Incidental Mutation 'R1944:Adamts16'
| ID |
216503 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts16
|
| Ensembl Gene |
ENSMUSG00000049538 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 16 |
| Synonyms |
|
| MMRRC Submission |
039962-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1944 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
70875921-70989930 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 70940005 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Asparagine
at position 406
(S406N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105316
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080145]
[ENSMUST00000109694]
[ENSMUST00000123552]
|
| AlphaFold |
Q69Z28 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080145
AA Change: S406N
PolyPhen 2
Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
AA Change: S406N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109694
AA Change: S406N
PolyPhen 2
Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
AA Change: S406N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000123552
AA Change: S406N
PolyPhen 2
Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000122031
Gene: ENSMUSG00000049538
AA Change: S406N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
5.9e-33 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
5.1e-14 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
2.2e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
1.2e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
1.2e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
9.7e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
A |
T |
5: 8,980,796 (GRCm39) |
N593Y |
probably damaging |
Het |
| Adgrg1 |
G |
A |
8: 95,733,928 (GRCm39) |
V350I |
probably damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,659,030 (GRCm39) |
D2051E |
probably damaging |
Het |
| Adrb2 |
C |
A |
18: 62,312,484 (GRCm39) |
V114L |
probably damaging |
Het |
| Ago3 |
A |
G |
4: 126,247,520 (GRCm39) |
V599A |
probably damaging |
Het |
| AI837181 |
T |
C |
19: 5,476,257 (GRCm39) |
V140A |
probably damaging |
Het |
| Ankrd16 |
T |
A |
2: 11,788,443 (GRCm39) |
|
probably null |
Het |
| Arnt2 |
A |
G |
7: 83,992,959 (GRCm39) |
S194P |
probably benign |
Het |
| Art2b |
T |
C |
7: 101,229,153 (GRCm39) |
N249D |
probably benign |
Het |
| Atat1 |
A |
G |
17: 36,220,232 (GRCm39) |
L60P |
probably damaging |
Het |
| Atp2b1 |
A |
T |
10: 98,858,793 (GRCm39) |
I1159F |
probably damaging |
Het |
| Atrip |
T |
A |
9: 108,900,935 (GRCm39) |
I135F |
probably damaging |
Het |
| Bbs4 |
T |
G |
9: 59,237,698 (GRCm39) |
|
probably null |
Het |
| Bdp1 |
A |
T |
13: 100,210,889 (GRCm39) |
|
probably null |
Het |
| Best2 |
A |
G |
8: 85,737,390 (GRCm39) |
|
probably null |
Het |
| Cacna1c |
A |
G |
6: 118,583,227 (GRCm39) |
I1516T |
probably damaging |
Het |
| Cadps2 |
T |
C |
6: 23,599,479 (GRCm39) |
I276V |
probably damaging |
Het |
| Carmil3 |
T |
C |
14: 55,736,087 (GRCm39) |
S610P |
probably damaging |
Het |
| Caskin1 |
A |
G |
17: 24,719,745 (GRCm39) |
I375V |
probably damaging |
Het |
| Ccdc168 |
G |
A |
1: 44,101,009 (GRCm39) |
P30S |
probably damaging |
Het |
| Ccdc92b |
A |
G |
11: 74,520,835 (GRCm39) |
I46V |
probably benign |
Het |
| Clec11a |
G |
T |
7: 43,954,098 (GRCm39) |
T285K |
probably benign |
Het |
| Clk3 |
G |
T |
9: 57,672,469 (GRCm39) |
T111K |
probably benign |
Het |
| Col6a6 |
G |
A |
9: 105,586,583 (GRCm39) |
R1813C |
probably damaging |
Het |
| Col7a1 |
G |
A |
9: 108,789,078 (GRCm39) |
V798I |
unknown |
Het |
| Ctrb1 |
C |
A |
8: 112,416,151 (GRCm39) |
W45L |
probably damaging |
Het |
| Cubn |
T |
A |
2: 13,283,349 (GRCm39) |
S3530C |
probably benign |
Het |
| Dio1 |
A |
G |
4: 107,163,977 (GRCm39) |
|
probably null |
Het |
| Dock5 |
A |
T |
14: 67,994,584 (GRCm39) |
Y1825* |
probably null |
Het |
| Duox1 |
A |
T |
2: 122,177,001 (GRCm39) |
Q1476L |
probably damaging |
Het |
| Dync2h1 |
A |
T |
9: 7,001,377 (GRCm39) |
H3877Q |
probably damaging |
Het |
| Enkd1 |
A |
G |
8: 106,434,208 (GRCm39) |
S85P |
probably damaging |
Het |
| Erap1 |
A |
G |
13: 74,794,758 (GRCm39) |
D139G |
probably benign |
Het |
| Ern1 |
A |
G |
11: 106,312,776 (GRCm39) |
S202P |
probably damaging |
Het |
| F11r |
T |
C |
1: 171,289,459 (GRCm39) |
Y261H |
probably damaging |
Het |
| Glp2r |
A |
T |
11: 67,637,618 (GRCm39) |
S138T |
probably benign |
Het |
| Gpt2 |
A |
G |
8: 86,244,625 (GRCm39) |
Y306C |
probably damaging |
Het |
| Grid2 |
G |
C |
6: 63,886,045 (GRCm39) |
R147P |
probably damaging |
Het |
| Gtdc1 |
A |
G |
2: 44,642,198 (GRCm39) |
F128L |
possibly damaging |
Het |
| H2-T15 |
A |
G |
17: 36,368,897 (GRCm39) |
F61S |
probably damaging |
Het |
| Hacd4 |
T |
C |
4: 88,341,303 (GRCm39) |
T154A |
possibly damaging |
Het |
| Heatr6 |
G |
T |
11: 83,660,046 (GRCm39) |
L530F |
probably damaging |
Het |
| Hoxd8 |
A |
T |
2: 74,537,056 (GRCm39) |
D256V |
probably damaging |
Het |
| Ints6 |
T |
C |
14: 62,931,089 (GRCm39) |
N865D |
probably benign |
Het |
| Itpkc |
G |
T |
7: 26,927,084 (GRCm39) |
P277T |
possibly damaging |
Het |
| Klc4 |
T |
C |
17: 46,947,553 (GRCm39) |
N383S |
probably damaging |
Het |
| Klra6 |
T |
C |
6: 129,995,908 (GRCm39) |
Y150C |
possibly damaging |
Het |
| Krt32 |
T |
A |
11: 99,975,670 (GRCm39) |
|
probably null |
Het |
| Krt33a |
T |
C |
11: 99,903,535 (GRCm39) |
N199S |
probably benign |
Het |
| Krt39 |
A |
C |
11: 99,410,649 (GRCm39) |
D174E |
probably damaging |
Het |
| Krt82 |
G |
A |
15: 101,456,970 (GRCm39) |
R137W |
probably damaging |
Het |
| Lgmn |
A |
T |
12: 102,368,183 (GRCm39) |
S193T |
probably damaging |
Het |
| Limch1 |
G |
A |
5: 67,156,442 (GRCm39) |
R300H |
probably damaging |
Het |
| Lrpap1 |
T |
A |
5: 35,254,974 (GRCm39) |
I221F |
probably benign |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Macf1 |
T |
C |
4: 123,264,459 (GRCm39) |
D4883G |
probably damaging |
Het |
| Man2b2 |
A |
G |
5: 36,973,524 (GRCm39) |
V485A |
probably benign |
Het |
| Map3k19 |
T |
C |
1: 127,750,859 (GRCm39) |
T831A |
probably benign |
Het |
| Mdfic2 |
A |
G |
6: 98,225,151 (GRCm39) |
I44T |
probably benign |
Het |
| Megf6 |
C |
G |
4: 154,340,523 (GRCm39) |
D471E |
possibly damaging |
Het |
| Mettl8 |
A |
T |
2: 70,803,623 (GRCm39) |
F268L |
probably damaging |
Het |
| Miip |
T |
C |
4: 147,950,422 (GRCm39) |
E58G |
probably benign |
Het |
| Mycbp2 |
T |
A |
14: 103,466,840 (GRCm39) |
S1308C |
probably damaging |
Het |
| Myo15a |
T |
C |
11: 60,392,909 (GRCm39) |
F2194L |
probably damaging |
Het |
| Nav3 |
T |
C |
10: 109,552,391 (GRCm39) |
N1817S |
probably damaging |
Het |
| Ndel1 |
A |
T |
11: 68,720,746 (GRCm39) |
H313Q |
probably benign |
Het |
| Neb |
A |
T |
2: 52,118,862 (GRCm39) |
H3931Q |
probably benign |
Het |
| Nfkb2 |
T |
A |
19: 46,296,491 (GRCm39) |
V253E |
probably damaging |
Het |
| Niban1 |
T |
C |
1: 151,571,979 (GRCm39) |
I308T |
probably damaging |
Het |
| Nono |
T |
C |
X: 100,485,429 (GRCm39) |
|
probably null |
Het |
| Npc1l1 |
T |
A |
11: 6,164,588 (GRCm39) |
I1154F |
possibly damaging |
Het |
| Nr2e1 |
T |
C |
10: 42,448,774 (GRCm39) |
T155A |
probably benign |
Het |
| Oosp2 |
C |
T |
19: 11,626,959 (GRCm39) |
|
probably null |
Het |
| Or2b2 |
A |
T |
13: 21,887,287 (GRCm39) |
I39F |
possibly damaging |
Het |
| Pdap1 |
G |
A |
5: 145,069,726 (GRCm39) |
T93I |
probably benign |
Het |
| Pde6c |
T |
A |
19: 38,145,967 (GRCm39) |
D418E |
probably damaging |
Het |
| Pdha1 |
T |
A |
X: 158,910,354 (GRCm39) |
D255V |
probably damaging |
Het |
| Polr2h |
T |
A |
16: 20,537,796 (GRCm39) |
D64E |
probably benign |
Het |
| Psmb3 |
T |
C |
11: 97,601,981 (GRCm39) |
F117S |
probably benign |
Het |
| Ptprq |
A |
T |
10: 107,418,249 (GRCm39) |
M1709K |
probably benign |
Het |
| Rbm15 |
C |
T |
3: 107,238,868 (GRCm39) |
R510H |
probably damaging |
Het |
| Rgs7 |
A |
T |
1: 174,980,769 (GRCm39) |
M85K |
possibly damaging |
Het |
| Rpl27-ps3 |
T |
A |
18: 6,332,669 (GRCm39) |
V13D |
probably damaging |
Het |
| Rtp2 |
T |
A |
16: 23,746,316 (GRCm39) |
D105V |
possibly damaging |
Het |
| Scd3 |
T |
C |
19: 44,224,219 (GRCm39) |
Y151H |
probably benign |
Het |
| Slc30a6 |
T |
G |
17: 74,715,858 (GRCm39) |
V106G |
probably damaging |
Het |
| Slco1a4 |
T |
C |
6: 141,785,276 (GRCm39) |
I105V |
probably benign |
Het |
| Sun3 |
T |
C |
11: 8,988,296 (GRCm39) |
I9V |
probably benign |
Het |
| Syne2 |
T |
C |
12: 76,121,318 (GRCm39) |
V5928A |
probably damaging |
Het |
| Tbr1 |
T |
A |
2: 61,642,600 (GRCm39) |
S622T |
probably damaging |
Het |
| Tgm3 |
A |
G |
2: 129,871,889 (GRCm39) |
N306D |
probably damaging |
Het |
| Tmem132d |
A |
G |
5: 127,860,828 (GRCm39) |
*1098Q |
probably null |
Het |
| Tmem140 |
T |
C |
6: 34,849,747 (GRCm39) |
Y88H |
probably damaging |
Het |
| Trim60 |
A |
T |
8: 65,453,964 (GRCm39) |
V95E |
possibly damaging |
Het |
| Vamp3 |
A |
G |
4: 151,140,617 (GRCm39) |
|
probably null |
Het |
| Vmn1r235 |
A |
C |
17: 21,481,785 (GRCm39) |
T37P |
probably damaging |
Het |
| Vmn2r81 |
T |
G |
10: 79,129,571 (GRCm39) |
L821V |
probably damaging |
Het |
| Vmn2r97 |
A |
G |
17: 19,160,500 (GRCm39) |
D545G |
probably benign |
Het |
| Vps13c |
A |
T |
9: 67,793,558 (GRCm39) |
D437V |
probably damaging |
Het |
| Wtip |
A |
T |
7: 33,818,363 (GRCm39) |
M268K |
probably benign |
Het |
| Zfhx2 |
G |
T |
14: 55,312,189 (GRCm39) |
F168L |
probably benign |
Het |
| Zscan22 |
G |
A |
7: 12,637,767 (GRCm39) |
R53K |
probably damaging |
Het |
|
| Other mutations in Adamts16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Adamts16
|
APN |
13 |
70,943,603 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01338:Adamts16
|
APN |
13 |
70,984,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01663:Adamts16
|
APN |
13 |
70,941,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01804:Adamts16
|
APN |
13 |
70,949,080 (GRCm39) |
nonsense |
probably null |
|
|
IGL01874:Adamts16
|
APN |
13 |
70,916,823 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01984:Adamts16
|
APN |
13 |
70,935,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02305:Adamts16
|
APN |
13 |
70,921,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02357:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Adamts16
|
APN |
13 |
70,935,289 (GRCm39) |
splice site |
probably benign |
|
|
IGL02450:Adamts16
|
APN |
13 |
70,984,419 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02807:Adamts16
|
APN |
13 |
70,886,897 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03356:Adamts16
|
APN |
13 |
70,901,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
swap
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
switcheroo
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0201:Adamts16
|
UTSW |
13 |
70,927,763 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0326:Adamts16
|
UTSW |
13 |
70,927,730 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0336:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R0369:Adamts16
|
UTSW |
13 |
70,927,671 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0422:Adamts16
|
UTSW |
13 |
70,887,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Adamts16
|
UTSW |
13 |
70,916,766 (GRCm39) |
missense |
probably benign |
|
|
R0524:Adamts16
|
UTSW |
13 |
70,949,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0590:Adamts16
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0734:Adamts16
|
UTSW |
13 |
70,886,600 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Adamts16
|
UTSW |
13 |
70,886,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Adamts16
|
UTSW |
13 |
70,916,811 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0920:Adamts16
|
UTSW |
13 |
70,911,680 (GRCm39) |
splice site |
probably benign |
|
|
R1027:Adamts16
|
UTSW |
13 |
70,915,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1535:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Adamts16
|
UTSW |
13 |
70,946,154 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1700:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1734:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1736:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1737:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1738:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1746:Adamts16
|
UTSW |
13 |
70,927,717 (GRCm39) |
splice site |
probably null |
|
|
R1869:Adamts16
|
UTSW |
13 |
70,883,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Adamts16
|
UTSW |
13 |
70,901,386 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2018:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2135:Adamts16
|
UTSW |
13 |
70,949,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2228:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R3410:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3842:Adamts16
|
UTSW |
13 |
70,887,010 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4117:Adamts16
|
UTSW |
13 |
70,916,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4435:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4436:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4526:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4552:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4555:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4556:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4557:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4579:Adamts16
|
UTSW |
13 |
70,927,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4639:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4640:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4641:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4642:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4672:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R5350:Adamts16
|
UTSW |
13 |
70,901,315 (GRCm39) |
nonsense |
probably null |
|
|
R5464:Adamts16
|
UTSW |
13 |
70,909,868 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5613:Adamts16
|
UTSW |
13 |
70,878,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5667:Adamts16
|
UTSW |
13 |
70,984,494 (GRCm39) |
nonsense |
probably null |
|
|
R5735:Adamts16
|
UTSW |
13 |
70,984,337 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5762:Adamts16
|
UTSW |
13 |
70,886,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5907:Adamts16
|
UTSW |
13 |
70,877,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Adamts16
|
UTSW |
13 |
70,918,393 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Adamts16
|
UTSW |
13 |
70,984,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Adamts16
|
UTSW |
13 |
70,927,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Adamts16
|
UTSW |
13 |
70,877,017 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6982:Adamts16
|
UTSW |
13 |
70,916,639 (GRCm39) |
splice site |
probably null |
|
|
R6996:Adamts16
|
UTSW |
13 |
70,946,157 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7313:Adamts16
|
UTSW |
13 |
70,921,074 (GRCm39) |
nonsense |
probably null |
|
|
R7356:Adamts16
|
UTSW |
13 |
70,984,399 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7509:Adamts16
|
UTSW |
13 |
70,935,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Adamts16
|
UTSW |
13 |
70,878,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Adamts16
|
UTSW |
13 |
70,984,265 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7968:Adamts16
|
UTSW |
13 |
70,886,701 (GRCm39) |
missense |
probably benign |
|
|
R8231:Adamts16
|
UTSW |
13 |
70,925,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8232:Adamts16
|
UTSW |
13 |
70,941,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Adamts16
|
UTSW |
13 |
70,984,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8485:Adamts16
|
UTSW |
13 |
70,886,794 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8772:Adamts16
|
UTSW |
13 |
70,984,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Adamts16
|
UTSW |
13 |
70,941,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8921:Adamts16
|
UTSW |
13 |
70,939,910 (GRCm39) |
splice site |
probably benign |
|
|
R8973:Adamts16
|
UTSW |
13 |
70,886,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9132:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9149:Adamts16
|
UTSW |
13 |
70,883,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9159:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9312:Adamts16
|
UTSW |
13 |
70,949,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Adamts16
|
UTSW |
13 |
70,949,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adamts16
|
UTSW |
13 |
70,909,892 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTCTGTCCAGTCAGATGG -3'
(R):5'- ATGTATCATCTTTACATGGCTGCC -3'
Sequencing Primer
(F):5'- TGTACCATAAGAGCAGCCTACTGG -3'
(R):5'- TTTACATGGCTGCCCAAGAG -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation