Incidental Mutation 'R1935:Sipa1l1'
| ID |
215943 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l1
|
| Ensembl Gene |
ENSMUSG00000042700 |
| Gene Name |
signal-induced proliferation-associated 1 like 1 |
| Synonyms |
Spar, 4931426N11Rik |
| MMRRC Submission |
039953-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1935 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
82216138-82498560 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 82419208 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 629
(Y629H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152212
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053969]
[ENSMUST00000166429]
[ENSMUST00000220963]
[ENSMUST00000222298]
[ENSMUST00000222714]
|
| AlphaFold |
Q8C0T5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000053969
AA Change: Y629H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000061014
Gene: ENSMUSG00000042700
AA Change: Y629H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
92 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
362 |
377 |
N/A |
INTRINSIC |
|
low complexity region
|
430 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
628 |
810 |
8.9e-70 |
PFAM |
|
PDZ
|
962 |
1028 |
2.63e-9 |
SMART |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1315 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1447 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1483 |
1727 |
4.4e-86 |
PFAM |
|
low complexity region
|
1731 |
1746 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166429
AA Change: Y629H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131030
Gene: ENSMUSG00000042700
AA Change: Y629H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
92 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
362 |
377 |
N/A |
INTRINSIC |
|
low complexity region
|
430 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
628 |
816 |
1.3e-64 |
PFAM |
|
PDZ
|
962 |
1028 |
1.3e-11 |
SMART |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1315 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1447 |
N/A |
INTRINSIC |
|
Pfam:DUF3401
|
1483 |
1727 |
1.8e-91 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220766
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220963
AA Change: Y629H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222298
AA Change: Y629H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222714
AA Change: Y629H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.8377 |
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 94.9%
- 20x: 91.6%
|
| Validation Efficiency |
95% (95/100) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
G |
A |
3: 121,846,572 (GRCm39) |
V30M |
probably benign |
Het |
| Abcg8 |
C |
T |
17: 85,002,417 (GRCm39) |
|
probably benign |
Het |
| Ablim1 |
T |
A |
19: 57,204,397 (GRCm39) |
|
probably null |
Het |
| Acvr1c |
A |
T |
2: 58,173,517 (GRCm39) |
N248K |
probably damaging |
Het |
| Adgrf3 |
A |
T |
5: 30,407,304 (GRCm39) |
N207K |
probably benign |
Het |
| Anapc4 |
T |
A |
5: 52,997,010 (GRCm39) |
D94E |
probably damaging |
Het |
| Arfgef2 |
A |
G |
2: 166,705,523 (GRCm39) |
N918S |
probably benign |
Het |
| Arhgap45 |
A |
G |
10: 79,866,788 (GRCm39) |
N1097S |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,676,563 (GRCm39) |
P184S |
probably damaging |
Het |
| Atg2a |
A |
G |
19: 6,302,566 (GRCm39) |
Y963C |
probably damaging |
Het |
| Atp8a2 |
T |
C |
14: 60,097,719 (GRCm39) |
K770E |
probably benign |
Het |
| Atrn |
T |
C |
2: 130,799,955 (GRCm39) |
V444A |
probably damaging |
Het |
| Avpr1a |
G |
A |
10: 122,285,695 (GRCm39) |
|
probably null |
Het |
| Best3 |
A |
C |
10: 116,860,291 (GRCm39) |
Q517P |
probably benign |
Het |
| C3 |
A |
G |
17: 57,525,829 (GRCm39) |
L851P |
probably damaging |
Het |
| Cacna2d2 |
T |
C |
9: 107,386,455 (GRCm39) |
F194S |
probably damaging |
Het |
| Carns1 |
T |
C |
19: 4,215,473 (GRCm39) |
E903G |
probably damaging |
Het |
| Chn1 |
A |
G |
2: 73,455,245 (GRCm39) |
C39R |
probably damaging |
Het |
| Ciao1 |
A |
G |
2: 127,088,380 (GRCm39) |
S148P |
possibly damaging |
Het |
| Clrn3 |
A |
C |
7: 135,115,753 (GRCm39) |
I199S |
possibly damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,320 (GRCm39) |
G154W |
probably damaging |
Het |
| Cnot2 |
G |
C |
10: 116,334,320 (GRCm39) |
P274R |
possibly damaging |
Het |
| Cops7a |
G |
A |
6: 124,939,359 (GRCm39) |
R97* |
probably null |
Het |
| Coro7 |
T |
C |
16: 4,446,596 (GRCm39) |
E843G |
probably benign |
Het |
| Crocc |
T |
C |
4: 140,761,369 (GRCm39) |
R755G |
possibly damaging |
Het |
| Crtam |
G |
C |
9: 40,915,846 (GRCm39) |
P13A |
probably benign |
Het |
| Ddrgk1 |
G |
T |
2: 130,505,480 (GRCm39) |
|
probably benign |
Het |
| Defb26 |
T |
A |
2: 152,350,195 (GRCm39) |
K28N |
possibly damaging |
Het |
| Dnah8 |
G |
A |
17: 30,945,870 (GRCm39) |
|
probably benign |
Het |
| Dnah8 |
A |
G |
17: 30,854,479 (GRCm39) |
E47G |
unknown |
Het |
| Dnhd1 |
A |
T |
7: 105,323,183 (GRCm39) |
M564L |
probably benign |
Het |
| Dusp15 |
A |
G |
2: 152,787,341 (GRCm39) |
|
probably benign |
Het |
| Dync2h1 |
A |
G |
9: 7,139,159 (GRCm39) |
|
probably null |
Het |
| Eapp |
A |
T |
12: 54,720,513 (GRCm39) |
M234K |
probably benign |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Gfi1b |
T |
C |
2: 28,500,125 (GRCm39) |
K302R |
possibly damaging |
Het |
| Gpatch1 |
A |
G |
7: 34,994,947 (GRCm39) |
S440P |
probably damaging |
Het |
| Gpr6 |
T |
C |
10: 40,947,477 (GRCm39) |
E35G |
probably benign |
Het |
| H2-Q1 |
A |
T |
17: 35,542,469 (GRCm39) |
M305L |
probably benign |
Het |
| Hoxa10 |
C |
A |
6: 52,211,350 (GRCm39) |
G189C |
possibly damaging |
Het |
| Kbtbd4 |
T |
C |
2: 90,737,895 (GRCm39) |
V215A |
probably damaging |
Het |
| Klf16 |
G |
A |
10: 80,412,739 (GRCm39) |
A99V |
probably benign |
Het |
| Lvrn |
A |
T |
18: 47,011,387 (GRCm39) |
Y448F |
probably benign |
Het |
| Med19 |
A |
G |
2: 84,516,002 (GRCm39) |
H177R |
possibly damaging |
Het |
| Mif |
G |
T |
10: 75,695,681 (GRCm39) |
H41N |
possibly damaging |
Het |
| Mpl |
A |
G |
4: 118,312,936 (GRCm39) |
M132T |
probably benign |
Het |
| Mtcl1 |
G |
T |
17: 66,686,409 (GRCm39) |
H480Q |
probably benign |
Het |
| Myo18b |
T |
C |
5: 112,908,222 (GRCm39) |
N2017S |
probably benign |
Het |
| Neurl4 |
C |
T |
11: 69,797,959 (GRCm39) |
R740C |
probably damaging |
Het |
| Nlgn1 |
G |
T |
3: 26,385,939 (GRCm39) |
|
probably benign |
Het |
| Or14j7 |
T |
A |
17: 38,234,993 (GRCm39) |
C179S |
probably damaging |
Het |
| Or2ak6 |
T |
A |
11: 58,593,172 (GRCm39) |
L215Q |
probably damaging |
Het |
| Or4c11 |
A |
C |
2: 88,695,524 (GRCm39) |
M192L |
probably benign |
Het |
| Or6c214 |
A |
G |
10: 129,590,584 (GRCm39) |
V245A |
probably damaging |
Het |
| Paip1 |
T |
A |
13: 119,593,550 (GRCm39) |
M463K |
probably damaging |
Het |
| Parp3 |
T |
A |
9: 106,351,931 (GRCm39) |
Y147F |
probably damaging |
Het |
| Pgrmc2 |
C |
A |
3: 41,037,473 (GRCm39) |
|
probably benign |
Het |
| Phldb3 |
G |
A |
7: 24,316,832 (GRCm39) |
A278T |
probably benign |
Het |
| Plxnb1 |
T |
C |
9: 108,924,715 (GRCm39) |
|
probably null |
Het |
| Pom121 |
G |
A |
5: 135,412,740 (GRCm39) |
R481C |
unknown |
Het |
| Psg22 |
A |
T |
7: 18,453,635 (GRCm39) |
N149I |
probably damaging |
Het |
| Recql5 |
T |
C |
11: 115,788,017 (GRCm39) |
Y434C |
probably benign |
Het |
| Rexo1 |
A |
G |
10: 80,386,303 (GRCm39) |
S252P |
probably benign |
Het |
| Rtl1 |
A |
G |
12: 109,558,354 (GRCm39) |
S1162P |
probably benign |
Het |
| Samd9l |
G |
T |
6: 3,376,269 (GRCm39) |
Q331K |
probably benign |
Het |
| Slc12a2 |
A |
T |
18: 58,037,425 (GRCm39) |
I512L |
possibly damaging |
Het |
| Slc17a8 |
T |
C |
10: 89,413,777 (GRCm39) |
M484V |
probably benign |
Het |
| Slc25a24 |
A |
T |
3: 109,043,581 (GRCm39) |
E79D |
probably damaging |
Het |
| Snw1 |
T |
A |
12: 87,506,247 (GRCm39) |
I218F |
probably damaging |
Het |
| Sorcs1 |
T |
C |
19: 50,221,082 (GRCm39) |
D545G |
probably damaging |
Het |
| Sorcs2 |
A |
G |
5: 36,228,731 (GRCm39) |
S104P |
possibly damaging |
Het |
| Spry4 |
A |
G |
18: 38,723,142 (GRCm39) |
I207T |
possibly damaging |
Het |
| Tex101 |
A |
G |
7: 24,367,650 (GRCm39) |
V234A |
probably benign |
Het |
| Thra |
T |
A |
11: 98,653,899 (GRCm39) |
|
probably benign |
Het |
| Tmem161b |
T |
A |
13: 84,441,585 (GRCm39) |
L210Q |
probably damaging |
Het |
| Tmem50a |
A |
G |
4: 134,630,953 (GRCm39) |
|
probably benign |
Het |
| Tmem63b |
A |
G |
17: 45,989,887 (GRCm39) |
|
probably null |
Het |
| Tnrc6c |
A |
G |
11: 117,646,849 (GRCm39) |
D1450G |
possibly damaging |
Het |
| Trdmt1 |
A |
G |
2: 13,516,420 (GRCm39) |
L386P |
probably damaging |
Het |
| Trip12 |
T |
C |
1: 84,771,822 (GRCm39) |
S109G |
possibly damaging |
Het |
| Trit1 |
T |
C |
4: 122,948,033 (GRCm39) |
I451T |
probably benign |
Het |
| Ttc34 |
G |
A |
4: 154,950,139 (GRCm39) |
A1031T |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,577,522 (GRCm39) |
D24457V |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,715,834 (GRCm39) |
|
probably benign |
Het |
| Tubgcp4 |
A |
T |
2: 121,009,147 (GRCm39) |
|
probably benign |
Het |
| Ubiad1 |
A |
G |
4: 148,528,468 (GRCm39) |
L147P |
probably damaging |
Het |
| Vps72 |
T |
A |
3: 95,029,851 (GRCm39) |
V290D |
probably benign |
Het |
| Zfp408 |
A |
T |
2: 91,480,093 (GRCm39) |
M1K |
probably null |
Het |
| Zfy2 |
C |
A |
Y: 2,121,496 (GRCm39) |
M132I |
probably benign |
Het |
|
| Other mutations in Sipa1l1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Sipa1l1
|
APN |
12 |
82,434,470 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01478:Sipa1l1
|
APN |
12 |
82,493,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01620:Sipa1l1
|
APN |
12 |
82,469,263 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02496:Sipa1l1
|
APN |
12 |
82,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02550:Sipa1l1
|
APN |
12 |
82,487,723 (GRCm39) |
nonsense |
probably null |
|
|
IGL02689:Sipa1l1
|
APN |
12 |
82,487,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02706:Sipa1l1
|
APN |
12 |
82,444,207 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02995:Sipa1l1
|
APN |
12 |
82,404,105 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03104:Sipa1l1
|
APN |
12 |
82,388,904 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03295:Sipa1l1
|
APN |
12 |
82,479,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bullae
|
UTSW |
12 |
82,389,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bullish
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
ebullient
|
UTSW |
12 |
82,388,446 (GRCm39) |
missense |
probably benign |
0.18 |
|
PIT4431001:Sipa1l1
|
UTSW |
12 |
82,443,290 (GRCm39) |
missense |
probably benign |
0.34 |
|
R0140:Sipa1l1
|
UTSW |
12 |
82,442,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0348:Sipa1l1
|
UTSW |
12 |
82,431,530 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0534:Sipa1l1
|
UTSW |
12 |
82,472,054 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0538:Sipa1l1
|
UTSW |
12 |
82,471,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0547:Sipa1l1
|
UTSW |
12 |
82,484,510 (GRCm39) |
missense |
probably benign |
|
|
R0980:Sipa1l1
|
UTSW |
12 |
82,388,994 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1051:Sipa1l1
|
UTSW |
12 |
82,496,119 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1244:Sipa1l1
|
UTSW |
12 |
82,472,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1473:Sipa1l1
|
UTSW |
12 |
82,387,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1508:Sipa1l1
|
UTSW |
12 |
82,487,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1563:Sipa1l1
|
UTSW |
12 |
82,387,935 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1671:Sipa1l1
|
UTSW |
12 |
82,444,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Sipa1l1
|
UTSW |
12 |
82,388,233 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2191:Sipa1l1
|
UTSW |
12 |
82,443,465 (GRCm39) |
nonsense |
probably null |
|
|
R2249:Sipa1l1
|
UTSW |
12 |
82,388,890 (GRCm39) |
missense |
probably benign |
|
|
R2909:Sipa1l1
|
UTSW |
12 |
82,404,105 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4012:Sipa1l1
|
UTSW |
12 |
82,388,556 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4154:Sipa1l1
|
UTSW |
12 |
82,471,988 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4382:Sipa1l1
|
UTSW |
12 |
82,493,596 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4448:Sipa1l1
|
UTSW |
12 |
82,388,524 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4651:Sipa1l1
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Sipa1l1
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
R4751:Sipa1l1
|
UTSW |
12 |
82,387,968 (GRCm39) |
missense |
probably benign |
|
|
R4755:Sipa1l1
|
UTSW |
12 |
82,419,160 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4888:Sipa1l1
|
UTSW |
12 |
82,389,107 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4912:Sipa1l1
|
UTSW |
12 |
82,443,452 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4937:Sipa1l1
|
UTSW |
12 |
82,388,103 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5068:Sipa1l1
|
UTSW |
12 |
82,484,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Sipa1l1
|
UTSW |
12 |
82,487,682 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5114:Sipa1l1
|
UTSW |
12 |
82,487,682 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5240:Sipa1l1
|
UTSW |
12 |
82,388,362 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6041:Sipa1l1
|
UTSW |
12 |
82,389,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6048:Sipa1l1
|
UTSW |
12 |
82,487,643 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6170:Sipa1l1
|
UTSW |
12 |
82,388,446 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6185:Sipa1l1
|
UTSW |
12 |
82,471,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Sipa1l1
|
UTSW |
12 |
82,419,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Sipa1l1
|
UTSW |
12 |
82,467,320 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Sipa1l1
|
UTSW |
12 |
82,409,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7058:Sipa1l1
|
UTSW |
12 |
82,449,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7069:Sipa1l1
|
UTSW |
12 |
82,388,180 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7122:Sipa1l1
|
UTSW |
12 |
82,469,236 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7310:Sipa1l1
|
UTSW |
12 |
82,419,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7469:Sipa1l1
|
UTSW |
12 |
82,467,438 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7718:Sipa1l1
|
UTSW |
12 |
82,389,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Sipa1l1
|
UTSW |
12 |
82,496,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7844:Sipa1l1
|
UTSW |
12 |
82,444,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7893:Sipa1l1
|
UTSW |
12 |
82,388,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7953:Sipa1l1
|
UTSW |
12 |
82,496,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8043:Sipa1l1
|
UTSW |
12 |
82,496,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8099:Sipa1l1
|
UTSW |
12 |
82,480,600 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8135:Sipa1l1
|
UTSW |
12 |
82,388,075 (GRCm39) |
missense |
probably benign |
|
|
R8229:Sipa1l1
|
UTSW |
12 |
82,484,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8348:Sipa1l1
|
UTSW |
12 |
82,443,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8388:Sipa1l1
|
UTSW |
12 |
82,216,259 (GRCm39) |
unclassified |
probably benign |
|
|
R8693:Sipa1l1
|
UTSW |
12 |
82,216,517 (GRCm39) |
unclassified |
probably benign |
|
|
R8826:Sipa1l1
|
UTSW |
12 |
82,389,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8884:Sipa1l1
|
UTSW |
12 |
82,409,871 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8940:Sipa1l1
|
UTSW |
12 |
82,404,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8975:Sipa1l1
|
UTSW |
12 |
82,479,612 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9145:Sipa1l1
|
UTSW |
12 |
82,443,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9328:Sipa1l1
|
UTSW |
12 |
82,388,792 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9455:Sipa1l1
|
UTSW |
12 |
82,434,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9486:Sipa1l1
|
UTSW |
12 |
82,404,139 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9631:Sipa1l1
|
UTSW |
12 |
82,387,776 (GRCm39) |
start codon destroyed |
probably null |
0.39 |
|
R9727:Sipa1l1
|
UTSW |
12 |
82,471,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9753:Sipa1l1
|
UTSW |
12 |
82,463,763 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAAAAGGATTCCCCGAGAAGG -3'
(R):5'- CTGATTTTCTGCAGCAAGAGGC -3'
Sequencing Primer
(F):5'- CCGAGAAGGGAGCTAGCTAGC -3'
(R):5'- GGATGATGGTTTAGCAAATGCACATC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation