Incidental Mutation 'R1927:Nynrin'
ID |
214987 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nynrin
|
Ensembl Gene |
ENSMUSG00000075592 |
Gene Name |
NYN domain and retroviral integrase containing |
Synonyms |
|
MMRRC Submission |
039945-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1927 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
14 |
Chromosomal Location |
56091572-56112193 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 56101049 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 280
(T280A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129557
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100529]
[ENSMUST00000168479]
[ENSMUST00000227465]
|
AlphaFold |
Q5DTZ0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000100529
AA Change: T280A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000098098 Gene: ENSMUSG00000075592 AA Change: T280A
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
1.6e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000168479
AA Change: T280A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000129557 Gene: ENSMUSG00000075592 AA Change: T280A
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
5.5e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181218
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227465
|
Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.5%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A2m |
T |
C |
6: 121,613,338 (GRCm39) |
S31P |
probably damaging |
Het |
Abca12 |
G |
T |
1: 71,283,999 (GRCm39) |
H2524Q |
probably damaging |
Het |
Acsl5 |
T |
C |
19: 55,266,586 (GRCm39) |
V135A |
probably benign |
Het |
Actl11 |
T |
G |
9: 107,806,736 (GRCm39) |
L353R |
possibly damaging |
Het |
Adcy6 |
G |
T |
15: 98,496,379 (GRCm39) |
|
probably null |
Het |
B230104I21Rik |
A |
G |
4: 154,425,694 (GRCm39) |
I697T |
probably damaging |
Het |
BC061237 |
G |
A |
14: 44,738,700 (GRCm39) |
R33K |
possibly damaging |
Het |
Brf1 |
C |
A |
12: 112,963,964 (GRCm39) |
V5F |
possibly damaging |
Het |
Chmp2a |
C |
T |
7: 12,767,863 (GRCm39) |
A21T |
possibly damaging |
Het |
Cwh43 |
A |
G |
5: 73,610,417 (GRCm39) |
N607S |
probably benign |
Het |
Ddhd2 |
G |
A |
8: 26,231,688 (GRCm39) |
L445F |
possibly damaging |
Het |
Dicer1 |
C |
A |
12: 104,669,143 (GRCm39) |
D1180Y |
possibly damaging |
Het |
Dnaaf4 |
A |
T |
9: 72,867,909 (GRCm39) |
I57L |
probably damaging |
Het |
Dock5 |
A |
T |
14: 68,083,511 (GRCm39) |
S133T |
possibly damaging |
Het |
Efs |
A |
T |
14: 55,154,620 (GRCm39) |
C540S |
possibly damaging |
Het |
Ehd4 |
C |
T |
2: 119,921,973 (GRCm39) |
G428S |
probably benign |
Het |
Eml1 |
C |
T |
12: 108,504,476 (GRCm39) |
R812* |
probably null |
Het |
Enpp1 |
C |
T |
10: 24,530,786 (GRCm39) |
D557N |
possibly damaging |
Het |
Fn3krp |
A |
G |
11: 121,315,803 (GRCm39) |
T65A |
probably damaging |
Het |
Galnt5 |
A |
G |
2: 57,888,615 (GRCm39) |
R72G |
probably benign |
Het |
Gfod1 |
C |
T |
13: 43,354,336 (GRCm39) |
R213H |
possibly damaging |
Het |
Gm10518 |
A |
G |
1: 179,631,210 (GRCm39) |
|
probably benign |
Het |
Gm5431 |
A |
G |
11: 48,780,082 (GRCm39) |
F558S |
probably damaging |
Het |
Got1 |
C |
T |
19: 43,504,119 (GRCm39) |
|
probably null |
Het |
Gucy2g |
C |
T |
19: 55,226,191 (GRCm39) |
V242I |
probably benign |
Het |
Hdgfl2 |
T |
A |
17: 56,406,874 (GRCm39) |
V606E |
possibly damaging |
Het |
Hoxa3 |
T |
C |
6: 52,146,979 (GRCm39) |
|
probably benign |
Het |
Iqub |
T |
A |
6: 24,491,670 (GRCm39) |
I339L |
probably benign |
Het |
Kdm4c |
C |
T |
4: 74,263,720 (GRCm39) |
T668I |
probably benign |
Het |
Klhl32 |
T |
C |
4: 24,617,474 (GRCm39) |
I592V |
probably benign |
Het |
Mfsd12 |
G |
T |
10: 81,197,921 (GRCm39) |
M296I |
probably benign |
Het |
Mfsd4b4 |
C |
T |
10: 39,768,437 (GRCm39) |
A219T |
probably damaging |
Het |
Mrpl52 |
T |
C |
14: 54,664,414 (GRCm39) |
S9P |
possibly damaging |
Het |
Nbr1 |
A |
G |
11: 101,458,040 (GRCm39) |
Y273C |
possibly damaging |
Het |
Ncf4 |
G |
T |
15: 78,144,846 (GRCm39) |
G217V |
probably damaging |
Het |
Neo1 |
T |
C |
9: 58,897,668 (GRCm39) |
E96G |
probably benign |
Het |
Nid2 |
T |
A |
14: 19,818,344 (GRCm39) |
N279K |
probably damaging |
Het |
Nr5a2 |
A |
G |
1: 136,872,732 (GRCm39) |
Y56H |
probably damaging |
Het |
Ntn4 |
C |
T |
10: 93,543,215 (GRCm39) |
R314W |
probably damaging |
Het |
Or1o2 |
A |
G |
17: 37,542,434 (GRCm39) |
Y276H |
probably damaging |
Het |
Or2b28 |
T |
A |
13: 21,531,116 (GRCm39) |
I6N |
probably benign |
Het |
Or2w2 |
A |
G |
13: 21,758,426 (GRCm39) |
F67L |
probably benign |
Het |
Or55b10 |
A |
G |
7: 102,143,266 (GRCm39) |
S239P |
possibly damaging |
Het |
Or5b109 |
T |
C |
19: 13,212,393 (GRCm39) |
Y260H |
probably damaging |
Het |
Otog |
G |
A |
7: 45,895,707 (GRCm39) |
C107Y |
probably damaging |
Het |
Ptprn |
A |
G |
1: 75,230,766 (GRCm39) |
V565A |
probably benign |
Het |
Rbm6 |
T |
G |
9: 107,730,102 (GRCm39) |
D182A |
probably damaging |
Het |
Rhbg |
A |
G |
3: 88,151,859 (GRCm39) |
F400L |
probably benign |
Het |
Rpl22l1 |
T |
A |
3: 28,860,738 (GRCm39) |
N33K |
possibly damaging |
Het |
Rtp1 |
T |
A |
16: 23,249,959 (GRCm39) |
I108N |
probably damaging |
Het |
Sema6b |
A |
T |
17: 56,439,797 (GRCm39) |
F15I |
probably benign |
Het |
Sirpa |
C |
T |
2: 129,458,296 (GRCm39) |
T304I |
possibly damaging |
Het |
Slc22a29 |
A |
G |
19: 8,184,430 (GRCm39) |
I257T |
probably benign |
Het |
Slc41a1 |
T |
C |
1: 131,768,938 (GRCm39) |
I256T |
probably damaging |
Het |
Smg6 |
A |
G |
11: 75,033,674 (GRCm39) |
K1208R |
probably damaging |
Het |
Sorcs1 |
G |
T |
19: 50,210,633 (GRCm39) |
P744Q |
probably damaging |
Het |
Sptbn5 |
T |
C |
2: 119,900,943 (GRCm39) |
T213A |
probably benign |
Het |
St18 |
A |
G |
1: 6,872,936 (GRCm39) |
T224A |
probably benign |
Het |
Stat3 |
T |
C |
11: 100,785,655 (GRCm39) |
N465S |
probably damaging |
Het |
Stmn2 |
T |
A |
3: 8,610,636 (GRCm39) |
M40K |
probably benign |
Het |
Tespa1 |
A |
G |
10: 130,184,108 (GRCm39) |
D63G |
probably benign |
Het |
Thrb |
T |
A |
14: 18,008,674 (GRCm38) |
C133S |
probably damaging |
Het |
Tmem25 |
C |
T |
9: 44,707,780 (GRCm39) |
V172M |
possibly damaging |
Het |
Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
Trhde |
T |
A |
10: 114,636,754 (GRCm39) |
Y151F |
probably damaging |
Het |
Trp53bp2 |
A |
G |
1: 182,280,229 (GRCm39) |
T912A |
probably damaging |
Het |
Unc79 |
C |
A |
12: 103,135,951 (GRCm39) |
A2269E |
probably damaging |
Het |
Zfp507 |
C |
T |
7: 35,493,150 (GRCm39) |
R631Q |
probably damaging |
Het |
Zfp758 |
T |
G |
17: 22,594,823 (GRCm39) |
S436R |
probably damaging |
Het |
Zfp791 |
G |
T |
8: 85,837,312 (GRCm39) |
T184K |
probably benign |
Het |
Znrf3 |
A |
G |
11: 5,231,062 (GRCm39) |
V817A |
probably benign |
Het |
|
Other mutations in Nynrin |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01020:Nynrin
|
APN |
14 |
56,105,905 (GRCm39) |
missense |
probably benign |
0.38 |
IGL01131:Nynrin
|
APN |
14 |
56,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01357:Nynrin
|
APN |
14 |
56,107,874 (GRCm39) |
missense |
probably benign |
|
IGL01537:Nynrin
|
APN |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01583:Nynrin
|
APN |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01726:Nynrin
|
APN |
14 |
56,101,611 (GRCm39) |
missense |
probably benign |
|
IGL02161:Nynrin
|
APN |
14 |
56,101,441 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02167:Nynrin
|
APN |
14 |
56,100,792 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02247:Nynrin
|
APN |
14 |
56,109,167 (GRCm39) |
nonsense |
probably null |
|
IGL02302:Nynrin
|
APN |
14 |
56,105,962 (GRCm39) |
missense |
probably benign |
0.43 |
IGL02524:Nynrin
|
APN |
14 |
56,108,931 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL02600:Nynrin
|
APN |
14 |
56,101,449 (GRCm39) |
missense |
probably benign |
0.38 |
IGL02639:Nynrin
|
APN |
14 |
56,108,112 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02654:Nynrin
|
APN |
14 |
56,100,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02659:Nynrin
|
APN |
14 |
56,103,554 (GRCm39) |
unclassified |
probably benign |
|
IGL02736:Nynrin
|
APN |
14 |
56,108,366 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02949:Nynrin
|
APN |
14 |
56,109,837 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4458001:Nynrin
|
UTSW |
14 |
56,101,425 (GRCm39) |
missense |
probably benign |
0.39 |
R0017:Nynrin
|
UTSW |
14 |
56,109,852 (GRCm39) |
missense |
probably damaging |
1.00 |
R0078:Nynrin
|
UTSW |
14 |
56,100,789 (GRCm39) |
missense |
probably damaging |
1.00 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0413:Nynrin
|
UTSW |
14 |
56,109,648 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0609:Nynrin
|
UTSW |
14 |
56,110,218 (GRCm39) |
missense |
probably damaging |
1.00 |
R0626:Nynrin
|
UTSW |
14 |
56,105,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R1205:Nynrin
|
UTSW |
14 |
56,091,646 (GRCm39) |
intron |
probably benign |
|
R1222:Nynrin
|
UTSW |
14 |
56,100,998 (GRCm39) |
missense |
probably benign |
0.02 |
R1385:Nynrin
|
UTSW |
14 |
56,102,356 (GRCm39) |
missense |
probably benign |
0.00 |
R1820:Nynrin
|
UTSW |
14 |
56,107,835 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1829:Nynrin
|
UTSW |
14 |
56,110,404 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1874:Nynrin
|
UTSW |
14 |
56,100,950 (GRCm39) |
missense |
probably benign |
0.04 |
R2233:Nynrin
|
UTSW |
14 |
56,109,524 (GRCm39) |
missense |
possibly damaging |
0.83 |
R3018:Nynrin
|
UTSW |
14 |
56,100,867 (GRCm39) |
missense |
probably benign |
0.00 |
R3154:Nynrin
|
UTSW |
14 |
56,101,044 (GRCm39) |
missense |
possibly damaging |
0.46 |
R3853:Nynrin
|
UTSW |
14 |
56,101,562 (GRCm39) |
missense |
probably benign |
0.24 |
R4648:Nynrin
|
UTSW |
14 |
56,110,351 (GRCm39) |
nonsense |
probably null |
|
R4722:Nynrin
|
UTSW |
14 |
56,091,852 (GRCm39) |
missense |
probably damaging |
0.97 |
R4735:Nynrin
|
UTSW |
14 |
56,107,625 (GRCm39) |
missense |
probably benign |
0.03 |
R4736:Nynrin
|
UTSW |
14 |
56,101,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R4780:Nynrin
|
UTSW |
14 |
56,100,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R4804:Nynrin
|
UTSW |
14 |
56,102,326 (GRCm39) |
missense |
probably benign |
|
R4816:Nynrin
|
UTSW |
14 |
56,109,458 (GRCm39) |
missense |
probably damaging |
1.00 |
R5307:Nynrin
|
UTSW |
14 |
56,101,263 (GRCm39) |
missense |
probably damaging |
1.00 |
R5372:Nynrin
|
UTSW |
14 |
56,105,948 (GRCm39) |
missense |
probably benign |
0.01 |
R5432:Nynrin
|
UTSW |
14 |
56,101,923 (GRCm39) |
missense |
possibly damaging |
0.80 |
R5800:Nynrin
|
UTSW |
14 |
56,108,088 (GRCm39) |
missense |
probably damaging |
1.00 |
R5825:Nynrin
|
UTSW |
14 |
56,101,683 (GRCm39) |
missense |
probably benign |
0.00 |
R6149:Nynrin
|
UTSW |
14 |
56,091,780 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6244:Nynrin
|
UTSW |
14 |
56,105,485 (GRCm39) |
missense |
probably damaging |
1.00 |
R6350:Nynrin
|
UTSW |
14 |
56,105,533 (GRCm39) |
missense |
probably benign |
0.19 |
R6379:Nynrin
|
UTSW |
14 |
56,107,848 (GRCm39) |
missense |
probably damaging |
1.00 |
R6437:Nynrin
|
UTSW |
14 |
56,109,227 (GRCm39) |
missense |
probably benign |
0.00 |
R6501:Nynrin
|
UTSW |
14 |
56,100,989 (GRCm39) |
missense |
probably benign |
|
R6702:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6703:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6907:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6908:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6928:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6934:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6935:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R7197:Nynrin
|
UTSW |
14 |
56,109,380 (GRCm39) |
missense |
probably benign |
0.00 |
R7204:Nynrin
|
UTSW |
14 |
56,110,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R7272:Nynrin
|
UTSW |
14 |
56,107,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Nynrin
|
UTSW |
14 |
56,101,371 (GRCm39) |
missense |
probably benign |
|
R7361:Nynrin
|
UTSW |
14 |
56,107,857 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7368:Nynrin
|
UTSW |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
R7443:Nynrin
|
UTSW |
14 |
56,108,873 (GRCm39) |
missense |
probably benign |
0.18 |
R7584:Nynrin
|
UTSW |
14 |
56,109,041 (GRCm39) |
missense |
probably damaging |
1.00 |
R7677:Nynrin
|
UTSW |
14 |
56,107,693 (GRCm39) |
missense |
probably benign |
|
R7723:Nynrin
|
UTSW |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7776:Nynrin
|
UTSW |
14 |
56,103,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R7787:Nynrin
|
UTSW |
14 |
56,107,980 (GRCm39) |
missense |
probably benign |
|
R7842:Nynrin
|
UTSW |
14 |
56,102,553 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Nynrin
|
UTSW |
14 |
56,108,886 (GRCm39) |
missense |
probably damaging |
0.96 |
R8040:Nynrin
|
UTSW |
14 |
56,108,982 (GRCm39) |
missense |
probably benign |
0.01 |
R8159:Nynrin
|
UTSW |
14 |
56,102,517 (GRCm39) |
missense |
probably benign |
|
R8159:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R8258:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8259:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8343:Nynrin
|
UTSW |
14 |
56,101,248 (GRCm39) |
missense |
probably benign |
|
R8504:Nynrin
|
UTSW |
14 |
56,107,703 (GRCm39) |
missense |
probably benign |
0.01 |
R8671:Nynrin
|
UTSW |
14 |
56,107,899 (GRCm39) |
missense |
possibly damaging |
0.52 |
R8691:Nynrin
|
UTSW |
14 |
56,110,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R8777-TAIL:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R9041:Nynrin
|
UTSW |
14 |
56,108,753 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9346:Nynrin
|
UTSW |
14 |
56,100,495 (GRCm39) |
missense |
probably benign |
0.01 |
R9366:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R9690:Nynrin
|
UTSW |
14 |
56,108,204 (GRCm39) |
missense |
probably benign |
0.00 |
RF007:Nynrin
|
UTSW |
14 |
56,103,658 (GRCm39) |
splice site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TGGCATCTCTGGTACTTGCC -3'
(R):5'- GATTCTCAGAGTCCTGGCTG -3'
Sequencing Primer
(F):5'- TGGTACTTGCCCCAACCCAG -3'
(R):5'- CAGAGTCCTGGCTGCTGGTG -3'
|
Posted On |
2014-07-14 |