Incidental Mutation 'R1934:Lrp4'
| ID |
215643 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
039952-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R1934 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 91310777 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 606
(D606G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028689
AA Change: D606G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: D606G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123897
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143874
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151907
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
T |
C |
6: 121,626,792 (GRCm39) |
L548P |
probably damaging |
Het |
| Abca6 |
A |
G |
11: 110,100,909 (GRCm39) |
|
probably null |
Het |
| Abcb5 |
A |
G |
12: 118,871,235 (GRCm39) |
|
probably null |
Het |
| Acacb |
G |
A |
5: 114,336,343 (GRCm39) |
A686T |
probably benign |
Het |
| Acot6 |
T |
C |
12: 84,153,367 (GRCm39) |
V203A |
probably benign |
Het |
| Adam25 |
A |
T |
8: 41,207,922 (GRCm39) |
Y396F |
probably benign |
Het |
| Adamts9 |
A |
G |
6: 92,920,102 (GRCm39) |
L12P |
possibly damaging |
Het |
| Adamtsl2 |
A |
T |
2: 26,979,605 (GRCm39) |
D258V |
probably damaging |
Het |
| Aox4 |
G |
A |
1: 58,285,095 (GRCm39) |
V616I |
probably benign |
Het |
| Ap1m1 |
A |
G |
8: 73,009,637 (GRCm39) |
I382V |
probably damaging |
Het |
| Arhgef2 |
G |
A |
3: 88,537,098 (GRCm39) |
R8Q |
probably damaging |
Het |
| Arhgef37 |
T |
G |
18: 61,657,014 (GRCm39) |
E17A |
probably benign |
Het |
| Arhgef7 |
C |
A |
8: 11,858,713 (GRCm39) |
|
probably null |
Het |
| Arih1 |
T |
C |
9: 59,302,215 (GRCm39) |
D431G |
probably damaging |
Het |
| Astn2 |
C |
T |
4: 65,353,426 (GRCm39) |
V1115M |
probably damaging |
Het |
| Atg7 |
T |
A |
6: 114,678,196 (GRCm39) |
M280K |
probably damaging |
Het |
| Birc2 |
T |
C |
9: 7,854,500 (GRCm39) |
T397A |
possibly damaging |
Het |
| Ccdc110 |
A |
G |
8: 46,396,287 (GRCm39) |
N726S |
probably damaging |
Het |
| Cdadc1 |
A |
T |
14: 59,827,309 (GRCm39) |
S121T |
possibly damaging |
Het |
| Cdh16 |
A |
G |
8: 105,344,595 (GRCm39) |
V7A |
possibly damaging |
Het |
| Cenpb |
A |
G |
2: 131,021,184 (GRCm39) |
S205P |
probably benign |
Het |
| Chsy1 |
T |
C |
7: 65,821,991 (GRCm39) |
V742A |
probably damaging |
Het |
| Col12a1 |
G |
A |
9: 79,511,804 (GRCm39) |
R133* |
probably null |
Het |
| Col18a1 |
A |
C |
10: 76,948,578 (GRCm39) |
S311R |
possibly damaging |
Het |
| Col9a3 |
G |
A |
2: 180,248,927 (GRCm39) |
V260M |
probably damaging |
Het |
| Coq2 |
T |
A |
5: 100,809,731 (GRCm39) |
R17S |
probably damaging |
Het |
| Ctf1 |
A |
G |
7: 127,311,936 (GRCm39) |
R4G |
probably damaging |
Het |
| Cwc27 |
T |
C |
13: 104,768,184 (GRCm39) |
D437G |
probably benign |
Het |
| Cyp4f14 |
T |
C |
17: 33,125,289 (GRCm39) |
N430D |
probably damaging |
Het |
| Dars2 |
A |
G |
1: 160,890,811 (GRCm39) |
|
probably null |
Het |
| Dgkz |
A |
T |
2: 91,767,449 (GRCm39) |
M848K |
possibly damaging |
Het |
| Dnhd1 |
T |
G |
7: 105,357,789 (GRCm39) |
V3208G |
probably benign |
Het |
| Dsg1b |
A |
G |
18: 20,528,963 (GRCm39) |
Y233C |
probably damaging |
Het |
| Edem3 |
A |
T |
1: 151,680,034 (GRCm39) |
D460V |
probably damaging |
Het |
| Ednra |
A |
G |
8: 78,415,747 (GRCm39) |
S167P |
possibly damaging |
Het |
| Eif3m |
A |
T |
2: 104,831,624 (GRCm39) |
V180D |
probably damaging |
Het |
| Fam217a |
T |
A |
13: 35,094,864 (GRCm39) |
R207S |
probably damaging |
Het |
| Fcgbp |
G |
A |
7: 27,806,518 (GRCm39) |
G2162D |
probably damaging |
Het |
| Fhod3 |
A |
T |
18: 25,223,335 (GRCm39) |
I894F |
probably benign |
Het |
| Fpgs |
A |
T |
2: 32,577,993 (GRCm39) |
I143N |
probably damaging |
Het |
| Fpr-rs6 |
A |
G |
17: 20,403,152 (GRCm39) |
S70P |
probably benign |
Het |
| Frs2 |
T |
C |
10: 116,914,806 (GRCm39) |
M38V |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,810,902 (GRCm39) |
N2407S |
possibly damaging |
Het |
| Gabrg2 |
T |
A |
11: 41,811,297 (GRCm39) |
T283S |
probably benign |
Het |
| Gas2l1 |
T |
A |
11: 5,011,408 (GRCm39) |
T474S |
probably benign |
Het |
| Gli1 |
A |
T |
10: 127,167,108 (GRCm39) |
M715K |
possibly damaging |
Het |
| Glra3 |
G |
T |
8: 56,393,942 (GRCm39) |
A18S |
probably benign |
Het |
| Gm5800 |
T |
A |
14: 51,949,396 (GRCm39) |
N183I |
possibly damaging |
Het |
| Gm8674 |
T |
A |
13: 50,055,471 (GRCm39) |
|
noncoding transcript |
Het |
| Gnat3 |
A |
T |
5: 18,224,508 (GRCm39) |
I303F |
possibly damaging |
Het |
| Grin2d |
C |
T |
7: 45,506,251 (GRCm39) |
V547M |
probably damaging |
Het |
| Grpr |
C |
A |
X: 162,332,137 (GRCm39) |
V53L |
probably benign |
Het |
| Heatr5b |
T |
C |
17: 79,103,347 (GRCm39) |
I1169V |
possibly damaging |
Het |
| Icam5 |
A |
G |
9: 20,946,082 (GRCm39) |
T305A |
probably benign |
Het |
| Itga11 |
T |
A |
9: 62,651,796 (GRCm39) |
N309K |
probably damaging |
Het |
| Itgb6 |
T |
C |
2: 60,499,493 (GRCm39) |
D100G |
probably benign |
Het |
| Kdm3b |
A |
G |
18: 34,946,597 (GRCm39) |
K862R |
probably benign |
Het |
| Kif7 |
T |
C |
7: 79,361,286 (GRCm39) |
D135G |
probably benign |
Het |
| Lrrtm1 |
A |
T |
6: 77,221,949 (GRCm39) |
|
probably null |
Het |
| Metap1d |
A |
T |
2: 71,352,927 (GRCm39) |
H252L |
possibly damaging |
Het |
| Mfhas1 |
A |
G |
8: 36,058,251 (GRCm39) |
K909E |
possibly damaging |
Het |
| Mrgprh |
C |
T |
17: 13,095,838 (GRCm39) |
T26I |
probably damaging |
Het |
| Myo15b |
T |
C |
11: 115,754,310 (GRCm39) |
S937P |
probably benign |
Het |
| Neto2 |
A |
T |
8: 86,397,033 (GRCm39) |
I73N |
possibly damaging |
Het |
| Nod2 |
T |
C |
8: 89,390,347 (GRCm39) |
I196T |
probably benign |
Het |
| Nvl |
T |
G |
1: 180,926,693 (GRCm39) |
T788P |
probably damaging |
Het |
| Or13a25 |
C |
A |
7: 140,247,951 (GRCm39) |
C243* |
probably null |
Het |
| Or2h2 |
A |
T |
17: 37,396,906 (GRCm39) |
D50E |
possibly damaging |
Het |
| Pax3 |
G |
A |
1: 78,080,117 (GRCm39) |
T423I |
possibly damaging |
Het |
| Pde4dip |
A |
G |
3: 97,600,007 (GRCm39) |
V2403A |
possibly damaging |
Het |
| Phip |
C |
T |
9: 82,785,235 (GRCm39) |
V827I |
probably benign |
Het |
| Plcb3 |
A |
G |
19: 6,941,977 (GRCm39) |
F285L |
probably damaging |
Het |
| Pnp2 |
A |
G |
14: 51,193,675 (GRCm39) |
I16V |
probably benign |
Het |
| Pola2 |
A |
G |
19: 6,003,769 (GRCm39) |
L202P |
probably damaging |
Het |
| Ppfia1 |
A |
T |
7: 144,058,847 (GRCm39) |
N651K |
probably benign |
Het |
| Prss53 |
T |
C |
7: 127,485,920 (GRCm39) |
|
probably null |
Het |
| Rasgrf1 |
G |
T |
9: 89,835,966 (GRCm39) |
Q231H |
probably damaging |
Het |
| Rasgrf2 |
A |
T |
13: 92,131,825 (GRCm39) |
|
probably null |
Het |
| Rccd1 |
T |
A |
7: 79,970,272 (GRCm39) |
N115I |
possibly damaging |
Het |
| Rpgrip1 |
A |
T |
14: 52,352,101 (GRCm39) |
T26S |
possibly damaging |
Het |
| Rpn1 |
T |
A |
6: 88,070,841 (GRCm39) |
V237E |
probably damaging |
Het |
| Sema4f |
G |
T |
6: 82,907,908 (GRCm39) |
P180Q |
probably damaging |
Het |
| Slc36a4 |
T |
C |
9: 15,632,085 (GRCm39) |
V87A |
probably damaging |
Het |
| Slc5a4b |
A |
T |
10: 75,917,307 (GRCm39) |
V243E |
possibly damaging |
Het |
| Sos2 |
T |
G |
12: 69,695,315 (GRCm39) |
I141L |
probably damaging |
Het |
| Srbd1 |
A |
G |
17: 86,410,321 (GRCm39) |
V537A |
probably damaging |
Het |
| Sugp1 |
A |
G |
8: 70,509,225 (GRCm39) |
E166G |
possibly damaging |
Het |
| Tktl2 |
G |
A |
8: 66,964,999 (GRCm39) |
V186M |
probably damaging |
Het |
| Tshr |
T |
C |
12: 91,503,955 (GRCm39) |
S298P |
probably damaging |
Het |
| Tspan14 |
T |
C |
14: 40,656,209 (GRCm39) |
Y6C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,577,384 (GRCm39) |
V24503E |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,851,045 (GRCm39) |
N1305I |
probably damaging |
Het |
| Vmn2r81 |
A |
G |
10: 79,083,628 (GRCm39) |
M1V |
probably null |
Het |
| Vps39 |
A |
T |
2: 120,148,558 (GRCm39) |
V873E |
probably damaging |
Het |
| Vstm2a |
A |
T |
11: 16,359,734 (GRCm39) |
D270V |
unknown |
Het |
| Wdr24 |
A |
T |
17: 26,043,240 (GRCm39) |
M21L |
possibly damaging |
Het |
| Wee1 |
A |
G |
7: 109,721,698 (GRCm39) |
T48A |
probably benign |
Het |
| Zfp369 |
T |
C |
13: 65,444,965 (GRCm39) |
C703R |
probably damaging |
Het |
| Zfp532 |
A |
T |
18: 65,818,682 (GRCm39) |
D1114V |
probably damaging |
Het |
| Zfp758 |
A |
G |
17: 22,592,633 (GRCm39) |
T46A |
probably damaging |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCGTGGCTGTCATTCATC -3'
(R):5'- TCAAACACTGTGATGGCAAAGG -3'
Sequencing Primer
(F):5'- GTGGCTGTCATTCATCAGTCC -3'
(R):5'- GGAGACAGTCCAAAAAGACCTTAGTC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation