Incidental Mutation 'R1942:Or10g6'
ID 216296
Institutional Source Beutler Lab
Gene Symbol Or10g6
Ensembl Gene ENSMUSG00000046678
Gene Name olfactory receptor family 10 subfamily G member 6
Synonyms MOR223-8, GA_x6K02T2PVTD-33720892-33721824, Olfr981
MMRRC Submission 039960-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # R1942 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39933691-39934623 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39934031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 114 (L114H)
Ref Sequence ENSEMBL: ENSMUSP00000149436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059859] [ENSMUST00000215956]
AlphaFold Q8VEU2
Predicted Effect probably damaging
Transcript: ENSMUST00000059859
AA Change: L114H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057952
Gene: ENSMUSG00000046678
AA Change: L114H

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.4e-54 PFAM
Pfam:7tm_1 41 288 8.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215956
AA Change: L114H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219526
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220338
Meta Mutation Damage Score 0.1361 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.7%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A T 15: 81,949,625 (GRCm39) Y1174F probably damaging Het
Ahnak A G 19: 8,992,447 (GRCm39) E4577G probably damaging Het
Anapc4 T C 5: 53,004,056 (GRCm39) V291A probably benign Het
Apba2 A G 7: 64,345,218 (GRCm39) E136G possibly damaging Het
Arhgap20 C A 9: 51,742,998 (GRCm39) Q279K probably benign Het
B3galnt1 A T 3: 69,483,258 (GRCm39) M1K probably null Het
C4bp C A 1: 130,583,804 (GRCm39) probably benign Het
Catsperg1 G A 7: 28,906,232 (GRCm39) T157I possibly damaging Het
Cfap90 A C 13: 68,761,090 (GRCm39) I171L probably benign Het
Chrm1 T A 19: 8,655,637 (GRCm39) M114K probably damaging Het
Clasp1 A G 1: 118,429,078 (GRCm39) E329G possibly damaging Het
Clrn2 A C 5: 45,611,337 (GRCm39) Y62S probably benign Het
Col12a1 T G 9: 79,542,748 (GRCm39) D2339A probably damaging Het
Copa T A 1: 171,939,455 (GRCm39) L564Q probably damaging Het
Cpeb2 C A 5: 43,392,596 (GRCm39) probably benign Het
Dhx57 A T 17: 80,572,573 (GRCm39) M647K probably damaging Het
Diaph3 C T 14: 87,378,556 (GRCm39) probably benign Het
Eomes A G 9: 118,313,716 (GRCm39) D587G probably benign Het
Gm5142 T A 14: 59,416,156 (GRCm39) M1L probably benign Het
Gnl2 A G 4: 124,923,957 (GRCm39) I12V probably benign Het
Gprin1 C T 13: 54,887,752 (GRCm39) C174Y probably benign Het
Grin2b A T 6: 135,709,730 (GRCm39) V1272E possibly damaging Het
Hdac9 A G 12: 34,479,544 (GRCm39) L227S probably damaging Het
Helz T A 11: 107,493,318 (GRCm39) L247Q probably benign Het
Hs6st1 T C 1: 36,107,803 (GRCm39) V22A probably benign Het
Hspg2 C A 4: 137,269,863 (GRCm39) A2304E possibly damaging Het
Htr3a T C 9: 48,819,911 (GRCm39) Y73C probably damaging Het
Il1rap A C 16: 26,541,205 (GRCm39) E482A probably damaging Het
Itsn2 T A 12: 4,689,670 (GRCm39) L581* probably null Het
Msmb A G 14: 31,870,034 (GRCm39) E2G probably benign Het
Muc19 T C 15: 91,776,666 (GRCm39) noncoding transcript Het
Muc4 A C 16: 32,569,460 (GRCm39) L173F probably damaging Het
Muc5b A T 7: 141,411,421 (GRCm39) S1456C unknown Het
Mylip A T 13: 45,560,172 (GRCm39) I203F probably damaging Het
Nckap5 A T 1: 125,952,039 (GRCm39) D1504E probably damaging Het
Neil1 C G 9: 57,053,891 (GRCm39) R143P probably benign Het
Nlrp2 T A 7: 5,325,447 (GRCm39) T742S probably damaging Het
Nme8 A G 13: 19,859,978 (GRCm39) V214A probably damaging Het
Nsun7 C T 5: 66,441,588 (GRCm39) T419I probably benign Het
Nup210l G A 3: 90,058,544 (GRCm39) E648K probably benign Het
Or2y1c T C 11: 49,360,981 (GRCm39) M1T probably null Het
Or8s2 A G 15: 98,276,445 (GRCm39) L182P probably damaging Het
Parp11 A C 6: 127,447,663 (GRCm39) probably null Het
Pomgnt1 G T 4: 116,012,472 (GRCm39) probably null Het
Ppp1r14c T C 10: 3,413,417 (GRCm39) I150T probably damaging Het
Psd4 A G 2: 24,295,805 (GRCm39) E908G probably damaging Het
Psmd6 A T 14: 14,116,442 (GRCm38) V91E probably damaging Het
Ptk2b A T 14: 66,406,830 (GRCm39) V634D probably damaging Het
Rapgef6 A G 11: 54,548,089 (GRCm39) I753V possibly damaging Het
Rbm45 G A 2: 76,205,823 (GRCm39) probably null Het
Ric1 A G 19: 29,578,416 (GRCm39) probably benign Het
Sh3rf2 A G 18: 42,282,689 (GRCm39) K416E probably damaging Het
Six5 C T 7: 18,830,858 (GRCm39) A495V possibly damaging Het
Slc27a6 T A 18: 58,689,870 (GRCm39) M112K probably damaging Het
Slc5a4a T C 10: 75,983,422 (GRCm39) S20P unknown Het
Smg1 A G 7: 117,757,326 (GRCm39) probably benign Het
Sntb2 G A 8: 107,737,984 (GRCm39) A511T probably damaging Het
Stk31 A T 6: 49,416,061 (GRCm39) N622I probably damaging Het
Sulf1 T C 1: 12,918,397 (GRCm39) F38S probably damaging Het
Szt2 G T 4: 118,249,817 (GRCm39) T521K probably benign Het
Terf1 G T 1: 15,876,038 (GRCm39) R46I probably benign Het
Tmem245 A G 4: 56,923,511 (GRCm39) probably benign Het
Tmigd1 T C 11: 76,804,905 (GRCm39) probably null Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Umod A G 7: 119,076,155 (GRCm39) Y204H probably damaging Het
Vcan T A 13: 89,851,543 (GRCm39) Q1139L probably benign Het
Vmn1r85 T A 7: 12,818,668 (GRCm39) T159S possibly damaging Het
Vmn2r103 T A 17: 20,032,562 (GRCm39) S779T probably benign Het
Vmn2r27 C T 6: 124,200,722 (GRCm39) A412T probably damaging Het
Zc3h12d A C 10: 7,729,077 (GRCm39) D147A probably damaging Het
Zfp800 A T 6: 28,243,272 (GRCm39) D564E probably benign Het
Zfp932 A G 5: 110,154,853 (GRCm39) E17G probably damaging Het
Other mutations in Or10g6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01481:Or10g6 APN 9 39,934,574 (GRCm39) missense possibly damaging 0.61
IGL02089:Or10g6 APN 9 39,934,066 (GRCm39) missense probably damaging 1.00
R0722:Or10g6 UTSW 9 39,934,295 (GRCm39) missense probably damaging 1.00
R1117:Or10g6 UTSW 9 39,934,058 (GRCm39) missense probably damaging 0.99
R1781:Or10g6 UTSW 9 39,934,541 (GRCm39) missense probably damaging 1.00
R1874:Or10g6 UTSW 9 39,934,151 (GRCm39) missense possibly damaging 0.86
R1893:Or10g6 UTSW 9 39,934,270 (GRCm39) missense possibly damaging 0.64
R1942:Or10g6 UTSW 9 39,934,048 (GRCm39) missense probably damaging 1.00
R1999:Or10g6 UTSW 9 39,933,985 (GRCm39) missense probably benign
R2000:Or10g6 UTSW 9 39,933,985 (GRCm39) missense probably benign
R2173:Or10g6 UTSW 9 39,934,550 (GRCm39) missense probably damaging 0.97
R2760:Or10g6 UTSW 9 39,933,692 (GRCm39) start codon destroyed probably null 0.00
R4300:Or10g6 UTSW 9 39,934,435 (GRCm39) missense probably benign 0.02
R4530:Or10g6 UTSW 9 39,934,589 (GRCm39) missense probably benign
R4614:Or10g6 UTSW 9 39,934,255 (GRCm39) missense probably damaging 1.00
R4661:Or10g6 UTSW 9 39,933,823 (GRCm39) missense probably damaging 1.00
R4777:Or10g6 UTSW 9 39,933,994 (GRCm39) missense possibly damaging 0.90
R5017:Or10g6 UTSW 9 39,933,672 (GRCm39) start gained probably benign
R5065:Or10g6 UTSW 9 39,934,546 (GRCm39) missense probably benign 0.44
R5467:Or10g6 UTSW 9 39,933,733 (GRCm39) missense probably benign 0.00
R5668:Or10g6 UTSW 9 39,933,964 (GRCm39) missense probably damaging 1.00
R5687:Or10g6 UTSW 9 39,933,731 (GRCm39) missense probably damaging 1.00
R6432:Or10g6 UTSW 9 39,933,824 (GRCm39) missense probably damaging 1.00
R6620:Or10g6 UTSW 9 39,934,225 (GRCm39) missense probably damaging 1.00
R6992:Or10g6 UTSW 9 39,933,896 (GRCm39) nonsense probably null
R7156:Or10g6 UTSW 9 39,934,526 (GRCm39) missense probably benign 0.23
R7250:Or10g6 UTSW 9 39,934,050 (GRCm39) nonsense probably null
R7273:Or10g6 UTSW 9 39,933,961 (GRCm39) missense probably benign 0.04
R8006:Or10g6 UTSW 9 39,933,770 (GRCm39) missense probably damaging 1.00
R8701:Or10g6 UTSW 9 39,933,815 (GRCm39) missense probably damaging 1.00
R8835:Or10g6 UTSW 9 39,934,171 (GRCm39) missense possibly damaging 0.48
R9497:Or10g6 UTSW 9 39,934,616 (GRCm39) missense probably benign
R9733:Or10g6 UTSW 9 39,934,171 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCACTGTCTTGGTGGACATCC -3'
(R):5'- GTCACAGAAGAAGTAGTCAACTCG -3'

Sequencing Primer
(F):5'- TCTTGGTGGACATCCGGCTC -3'
(R):5'- AAGTAGTCAACTCGGTTTGGGCC -3'
Posted On 2014-08-01