |
T |
5: 110,983,926 (GRCm39) |
H63N |
probably benign |
Het |
| Itpr3 |
A |
G |
17: 27,330,191 (GRCm39) |
E1603G |
probably damaging |
Het |
| Ivl |
T |
A |
3: 92,480,056 (GRCm39) |
H3L |
probably benign |
Het |
| Klhl26 |
C |
A |
8: 70,904,911 (GRCm39) |
R252L |
probably damaging |
Het |
| Krt31 |
T |
A |
11: 99,939,069 (GRCm39) |
T251S |
probably benign |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Lhx3 |
T |
C |
2: 26,093,974 (GRCm39) |
D83G |
probably benign |
Het |
| Lss |
C |
A |
10: 76,381,296 (GRCm39) |
N427K |
possibly damaging |
Het |
| Mettl24 |
G |
A |
10: 40,613,722 (GRCm39) |
A154T |
probably benign |
Het |
| Mgat4a |
A |
T |
1: 37,575,118 (GRCm39) |
|
probably null |
Het |
| Moxd2 |
C |
T |
6: 40,860,466 (GRCm39) |
R326Q |
probably damaging |
Het |
| Mpdz |
G |
A |
4: 81,279,680 (GRCm39) |
A669V |
probably benign |
Het |
| Msra |
G |
A |
14: 64,522,505 (GRCm39) |
|
probably benign |
Het |
| Muc13 |
A |
T |
16: 33,628,281 (GRCm39) |
T344S |
probably benign |
Het |
| Myo3b |
T |
C |
2: 70,088,419 (GRCm39) |
I866T |
probably benign |
Het |
| Nbea |
T |
C |
3: 55,860,521 (GRCm39) |
S1852G |
possibly damaging |
Het |
| Ncf2 |
A |
G |
1: 152,709,815 (GRCm39) |
|
probably benign |
Het |
| Nfyc |
C |
A |
4: 120,630,861 (GRCm39) |
|
probably benign |
Het |
| Nop2 |
T |
C |
6: 125,111,597 (GRCm39) |
V110A |
probably benign |
Het |
| Nrg2 |
C |
A |
18: 36,329,897 (GRCm39) |
|
probably benign |
Het |
| Nrl |
A |
G |
14: 55,759,892 (GRCm39) |
Y12H |
probably damaging |
Het |
| Nrxn3 |
T |
C |
12: 89,227,151 (GRCm39) |
V635A |
probably damaging |
Het |
| Or4d11 |
A |
C |
19: 12,013,275 (GRCm39) |
V277G |
probably benign |
Het |
| Or6b2b |
T |
A |
1: 92,419,457 (GRCm39) |
T7S |
probably benign |
Het |
| Or8k41 |
T |
A |
2: 86,313,703 (GRCm39) |
K128* |
probably null |
Het |
| Or9g8 |
T |
A |
2: 85,607,515 (GRCm39) |
S196T |
probably benign |
Het |
| Papolg |
A |
T |
11: 23,817,279 (GRCm39) |
N639K |
probably benign |
Het |
| Paqr4 |
T |
C |
17: 23,956,638 (GRCm39) |
I242V |
probably damaging |
Het |
| Pramel6 |
A |
T |
2: 87,339,076 (GRCm39) |
K92M |
probably damaging |
Het |
| Prg4 |
T |
C |
1: 150,331,774 (GRCm39) |
T300A |
possibly damaging |
Het |
| Ptprb |
A |
T |
10: 116,155,515 (GRCm39) |
|
probably benign |
Het |
| Rab28 |
A |
T |
5: 41,783,133 (GRCm39) |
S216T |
probably benign |
Het |
| Rrp1b |
A |
T |
17: 32,275,819 (GRCm39) |
R455S |
possibly damaging |
Het |
| Sash1 |
A |
T |
10: 8,605,696 (GRCm39) |
M898K |
probably benign |
Het |
| Scn8a |
C |
T |
15: 100,868,085 (GRCm39) |
T310I |
probably benign |
Het |
| Secisbp2l |
C |
A |
2: 125,582,259 (GRCm39) |
D1066Y |
probably damaging |
Het |
| Sipa1l2 |
A |
G |
8: 126,206,887 (GRCm39) |
|
probably benign |
Het |
| Slc12a1 |
A |
G |
2: 125,036,113 (GRCm39) |
T662A |
probably benign |
Het |
| Slc12a4 |
T |
C |
8: 106,672,669 (GRCm39) |
I749V |
probably benign |
Het |
| Slc22a27 |
A |
G |
19: 7,887,092 (GRCm39) |
S266P |
probably damaging |
Het |
| Slc25a14 |
G |
A |
X: 47,740,840 (GRCm39) |
V210I |
probably benign |
Het |
| Slit1 |
T |
A |
19: 41,619,215 (GRCm39) |
N762I |
probably damaging |
Het |
| Spata31d1b |
C |
A |
13: 59,865,835 (GRCm39) |
D994E |
possibly damaging |
Het |
| Sphk1 |
A |
G |
11: 116,426,676 (GRCm39) |
I204V |
probably benign |
Het |
| Srsf6 |
C |
T |
2: 162,776,403 (GRCm39) |
|
probably benign |
Het |
| Tet2 |
T |
C |
3: 133,194,399 (GRCm39) |
T12A |
possibly damaging |
Het |
| Tgfbi |
A |
T |
13: 56,762,127 (GRCm39) |
Q70L |
possibly damaging |
Het |
| Tlr9 |
T |
C |
9: 106,101,846 (GRCm39) |
L379P |
probably damaging |
Het |
| Tnrc6c |
A |
G |
11: 117,646,849 (GRCm39) |
D1450G |
possibly damaging |
Het |
| Tra2b |
A |
G |
16: 22,073,795 (GRCm39) |
|
probably benign |
Het |
| Trit1 |
T |
C |
4: 122,948,033 (GRCm39) |
I451T |
probably benign |
Het |
| Trnau1ap |
A |
G |
4: 132,049,114 (GRCm39) |
Y30H |
probably damaging |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Ush2a |
A |
G |
1: 188,683,758 (GRCm39) |
D4979G |
probably null |
Het |
| Usp50 |
C |
T |
2: 126,619,943 (GRCm39) |
R123Q |
probably benign |
Het |
| Vmn2r117 |
A |
T |
17: 23,696,454 (GRCm39) |
Y318N |
probably damaging |
Het |
| Whamm |
C |
T |
7: 81,228,047 (GRCm39) |
T304I |
probably null |
Het |
| Wipf2 |
C |
T |
11: 98,783,236 (GRCm39) |
R221* |
probably null |
Het |
| Ythdf3 |
A |
G |
3: 16,259,256 (GRCm39) |
N468D |
possibly damaging |
Het |
| Zbtb17 |
T |
C |
4: 141,192,859 (GRCm39) |
I486T |
possibly damaging |
Het |
| Zfp3 |
T |
C |
11: 70,662,202 (GRCm39) |
S54P |
probably benign |
Het |
| Zscan10 |
A |
T |
17: 23,828,826 (GRCm39) |
H379L |
probably damaging |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCTGACTTGCTTCTCAGGC -3'
(R):5'- CGTTCCTGGTGTTTTCAAACCAG -3'
Sequencing Primer
(F):5'- ACACTATATGGAGGACTGGCTATTG -3'
(R):5'- CCTGGTGTTTTCAAACCAGTAACGG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation