Incidental Mutation 'R1942:Rapgef6'
| ID |
216310 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
| MMRRC Submission |
039960-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1942 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 54548089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 753
(I753V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094536
AA Change: I468V
PolyPhen 2
Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
AA Change: I468V
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000101206
AA Change: I753V
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: I753V
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102743
AA Change: I753V
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: I753V
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108894
AA Change: I468V
PolyPhen 2
Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
AA Change: I468V
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175600
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
AA Change: I758V
PolyPhen 2
Score 0.282 (Sensitivity: 0.91; Specificity: 0.88)
|
| Meta Mutation Damage Score |
0.0733 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.7%
|
| Validation Efficiency |
100% (75/75) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930407I10Rik |
A |
T |
15: 81,949,625 (GRCm39) |
Y1174F |
probably damaging |
Het |
| Ahnak |
A |
G |
19: 8,992,447 (GRCm39) |
E4577G |
probably damaging |
Het |
| Anapc4 |
T |
C |
5: 53,004,056 (GRCm39) |
V291A |
probably benign |
Het |
| Apba2 |
A |
G |
7: 64,345,218 (GRCm39) |
E136G |
possibly damaging |
Het |
| Arhgap20 |
C |
A |
9: 51,742,998 (GRCm39) |
Q279K |
probably benign |
Het |
| B3galnt1 |
A |
T |
3: 69,483,258 (GRCm39) |
M1K |
probably null |
Het |
| C4bp |
C |
A |
1: 130,583,804 (GRCm39) |
|
probably benign |
Het |
| Catsperg1 |
G |
A |
7: 28,906,232 (GRCm39) |
T157I |
possibly damaging |
Het |
| Cfap90 |
A |
C |
13: 68,761,090 (GRCm39) |
I171L |
probably benign |
Het |
| Chrm1 |
T |
A |
19: 8,655,637 (GRCm39) |
M114K |
probably damaging |
Het |
| Clasp1 |
A |
G |
1: 118,429,078 (GRCm39) |
E329G |
possibly damaging |
Het |
| Clrn2 |
A |
C |
5: 45,611,337 (GRCm39) |
Y62S |
probably benign |
Het |
| Col12a1 |
T |
G |
9: 79,542,748 (GRCm39) |
D2339A |
probably damaging |
Het |
| Copa |
T |
A |
1: 171,939,455 (GRCm39) |
L564Q |
probably damaging |
Het |
| Cpeb2 |
C |
A |
5: 43,392,596 (GRCm39) |
|
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,572,573 (GRCm39) |
M647K |
probably damaging |
Het |
| Diaph3 |
C |
T |
14: 87,378,556 (GRCm39) |
|
probably benign |
Het |
| Eomes |
A |
G |
9: 118,313,716 (GRCm39) |
D587G |
probably benign |
Het |
| Gm5142 |
T |
A |
14: 59,416,156 (GRCm39) |
M1L |
probably benign |
Het |
| Gnl2 |
A |
G |
4: 124,923,957 (GRCm39) |
I12V |
probably benign |
Het |
| Gprin1 |
C |
T |
13: 54,887,752 (GRCm39) |
C174Y |
probably benign |
Het |
| Grin2b |
A |
T |
6: 135,709,730 (GRCm39) |
V1272E |
possibly damaging |
Het |
| Hdac9 |
A |
G |
12: 34,479,544 (GRCm39) |
L227S |
probably damaging |
Het |
| Helz |
T |
A |
11: 107,493,318 (GRCm39) |
L247Q |
probably benign |
Het |
| Hs6st1 |
T |
C |
1: 36,107,803 (GRCm39) |
V22A |
probably benign |
Het |
| Hspg2 |
C |
A |
4: 137,269,863 (GRCm39) |
A2304E |
possibly damaging |
Het |
| Htr3a |
T |
C |
9: 48,819,911 (GRCm39) |
Y73C |
probably damaging |
Het |
| Il1rap |
A |
C |
16: 26,541,205 (GRCm39) |
E482A |
probably damaging |
Het |
| Itsn2 |
T |
A |
12: 4,689,670 (GRCm39) |
L581* |
probably null |
Het |
| Msmb |
A |
G |
14: 31,870,034 (GRCm39) |
E2G |
probably benign |
Het |
| Muc19 |
T |
C |
15: 91,776,666 (GRCm39) |
|
noncoding transcript |
Het |
| Muc4 |
A |
C |
16: 32,569,460 (GRCm39) |
L173F |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,411,421 (GRCm39) |
S1456C |
unknown |
Het |
| Mylip |
A |
T |
13: 45,560,172 (GRCm39) |
I203F |
probably damaging |
Het |
| Nckap5 |
A |
T |
1: 125,952,039 (GRCm39) |
D1504E |
probably damaging |
Het |
| Neil1 |
C |
G |
9: 57,053,891 (GRCm39) |
R143P |
probably benign |
Het |
| Nlrp2 |
T |
A |
7: 5,325,447 (GRCm39) |
T742S |
probably damaging |
Het |
| Nme8 |
A |
G |
13: 19,859,978 (GRCm39) |
V214A |
probably damaging |
Het |
| Nsun7 |
C |
T |
5: 66,441,588 (GRCm39) |
T419I |
probably benign |
Het |
| Nup210l |
G |
A |
3: 90,058,544 (GRCm39) |
E648K |
probably benign |
Het |
| Or10g6 |
T |
A |
9: 39,934,031 (GRCm39) |
L114H |
probably damaging |
Het |
| Or10g6 |
T |
C |
9: 39,934,048 (GRCm39) |
Y120H |
probably damaging |
Het |
| Or2y1c |
T |
C |
11: 49,360,981 (GRCm39) |
M1T |
probably null |
Het |
| Or8s2 |
A |
G |
15: 98,276,445 (GRCm39) |
L182P |
probably damaging |
Het |
| Parp11 |
A |
C |
6: 127,447,663 (GRCm39) |
|
probably null |
Het |
| Pomgnt1 |
G |
T |
4: 116,012,472 (GRCm39) |
|
probably null |
Het |
| Ppp1r14c |
T |
C |
10: 3,413,417 (GRCm39) |
I150T |
probably damaging |
Het |
| Psd4 |
A |
G |
2: 24,295,805 (GRCm39) |
E908G |
probably damaging |
Het |
| Psmd6 |
A |
T |
14: 14,116,442 (GRCm38) |
V91E |
probably damaging |
Het |
| Ptk2b |
A |
T |
14: 66,406,830 (GRCm39) |
V634D |
probably damaging |
Het |
| Rbm45 |
G |
A |
2: 76,205,823 (GRCm39) |
|
probably null |
Het |
| Ric1 |
A |
G |
19: 29,578,416 (GRCm39) |
|
probably benign |
Het |
| Sh3rf2 |
A |
G |
18: 42,282,689 (GRCm39) |
K416E |
probably damaging |
Het |
| Six5 |
C |
T |
7: 18,830,858 (GRCm39) |
A495V |
possibly damaging |
Het |
| Slc27a6 |
T |
A |
18: 58,689,870 (GRCm39) |
M112K |
probably damaging |
Het |
| Slc5a4a |
T |
C |
10: 75,983,422 (GRCm39) |
S20P |
unknown |
Het |
| Smg1 |
A |
G |
7: 117,757,326 (GRCm39) |
|
probably benign |
Het |
| Sntb2 |
G |
A |
8: 107,737,984 (GRCm39) |
A511T |
probably damaging |
Het |
| Stk31 |
A |
T |
6: 49,416,061 (GRCm39) |
N622I |
probably damaging |
Het |
| Sulf1 |
T |
C |
1: 12,918,397 (GRCm39) |
F38S |
probably damaging |
Het |
| Szt2 |
G |
T |
4: 118,249,817 (GRCm39) |
T521K |
probably benign |
Het |
| Terf1 |
G |
T |
1: 15,876,038 (GRCm39) |
R46I |
probably benign |
Het |
| Tmem245 |
A |
G |
4: 56,923,511 (GRCm39) |
|
probably benign |
Het |
| Tmigd1 |
T |
C |
11: 76,804,905 (GRCm39) |
|
probably null |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Umod |
A |
G |
7: 119,076,155 (GRCm39) |
Y204H |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,851,543 (GRCm39) |
Q1139L |
probably benign |
Het |
| Vmn1r85 |
T |
A |
7: 12,818,668 (GRCm39) |
T159S |
possibly damaging |
Het |
| Vmn2r103 |
T |
A |
17: 20,032,562 (GRCm39) |
S779T |
probably benign |
Het |
| Vmn2r27 |
C |
T |
6: 124,200,722 (GRCm39) |
A412T |
probably damaging |
Het |
| Zc3h12d |
A |
C |
10: 7,729,077 (GRCm39) |
D147A |
probably damaging |
Het |
| Zfp800 |
A |
T |
6: 28,243,272 (GRCm39) |
D564E |
probably benign |
Het |
| Zfp932 |
A |
G |
5: 110,154,853 (GRCm39) |
E17G |
probably damaging |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGTACTCTTCCTACTTGTTAAC -3'
(R):5'- TTTGGAGAACTGGTCCGGAAG -3'
Sequencing Primer
(F):5'- GTCCCAGATCCTACATGATGG -3'
(R):5'- AGAACTGGTCCGGAAGTCTTCTC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation