Incidental Mutation 'R1932:Tiam2'
| ID |
215516 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
039950-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1932 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 3565000 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 1413
(R1413C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041003]
[ENSMUST00000072156]
[ENSMUST00000169838]
[ENSMUST00000227405]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041003
|
| SMART Domains |
Protein: ENSMUSP00000035291
Gene: ENSMUSG00000036983
| Domain | Start | End | E-Value | Type |
|---|
|
rADc
|
43 |
234 |
5.56e-69 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072156
AA Change: R1413C
PolyPhen 2
Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: R1413C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169838
AA Change: R1413C
PolyPhen 2
Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: R1413C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226913
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226997
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227405
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
T |
A |
9: 44,190,691 (GRCm39) |
Q278H |
probably benign |
Het |
| Ace3 |
T |
C |
11: 105,895,436 (GRCm39) |
|
probably null |
Het |
| Aco1 |
T |
C |
4: 40,176,499 (GRCm39) |
V221A |
probably damaging |
Het |
| Adamts20 |
T |
A |
15: 94,301,891 (GRCm39) |
H27L |
probably benign |
Het |
| Adamts8 |
A |
G |
9: 30,867,808 (GRCm39) |
D544G |
probably benign |
Het |
| Angptl4 |
C |
A |
17: 34,000,249 (GRCm39) |
E40* |
probably null |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atf7ip2 |
T |
A |
16: 10,059,567 (GRCm39) |
I369N |
possibly damaging |
Het |
| Atp6ap1l |
T |
A |
13: 91,031,806 (GRCm39) |
Y292F |
probably damaging |
Het |
| Atp6v1b2 |
A |
T |
8: 69,555,459 (GRCm39) |
K217* |
probably null |
Het |
| Bid |
C |
T |
6: 120,874,216 (GRCm39) |
A110T |
possibly damaging |
Het |
| Blvra |
T |
A |
2: 126,937,068 (GRCm39) |
W174R |
probably damaging |
Het |
| Catsperg1 |
C |
T |
7: 28,897,568 (GRCm39) |
G239R |
probably damaging |
Het |
| Ccdc157 |
G |
T |
11: 4,096,549 (GRCm39) |
A400D |
probably damaging |
Het |
| Chd2 |
G |
T |
7: 73,104,193 (GRCm39) |
P1298T |
probably damaging |
Het |
| CK137956 |
G |
A |
4: 127,840,651 (GRCm39) |
L352F |
possibly damaging |
Het |
| Col22a1 |
G |
A |
15: 71,741,989 (GRCm39) |
P503S |
unknown |
Het |
| Cox15 |
C |
T |
19: 43,735,224 (GRCm39) |
R181H |
probably benign |
Het |
| Crem |
C |
T |
18: 3,299,284 (GRCm39) |
G47R |
probably benign |
Het |
| Crygs |
T |
A |
16: 22,625,304 (GRCm39) |
T46S |
probably benign |
Het |
| Cts8 |
T |
A |
13: 61,401,429 (GRCm39) |
H62L |
probably damaging |
Het |
| Cyp4a32 |
T |
A |
4: 115,468,474 (GRCm39) |
F319I |
possibly damaging |
Het |
| Dchs1 |
T |
C |
7: 105,415,109 (GRCm39) |
S692G |
probably damaging |
Het |
| Ddx23 |
G |
A |
15: 98,548,599 (GRCm39) |
R370W |
possibly damaging |
Het |
| Defa29 |
A |
T |
8: 21,816,865 (GRCm39) |
S43T |
probably damaging |
Het |
| Dnajc14 |
A |
G |
10: 128,652,661 (GRCm39) |
D573G |
probably damaging |
Het |
| Drd5 |
A |
G |
5: 38,477,319 (GRCm39) |
Y104C |
probably benign |
Het |
| Efcab7 |
C |
T |
4: 99,768,215 (GRCm39) |
P102L |
probably damaging |
Het |
| Efhc1 |
A |
G |
1: 21,037,624 (GRCm39) |
Y267C |
probably damaging |
Het |
| Eif2ak4 |
T |
C |
2: 118,278,967 (GRCm39) |
Y243H |
probably damaging |
Het |
| Gfm2 |
T |
A |
13: 97,278,475 (GRCm39) |
I7N |
probably damaging |
Het |
| Gmds |
A |
G |
13: 32,311,980 (GRCm39) |
F150L |
possibly damaging |
Het |
| Gp2 |
T |
C |
7: 119,053,455 (GRCm39) |
T169A |
possibly damaging |
Het |
| Grb14 |
A |
G |
2: 64,743,146 (GRCm39) |
F508L |
probably damaging |
Het |
| Hdac5 |
T |
A |
11: 102,086,698 (GRCm39) |
|
probably benign |
Het |
| Heatr1 |
T |
A |
13: 12,450,066 (GRCm39) |
M620K |
probably damaging |
Het |
| Herc3 |
A |
G |
6: 58,853,778 (GRCm39) |
E608G |
probably damaging |
Het |
| Hoxb4 |
T |
C |
11: 96,210,867 (GRCm39) |
Y156H |
probably damaging |
Het |
| Ifi205 |
T |
A |
1: 173,855,980 (GRCm39) |
I17F |
possibly damaging |
Het |
| Il2rb |
A |
T |
15: 78,375,977 (GRCm39) |
S25T |
possibly damaging |
Het |
| Kansl1 |
T |
C |
11: 104,225,923 (GRCm39) |
T998A |
probably damaging |
Het |
| Kcna6 |
G |
T |
6: 126,715,451 (GRCm39) |
H479Q |
probably benign |
Het |
| Kif2a |
T |
C |
13: 107,114,599 (GRCm39) |
K350R |
probably benign |
Het |
| Lct |
G |
T |
1: 128,221,898 (GRCm39) |
A1547E |
probably damaging |
Het |
| Lhx9 |
T |
A |
1: 138,769,747 (GRCm39) |
|
probably benign |
Het |
| Lingo1 |
T |
A |
9: 56,526,934 (GRCm39) |
I552F |
possibly damaging |
Het |
| Lrp4 |
G |
A |
2: 91,327,700 (GRCm39) |
W1516* |
probably null |
Het |
| Lrp5 |
C |
T |
19: 3,660,131 (GRCm39) |
V978I |
probably benign |
Het |
| Ltbp1 |
T |
A |
17: 75,620,029 (GRCm39) |
D719E |
probably benign |
Het |
| Ltbp4 |
A |
G |
7: 27,007,191 (GRCm39) |
|
probably null |
Het |
| Macf1 |
A |
G |
4: 123,345,830 (GRCm39) |
I1326T |
probably damaging |
Het |
| Manba |
T |
C |
3: 135,250,501 (GRCm39) |
F376S |
probably benign |
Het |
| Mink1 |
T |
C |
11: 70,499,254 (GRCm39) |
|
probably null |
Het |
| Nfatc2ip |
C |
T |
7: 125,984,164 (GRCm39) |
V410I |
probably damaging |
Het |
| Nlrp1b |
A |
T |
11: 71,072,964 (GRCm39) |
I293N |
probably damaging |
Het |
| Or10aa3 |
T |
C |
1: 173,878,244 (GRCm39) |
Y102H |
probably damaging |
Het |
| Otol1 |
A |
C |
3: 69,935,437 (GRCm39) |
E476D |
probably benign |
Het |
| Pcdhb4 |
C |
T |
18: 37,442,594 (GRCm39) |
P635S |
probably benign |
Het |
| Pfkfb4 |
T |
A |
9: 108,828,237 (GRCm39) |
F91I |
probably damaging |
Het |
| Polq |
G |
A |
16: 36,882,666 (GRCm39) |
R1610Q |
possibly damaging |
Het |
| Polr3c |
A |
T |
3: 96,626,614 (GRCm39) |
L270H |
probably damaging |
Het |
| Ppp1r15b |
C |
T |
1: 133,059,363 (GRCm39) |
|
probably benign |
Het |
| Prkca |
T |
G |
11: 108,082,975 (GRCm39) |
D90A |
probably benign |
Het |
| Sall3 |
T |
C |
18: 81,012,968 (GRCm39) |
D1156G |
probably benign |
Het |
| Scn7a |
A |
T |
2: 66,506,446 (GRCm39) |
L1481H |
probably damaging |
Het |
| Selenon |
A |
T |
4: 134,271,929 (GRCm39) |
I292N |
probably damaging |
Het |
| Sema6d |
T |
A |
2: 124,501,806 (GRCm39) |
|
probably null |
Het |
| Sgpp1 |
G |
T |
12: 75,762,953 (GRCm39) |
Y409* |
probably null |
Het |
| Sh3pxd2a |
A |
G |
19: 47,255,947 (GRCm39) |
S924P |
probably benign |
Het |
| Slc25a13 |
A |
G |
6: 6,042,264 (GRCm39) |
V638A |
probably benign |
Het |
| Snhg11 |
T |
C |
2: 158,218,746 (GRCm39) |
|
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,249,389 (GRCm39) |
Q800R |
probably benign |
Het |
| Srf |
C |
A |
17: 46,860,912 (GRCm39) |
G401C |
probably damaging |
Het |
| Stradb |
A |
C |
1: 59,030,264 (GRCm39) |
N173H |
probably benign |
Het |
| Swap70 |
C |
T |
7: 109,878,470 (GRCm39) |
A480V |
possibly damaging |
Het |
| Sycp2 |
A |
G |
2: 178,023,750 (GRCm39) |
V422A |
probably damaging |
Het |
| Taf4 |
G |
A |
2: 179,573,822 (GRCm39) |
T682M |
probably damaging |
Het |
| Tet3 |
T |
C |
6: 83,381,361 (GRCm39) |
N269S |
possibly damaging |
Het |
| Thap12 |
A |
T |
7: 98,366,045 (GRCm39) |
I738F |
possibly damaging |
Het |
| Tmem229a |
A |
T |
6: 24,955,010 (GRCm39) |
F248Y |
probably damaging |
Het |
| Tmprss7 |
G |
A |
16: 45,504,956 (GRCm39) |
Q145* |
probably null |
Het |
| Tnc |
A |
T |
4: 63,911,262 (GRCm39) |
|
probably null |
Het |
| Tonsl |
A |
T |
15: 76,508,797 (GRCm39) |
Y21N |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,297,414 (GRCm39) |
D1009G |
probably benign |
Het |
| Trpm2 |
G |
A |
10: 77,776,992 (GRCm39) |
A435V |
probably damaging |
Het |
| Ubr3 |
T |
A |
2: 69,783,820 (GRCm39) |
|
probably null |
Het |
| Vcan |
T |
C |
13: 89,853,653 (GRCm39) |
N436D |
possibly damaging |
Het |
| Vmn2r104 |
T |
A |
17: 20,261,031 (GRCm39) |
Y464F |
probably damaging |
Het |
| Vmn2r44 |
T |
A |
7: 8,370,981 (GRCm39) |
R688S |
probably benign |
Het |
| Wdr74 |
G |
T |
19: 8,715,311 (GRCm39) |
V157L |
probably benign |
Het |
| Wnt7a |
T |
A |
6: 91,371,530 (GRCm39) |
D144V |
probably benign |
Het |
| Zfp106 |
C |
T |
2: 120,362,162 (GRCm39) |
A986T |
possibly damaging |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGAGAACTGGGTGTGTACC -3'
(R):5'- ATGCACATCAAGCCTGGAG -3'
Sequencing Primer
(F):5'- CTGGTTTGTATGTATCTTAGGCACAC -3'
(R):5'- CAGAGGTGTGCTCTCAGTCACTAAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation