Incidental Mutation 'R1907:Myo7b'
| ID |
214520 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo7b
|
| Ensembl Gene |
ENSMUSG00000024388 |
| Gene Name |
myosin VIIB |
| Synonyms |
|
| MMRRC Submission |
039926-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1907 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
32092287-32169984 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 32110052 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 1137
(C1137S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000134663]
|
| AlphaFold |
Q99MZ6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000134663
AA Change: C1137S
PolyPhen 2
Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000118046
Gene: ENSMUSG00000024388
AA Change: C1137S
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
59 |
761 |
N/A |
SMART |
|
IQ
|
762 |
784 |
1.07e-1 |
SMART |
|
IQ
|
785 |
807 |
7.01e-6 |
SMART |
|
IQ
|
831 |
853 |
4.93e-1 |
SMART |
|
IQ
|
854 |
876 |
1.63e-1 |
SMART |
|
MyTH4
|
989 |
1189 |
1.14e-71 |
SMART |
|
B41
|
1190 |
1409 |
3.66e-16 |
SMART |
|
SH3
|
1501 |
1563 |
3.25e-7 |
SMART |
|
MyTH4
|
1641 |
1790 |
7.66e-55 |
SMART |
|
B41
|
1792 |
2009 |
8.19e-28 |
SMART |
|
| Meta Mutation Damage Score |
0.2537 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.4%
|
| Validation Efficiency |
98% (104/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
C |
A |
3: 121,862,661 (GRCm39) |
S206R |
probably damaging |
Het |
| Abcc6 |
G |
T |
7: 45,663,593 (GRCm39) |
A357E |
probably benign |
Het |
| Abhd13 |
T |
A |
8: 10,038,170 (GRCm39) |
C256S |
probably benign |
Het |
| Actrt3 |
A |
G |
3: 30,652,716 (GRCm39) |
V126A |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,740,670 (GRCm39) |
|
probably benign |
Het |
| Alyref2 |
A |
G |
1: 171,331,838 (GRCm39) |
D205G |
probably damaging |
Het |
| Amigo3 |
G |
A |
9: 107,930,835 (GRCm39) |
R86Q |
probably benign |
Het |
| Ankrd50 |
G |
C |
3: 38,508,201 (GRCm39) |
P1389A |
probably damaging |
Het |
| Aoah |
A |
G |
13: 21,094,264 (GRCm39) |
D183G |
probably damaging |
Het |
| Arap3 |
A |
T |
18: 38,129,724 (GRCm39) |
S146T |
probably benign |
Het |
| Atp2c2 |
T |
C |
8: 120,476,615 (GRCm39) |
|
probably benign |
Het |
| Atp8b2 |
C |
T |
3: 89,853,583 (GRCm39) |
V682M |
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,259,465 (GRCm39) |
I1245T |
probably damaging |
Het |
| Card14 |
A |
G |
11: 119,222,085 (GRCm39) |
N460S |
probably benign |
Het |
| Ceacam5 |
A |
G |
7: 17,486,309 (GRCm39) |
D602G |
possibly damaging |
Het |
| Cecr2 |
T |
A |
6: 120,738,121 (GRCm39) |
H921Q |
probably benign |
Het |
| Cyb5d1 |
T |
C |
11: 69,285,566 (GRCm39) |
D115G |
probably benign |
Het |
| Dbp |
C |
T |
7: 45,357,744 (GRCm39) |
T67I |
possibly damaging |
Het |
| Dennd5b |
C |
T |
6: 148,943,074 (GRCm39) |
V601I |
probably benign |
Het |
| Dnah11 |
G |
A |
12: 118,091,291 (GRCm39) |
A947V |
possibly damaging |
Het |
| Dpysl3 |
T |
A |
18: 43,571,193 (GRCm39) |
D27V |
probably damaging |
Het |
| Drd1 |
A |
T |
13: 54,207,271 (GRCm39) |
D307E |
possibly damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,651,778 (GRCm39) |
G277D |
probably damaging |
Het |
| Eif4g3 |
C |
T |
4: 137,885,726 (GRCm39) |
R842W |
probably damaging |
Het |
| Enam |
C |
T |
5: 88,652,481 (GRCm39) |
T1330I |
possibly damaging |
Het |
| Fabp6 |
T |
C |
11: 43,486,994 (GRCm39) |
|
probably null |
Het |
| Fcsk |
A |
T |
8: 111,620,010 (GRCm39) |
L289* |
probably null |
Het |
| Fhip1a |
T |
C |
3: 85,579,940 (GRCm39) |
D755G |
probably benign |
Het |
| Fsip2 |
C |
T |
2: 82,813,772 (GRCm39) |
P3364S |
possibly damaging |
Het |
| Gad1 |
C |
T |
2: 70,409,482 (GRCm39) |
S191F |
possibly damaging |
Het |
| Gcm1 |
A |
C |
9: 77,972,055 (GRCm39) |
N332T |
probably benign |
Het |
| Gin1 |
G |
A |
1: 97,703,172 (GRCm39) |
|
probably benign |
Het |
| Gpr25 |
T |
C |
1: 136,188,538 (GRCm39) |
D25G |
probably benign |
Het |
| Gstm4 |
T |
C |
3: 107,948,593 (GRCm39) |
T172A |
probably benign |
Het |
| Hnrnpll |
A |
G |
17: 80,342,758 (GRCm39) |
|
probably null |
Het |
| Il12rb2 |
T |
A |
6: 67,272,270 (GRCm39) |
K339* |
probably null |
Het |
| Inpp1 |
A |
G |
1: 52,828,829 (GRCm39) |
*397Q |
probably null |
Het |
| Kcp |
G |
T |
6: 29,497,834 (GRCm39) |
|
probably benign |
Het |
| Kdm1b |
G |
A |
13: 47,217,596 (GRCm39) |
V352I |
probably benign |
Het |
| Klhdc2 |
G |
T |
12: 69,343,734 (GRCm39) |
|
probably benign |
Het |
| Krt75 |
T |
A |
15: 101,481,801 (GRCm39) |
T156S |
possibly damaging |
Het |
| Lag3 |
T |
A |
6: 124,886,450 (GRCm39) |
I168F |
possibly damaging |
Het |
| Lama4 |
T |
G |
10: 38,948,754 (GRCm39) |
V839G |
probably benign |
Het |
| Lmtk2 |
G |
T |
5: 144,111,928 (GRCm39) |
V883L |
probably benign |
Het |
| Lrrc37a |
C |
A |
11: 103,347,982 (GRCm39) |
K2904N |
unknown |
Het |
| Macf1 |
A |
T |
4: 123,266,192 (GRCm39) |
I4775N |
probably damaging |
Het |
| Map2k3 |
T |
G |
11: 60,823,055 (GRCm39) |
S3A |
possibly damaging |
Het |
| Mast1 |
G |
A |
8: 85,642,895 (GRCm39) |
R967C |
probably damaging |
Het |
| Mettl2 |
T |
G |
11: 105,017,666 (GRCm39) |
S59A |
probably benign |
Het |
| Mtr |
G |
A |
13: 12,240,418 (GRCm39) |
T530I |
probably damaging |
Het |
| Nacad |
T |
A |
11: 6,552,540 (GRCm39) |
H217L |
probably benign |
Het |
| Ncstn |
A |
T |
1: 171,899,710 (GRCm39) |
V324E |
probably damaging |
Het |
| Ndufaf7 |
C |
A |
17: 79,249,546 (GRCm39) |
H148N |
possibly damaging |
Het |
| Or10a49 |
T |
A |
7: 108,467,705 (GRCm39) |
I219F |
possibly damaging |
Het |
| Or52a24 |
T |
A |
7: 103,381,190 (GRCm39) |
I19N |
probably damaging |
Het |
| Or52n2b |
G |
A |
7: 104,566,272 (GRCm39) |
T77I |
probably damaging |
Het |
| Or7g12 |
T |
C |
9: 18,899,737 (GRCm39) |
I151T |
possibly damaging |
Het |
| Or8b12 |
T |
G |
9: 37,657,729 (GRCm39) |
L100V |
probably benign |
Het |
| Or8k17 |
T |
C |
2: 86,066,454 (GRCm39) |
K242E |
possibly damaging |
Het |
| Pcdh20 |
T |
C |
14: 88,706,140 (GRCm39) |
I387V |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,728,525 (GRCm39) |
|
probably benign |
Het |
| Pcp2 |
G |
A |
8: 3,674,904 (GRCm39) |
|
probably benign |
Het |
| Pde1a |
T |
A |
2: 79,698,651 (GRCm39) |
D393V |
probably damaging |
Het |
| Pias4 |
T |
C |
10: 80,990,197 (GRCm39) |
D421G |
possibly damaging |
Het |
| Pign |
T |
C |
1: 105,565,940 (GRCm39) |
T362A |
possibly damaging |
Het |
| Pik3c2g |
A |
C |
6: 139,789,768 (GRCm39) |
K304Q |
probably damaging |
Het |
| Pkd2 |
T |
A |
5: 104,634,672 (GRCm39) |
W568R |
probably damaging |
Het |
| Pld2 |
T |
A |
11: 70,435,010 (GRCm39) |
I306N |
probably damaging |
Het |
| Plppr3 |
T |
C |
10: 79,709,903 (GRCm39) |
K9R |
probably damaging |
Het |
| Pramel11 |
T |
A |
4: 143,622,061 (GRCm39) |
R431S |
possibly damaging |
Het |
| Psme4 |
T |
C |
11: 30,760,922 (GRCm39) |
V397A |
probably damaging |
Het |
| Ptbp2 |
A |
T |
3: 119,555,398 (GRCm39) |
S23R |
probably damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,728,575 (GRCm39) |
D2074G |
probably null |
Het |
| Rab34 |
T |
A |
11: 78,082,081 (GRCm39) |
L166H |
probably damaging |
Het |
| Rabgap1l |
T |
A |
1: 160,472,880 (GRCm39) |
R519S |
probably benign |
Het |
| Rasa1 |
A |
T |
13: 85,374,691 (GRCm39) |
L218* |
probably null |
Het |
| Reln |
A |
G |
5: 22,249,960 (GRCm39) |
|
probably null |
Het |
| Rer1 |
T |
C |
4: 155,162,956 (GRCm39) |
D94G |
possibly damaging |
Het |
| Rhpn1 |
T |
C |
15: 75,583,673 (GRCm39) |
V386A |
probably benign |
Het |
| Samd3 |
T |
A |
10: 26,147,754 (GRCm39) |
C476* |
probably null |
Het |
| Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
| Sipa1l3 |
A |
G |
7: 29,038,592 (GRCm39) |
S352P |
possibly damaging |
Het |
| Slc27a2 |
A |
G |
2: 126,428,262 (GRCm39) |
Y549C |
probably benign |
Het |
| Slc7a9 |
A |
G |
7: 35,149,279 (GRCm39) |
T7A |
probably benign |
Het |
| Slco4c1 |
C |
T |
1: 96,770,224 (GRCm39) |
G280D |
probably damaging |
Het |
| Snx19 |
T |
A |
9: 30,344,872 (GRCm39) |
V657E |
probably damaging |
Het |
| Spata31d1c |
A |
G |
13: 65,183,690 (GRCm39) |
M411V |
probably benign |
Het |
| Spice1 |
T |
A |
16: 44,178,193 (GRCm39) |
L72* |
probably null |
Het |
| Stard9 |
G |
T |
2: 120,544,293 (GRCm39) |
V4471L |
probably damaging |
Het |
| Syt14 |
A |
G |
1: 192,584,143 (GRCm39) |
L707P |
probably damaging |
Het |
| Tab1 |
T |
C |
15: 80,037,869 (GRCm39) |
I234T |
probably damaging |
Het |
| Tas2r107 |
T |
C |
6: 131,636,951 (GRCm39) |
M33V |
probably benign |
Het |
| Tbx4 |
T |
A |
11: 85,805,349 (GRCm39) |
S479R |
possibly damaging |
Het |
| Tssk5 |
C |
T |
15: 76,257,093 (GRCm39) |
R263Q |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,701,200 (GRCm39) |
|
probably benign |
Het |
| Ugt2b5 |
T |
A |
5: 87,287,489 (GRCm39) |
Q226L |
probably benign |
Het |
| Ush2a |
C |
T |
1: 188,447,261 (GRCm39) |
S2483L |
probably benign |
Het |
| Wdr95 |
A |
G |
5: 149,475,891 (GRCm39) |
Y63C |
probably damaging |
Het |
| Xirp2 |
A |
G |
2: 67,346,700 (GRCm39) |
I2980M |
probably damaging |
Het |
| Yeats4 |
G |
A |
10: 117,051,636 (GRCm39) |
T207I |
probably benign |
Het |
| Ythdc1 |
A |
G |
5: 86,978,489 (GRCm39) |
R561G |
probably damaging |
Het |
| Zbtb14 |
G |
A |
17: 69,694,385 (GRCm39) |
E28K |
possibly damaging |
Het |
| Zfp931 |
A |
T |
2: 177,711,684 (GRCm39) |
L21Q |
probably damaging |
Het |
| Zyg11b |
A |
C |
4: 108,112,423 (GRCm39) |
M415R |
probably damaging |
Het |
|
| Other mutations in Myo7b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00391:Myo7b
|
APN |
18 |
32,154,609 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL01799:Myo7b
|
APN |
18 |
32,095,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01881:Myo7b
|
APN |
18 |
32,133,320 (GRCm39) |
splice site |
probably benign |
|
|
IGL01883:Myo7b
|
APN |
18 |
32,131,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01934:Myo7b
|
APN |
18 |
32,134,394 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01980:Myo7b
|
APN |
18 |
32,094,953 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02506:Myo7b
|
APN |
18 |
32,100,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02704:Myo7b
|
APN |
18 |
32,100,014 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02929:Myo7b
|
APN |
18 |
32,127,978 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03149:Myo7b
|
APN |
18 |
32,147,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03335:Myo7b
|
APN |
18 |
32,118,073 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03372:Myo7b
|
APN |
18 |
32,131,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03385:Myo7b
|
APN |
18 |
32,122,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4131001:Myo7b
|
UTSW |
18 |
32,094,259 (GRCm39) |
missense |
probably benign |
0.17 |
|
PIT4445001:Myo7b
|
UTSW |
18 |
32,095,405 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4445001:Myo7b
|
UTSW |
18 |
32,092,519 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0034:Myo7b
|
UTSW |
18 |
32,093,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0138:Myo7b
|
UTSW |
18 |
32,143,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Myo7b
|
UTSW |
18 |
32,147,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Myo7b
|
UTSW |
18 |
32,105,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Myo7b
|
UTSW |
18 |
32,147,390 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0361:Myo7b
|
UTSW |
18 |
32,147,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Myo7b
|
UTSW |
18 |
32,097,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0524:Myo7b
|
UTSW |
18 |
32,146,477 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0645:Myo7b
|
UTSW |
18 |
32,127,962 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0724:Myo7b
|
UTSW |
18 |
32,138,602 (GRCm39) |
splice site |
probably benign |
|
|
R0731:Myo7b
|
UTSW |
18 |
32,094,878 (GRCm39) |
splice site |
probably null |
|
|
R0762:Myo7b
|
UTSW |
18 |
32,116,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0843:Myo7b
|
UTSW |
18 |
32,107,137 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0894:Myo7b
|
UTSW |
18 |
32,133,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0966:Myo7b
|
UTSW |
18 |
32,131,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Myo7b
|
UTSW |
18 |
32,127,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1387:Myo7b
|
UTSW |
18 |
32,116,805 (GRCm39) |
splice site |
probably benign |
|
|
R1523:Myo7b
|
UTSW |
18 |
32,099,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1544:Myo7b
|
UTSW |
18 |
32,127,962 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1623:Myo7b
|
UTSW |
18 |
32,133,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Myo7b
|
UTSW |
18 |
32,094,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Myo7b
|
UTSW |
18 |
32,127,950 (GRCm39) |
missense |
probably benign |
|
|
R1786:Myo7b
|
UTSW |
18 |
32,127,950 (GRCm39) |
missense |
probably benign |
|
|
R1796:Myo7b
|
UTSW |
18 |
32,119,728 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2027:Myo7b
|
UTSW |
18 |
32,118,013 (GRCm39) |
missense |
probably benign |
|
|
R2102:Myo7b
|
UTSW |
18 |
32,133,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2174:Myo7b
|
UTSW |
18 |
32,116,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2272:Myo7b
|
UTSW |
18 |
32,110,096 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2323:Myo7b
|
UTSW |
18 |
32,104,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2365:Myo7b
|
UTSW |
18 |
32,147,384 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3078:Myo7b
|
UTSW |
18 |
32,100,237 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3522:Myo7b
|
UTSW |
18 |
32,143,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3788:Myo7b
|
UTSW |
18 |
32,107,165 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3880:Myo7b
|
UTSW |
18 |
32,102,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4334:Myo7b
|
UTSW |
18 |
32,110,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4343:Myo7b
|
UTSW |
18 |
32,116,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4497:Myo7b
|
UTSW |
18 |
32,147,282 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4498:Myo7b
|
UTSW |
18 |
32,147,282 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4551:Myo7b
|
UTSW |
18 |
32,118,161 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4593:Myo7b
|
UTSW |
18 |
32,146,428 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R4616:Myo7b
|
UTSW |
18 |
32,136,540 (GRCm39) |
splice site |
probably null |
|
|
R4646:Myo7b
|
UTSW |
18 |
32,127,422 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4648:Myo7b
|
UTSW |
18 |
32,100,178 (GRCm39) |
splice site |
probably null |
|
|
R4737:Myo7b
|
UTSW |
18 |
32,131,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4765:Myo7b
|
UTSW |
18 |
32,094,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4790:Myo7b
|
UTSW |
18 |
32,133,158 (GRCm39) |
splice site |
probably null |
|
|
R4909:Myo7b
|
UTSW |
18 |
32,097,489 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5027:Myo7b
|
UTSW |
18 |
32,108,265 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5034:Myo7b
|
UTSW |
18 |
32,104,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5112:Myo7b
|
UTSW |
18 |
32,116,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5266:Myo7b
|
UTSW |
18 |
32,131,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Myo7b
|
UTSW |
18 |
32,131,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5348:Myo7b
|
UTSW |
18 |
32,116,972 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5457:Myo7b
|
UTSW |
18 |
32,104,503 (GRCm39) |
splice site |
probably null |
|
|
R5540:Myo7b
|
UTSW |
18 |
32,140,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5628:Myo7b
|
UTSW |
18 |
32,107,240 (GRCm39) |
missense |
probably benign |
|
|
R5815:Myo7b
|
UTSW |
18 |
32,099,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6062:Myo7b
|
UTSW |
18 |
32,101,043 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6137:Myo7b
|
UTSW |
18 |
32,133,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Myo7b
|
UTSW |
18 |
32,121,602 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6218:Myo7b
|
UTSW |
18 |
32,092,507 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6256:Myo7b
|
UTSW |
18 |
32,116,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6257:Myo7b
|
UTSW |
18 |
32,146,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Myo7b
|
UTSW |
18 |
32,131,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6302:Myo7b
|
UTSW |
18 |
32,127,439 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6438:Myo7b
|
UTSW |
18 |
32,099,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6654:Myo7b
|
UTSW |
18 |
32,123,322 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7030:Myo7b
|
UTSW |
18 |
32,104,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7090:Myo7b
|
UTSW |
18 |
32,131,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7210:Myo7b
|
UTSW |
18 |
32,140,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7218:Myo7b
|
UTSW |
18 |
32,114,054 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7378:Myo7b
|
UTSW |
18 |
32,099,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Myo7b
|
UTSW |
18 |
32,121,604 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7517:Myo7b
|
UTSW |
18 |
32,146,320 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7559:Myo7b
|
UTSW |
18 |
32,116,413 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7667:Myo7b
|
UTSW |
18 |
32,094,958 (GRCm39) |
missense |
probably benign |
|
|
R7737:Myo7b
|
UTSW |
18 |
32,147,257 (GRCm39) |
nonsense |
probably null |
|
|
R7942:Myo7b
|
UTSW |
18 |
32,146,422 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Myo7b
|
UTSW |
18 |
32,131,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8114:Myo7b
|
UTSW |
18 |
32,098,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Myo7b
|
UTSW |
18 |
32,104,408 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8341:Myo7b
|
UTSW |
18 |
32,116,979 (GRCm39) |
missense |
probably benign |
0.39 |
|
R8406:Myo7b
|
UTSW |
18 |
32,092,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Myo7b
|
UTSW |
18 |
32,095,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8517:Myo7b
|
UTSW |
18 |
32,100,244 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8537:Myo7b
|
UTSW |
18 |
32,110,142 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8546:Myo7b
|
UTSW |
18 |
32,123,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8721:Myo7b
|
UTSW |
18 |
32,140,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8770:Myo7b
|
UTSW |
18 |
32,114,124 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8841:Myo7b
|
UTSW |
18 |
32,097,490 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8853:Myo7b
|
UTSW |
18 |
32,119,744 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8960:Myo7b
|
UTSW |
18 |
32,127,299 (GRCm39) |
splice site |
probably benign |
|
|
R8984:Myo7b
|
UTSW |
18 |
32,099,402 (GRCm39) |
missense |
probably null |
0.68 |
|
R9356:Myo7b
|
UTSW |
18 |
32,110,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Myo7b
|
UTSW |
18 |
32,093,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9364:Myo7b
|
UTSW |
18 |
32,133,413 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9405:Myo7b
|
UTSW |
18 |
32,109,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9533:Myo7b
|
UTSW |
18 |
32,108,297 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9776:Myo7b
|
UTSW |
18 |
32,133,068 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0027:Myo7b
|
UTSW |
18 |
32,098,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myo7b
|
UTSW |
18 |
32,114,051 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Z1177:Myo7b
|
UTSW |
18 |
32,118,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTAGAGCATCCTTTCAGATGGG -3'
(R):5'- AGATGGACACCAGAGCTCTG -3'
Sequencing Primer
(F):5'- GCATCCTTTCAGATGGGAAAATTGAG -3'
(R):5'- CAGAGCTCTGGGAAGACACC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation