Incidental Mutation 'R1932:Mink1'
| ID |
215489 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mink1
|
| Ensembl Gene |
ENSMUSG00000020827 |
| Gene Name |
misshapen-like kinase 1 (zebrafish) |
| Synonyms |
Misshapen/NIKs-related kinase, Map4k6, Ysk2, MINK |
| MMRRC Submission |
039950-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1932 (G1)
|
| Quality Score |
221 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
70453707-70505309 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 70499254 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072237]
[ENSMUST00000072237]
[ENSMUST00000072873]
[ENSMUST00000072873]
[ENSMUST00000079244]
[ENSMUST00000079244]
[ENSMUST00000102558]
[ENSMUST00000102558]
[ENSMUST00000102559]
[ENSMUST00000102559]
|
| AlphaFold |
Q9JM52 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000072237
|
| SMART Domains |
Protein: ENSMUSP00000072091
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
874 |
N/A |
INTRINSIC |
|
CNH
|
1026 |
1324 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000072237
|
| SMART Domains |
Protein: ENSMUSP00000072091
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
874 |
N/A |
INTRINSIC |
|
CNH
|
1026 |
1324 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000072873
|
| SMART Domains |
Protein: ENSMUSP00000072649
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
853 |
N/A |
INTRINSIC |
|
CNH
|
1019 |
1317 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000072873
|
| SMART Domains |
Protein: ENSMUSP00000072649
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
853 |
N/A |
INTRINSIC |
|
CNH
|
1019 |
1317 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000079244
|
| SMART Domains |
Protein: ENSMUSP00000078234
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
314 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
348 |
493 |
N/A |
INTRINSIC |
|
low complexity region
|
554 |
566 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
656 |
N/A |
INTRINSIC |
|
low complexity region
|
716 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
826 |
850 |
N/A |
INTRINSIC |
|
CNH
|
1016 |
1314 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000079244
|
| SMART Domains |
Protein: ENSMUSP00000078234
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
314 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
348 |
493 |
N/A |
INTRINSIC |
|
low complexity region
|
554 |
566 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
656 |
N/A |
INTRINSIC |
|
low complexity region
|
716 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
826 |
850 |
N/A |
INTRINSIC |
|
CNH
|
1016 |
1314 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102558
|
| SMART Domains |
Protein: ENSMUSP00000099618
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
816 |
N/A |
INTRINSIC |
|
CNH
|
982 |
1280 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102558
|
| SMART Domains |
Protein: ENSMUSP00000099618
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
816 |
N/A |
INTRINSIC |
|
CNH
|
982 |
1280 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102559
|
| SMART Domains |
Protein: ENSMUSP00000099619
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
800 |
824 |
N/A |
INTRINSIC |
|
CNH
|
990 |
1288 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000102559
|
| SMART Domains |
Protein: ENSMUSP00000099619
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
800 |
824 |
N/A |
INTRINSIC |
|
CNH
|
990 |
1288 |
1.58e-113 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125853
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132208
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000136663
|
| SMART Domains |
Protein: ENSMUSP00000117959
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
1 |
140 |
2.3e-22 |
PFAM |
|
Pfam:Pkinase
|
1 |
143 |
1.6e-30 |
PFAM |
|
low complexity region
|
161 |
192 |
N/A |
INTRINSIC |
|
coiled coil region
|
204 |
349 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
423 |
N/A |
INTRINSIC |
|
low complexity region
|
474 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
500 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
728 |
N/A |
INTRINSIC |
|
CNH
|
880 |
1178 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000136663
|
| SMART Domains |
Protein: ENSMUSP00000117959
Gene: ENSMUSG00000020827
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
1 |
140 |
2.3e-22 |
PFAM |
|
Pfam:Pkinase
|
1 |
143 |
1.6e-30 |
PFAM |
|
low complexity region
|
161 |
192 |
N/A |
INTRINSIC |
|
coiled coil region
|
204 |
349 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
423 |
N/A |
INTRINSIC |
|
low complexity region
|
474 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
500 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
728 |
N/A |
INTRINSIC |
|
CNH
|
880 |
1178 |
1.58e-113 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142650
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133310
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153503
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152857
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149845
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178764
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
T |
A |
9: 44,190,691 (GRCm39) |
Q278H |
probably benign |
Het |
| Ace3 |
T |
C |
11: 105,895,436 (GRCm39) |
|
probably null |
Het |
| Aco1 |
T |
C |
4: 40,176,499 (GRCm39) |
V221A |
probably damaging |
Het |
| Adamts20 |
T |
A |
15: 94,301,891 (GRCm39) |
H27L |
probably benign |
Het |
| Adamts8 |
A |
G |
9: 30,867,808 (GRCm39) |
D544G |
probably benign |
Het |
| Angptl4 |
C |
A |
17: 34,000,249 (GRCm39) |
E40* |
probably null |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atf7ip2 |
T |
A |
16: 10,059,567 (GRCm39) |
I369N |
possibly damaging |
Het |
| Atp6ap1l |
T |
A |
13: 91,031,806 (GRCm39) |
Y292F |
probably damaging |
Het |
| Atp6v1b2 |
A |
T |
8: 69,555,459 (GRCm39) |
K217* |
probably null |
Het |
| Bid |
C |
T |
6: 120,874,216 (GRCm39) |
A110T |
possibly damaging |
Het |
| Blvra |
T |
A |
2: 126,937,068 (GRCm39) |
W174R |
probably damaging |
Het |
| Catsperg1 |
C |
T |
7: 28,897,568 (GRCm39) |
G239R |
probably damaging |
Het |
| Ccdc157 |
G |
T |
11: 4,096,549 (GRCm39) |
A400D |
probably damaging |
Het |
| Chd2 |
G |
T |
7: 73,104,193 (GRCm39) |
P1298T |
probably damaging |
Het |
| CK137956 |
G |
A |
4: 127,840,651 (GRCm39) |
L352F |
possibly damaging |
Het |
| Col22a1 |
G |
A |
15: 71,741,989 (GRCm39) |
P503S |
unknown |
Het |
| Cox15 |
C |
T |
19: 43,735,224 (GRCm39) |
R181H |
probably benign |
Het |
| Crem |
C |
T |
18: 3,299,284 (GRCm39) |
G47R |
probably benign |
Het |
| Crygs |
T |
A |
16: 22,625,304 (GRCm39) |
T46S |
probably benign |
Het |
| Cts8 |
T |
A |
13: 61,401,429 (GRCm39) |
H62L |
probably damaging |
Het |
| Cyp4a32 |
T |
A |
4: 115,468,474 (GRCm39) |
F319I |
possibly damaging |
Het |
| Dchs1 |
T |
C |
7: 105,415,109 (GRCm39) |
S692G |
probably damaging |
Het |
| Ddx23 |
G |
A |
15: 98,548,599 (GRCm39) |
R370W |
possibly damaging |
Het |
| Defa29 |
A |
T |
8: 21,816,865 (GRCm39) |
S43T |
probably damaging |
Het |
| Dnajc14 |
A |
G |
10: 128,652,661 (GRCm39) |
D573G |
probably damaging |
Het |
| Drd5 |
A |
G |
5: 38,477,319 (GRCm39) |
Y104C |
probably benign |
Het |
| Efcab7 |
C |
T |
4: 99,768,215 (GRCm39) |
P102L |
probably damaging |
Het |
| Efhc1 |
A |
G |
1: 21,037,624 (GRCm39) |
Y267C |
probably damaging |
Het |
| Eif2ak4 |
T |
C |
2: 118,278,967 (GRCm39) |
Y243H |
probably damaging |
Het |
| Gfm2 |
T |
A |
13: 97,278,475 (GRCm39) |
I7N |
probably damaging |
Het |
| Gmds |
A |
G |
13: 32,311,980 (GRCm39) |
F150L |
possibly damaging |
Het |
| Gp2 |
T |
C |
7: 119,053,455 (GRCm39) |
T169A |
possibly damaging |
Het |
| Grb14 |
A |
G |
2: 64,743,146 (GRCm39) |
F508L |
probably damaging |
Het |
| Hdac5 |
T |
A |
11: 102,086,698 (GRCm39) |
|
probably benign |
Het |
| Heatr1 |
T |
A |
13: 12,450,066 (GRCm39) |
M620K |
probably damaging |
Het |
| Herc3 |
A |
G |
6: 58,853,778 (GRCm39) |
E608G |
probably damaging |
Het |
| Hoxb4 |
T |
C |
11: 96,210,867 (GRCm39) |
Y156H |
probably damaging |
Het |
| Ifi205 |
T |
A |
1: 173,855,980 (GRCm39) |
I17F |
possibly damaging |
Het |
| Il2rb |
A |
T |
15: 78,375,977 (GRCm39) |
S25T |
possibly damaging |
Het |
| Kansl1 |
T |
C |
11: 104,225,923 (GRCm39) |
T998A |
probably damaging |
Het |
| Kcna6 |
G |
T |
6: 126,715,451 (GRCm39) |
H479Q |
probably benign |
Het |
| Kif2a |
T |
C |
13: 107,114,599 (GRCm39) |
K350R |
probably benign |
Het |
| Lct |
G |
T |
1: 128,221,898 (GRCm39) |
A1547E |
probably damaging |
Het |
| Lhx9 |
T |
A |
1: 138,769,747 (GRCm39) |
|
probably benign |
Het |
| Lingo1 |
T |
A |
9: 56,526,934 (GRCm39) |
I552F |
possibly damaging |
Het |
| Lrp4 |
G |
A |
2: 91,327,700 (GRCm39) |
W1516* |
probably null |
Het |
| Lrp5 |
C |
T |
19: 3,660,131 (GRCm39) |
V978I |
probably benign |
Het |
| Ltbp1 |
T |
A |
17: 75,620,029 (GRCm39) |
D719E |
probably benign |
Het |
| Ltbp4 |
A |
G |
7: 27,007,191 (GRCm39) |
|
probably null |
Het |
| Macf1 |
A |
G |
4: 123,345,830 (GRCm39) |
I1326T |
probably damaging |
Het |
| Manba |
T |
C |
3: 135,250,501 (GRCm39) |
F376S |
probably benign |
Het |
| Nfatc2ip |
C |
T |
7: 125,984,164 (GRCm39) |
V410I |
probably damaging |
Het |
| Nlrp1b |
A |
T |
11: 71,072,964 (GRCm39) |
I293N |
probably damaging |
Het |
| Or10aa3 |
T |
C |
1: 173,878,244 (GRCm39) |
Y102H |
probably damaging |
Het |
| Otol1 |
A |
C |
3: 69,935,437 (GRCm39) |
E476D |
probably benign |
Het |
| Pcdhb4 |
C |
T |
18: 37,442,594 (GRCm39) |
P635S |
probably benign |
Het |
| Pfkfb4 |
T |
A |
9: 108,828,237 (GRCm39) |
F91I |
probably damaging |
Het |
| Polq |
G |
A |
16: 36,882,666 (GRCm39) |
R1610Q |
possibly damaging |
Het |
| Polr3c |
A |
T |
3: 96,626,614 (GRCm39) |
L270H |
probably damaging |
Het |
| Ppp1r15b |
C |
T |
1: 133,059,363 (GRCm39) |
|
probably benign |
Het |
| Prkca |
T |
G |
11: 108,082,975 (GRCm39) |
D90A |
probably benign |
Het |
| Sall3 |
T |
C |
18: 81,012,968 (GRCm39) |
D1156G |
probably benign |
Het |
| Scn7a |
A |
T |
2: 66,506,446 (GRCm39) |
L1481H |
probably damaging |
Het |
| Selenon |
A |
T |
4: 134,271,929 (GRCm39) |
I292N |
probably damaging |
Het |
| Sema6d |
T |
A |
2: 124,501,806 (GRCm39) |
|
probably null |
Het |
| Sgpp1 |
G |
T |
12: 75,762,953 (GRCm39) |
Y409* |
probably null |
Het |
| Sh3pxd2a |
A |
G |
19: 47,255,947 (GRCm39) |
S924P |
probably benign |
Het |
| Slc25a13 |
A |
G |
6: 6,042,264 (GRCm39) |
V638A |
probably benign |
Het |
| Snhg11 |
T |
C |
2: 158,218,746 (GRCm39) |
|
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,249,389 (GRCm39) |
Q800R |
probably benign |
Het |
| Srf |
C |
A |
17: 46,860,912 (GRCm39) |
G401C |
probably damaging |
Het |
| Stradb |
A |
C |
1: 59,030,264 (GRCm39) |
N173H |
probably benign |
Het |
| Swap70 |
C |
T |
7: 109,878,470 (GRCm39) |
A480V |
possibly damaging |
Het |
| Sycp2 |
A |
G |
2: 178,023,750 (GRCm39) |
V422A |
probably damaging |
Het |
| Taf4 |
G |
A |
2: 179,573,822 (GRCm39) |
T682M |
probably damaging |
Het |
| Tet3 |
T |
C |
6: 83,381,361 (GRCm39) |
N269S |
possibly damaging |
Het |
| Thap12 |
A |
T |
7: 98,366,045 (GRCm39) |
I738F |
possibly damaging |
Het |
| Tiam2 |
C |
T |
17: 3,565,000 (GRCm39) |
R1413C |
possibly damaging |
Het |
| Tmem229a |
A |
T |
6: 24,955,010 (GRCm39) |
F248Y |
probably damaging |
Het |
| Tmprss7 |
G |
A |
16: 45,504,956 (GRCm39) |
Q145* |
probably null |
Het |
| Tnc |
A |
T |
4: 63,911,262 (GRCm39) |
|
probably null |
Het |
| Tonsl |
A |
T |
15: 76,508,797 (GRCm39) |
Y21N |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,297,414 (GRCm39) |
D1009G |
probably benign |
Het |
| Trpm2 |
G |
A |
10: 77,776,992 (GRCm39) |
A435V |
probably damaging |
Het |
| Ubr3 |
T |
A |
2: 69,783,820 (GRCm39) |
|
probably null |
Het |
| Vcan |
T |
C |
13: 89,853,653 (GRCm39) |
N436D |
possibly damaging |
Het |
| Vmn2r104 |
T |
A |
17: 20,261,031 (GRCm39) |
Y464F |
probably damaging |
Het |
| Vmn2r44 |
T |
A |
7: 8,370,981 (GRCm39) |
R688S |
probably benign |
Het |
| Wdr74 |
G |
T |
19: 8,715,311 (GRCm39) |
V157L |
probably benign |
Het |
| Wnt7a |
T |
A |
6: 91,371,530 (GRCm39) |
D144V |
probably benign |
Het |
| Zfp106 |
C |
T |
2: 120,362,162 (GRCm39) |
A986T |
possibly damaging |
Het |
|
| Other mutations in Mink1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00501:Mink1
|
APN |
11 |
70,494,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00709:Mink1
|
APN |
11 |
70,503,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01064:Mink1
|
APN |
11 |
70,494,307 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02612:Mink1
|
APN |
11 |
70,488,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02797:Mink1
|
APN |
11 |
70,501,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03056:Mink1
|
APN |
11 |
70,503,409 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03066:Mink1
|
APN |
11 |
70,499,715 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03185:Mink1
|
APN |
11 |
70,494,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4498001:Mink1
|
UTSW |
11 |
70,489,714 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0488:Mink1
|
UTSW |
11 |
70,488,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0637:Mink1
|
UTSW |
11 |
70,492,502 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0828:Mink1
|
UTSW |
11 |
70,500,971 (GRCm39) |
nonsense |
probably null |
|
|
R1081:Mink1
|
UTSW |
11 |
70,497,861 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1175:Mink1
|
UTSW |
11 |
70,502,166 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1441:Mink1
|
UTSW |
11 |
70,497,940 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1532:Mink1
|
UTSW |
11 |
70,492,833 (GRCm39) |
missense |
probably null |
1.00 |
|
R1545:Mink1
|
UTSW |
11 |
70,489,717 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1634:Mink1
|
UTSW |
11 |
70,499,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2033:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2184:Mink1
|
UTSW |
11 |
70,494,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2859:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3713:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3714:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3715:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3716:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3717:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4607:Mink1
|
UTSW |
11 |
70,496,893 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4735:Mink1
|
UTSW |
11 |
70,500,086 (GRCm39) |
splice site |
probably null |
|
|
R4790:Mink1
|
UTSW |
11 |
70,489,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4847:Mink1
|
UTSW |
11 |
70,492,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Mink1
|
UTSW |
11 |
70,502,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4860:Mink1
|
UTSW |
11 |
70,502,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5081:Mink1
|
UTSW |
11 |
70,495,970 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5310:Mink1
|
UTSW |
11 |
70,498,169 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5677:Mink1
|
UTSW |
11 |
70,495,991 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5767:Mink1
|
UTSW |
11 |
70,496,901 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5795:Mink1
|
UTSW |
11 |
70,498,616 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5888:Mink1
|
UTSW |
11 |
70,500,885 (GRCm39) |
unclassified |
probably benign |
|
|
R5950:Mink1
|
UTSW |
11 |
70,500,412 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6024:Mink1
|
UTSW |
11 |
70,489,915 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6058:Mink1
|
UTSW |
11 |
70,502,546 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6144:Mink1
|
UTSW |
11 |
70,501,478 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6154:Mink1
|
UTSW |
11 |
70,500,927 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6218:Mink1
|
UTSW |
11 |
70,489,720 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6262:Mink1
|
UTSW |
11 |
70,494,151 (GRCm39) |
splice site |
probably null |
|
|
R6269:Mink1
|
UTSW |
11 |
70,489,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Mink1
|
UTSW |
11 |
70,502,261 (GRCm39) |
nonsense |
probably null |
|
|
R6301:Mink1
|
UTSW |
11 |
70,503,120 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6603:Mink1
|
UTSW |
11 |
70,500,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6876:Mink1
|
UTSW |
11 |
70,498,261 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7030:Mink1
|
UTSW |
11 |
70,498,601 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7050:Mink1
|
UTSW |
11 |
70,503,158 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7094:Mink1
|
UTSW |
11 |
70,500,901 (GRCm39) |
splice site |
probably null |
|
|
R7135:Mink1
|
UTSW |
11 |
70,494,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Mink1
|
UTSW |
11 |
70,502,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7320:Mink1
|
UTSW |
11 |
70,489,899 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7396:Mink1
|
UTSW |
11 |
70,495,994 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7446:Mink1
|
UTSW |
11 |
70,500,455 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7723:Mink1
|
UTSW |
11 |
70,503,736 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7896:Mink1
|
UTSW |
11 |
70,503,108 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8058:Mink1
|
UTSW |
11 |
70,494,594 (GRCm39) |
nonsense |
probably null |
|
|
R8082:Mink1
|
UTSW |
11 |
70,504,103 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8160:Mink1
|
UTSW |
11 |
70,496,907 (GRCm39) |
nonsense |
probably null |
|
|
R8335:Mink1
|
UTSW |
11 |
70,500,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8353:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8453:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8732:Mink1
|
UTSW |
11 |
70,500,902 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9072:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9073:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9324:Mink1
|
UTSW |
11 |
70,502,477 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9596:Mink1
|
UTSW |
11 |
70,497,915 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAACCCATTTGTTTCTCTGTGAG -3'
(R):5'- CGCCTCTGCAGATAGATTTGC -3'
Sequencing Primer
(F):5'- TGCTGAGGACTGCGTTCCTC -3'
(R):5'- CTCTGCAGATAGATTTGCCAGGC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation