Mutagenetix > Incidental Mutation

Incidental Mutation 'R1932:Dchs1'

215471

Institutional Source

Beutler Lab

Gene Symbol

Dchs1

Ensembl Gene

ENSMUSG00000036862

Gene Name

dachsous cadherin related 1

Synonyms

C130033F22Rik, 3110041P15Rik

MMRRC Submission

039950-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1932 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105402197-105436861 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 105415109 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 692 (S692G)

Ref Sequence

ENSEMBL: ENSMUSP00000077574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078482]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000078482
AA Change: S692G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: S692G

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
CA	58	135	5.2e-11	SMART
CA	159	247	6.1e-17	SMART
CA	271	354	2.6e-30	SMART
CA	382	464	7.8e-26	SMART
CA	489	570	1.2e-34	SMART
CA	594	677	1.9e-27	SMART
CA	701	782	5.3e-11	SMART
CA	806	886	1e-12	SMART
CA	910	990	3.3e-14	SMART
CA	1016	1097	3.6e-18	SMART
CA	1121	1203	3.1e-34	SMART
CA	1233	1307	8.8e-16	SMART
low complexity region	1323	1335	N/A	INTRINSIC
CA	1344	1427	9.9e-9	SMART
CA	1451	1537	1.5e-23	SMART
CA	1560	1640	7.2e-32	SMART
CA	1664	1742	1.8e-31	SMART
CA	1765	1846	7.8e-30	SMART
CA	1870	1951	3.7e-26	SMART
low complexity region	1957	1965	N/A	INTRINSIC
CA	1979	2059	1.1e-6	SMART
CA	2083	2162	2.7e-18	SMART
CA	2186	2268	2.2e-26	SMART
CA	2291	2367	1e-18	SMART
CA	2391	2473	1.8e-23	SMART
CA	2497	2593	3.5e-21	SMART
CA	2617	2697	1.2e-25	SMART
CA	2721	2804	1.9e-18	SMART
CA	2828	2919	3e-3	SMART
transmembrane domain	2932	2954	N/A	INTRINSIC
low complexity region	3001	3017	N/A	INTRINSIC
low complexity region	3046	3055	N/A	INTRINSIC
low complexity region	3088	3097	N/A	INTRINSIC
low complexity region	3185	3196	N/A	INTRINSIC
low complexity region	3237	3259	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131504

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154659

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.6%
20x: 93.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg4	T	A	9: 44,190,691 (GRCm39)	Q278H	probably benign	Het
Ace3	T	C	11: 105,895,436 (GRCm39)		probably null	Het
Aco1	T	C	4: 40,176,499 (GRCm39)	V221A	probably damaging	Het
Adamts20	T	A	15: 94,301,891 (GRCm39)	H27L	probably benign	Het
Adamts8	A	G	9: 30,867,808 (GRCm39)	D544G	probably benign	Het
Angptl4	C	A	17: 34,000,249 (GRCm39)	E40*	probably null	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
Atf7ip2	T	A	16: 10,059,567 (GRCm39)	I369N	possibly damaging	Het
Atp6ap1l	T	A	13: 91,031,806 (GRCm39)	Y292F	probably damaging	Het
Atp6v1b2	A	T	8: 69,555,459 (GRCm39)	K217*	probably null	Het
Bid	C	T	6: 120,874,216 (GRCm39)	A110T	possibly damaging	Het
Blvra	T	A	2: 126,937,068 (GRCm39)	W174R	probably damaging	Het
Catsperg1	C	T	7: 28,897,568 (GRCm39)	G239R	probably damaging	Het
Ccdc157	G	T	11: 4,096,549 (GRCm39)	A400D	probably damaging	Het
Chd2	G	T	7: 73,104,193 (GRCm39)	P1298T	probably damaging	Het
CK137956	G	A	4: 127,840,651 (GRCm39)	L352F	possibly damaging	Het
Col22a1	G	A	15: 71,741,989 (GRCm39)	P503S	unknown	Het
Cox15	C	T	19: 43,735,224 (GRCm39)	R181H	probably benign	Het
Crem	C	T	18: 3,299,284 (GRCm39)	G47R	probably benign	Het
Crygs	T	A	16: 22,625,304 (GRCm39)	T46S	probably benign	Het
Cts8	T	A	13: 61,401,429 (GRCm39)	H62L	probably damaging	Het
Cyp4a32	T	A	4: 115,468,474 (GRCm39)	F319I	possibly damaging	Het
Ddx23	G	A	15: 98,548,599 (GRCm39)	R370W	possibly damaging	Het
Defa29	A	T	8: 21,816,865 (GRCm39)	S43T	probably damaging	Het
Dnajc14	A	G	10: 128,652,661 (GRCm39)	D573G	probably damaging	Het
Drd5	A	G	5: 38,477,319 (GRCm39)	Y104C	probably benign	Het
Efcab7	C	T	4: 99,768,215 (GRCm39)	P102L	probably damaging	Het
Efhc1	A	G	1: 21,037,624 (GRCm39)	Y267C	probably damaging	Het
Eif2ak4	T	C	2: 118,278,967 (GRCm39)	Y243H	probably damaging	Het
Gfm2	T	A	13: 97,278,475 (GRCm39)	I7N	probably damaging	Het
Gmds	A	G	13: 32,311,980 (GRCm39)	F150L	possibly damaging	Het
Gp2	T	C	7: 119,053,455 (GRCm39)	T169A	possibly damaging	Het
Grb14	A	G	2: 64,743,146 (GRCm39)	F508L	probably damaging	Het
Hdac5	T	A	11: 102,086,698 (GRCm39)		probably benign	Het
Heatr1	T	A	13: 12,450,066 (GRCm39)	M620K	probably damaging	Het
Herc3	A	G	6: 58,853,778 (GRCm39)	E608G	probably damaging	Het
Hoxb4	T	C	11: 96,210,867 (GRCm39)	Y156H	probably damaging	Het
Ifi205	T	A	1: 173,855,980 (GRCm39)	I17F	possibly damaging	Het
Il2rb	A	T	15: 78,375,977 (GRCm39)	S25T	possibly damaging	Het
Kansl1	T	C	11: 104,225,923 (GRCm39)	T998A	probably damaging	Het
Kcna6	G	T	6: 126,715,451 (GRCm39)	H479Q	probably benign	Het
Kif2a	T	C	13: 107,114,599 (GRCm39)	K350R	probably benign	Het
Lct	G	T	1: 128,221,898 (GRCm39)	A1547E	probably damaging	Het
Lhx9	T	A	1: 138,769,747 (GRCm39)		probably benign	Het
Lingo1	T	A	9: 56,526,934 (GRCm39)	I552F	possibly damaging	Het
Lrp4	G	A	2: 91,327,700 (GRCm39)	W1516*	probably null	Het
Lrp5	C	T	19: 3,660,131 (GRCm39)	V978I	probably benign	Het
Ltbp1	T	A	17: 75,620,029 (GRCm39)	D719E	probably benign	Het
Ltbp4	A	G	7: 27,007,191 (GRCm39)		probably null	Het
Macf1	A	G	4: 123,345,830 (GRCm39)	I1326T	probably damaging	Het
Manba	T	C	3: 135,250,501 (GRCm39)	F376S	probably benign	Het
Mink1	T	C	11: 70,499,254 (GRCm39)		probably null	Het
Nfatc2ip	C	T	7: 125,984,164 (GRCm39)	V410I	probably damaging	Het
Nlrp1b	A	T	11: 71,072,964 (GRCm39)	I293N	probably damaging	Het
Or10aa3	T	C	1: 173,878,244 (GRCm39)	Y102H	probably damaging	Het
Otol1	A	C	3: 69,935,437 (GRCm39)	E476D	probably benign	Het
Pcdhb4	C	T	18: 37,442,594 (GRCm39)	P635S	probably benign	Het
Pfkfb4	T	A	9: 108,828,237 (GRCm39)	F91I	probably damaging	Het
Polq	G	A	16: 36,882,666 (GRCm39)	R1610Q	possibly damaging	Het
Polr3c	A	T	3: 96,626,614 (GRCm39)	L270H	probably damaging	Het
Ppp1r15b	C	T	1: 133,059,363 (GRCm39)		probably benign	Het
Prkca	T	G	11: 108,082,975 (GRCm39)	D90A	probably benign	Het
Sall3	T	C	18: 81,012,968 (GRCm39)	D1156G	probably benign	Het
Scn7a	A	T	2: 66,506,446 (GRCm39)	L1481H	probably damaging	Het
Selenon	A	T	4: 134,271,929 (GRCm39)	I292N	probably damaging	Het
Sema6d	T	A	2: 124,501,806 (GRCm39)		probably null	Het
Sgpp1	G	T	12: 75,762,953 (GRCm39)	Y409*	probably null	Het
Sh3pxd2a	A	G	19: 47,255,947 (GRCm39)	S924P	probably benign	Het
Slc25a13	A	G	6: 6,042,264 (GRCm39)	V638A	probably benign	Het
Snhg11	T	C	2: 158,218,746 (GRCm39)		probably benign	Het
Sorbs2	A	G	8: 46,249,389 (GRCm39)	Q800R	probably benign	Het
Srf	C	A	17: 46,860,912 (GRCm39)	G401C	probably damaging	Het
Stradb	A	C	1: 59,030,264 (GRCm39)	N173H	probably benign	Het
Swap70	C	T	7: 109,878,470 (GRCm39)	A480V	possibly damaging	Het
Sycp2	A	G	2: 178,023,750 (GRCm39)	V422A	probably damaging	Het
Taf4	G	A	2: 179,573,822 (GRCm39)	T682M	probably damaging	Het
Tet3	T	C	6: 83,381,361 (GRCm39)	N269S	possibly damaging	Het
Thap12	A	T	7: 98,366,045 (GRCm39)	I738F	possibly damaging	Het
Tiam2	C	T	17: 3,565,000 (GRCm39)	R1413C	possibly damaging	Het
Tmem229a	A	T	6: 24,955,010 (GRCm39)	F248Y	probably damaging	Het
Tmprss7	G	A	16: 45,504,956 (GRCm39)	Q145*	probably null	Het
Tnc	A	T	4: 63,911,262 (GRCm39)		probably null	Het
Tonsl	A	T	15: 76,508,797 (GRCm39)	Y21N	probably damaging	Het
Tpr	A	G	1: 150,297,414 (GRCm39)	D1009G	probably benign	Het
Trpm2	G	A	10: 77,776,992 (GRCm39)	A435V	probably damaging	Het
Ubr3	T	A	2: 69,783,820 (GRCm39)		probably null	Het
Vcan	T	C	13: 89,853,653 (GRCm39)	N436D	possibly damaging	Het
Vmn2r104	T	A	17: 20,261,031 (GRCm39)	Y464F	probably damaging	Het
Vmn2r44	T	A	7: 8,370,981 (GRCm39)	R688S	probably benign	Het
Wdr74	G	T	19: 8,715,311 (GRCm39)	V157L	probably benign	Het
Wnt7a	T	A	6: 91,371,530 (GRCm39)	D144V	probably benign	Het
Zfp106	C	T	2: 120,362,162 (GRCm39)	A986T	possibly damaging	Het

Other mutations in Dchs1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Dchs1	APN	7	105,407,950 (GRCm39)	missense	probably damaging	1.00
IGL00422:Dchs1	APN	7	105,407,236 (GRCm39)	missense	possibly damaging	0.88
IGL00427:Dchs1	APN	7	105,407,631 (GRCm39)	missense	probably damaging	0.98
IGL00469:Dchs1	APN	7	105,404,468 (GRCm39)	missense	probably damaging	1.00
IGL00470:Dchs1	APN	7	105,407,414 (GRCm39)	missense	probably damaging	1.00
IGL00534:Dchs1	APN	7	105,407,150 (GRCm39)	missense	probably benign
IGL01292:Dchs1	APN	7	105,410,098 (GRCm39)	missense	probably damaging	0.98
IGL01380:Dchs1	APN	7	105,411,418 (GRCm39)	missense	probably damaging	1.00
IGL01396:Dchs1	APN	7	105,421,490 (GRCm39)	missense	probably damaging	1.00
IGL01448:Dchs1	APN	7	105,421,134 (GRCm39)	missense	probably damaging	0.98
IGL01759:Dchs1	APN	7	105,404,509 (GRCm39)	missense	probably benign	0.00
IGL01829:Dchs1	APN	7	105,404,604 (GRCm39)	missense	probably damaging	0.99
IGL01946:Dchs1	APN	7	105,408,312 (GRCm39)	missense	probably damaging	1.00
IGL01955:Dchs1	APN	7	105,406,798 (GRCm39)	missense	probably benign	0.00
IGL02012:Dchs1	APN	7	105,413,504 (GRCm39)	missense	probably damaging	0.98
IGL02222:Dchs1	APN	7	105,414,094 (GRCm39)	missense	probably damaging	1.00
IGL02261:Dchs1	APN	7	105,421,776 (GRCm39)	missense	probably damaging	1.00
IGL02365:Dchs1	APN	7	105,404,395 (GRCm39)	missense	probably benign	0.22
IGL02430:Dchs1	APN	7	105,421,178 (GRCm39)	missense	probably benign	0.34
IGL02500:Dchs1	APN	7	105,405,013 (GRCm39)	missense	probably benign
IGL02741:Dchs1	APN	7	105,406,530 (GRCm39)	missense	probably damaging	1.00
IGL02890:Dchs1	APN	7	105,405,698 (GRCm39)	missense	probably damaging	1.00
IGL03213:Dchs1	APN	7	105,404,279 (GRCm39)	missense	probably damaging	1.00
G1patch:Dchs1	UTSW	7	105,408,000 (GRCm39)	missense	probably damaging	0.99
P0026:Dchs1	UTSW	7	105,407,612 (GRCm39)	missense	probably damaging	0.99
PIT4377001:Dchs1	UTSW	7	105,406,795 (GRCm39)	missense	probably damaging	1.00
PIT4791001:Dchs1	UTSW	7	105,408,178 (GRCm39)	missense	probably damaging	1.00
R0013:Dchs1	UTSW	7	105,405,043 (GRCm39)	missense	possibly damaging	0.90
R0090:Dchs1	UTSW	7	105,405,139 (GRCm39)	missense	probably benign	0.18
R0091:Dchs1	UTSW	7	105,415,301 (GRCm39)	splice site	probably benign
R0193:Dchs1	UTSW	7	105,414,190 (GRCm39)	missense	probably benign	0.40
R0395:Dchs1	UTSW	7	105,407,745 (GRCm39)	missense	probably damaging	1.00
R0448:Dchs1	UTSW	7	105,415,134 (GRCm39)	missense	probably benign	0.00
R0480:Dchs1	UTSW	7	105,420,696 (GRCm39)	missense	probably benign	0.14
R0485:Dchs1	UTSW	7	105,421,934 (GRCm39)	missense	probably benign	0.00
R0566:Dchs1	UTSW	7	105,408,402 (GRCm39)	missense	probably benign	0.00
R0571:Dchs1	UTSW	7	105,421,203 (GRCm39)	missense	probably damaging	1.00
R0573:Dchs1	UTSW	7	105,407,985 (GRCm39)	missense	probably damaging	0.98
R0577:Dchs1	UTSW	7	105,413,462 (GRCm39)	missense	possibly damaging	0.78
R0622:Dchs1	UTSW	7	105,412,656 (GRCm39)	missense	probably damaging	1.00
R0654:Dchs1	UTSW	7	105,421,556 (GRCm39)	missense	probably damaging	1.00
R0677:Dchs1	UTSW	7	105,414,191 (GRCm39)	missense	probably damaging	1.00
R1171:Dchs1	UTSW	7	105,406,921 (GRCm39)	missense	probably benign
R1241:Dchs1	UTSW	7	105,407,385 (GRCm39)	missense	probably damaging	1.00
R1389:Dchs1	UTSW	7	105,404,778 (GRCm39)	missense	probably benign	0.40
R1427:Dchs1	UTSW	7	105,415,398 (GRCm39)	missense	probably benign	0.06
R1458:Dchs1	UTSW	7	105,404,451 (GRCm39)	missense	probably damaging	1.00
R1513:Dchs1	UTSW	7	105,421,278 (GRCm39)	nonsense	probably null
R1524:Dchs1	UTSW	7	105,413,732 (GRCm39)	missense	probably damaging	1.00
R1525:Dchs1	UTSW	7	105,408,138 (GRCm39)	missense	probably damaging	1.00
R1534:Dchs1	UTSW	7	105,421,247 (GRCm39)	missense	probably damaging	0.98
R1567:Dchs1	UTSW	7	105,421,068 (GRCm39)	missense	probably benign	0.01
R1577:Dchs1	UTSW	7	105,415,162 (GRCm39)	missense	probably damaging	1.00
R1603:Dchs1	UTSW	7	105,411,977 (GRCm39)	missense	probably benign	0.24
R1676:Dchs1	UTSW	7	105,404,128 (GRCm39)	missense	probably benign	0.40
R1794:Dchs1	UTSW	7	105,420,927 (GRCm39)	missense	probably benign	0.02
R1826:Dchs1	UTSW	7	105,406,834 (GRCm39)	missense	probably damaging	1.00
R1892:Dchs1	UTSW	7	105,413,363 (GRCm39)	missense	probably benign	0.00
R1924:Dchs1	UTSW	7	105,421,487 (GRCm39)	missense	possibly damaging	0.81
R1962:Dchs1	UTSW	7	105,413,408 (GRCm39)	missense	probably damaging	1.00
R1985:Dchs1	UTSW	7	105,421,605 (GRCm39)	missense	possibly damaging	0.72
R1993:Dchs1	UTSW	7	105,411,755 (GRCm39)	missense	probably benign	0.00
R2007:Dchs1	UTSW	7	105,404,532 (GRCm39)	missense	probably damaging	1.00
R2316:Dchs1	UTSW	7	105,413,411 (GRCm39)	missense	possibly damaging	0.71
R2351:Dchs1	UTSW	7	105,403,301 (GRCm39)	missense	probably benign
R2474:Dchs1	UTSW	7	105,422,045 (GRCm39)	missense	probably damaging	1.00
R2474:Dchs1	UTSW	7	105,404,281 (GRCm39)	missense	probably benign	0.37
R3429:Dchs1	UTSW	7	105,405,711 (GRCm39)	missense	possibly damaging	0.85
R3430:Dchs1	UTSW	7	105,405,711 (GRCm39)	missense	possibly damaging	0.85
R3737:Dchs1	UTSW	7	105,411,523 (GRCm39)	missense	possibly damaging	0.88
R3767:Dchs1	UTSW	7	105,406,292 (GRCm39)	missense	possibly damaging	0.67
R3874:Dchs1	UTSW	7	105,410,842 (GRCm39)	missense	probably damaging	1.00
R3883:Dchs1	UTSW	7	105,411,770 (GRCm39)	missense	probably damaging	1.00
R4105:Dchs1	UTSW	7	105,414,347 (GRCm39)	missense	probably damaging	1.00
R4209:Dchs1	UTSW	7	105,415,397 (GRCm39)	missense	probably damaging	0.99
R4329:Dchs1	UTSW	7	105,402,966 (GRCm39)	missense	probably damaging	1.00
R4516:Dchs1	UTSW	7	105,404,059 (GRCm39)	missense	probably damaging	1.00
R4579:Dchs1	UTSW	7	105,408,180 (GRCm39)	missense	probably benign
R4579:Dchs1	UTSW	7	105,403,972 (GRCm39)	missense	probably damaging	1.00
R4588:Dchs1	UTSW	7	105,405,248 (GRCm39)	missense	probably benign
R4613:Dchs1	UTSW	7	105,421,931 (GRCm39)	missense	probably damaging	1.00
R4632:Dchs1	UTSW	7	105,403,562 (GRCm39)	missense	probably benign	0.02
R4696:Dchs1	UTSW	7	105,413,834 (GRCm39)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,414,759 (GRCm39)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,404,460 (GRCm39)	missense	probably damaging	0.98
R4738:Dchs1	UTSW	7	105,407,880 (GRCm39)	missense	probably damaging	0.96
R4768:Dchs1	UTSW	7	105,420,827 (GRCm39)	missense	possibly damaging	0.96
R4784:Dchs1	UTSW	7	105,415,133 (GRCm39)	missense	probably damaging	1.00
R4864:Dchs1	UTSW	7	105,404,460 (GRCm39)	missense	probably damaging	0.98
R4880:Dchs1	UTSW	7	105,404,937 (GRCm39)	missense	probably benign	0.00
R4909:Dchs1	UTSW	7	105,415,462 (GRCm39)	missense	probably damaging	1.00
R5102:Dchs1	UTSW	7	105,421,384 (GRCm39)	missense	probably benign	0.09
R5109:Dchs1	UTSW	7	105,414,221 (GRCm39)	missense	probably benign
R5126:Dchs1	UTSW	7	105,402,724 (GRCm39)	missense	probably damaging	1.00
R5149:Dchs1	UTSW	7	105,404,865 (GRCm39)	missense	probably damaging	0.98
R5330:Dchs1	UTSW	7	105,403,809 (GRCm39)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,421,262 (GRCm39)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,407,236 (GRCm39)	missense	probably damaging	1.00
R5386:Dchs1	UTSW	7	105,407,236 (GRCm39)	missense	probably damaging	1.00
R5622:Dchs1	UTSW	7	105,404,500 (GRCm39)	missense	probably benign	0.11
R5623:Dchs1	UTSW	7	105,421,976 (GRCm39)	missense	probably damaging	1.00
R5708:Dchs1	UTSW	7	105,422,016 (GRCm39)	missense	probably damaging	1.00
R5718:Dchs1	UTSW	7	105,404,955 (GRCm39)	missense	probably benign	0.01
R5743:Dchs1	UTSW	7	105,420,803 (GRCm39)	missense	probably benign
R5759:Dchs1	UTSW	7	105,413,383 (GRCm39)	missense	probably damaging	0.99
R5772:Dchs1	UTSW	7	105,422,247 (GRCm39)	missense	probably damaging	1.00
R5860:Dchs1	UTSW	7	105,421,242 (GRCm39)	missense	probably damaging	1.00
R5916:Dchs1	UTSW	7	105,408,373 (GRCm39)	missense	probably damaging	1.00
R5965:Dchs1	UTSW	7	105,405,132 (GRCm39)	missense	probably damaging	1.00
R5997:Dchs1	UTSW	7	105,403,302 (GRCm39)	missense	probably benign	0.08
R6065:Dchs1	UTSW	7	105,404,628 (GRCm39)	missense	probably damaging	1.00
R6136:Dchs1	UTSW	7	105,410,132 (GRCm39)	missense	probably benign
R6137:Dchs1	UTSW	7	105,414,313 (GRCm39)	missense	probably damaging	0.99
R6324:Dchs1	UTSW	7	105,414,145 (GRCm39)	missense	probably benign	0.05
R6363:Dchs1	UTSW	7	105,407,679 (GRCm39)	missense	probably benign	0.12
R6466:Dchs1	UTSW	7	105,413,748 (GRCm39)	missense	probably benign	0.09
R6544:Dchs1	UTSW	7	105,407,385 (GRCm39)	missense	probably damaging	1.00
R6572:Dchs1	UTSW	7	105,408,013 (GRCm39)	missense	possibly damaging	0.94
R6579:Dchs1	UTSW	7	105,412,120 (GRCm39)	missense	probably benign	0.17
R6632:Dchs1	UTSW	7	105,411,085 (GRCm39)	missense	probably damaging	1.00
R6725:Dchs1	UTSW	7	105,408,000 (GRCm39)	missense	probably damaging	0.99
R6789:Dchs1	UTSW	7	105,406,210 (GRCm39)	missense	possibly damaging	0.61
R6868:Dchs1	UTSW	7	105,412,710 (GRCm39)	missense	possibly damaging	0.91
R7058:Dchs1	UTSW	7	105,406,228 (GRCm39)	missense	probably benign
R7064:Dchs1	UTSW	7	105,412,392 (GRCm39)	missense	probably damaging	0.99
R7076:Dchs1	UTSW	7	105,411,078 (GRCm39)	missense	probably benign	0.04
R7191:Dchs1	UTSW	7	105,414,646 (GRCm39)	missense	possibly damaging	0.89
R7298:Dchs1	UTSW	7	105,404,338 (GRCm39)	nonsense	probably null
R7380:Dchs1	UTSW	7	105,407,835 (GRCm39)	missense	probably benign	0.35
R7438:Dchs1	UTSW	7	105,404,155 (GRCm39)	missense	probably benign	0.30
R7496:Dchs1	UTSW	7	105,411,066 (GRCm39)	missense	probably damaging	1.00
R7534:Dchs1	UTSW	7	105,421,580 (GRCm39)	missense	probably benign	0.00
R7604:Dchs1	UTSW	7	105,415,189 (GRCm39)	missense	probably damaging	1.00
R7631:Dchs1	UTSW	7	105,408,445 (GRCm39)	missense	probably benign
R7821:Dchs1	UTSW	7	105,414,352 (GRCm39)	missense	probably benign	0.00
R7834:Dchs1	UTSW	7	105,414,774 (GRCm39)	missense	probably benign	0.39
R7841:Dchs1	UTSW	7	105,412,180 (GRCm39)	missense	probably benign
R7913:Dchs1	UTSW	7	105,408,435 (GRCm39)	missense	possibly damaging	0.61
R8041:Dchs1	UTSW	7	105,404,395 (GRCm39)	missense	probably benign	0.45
R8076:Dchs1	UTSW	7	105,411,189 (GRCm39)	missense	probably damaging	1.00
R8076:Dchs1	UTSW	7	105,405,128 (GRCm39)	missense	possibly damaging	0.52
R8087:Dchs1	UTSW	7	105,402,706 (GRCm39)	missense	probably benign	0.41
R8125:Dchs1	UTSW	7	105,414,089 (GRCm39)	missense	possibly damaging	0.91
R8223:Dchs1	UTSW	7	105,411,824 (GRCm39)	missense	possibly damaging	0.81
R8239:Dchs1	UTSW	7	105,414,718 (GRCm39)	missense	probably benign	0.22
R8476:Dchs1	UTSW	7	105,408,015 (GRCm39)	missense	probably benign	0.05
R8497:Dchs1	UTSW	7	105,408,168 (GRCm39)	missense	probably damaging	1.00
R8770:Dchs1	UTSW	7	105,420,945 (GRCm39)	missense	probably damaging	1.00
R8856:Dchs1	UTSW	7	105,410,064 (GRCm39)	missense	probably damaging	1.00
R8866:Dchs1	UTSW	7	105,404,597 (GRCm39)	missense	probably benign	0.00
R8948:Dchs1	UTSW	7	105,408,212 (GRCm39)	missense	probably benign	0.30
R8950:Dchs1	UTSW	7	105,408,212 (GRCm39)	missense	probably benign	0.30
R9029:Dchs1	UTSW	7	105,402,919 (GRCm39)	missense	probably benign	0.13
R9039:Dchs1	UTSW	7	105,405,215 (GRCm39)	missense	probably benign	0.11
R9081:Dchs1	UTSW	7	105,403,636 (GRCm39)	missense	probably benign	0.00
R9134:Dchs1	UTSW	7	105,404,910 (GRCm39)	missense	probably damaging	0.96
R9159:Dchs1	UTSW	7	105,415,126 (GRCm39)	missense	probably benign
R9162:Dchs1	UTSW	7	105,414,732 (GRCm39)	missense	probably damaging	1.00
R9169:Dchs1	UTSW	7	105,422,114 (GRCm39)	missense	probably damaging	1.00
R9262:Dchs1	UTSW	7	105,404,833 (GRCm39)	missense	probably damaging	1.00
R9292:Dchs1	UTSW	7	105,403,120 (GRCm39)	missense	probably damaging	1.00
R9325:Dchs1	UTSW	7	105,415,402 (GRCm39)	missense	possibly damaging	0.51
R9376:Dchs1	UTSW	7	105,414,981 (GRCm39)	critical splice donor site	probably null
R9392:Dchs1	UTSW	7	105,421,869 (GRCm39)	missense	probably benign	0.09
R9619:Dchs1	UTSW	7	105,413,662 (GRCm39)	missense	probably benign	0.07
R9680:Dchs1	UTSW	7	105,411,625 (GRCm39)	missense	probably damaging	1.00
R9687:Dchs1	UTSW	7	105,407,191 (GRCm39)	missense	probably damaging	0.99
R9747:Dchs1	UTSW	7	105,412,682 (GRCm39)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,406,900 (GRCm39)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,407,758 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTCAACAGCCCTGGAGAAG -3'
(R):5'- CTTCACGGTGACAGCTATCG -3'

Sequencing Primer
(F):5'- TCCTGGAAAGAGGAGACAATATTTAG -3'
(R):5'- CGGTGACAGCTATCGATGGG -3'

Posted On

2014-07-14