Incidental Mutation 'R1954:Ncoa6'
| ID |
217542 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ncoa6
|
| Ensembl Gene |
ENSMUSG00000038369 |
| Gene Name |
nuclear receptor coactivator 6 |
| Synonyms |
ASC-2, RAP250, NRC, AIB3, ASC2, PRIP |
| MMRRC Submission |
039968-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1954 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
155232585-155315741 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 155248741 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1521
(V1521A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043126]
[ENSMUST00000109670]
[ENSMUST00000123293]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000043126
AA Change: V1521A
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000045386
Gene: ENSMUSG00000038369
AA Change: V1521A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
47 |
190 |
3.3e-55 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109670
AA Change: V1521A
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000105295
Gene: ENSMUSG00000038369
AA Change: V1521A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
3.6e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123293
|
| SMART Domains |
Protein: ENSMUSP00000118113
Gene: ENSMUSG00000038369
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.4e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
low complexity region
|
564 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146942
|
| Meta Mutation Damage Score |
0.0598 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (101/104) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts15 |
T |
A |
9: 30,822,004 (GRCm39) |
M478L |
probably benign |
Het |
| Akap8l |
T |
A |
17: 32,555,710 (GRCm39) |
Y123F |
possibly damaging |
Het |
| Anapc4 |
T |
G |
5: 53,003,967 (GRCm39) |
|
probably benign |
Het |
| Arap3 |
A |
G |
18: 38,115,055 (GRCm39) |
V987A |
probably damaging |
Het |
| Atp2b4 |
T |
A |
1: 133,667,730 (GRCm39) |
T105S |
probably damaging |
Het |
| Atp6v0d1 |
A |
G |
8: 106,292,525 (GRCm39) |
L7P |
probably damaging |
Het |
| Atp6v1b2 |
T |
C |
8: 69,558,555 (GRCm39) |
V341A |
possibly damaging |
Het |
| Baz2b |
C |
A |
2: 59,799,087 (GRCm39) |
A346S |
probably benign |
Het |
| Brpf3 |
G |
A |
17: 29,025,533 (GRCm39) |
S202N |
probably benign |
Het |
| Btnl4 |
T |
C |
17: 34,691,904 (GRCm39) |
K233E |
possibly damaging |
Het |
| Capn7 |
A |
G |
14: 31,082,107 (GRCm39) |
T438A |
probably damaging |
Het |
| Cars2 |
A |
T |
8: 11,600,286 (GRCm39) |
Y68N |
probably damaging |
Het |
| Cbx2 |
G |
T |
11: 118,919,166 (GRCm39) |
G244W |
probably damaging |
Het |
| Ccr4 |
A |
T |
9: 114,321,753 (GRCm39) |
V104D |
probably damaging |
Het |
| Cdc5l |
T |
C |
17: 45,737,442 (GRCm39) |
|
probably null |
Het |
| Cep170 |
A |
T |
1: 176,583,950 (GRCm39) |
C810S |
probably benign |
Het |
| Cfap299 |
A |
T |
5: 98,714,612 (GRCm39) |
|
probably benign |
Het |
| Clp1 |
T |
C |
2: 84,554,395 (GRCm39) |
D258G |
probably damaging |
Het |
| Clstn3 |
T |
C |
6: 124,436,257 (GRCm39) |
E164G |
possibly damaging |
Het |
| Col28a1 |
T |
C |
6: 7,998,516 (GRCm39) |
E1131G |
probably damaging |
Het |
| Cps1 |
A |
G |
1: 67,234,355 (GRCm39) |
D914G |
possibly damaging |
Het |
| Ctnnal1 |
C |
T |
4: 56,817,242 (GRCm39) |
|
probably benign |
Het |
| Cyp2c38 |
A |
G |
19: 39,393,131 (GRCm39) |
L312P |
probably damaging |
Het |
| Cytip |
T |
C |
2: 58,038,265 (GRCm39) |
N99D |
possibly damaging |
Het |
| Dennd4a |
A |
T |
9: 64,759,749 (GRCm39) |
T285S |
probably benign |
Het |
| Dhx8 |
A |
G |
11: 101,644,105 (GRCm39) |
S842G |
probably damaging |
Het |
| Disp1 |
A |
T |
1: 182,870,107 (GRCm39) |
M771K |
probably damaging |
Het |
| Dnah17 |
A |
G |
11: 117,915,557 (GRCm39) |
I4326T |
probably damaging |
Het |
| Efcab7 |
T |
C |
4: 99,757,887 (GRCm39) |
F345L |
probably damaging |
Het |
| Erc1 |
G |
T |
6: 119,774,266 (GRCm39) |
Q230K |
probably damaging |
Het |
| Ern1 |
A |
T |
11: 106,312,800 (GRCm39) |
|
probably benign |
Het |
| Espl1 |
T |
C |
15: 102,206,823 (GRCm39) |
Y96H |
probably damaging |
Het |
| Fam135a |
A |
T |
1: 24,068,683 (GRCm39) |
L533I |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,201,910 (GRCm39) |
T388I |
probably benign |
Het |
| Galnt1 |
T |
G |
18: 24,404,831 (GRCm39) |
|
probably benign |
Het |
| Glmn |
A |
G |
5: 107,720,243 (GRCm39) |
F212S |
probably damaging |
Het |
| Gm3604 |
A |
T |
13: 62,517,025 (GRCm39) |
N444K |
probably damaging |
Het |
| Gvin-ps5 |
A |
C |
7: 105,928,888 (GRCm39) |
D336E |
probably damaging |
Het |
| H1f2 |
T |
C |
13: 23,923,385 (GRCm39) |
V185A |
unknown |
Het |
| H1f3 |
A |
G |
13: 23,739,690 (GRCm39) |
|
probably benign |
Het |
| H2-M10.3 |
T |
C |
17: 36,678,390 (GRCm39) |
D145G |
probably damaging |
Het |
| Hic2 |
T |
A |
16: 17,076,857 (GRCm39) |
L562Q |
probably damaging |
Het |
| Hip1r |
G |
T |
5: 124,139,907 (GRCm39) |
E1003D |
probably damaging |
Het |
| Hsfy2 |
C |
T |
1: 56,676,342 (GRCm39) |
C65Y |
probably benign |
Het |
| Inpp1 |
T |
C |
1: 52,833,788 (GRCm39) |
T103A |
probably damaging |
Het |
| Ints5 |
T |
C |
19: 8,872,260 (GRCm39) |
V73A |
probably damaging |
Het |
| Iqch |
A |
T |
9: 63,455,298 (GRCm39) |
D166E |
probably benign |
Het |
| Klhdc3 |
A |
T |
17: 46,988,901 (GRCm39) |
N96K |
probably damaging |
Het |
| Klk1b8 |
C |
T |
7: 43,603,272 (GRCm39) |
|
probably benign |
Het |
| Klrb1 |
T |
C |
6: 128,700,036 (GRCm39) |
|
probably null |
Het |
| Krt71 |
C |
A |
15: 101,643,901 (GRCm39) |
G446* |
probably null |
Het |
| Lars1 |
G |
A |
18: 42,343,115 (GRCm39) |
R1101C |
probably damaging |
Het |
| Lemd3 |
G |
T |
10: 120,814,845 (GRCm39) |
S129R |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,748,453 (GRCm39) |
L3015P |
probably damaging |
Het |
| Mdga2 |
T |
C |
12: 66,533,482 (GRCm39) |
|
probably benign |
Het |
| Mlst8 |
A |
T |
17: 24,696,195 (GRCm39) |
I178N |
probably damaging |
Het |
| Mon2 |
A |
T |
10: 122,874,388 (GRCm39) |
I320N |
probably damaging |
Het |
| Morc2b |
T |
C |
17: 33,356,464 (GRCm39) |
Y436C |
probably damaging |
Het |
| Moxd1 |
T |
A |
10: 24,155,781 (GRCm39) |
M295K |
probably benign |
Het |
| Mrps5 |
T |
A |
2: 127,438,817 (GRCm39) |
|
probably null |
Het |
| Mtor |
C |
A |
4: 148,552,730 (GRCm39) |
S744R |
probably damaging |
Het |
| Myo3a |
T |
A |
2: 22,246,037 (GRCm39) |
D61E |
probably damaging |
Het |
| Nars1 |
C |
T |
18: 64,633,635 (GRCm39) |
R545Q |
probably damaging |
Het |
| Ndor1 |
T |
C |
2: 25,145,305 (GRCm39) |
E20G |
possibly damaging |
Het |
| Nipsnap3b |
T |
C |
4: 53,017,213 (GRCm39) |
|
probably benign |
Het |
| Notch3 |
G |
T |
17: 32,385,652 (GRCm39) |
A39E |
probably benign |
Het |
| Or1j16 |
A |
G |
2: 36,530,227 (GRCm39) |
M59V |
possibly damaging |
Het |
| Or2a14 |
T |
C |
6: 43,130,911 (GRCm39) |
I224T |
possibly damaging |
Het |
| Or6z3 |
G |
T |
7: 6,464,144 (GRCm39) |
W212L |
probably benign |
Het |
| Otud3 |
T |
C |
4: 138,625,343 (GRCm39) |
K237R |
possibly damaging |
Het |
| Papola |
T |
A |
12: 105,794,532 (GRCm39) |
|
probably null |
Het |
| Parl |
T |
A |
16: 20,121,077 (GRCm39) |
M1L |
possibly damaging |
Het |
| Parp14 |
G |
T |
16: 35,678,671 (GRCm39) |
N432K |
probably benign |
Het |
| Patz1 |
T |
G |
11: 3,241,088 (GRCm39) |
S159A |
probably damaging |
Het |
| Prpf6 |
T |
G |
2: 181,273,870 (GRCm39) |
M338R |
probably benign |
Het |
| Psd3 |
A |
G |
8: 68,149,727 (GRCm39) |
L343P |
probably damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,215,393 (GRCm39) |
N1422K |
probably damaging |
Het |
| Rab19 |
A |
T |
6: 39,361,016 (GRCm39) |
T55S |
probably benign |
Het |
| Sh3yl1 |
A |
G |
12: 30,972,332 (GRCm39) |
K34E |
possibly damaging |
Het |
| Skint8 |
T |
A |
4: 111,807,278 (GRCm39) |
F321L |
possibly damaging |
Het |
| Slc25a46 |
A |
T |
18: 31,733,294 (GRCm39) |
|
probably null |
Het |
| Slc26a3 |
T |
C |
12: 31,500,815 (GRCm39) |
L184S |
probably damaging |
Het |
| Slc39a10 |
A |
T |
1: 46,874,334 (GRCm39) |
S323T |
possibly damaging |
Het |
| Sorbs2 |
G |
T |
8: 46,198,775 (GRCm39) |
R20L |
probably benign |
Het |
| Stk32a |
A |
T |
18: 43,345,090 (GRCm39) |
D13V |
probably benign |
Het |
| Tab2 |
T |
C |
10: 7,795,094 (GRCm39) |
T463A |
probably damaging |
Het |
| Tenm2 |
T |
A |
11: 35,938,374 (GRCm39) |
N1433I |
possibly damaging |
Het |
| Tmem200c |
A |
T |
17: 69,147,956 (GRCm39) |
I180F |
probably damaging |
Het |
| Tmem232 |
G |
T |
17: 65,791,482 (GRCm39) |
H129N |
probably benign |
Het |
| Tmem242 |
T |
C |
17: 5,489,854 (GRCm39) |
T47A |
possibly damaging |
Het |
| Ube2d1 |
A |
T |
10: 71,120,953 (GRCm39) |
M1K |
probably null |
Het |
| Ube2frt |
A |
G |
12: 36,140,595 (GRCm39) |
|
probably benign |
Het |
| Uckl1 |
T |
C |
2: 181,212,320 (GRCm39) |
Q332R |
probably benign |
Het |
| Unc5b |
T |
C |
10: 60,605,044 (GRCm39) |
|
probably benign |
Het |
| Vmn2r114 |
T |
C |
17: 23,530,086 (GRCm39) |
Y107C |
probably benign |
Het |
| Vmn2r82 |
A |
T |
10: 79,231,890 (GRCm39) |
S630C |
probably damaging |
Het |
| Wdr25 |
T |
A |
12: 108,864,467 (GRCm39) |
V204E |
probably damaging |
Het |
| Xab2 |
T |
A |
8: 3,666,094 (GRCm39) |
D227V |
probably damaging |
Het |
| Zfp286 |
A |
G |
11: 62,674,534 (GRCm39) |
S104P |
possibly damaging |
Het |
| Zfp345 |
T |
C |
2: 150,316,741 (GRCm39) |
D22G |
probably damaging |
Het |
|
| Other mutations in Ncoa6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Ncoa6
|
APN |
2 |
155,248,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00849:Ncoa6
|
APN |
2 |
155,263,608 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00933:Ncoa6
|
APN |
2 |
155,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00981:Ncoa6
|
APN |
2 |
155,248,099 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01420:Ncoa6
|
APN |
2 |
155,249,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ncoa6
|
APN |
2 |
155,263,003 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL03049:Ncoa6
|
APN |
2 |
155,260,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03194:Ncoa6
|
APN |
2 |
155,257,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03269:Ncoa6
|
APN |
2 |
155,248,409 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03299:Ncoa6
|
APN |
2 |
155,249,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03306:Ncoa6
|
APN |
2 |
155,247,427 (GRCm39) |
missense |
probably benign |
0.30 |
|
alcoa
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
Aluminum
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
balboa
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
mauna_loa
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4466001:Ncoa6
|
UTSW |
2 |
155,247,577 (GRCm39) |
missense |
probably benign |
|
|
R0011:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0014:Ncoa6
|
UTSW |
2 |
155,279,963 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0079:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0080:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0081:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0164:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0166:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0172:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0173:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0245:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0285:Ncoa6
|
UTSW |
2 |
155,257,621 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0285:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0288:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0539:Ncoa6
|
UTSW |
2 |
155,257,617 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0652:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0781:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1053:Ncoa6
|
UTSW |
2 |
155,275,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1110:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1420:Ncoa6
|
UTSW |
2 |
155,263,073 (GRCm39) |
nonsense |
probably null |
|
|
R1521:Ncoa6
|
UTSW |
2 |
155,257,142 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1541:Ncoa6
|
UTSW |
2 |
155,257,224 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1677:Ncoa6
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
R1858:Ncoa6
|
UTSW |
2 |
155,263,559 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1955:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2040:Ncoa6
|
UTSW |
2 |
155,248,000 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2087:Ncoa6
|
UTSW |
2 |
155,248,079 (GRCm39) |
nonsense |
probably null |
|
|
R2159:Ncoa6
|
UTSW |
2 |
155,249,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Ncoa6
|
UTSW |
2 |
155,249,570 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2696:Ncoa6
|
UTSW |
2 |
155,279,935 (GRCm39) |
missense |
probably benign |
0.45 |
|
R2891:Ncoa6
|
UTSW |
2 |
155,279,881 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3618:Ncoa6
|
UTSW |
2 |
155,249,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3747:Ncoa6
|
UTSW |
2 |
155,253,561 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3778:Ncoa6
|
UTSW |
2 |
155,263,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3784:Ncoa6
|
UTSW |
2 |
155,249,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Ncoa6
|
UTSW |
2 |
155,247,484 (GRCm39) |
missense |
probably benign |
|
|
R3820:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3821:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3822:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3870:Ncoa6
|
UTSW |
2 |
155,257,477 (GRCm39) |
splice site |
probably null |
|
|
R4037:Ncoa6
|
UTSW |
2 |
155,249,290 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4488:Ncoa6
|
UTSW |
2 |
155,249,396 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4719:Ncoa6
|
UTSW |
2 |
155,233,081 (GRCm39) |
unclassified |
probably benign |
|
|
R4732:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4733:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ncoa6
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4835:Ncoa6
|
UTSW |
2 |
155,249,053 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4883:Ncoa6
|
UTSW |
2 |
155,248,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4967:Ncoa6
|
UTSW |
2 |
155,263,252 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5021:Ncoa6
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5234:Ncoa6
|
UTSW |
2 |
155,279,933 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5356:Ncoa6
|
UTSW |
2 |
155,263,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5358:Ncoa6
|
UTSW |
2 |
155,248,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5375:Ncoa6
|
UTSW |
2 |
155,275,915 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5412:Ncoa6
|
UTSW |
2 |
155,249,701 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5579:Ncoa6
|
UTSW |
2 |
155,248,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5618:Ncoa6
|
UTSW |
2 |
155,279,817 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5641:Ncoa6
|
UTSW |
2 |
155,263,756 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5757:Ncoa6
|
UTSW |
2 |
155,253,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Ncoa6
|
UTSW |
2 |
155,250,061 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5778:Ncoa6
|
UTSW |
2 |
155,248,688 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5852:Ncoa6
|
UTSW |
2 |
155,247,419 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5940:Ncoa6
|
UTSW |
2 |
155,257,785 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6155:Ncoa6
|
UTSW |
2 |
155,249,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Ncoa6
|
UTSW |
2 |
155,263,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6389:Ncoa6
|
UTSW |
2 |
155,237,736 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6669:Ncoa6
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7097:Ncoa6
|
UTSW |
2 |
155,279,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7385:Ncoa6
|
UTSW |
2 |
155,249,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7963:Ncoa6
|
UTSW |
2 |
155,247,916 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8356:Ncoa6
|
UTSW |
2 |
155,248,172 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8698:Ncoa6
|
UTSW |
2 |
155,257,041 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8859:Ncoa6
|
UTSW |
2 |
155,248,388 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8870:Ncoa6
|
UTSW |
2 |
155,263,078 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9041:Ncoa6
|
UTSW |
2 |
155,257,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9062:Ncoa6
|
UTSW |
2 |
155,263,348 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9088:Ncoa6
|
UTSW |
2 |
155,249,726 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9225:Ncoa6
|
UTSW |
2 |
155,249,441 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9445:Ncoa6
|
UTSW |
2 |
155,250,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Ncoa6
|
UTSW |
2 |
155,248,238 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9514:Ncoa6
|
UTSW |
2 |
155,248,133 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9656:Ncoa6
|
UTSW |
2 |
155,274,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Ncoa6
|
UTSW |
2 |
155,250,304 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9732:Ncoa6
|
UTSW |
2 |
155,244,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF033:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF040:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF048:Ncoa6
|
UTSW |
2 |
155,263,632 (GRCm39) |
small deletion |
probably benign |
|
|
X0017:Ncoa6
|
UTSW |
2 |
155,248,460 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Ncoa6
|
UTSW |
2 |
155,263,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,263,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,248,062 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACGGGTCTTGACATTACTGG -3'
(R):5'- AAAATGGCTGTCCCTGAAGATC -3'
Sequencing Primer
(F):5'- CTTGACATTACTGGAGGGATGC -3'
(R):5'- ATGGCTGTCCCTGAAGATCAATCC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation