Incidental Mutation 'R1927:Or5b109'
ID 214999
Institutional Source Beutler Lab
Gene Symbol Or5b109
Ensembl Gene ENSMUSG00000096365
Gene Name olfactory receptor family 5 subfamily B member 109
Synonyms Olfr1463, GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
MMRRC Submission 039945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R1927 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13211616-13212548 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13212393 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 260 (Y260H)
Ref Sequence ENSEMBL: ENSMUSP00000146566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064102] [ENSMUST00000207246]
AlphaFold Q7TQR3
Predicted Effect probably damaging
Transcript: ENSMUST00000064102
AA Change: Y260H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070872
Gene: ENSMUSG00000096365
AA Change: Y260H

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 1e-51 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3.2e-6 PFAM
Pfam:7tm_1 42 291 1.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207246
AA Change: Y260H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,613,338 (GRCm39) S31P probably damaging Het
Abca12 G T 1: 71,283,999 (GRCm39) H2524Q probably damaging Het
Acsl5 T C 19: 55,266,586 (GRCm39) V135A probably benign Het
Actl11 T G 9: 107,806,736 (GRCm39) L353R possibly damaging Het
Adcy6 G T 15: 98,496,379 (GRCm39) probably null Het
B230104I21Rik A G 4: 154,425,694 (GRCm39) I697T probably damaging Het
BC061237 G A 14: 44,738,700 (GRCm39) R33K possibly damaging Het
Brf1 C A 12: 112,963,964 (GRCm39) V5F possibly damaging Het
Chmp2a C T 7: 12,767,863 (GRCm39) A21T possibly damaging Het
Cwh43 A G 5: 73,610,417 (GRCm39) N607S probably benign Het
Ddhd2 G A 8: 26,231,688 (GRCm39) L445F possibly damaging Het
Dicer1 C A 12: 104,669,143 (GRCm39) D1180Y possibly damaging Het
Dnaaf4 A T 9: 72,867,909 (GRCm39) I57L probably damaging Het
Dock5 A T 14: 68,083,511 (GRCm39) S133T possibly damaging Het
Efs A T 14: 55,154,620 (GRCm39) C540S possibly damaging Het
Ehd4 C T 2: 119,921,973 (GRCm39) G428S probably benign Het
Eml1 C T 12: 108,504,476 (GRCm39) R812* probably null Het
Enpp1 C T 10: 24,530,786 (GRCm39) D557N possibly damaging Het
Fn3krp A G 11: 121,315,803 (GRCm39) T65A probably damaging Het
Galnt5 A G 2: 57,888,615 (GRCm39) R72G probably benign Het
Gfod1 C T 13: 43,354,336 (GRCm39) R213H possibly damaging Het
Gm10518 A G 1: 179,631,210 (GRCm39) probably benign Het
Gm5431 A G 11: 48,780,082 (GRCm39) F558S probably damaging Het
Got1 C T 19: 43,504,119 (GRCm39) probably null Het
Gucy2g C T 19: 55,226,191 (GRCm39) V242I probably benign Het
Hdgfl2 T A 17: 56,406,874 (GRCm39) V606E possibly damaging Het
Hoxa3 T C 6: 52,146,979 (GRCm39) probably benign Het
Iqub T A 6: 24,491,670 (GRCm39) I339L probably benign Het
Kdm4c C T 4: 74,263,720 (GRCm39) T668I probably benign Het
Klhl32 T C 4: 24,617,474 (GRCm39) I592V probably benign Het
Mfsd12 G T 10: 81,197,921 (GRCm39) M296I probably benign Het
Mfsd4b4 C T 10: 39,768,437 (GRCm39) A219T probably damaging Het
Mrpl52 T C 14: 54,664,414 (GRCm39) S9P possibly damaging Het
Nbr1 A G 11: 101,458,040 (GRCm39) Y273C possibly damaging Het
Ncf4 G T 15: 78,144,846 (GRCm39) G217V probably damaging Het
Neo1 T C 9: 58,897,668 (GRCm39) E96G probably benign Het
Nid2 T A 14: 19,818,344 (GRCm39) N279K probably damaging Het
Nr5a2 A G 1: 136,872,732 (GRCm39) Y56H probably damaging Het
Ntn4 C T 10: 93,543,215 (GRCm39) R314W probably damaging Het
Nynrin A G 14: 56,101,049 (GRCm39) T280A probably benign Het
Or1o2 A G 17: 37,542,434 (GRCm39) Y276H probably damaging Het
Or2b28 T A 13: 21,531,116 (GRCm39) I6N probably benign Het
Or2w2 A G 13: 21,758,426 (GRCm39) F67L probably benign Het
Or55b10 A G 7: 102,143,266 (GRCm39) S239P possibly damaging Het
Otog G A 7: 45,895,707 (GRCm39) C107Y probably damaging Het
Ptprn A G 1: 75,230,766 (GRCm39) V565A probably benign Het
Rbm6 T G 9: 107,730,102 (GRCm39) D182A probably damaging Het
Rhbg A G 3: 88,151,859 (GRCm39) F400L probably benign Het
Rpl22l1 T A 3: 28,860,738 (GRCm39) N33K possibly damaging Het
Rtp1 T A 16: 23,249,959 (GRCm39) I108N probably damaging Het
Sema6b A T 17: 56,439,797 (GRCm39) F15I probably benign Het
Sirpa C T 2: 129,458,296 (GRCm39) T304I possibly damaging Het
Slc22a29 A G 19: 8,184,430 (GRCm39) I257T probably benign Het
Slc41a1 T C 1: 131,768,938 (GRCm39) I256T probably damaging Het
Smg6 A G 11: 75,033,674 (GRCm39) K1208R probably damaging Het
Sorcs1 G T 19: 50,210,633 (GRCm39) P744Q probably damaging Het
Sptbn5 T C 2: 119,900,943 (GRCm39) T213A probably benign Het
St18 A G 1: 6,872,936 (GRCm39) T224A probably benign Het
Stat3 T C 11: 100,785,655 (GRCm39) N465S probably damaging Het
Stmn2 T A 3: 8,610,636 (GRCm39) M40K probably benign Het
Tespa1 A G 10: 130,184,108 (GRCm39) D63G probably benign Het
Thrb T A 14: 18,008,674 (GRCm38) C133S probably damaging Het
Tmem25 C T 9: 44,707,780 (GRCm39) V172M possibly damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trhde T A 10: 114,636,754 (GRCm39) Y151F probably damaging Het
Trp53bp2 A G 1: 182,280,229 (GRCm39) T912A probably damaging Het
Unc79 C A 12: 103,135,951 (GRCm39) A2269E probably damaging Het
Zfp507 C T 7: 35,493,150 (GRCm39) R631Q probably damaging Het
Zfp758 T G 17: 22,594,823 (GRCm39) S436R probably damaging Het
Zfp791 G T 8: 85,837,312 (GRCm39) T184K probably benign Het
Znrf3 A G 11: 5,231,062 (GRCm39) V817A probably benign Het
Other mutations in Or5b109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01131:Or5b109 APN 19 13,212,103 (GRCm39) missense probably benign 0.01
IGL02596:Or5b109 APN 19 13,211,763 (GRCm39) missense probably damaging 1.00
IGL03030:Or5b109 APN 19 13,212,418 (GRCm39) missense probably damaging 0.98
IGL03232:Or5b109 APN 19 13,212,341 (GRCm39) nonsense probably null
IGL03380:Or5b109 APN 19 13,212,365 (GRCm39) missense probably benign 0.00
PIT4382001:Or5b109 UTSW 19 13,212,259 (GRCm39) missense probably damaging 1.00
PIT4519001:Or5b109 UTSW 19 13,212,216 (GRCm39) missense probably benign 0.00
R0652:Or5b109 UTSW 19 13,211,899 (GRCm39) missense possibly damaging 0.80
R0658:Or5b109 UTSW 19 13,212,424 (GRCm39) missense possibly damaging 0.94
R1181:Or5b109 UTSW 19 13,212,195 (GRCm39) missense probably benign 0.07
R1239:Or5b109 UTSW 19 13,212,040 (GRCm39) missense possibly damaging 0.80
R1316:Or5b109 UTSW 19 13,211,803 (GRCm39) missense probably damaging 1.00
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1900:Or5b109 UTSW 19 13,212,277 (GRCm39) missense possibly damaging 0.54
R2239:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R2380:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R3760:Or5b109 UTSW 19 13,212,250 (GRCm39) missense probably damaging 1.00
R3765:Or5b109 UTSW 19 13,211,795 (GRCm39) missense probably damaging 1.00
R3835:Or5b109 UTSW 19 13,212,103 (GRCm39) missense probably benign 0.18
R4690:Or5b109 UTSW 19 13,212,132 (GRCm39) missense possibly damaging 0.91
R4907:Or5b109 UTSW 19 13,212,157 (GRCm39) missense probably damaging 1.00
R5444:Or5b109 UTSW 19 13,212,322 (GRCm39) missense probably benign 0.28
R5465:Or5b109 UTSW 19 13,212,052 (GRCm39) missense probably benign 0.00
R6083:Or5b109 UTSW 19 13,211,889 (GRCm39) missense probably benign 0.01
R6259:Or5b109 UTSW 19 13,211,785 (GRCm39) missense probably damaging 0.98
R6324:Or5b109 UTSW 19 13,212,468 (GRCm39) missense possibly damaging 0.95
R6561:Or5b109 UTSW 19 13,212,394 (GRCm39) missense probably damaging 1.00
R6845:Or5b109 UTSW 19 13,211,997 (GRCm39) missense probably damaging 1.00
R7260:Or5b109 UTSW 19 13,212,388 (GRCm39) missense probably damaging 0.98
R7843:Or5b109 UTSW 19 13,211,901 (GRCm39) missense possibly damaging 0.48
R8560:Or5b109 UTSW 19 13,211,656 (GRCm39) missense possibly damaging 0.91
R8719:Or5b109 UTSW 19 13,211,836 (GRCm39) missense probably damaging 0.97
R9207:Or5b109 UTSW 19 13,212,400 (GRCm39) missense possibly damaging 0.60
R9273:Or5b109 UTSW 19 13,212,268 (GRCm39) missense probably damaging 1.00
R9607:Or5b109 UTSW 19 13,211,953 (GRCm39) missense
X0063:Or5b109 UTSW 19 13,211,999 (GRCm39) missense probably damaging 1.00
X0067:Or5b109 UTSW 19 13,212,061 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CGGATAGGCATATCAATGAGCTAGTAC -3'
(R):5'- GGCAAGAATAAGAACTCACATCATG -3'

Sequencing Primer
(F):5'- AGCTAGTACTTATTTATCTAGCCAGC -3'
(R):5'- TTAATATTATGGAGAATGCCAGGGCC -3'
Posted On 2014-07-14