Mutagenetix > Incidental Mutation

Incidental Mutation 'R1958:Syne2'

218061

Institutional Source

Beutler Lab

Gene Symbol

Syne2

Ensembl Gene

ENSMUSG00000063450

Gene Name

spectrin repeat containing, nuclear envelope 2

Synonyms

Nesp2g, diminished cone electroretinogram, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, D12Ertd777e

MMRRC Submission

039972-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.268) question?

Stock #

R1958 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

75865092-76157702 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 76016319 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 3301 (D3301E)

Ref Sequence

ENSEMBL: ENSMUSP00000119120 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044217] [ENSMUST00000143031]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000044217
AA Change: D3300E

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000047697
Gene: ENSMUSG00000063450
AA Change: D3300E

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
coiled coil region	844	869	N/A	INTRINSIC
coiled coil region	936	969	N/A	INTRINSIC
coiled coil region	1006	1032	N/A	INTRINSIC
SPEC	1427	1525	4.96e0	SMART
SPEC	1528	1632	2.48e-1	SMART
coiled coil region	1660	1699	N/A	INTRINSIC
SPEC	2034	2131	1.83e0	SMART
coiled coil region	2173	2194	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
coiled coil region	2316	2348	N/A	INTRINSIC
SPEC	2720	2820	1.44e-5	SMART
coiled coil region	2905	2934	N/A	INTRINSIC
coiled coil region	2962	2989	N/A	INTRINSIC
coiled coil region	3108	3136	N/A	INTRINSIC
low complexity region	3333	3350	N/A	INTRINSIC
low complexity region	3514	3523	N/A	INTRINSIC
low complexity region	3666	3676	N/A	INTRINSIC
coiled coil region	3678	3708	N/A	INTRINSIC
coiled coil region	3761	3788	N/A	INTRINSIC
coiled coil region	3846	3903	N/A	INTRINSIC
coiled coil region	4015	4067	N/A	INTRINSIC
low complexity region	4102	4115	N/A	INTRINSIC
coiled coil region	4483	4511	N/A	INTRINSIC
low complexity region	4557	4569	N/A	INTRINSIC
coiled coil region	4655	4688	N/A	INTRINSIC
low complexity region	4749	4763	N/A	INTRINSIC
SPEC	4827	4926	5.25e-1	SMART
SPEC	4933	5038	2.64e-4	SMART
SPEC	5048	5152	1.47e-2	SMART
SPEC	5159	5259	4.29e0	SMART
SPEC	5263	5371	4.47e0	SMART
low complexity region	5373	5393	N/A	INTRINSIC
SPEC	5583	5681	5.7e-1	SMART
Blast:SPEC	5690	5793	2e-53	BLAST
SPEC	5800	5900	2.11e0	SMART
SPEC	5907	6005	6.91e-8	SMART
SPEC	6012	6119	4.45e-11	SMART
SPEC	6126	6228	6.39e-12	SMART
SPEC	6235	6335	7.75e-11	SMART
SPEC	6539	6642	5.53e-7	SMART
SPEC	6649	6753	5.12e-2	SMART
KASH	6817	6874	8.17e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000143031
AA Change: D3301E

PolyPhen 2 Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000119120
Gene: ENSMUSG00000063450
AA Change: D3301E

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
coiled coil region	845	870	N/A	INTRINSIC
coiled coil region	937	970	N/A	INTRINSIC
coiled coil region	1007	1033	N/A	INTRINSIC
SPEC	1428	1526	4.96e0	SMART
SPEC	1529	1633	2.48e-1	SMART
coiled coil region	1661	1700	N/A	INTRINSIC
SPEC	2035	2132	1.83e0	SMART
coiled coil region	2174	2195	N/A	INTRINSIC
low complexity region	2296	2308	N/A	INTRINSIC
coiled coil region	2317	2349	N/A	INTRINSIC
SPEC	2721	2821	1.44e-5	SMART
coiled coil region	2906	2935	N/A	INTRINSIC
coiled coil region	2963	2990	N/A	INTRINSIC
coiled coil region	3109	3137	N/A	INTRINSIC
low complexity region	3334	3351	N/A	INTRINSIC
low complexity region	3515	3524	N/A	INTRINSIC
low complexity region	3667	3677	N/A	INTRINSIC
coiled coil region	3679	3709	N/A	INTRINSIC
coiled coil region	3762	3789	N/A	INTRINSIC
coiled coil region	3847	3904	N/A	INTRINSIC
coiled coil region	4016	4068	N/A	INTRINSIC
low complexity region	4103	4116	N/A	INTRINSIC
coiled coil region	4484	4512	N/A	INTRINSIC
low complexity region	4558	4570	N/A	INTRINSIC
coiled coil region	4656	4689	N/A	INTRINSIC
low complexity region	4750	4764	N/A	INTRINSIC
SPEC	4828	4927	5.25e-1	SMART
SPEC	4934	5039	2.64e-4	SMART
SPEC	5049	5153	1.47e-2	SMART
SPEC	5160	5260	4.29e0	SMART
SPEC	5264	5372	4.47e0	SMART
low complexity region	5374	5394	N/A	INTRINSIC
SPEC	5584	5682	5.7e-1	SMART
Blast:SPEC	5691	5794	2e-53	BLAST
SPEC	5801	5901	2.11e0	SMART
SPEC	5908	6006	6.91e-8	SMART
SPEC	6013	6120	4.45e-11	SMART
SPEC	6127	6229	6.39e-12	SMART
SPEC	6236	6336	7.75e-11	SMART
SPEC	6540	6643	5.53e-7	SMART
SPEC	6650	6754	5.12e-2	SMART
KASH	6813	6870	8.17e-34	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 94.0%

Validation Efficiency

97% (99/102)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture inprimary dermal fibroblasts and keratinocytes. Mice homozygous for a spontaneous mutation exhibit early retinal defects in photoreceptors, secondary Neurons, and muller glia. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted, knock-out(2) Gene trapped(3)

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933430I17Rik	A	T	4: 62,457,146 (GRCm39)	N155I	probably benign	Het
Abca14	A	G	7: 119,924,382 (GRCm39)	Y1678C	probably damaging	Het
Adamts19	A	T	18: 59,103,078 (GRCm39)	R706S	probably benign	Het
Adipor1	T	C	1: 134,350,771 (GRCm39)	S7P	probably benign	Het
Adss2	A	G	1: 177,597,544 (GRCm39)	I372T	probably damaging	Het
Arhgap15	T	A	2: 44,133,136 (GRCm39)	D347E	possibly damaging	Het
Arnt	C	T	3: 95,355,704 (GRCm39)	S16L	possibly damaging	Het
Asb8	T	C	15: 98,034,097 (GRCm39)	T153A	possibly damaging	Het
Aspscr1	G	T	11: 120,580,034 (GRCm39)	G191V	probably null	Het
Atm	T	C	9: 53,382,718 (GRCm39)	H1957R	probably damaging	Het
Atp13a5	A	G	16: 29,133,419 (GRCm39)	Y411H	probably damaging	Het
Cadm1	T	G	9: 47,761,633 (GRCm39)	I411S	probably damaging	Het
Cdh23	T	A	10: 60,246,652 (GRCm39)	M927L	probably benign	Het
Cdk15	A	T	1: 59,383,475 (GRCm39)	R423W	probably damaging	Het
Cep250	T	A	2: 155,818,301 (GRCm39)		probably null	Het
Cfap43	T	A	19: 47,885,649 (GRCm39)	Y322F	probably benign	Het
Cfap54	T	C	10: 92,833,204 (GRCm39)	S1141G	probably benign	Het
Clnk	T	C	5: 38,863,969 (GRCm39)	Y428C	possibly damaging	Het
Cnksr1	A	G	4: 133,955,727 (GRCm39)	S668P	probably benign	Het
Cpxm2	A	T	7: 131,663,876 (GRCm39)	I349N	probably damaging	Het
Csmd3	A	G	15: 47,868,035 (GRCm39)		probably null	Het
Cstdc3	T	C	16: 36,132,927 (GRCm39)	L68P	possibly damaging	Het
Dnmt1	C	T	9: 20,838,442 (GRCm39)	R207H	probably benign	Het
Dph2	A	T	4: 117,749,041 (GRCm39)	F5I	probably damaging	Het
Dst	T	A	1: 34,202,802 (GRCm39)	F325L	probably damaging	Het
Edem3	T	C	1: 151,680,076 (GRCm39)	L474S	probably damaging	Het
Emilin1	T	A	5: 31,075,160 (GRCm39)	L467Q	probably benign	Het
Fam170a	G	A	18: 50,415,181 (GRCm39)	E276K	probably benign	Het
Farp1	A	T	14: 121,456,787 (GRCm39)		probably null	Het
Fbrs	A	T	7: 127,085,163 (GRCm39)	T584S	possibly damaging	Het
Fbxo22	T	A	9: 55,116,626 (GRCm39)		probably null	Het
Fhod3	T	G	18: 25,223,522 (GRCm39)	L956R	probably damaging	Het
Fmo4	G	A	1: 162,631,259 (GRCm39)	T236I	probably benign	Het
Foxp4	C	T	17: 48,186,796 (GRCm39)	R378Q	unknown	Het
Gdf10	G	A	14: 33,654,710 (GRCm39)	A406T	probably benign	Het
Gm11444	A	T	11: 85,738,999 (GRCm39)		probably benign	Het
Gm14443	T	C	2: 175,011,497 (GRCm39)	I316M	probably benign	Het
Has3	A	T	8: 107,605,435 (GRCm39)	Y547F	probably benign	Het
Hdhd2	A	G	18: 77,052,841 (GRCm39)	T164A	probably benign	Het
Hoxb9	T	A	11: 96,162,880 (GRCm39)	D171E	possibly damaging	Het
Hpx	A	G	7: 105,245,603 (GRCm39)	Y118H	probably damaging	Het
Iqsec1	T	C	6: 90,647,441 (GRCm39)	K858E	probably damaging	Het
Kifc1	G	A	17: 34,103,685 (GRCm39)	R195C	probably benign	Het
Lama2	C	A	10: 26,857,594 (GRCm39)	R3085L	probably damaging	Het
Lyst	C	A	13: 13,791,203 (GRCm39)	A22E	probably damaging	Het
Man2a1	T	C	17: 65,057,830 (GRCm39)	F1079L	probably benign	Het
Marco	C	T	1: 120,412,593 (GRCm39)	G303R	probably damaging	Het
Marveld2	A	C	13: 100,733,858 (GRCm39)	I536R	probably damaging	Het
Mcm5	A	G	8: 75,848,257 (GRCm39)	D502G	probably benign	Het
Mdga1	A	T	17: 30,059,862 (GRCm39)	L653Q	probably damaging	Het
Mical2	A	G	7: 111,980,311 (GRCm39)	D161G	probably benign	Het
Mroh2a	C	T	1: 88,165,213 (GRCm39)	R445*	probably null	Het
Mrpl46	A	T	7: 78,431,146 (GRCm39)		probably null	Het
Nckipsd	C	A	9: 108,691,863 (GRCm39)		probably null	Het
Nek11	T	C	9: 105,170,916 (GRCm39)	D373G	probably benign	Het
Nle1	G	A	11: 82,795,068 (GRCm39)	S321F	probably benign	Het
Noxa1	A	G	2: 24,980,620 (GRCm39)	S130P	probably damaging	Het
Or10a5	A	G	7: 106,635,478 (GRCm39)	T39A	possibly damaging	Het
Or51v14	T	A	7: 103,260,618 (GRCm39)	*314L	probably null	Het
Or5l13	A	T	2: 87,779,809 (GRCm39)	L256H	probably damaging	Het
Or8b39	T	A	9: 37,996,419 (GRCm39)	C96S	probably damaging	Het
Parp3	T	G	9: 106,352,021 (GRCm39)		probably null	Het
Pask	A	T	1: 93,249,180 (GRCm39)	I740N	probably benign	Het
Pelp1	A	G	11: 70,289,347 (GRCm39)	F221S	probably damaging	Het
Pkd1l1	T	G	11: 8,824,161 (GRCm39)	K1135Q	probably benign	Het
Plcl2	A	T	17: 50,915,109 (GRCm39)	Q706L	probably damaging	Het
Psg26	T	C	7: 18,212,264 (GRCm39)	T364A	probably benign	Het
Ptprb	C	T	10: 116,177,441 (GRCm39)	T1047M	probably benign	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rab37	C	T	11: 115,051,177 (GRCm39)	A155V	probably damaging	Het
Rbbp6	A	C	7: 122,601,168 (GRCm39)		probably benign	Het
Rbmxl2	A	G	7: 106,809,405 (GRCm39)	D230G	probably benign	Het
Rsf1	CGGCGGCGGCGGCGGCGGCGGCGGCGGC	CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGC	7: 97,229,115 (GRCm39)		probably benign	Het
Sass6	G	T	3: 116,403,945 (GRCm39)	K194N	possibly damaging	Het
Sgpp1	T	G	12: 75,782,222 (GRCm39)	D39A	probably benign	Het
Shank3	T	C	15: 89,387,351 (GRCm39)	V198A	probably damaging	Het
Sin3a	T	A	9: 57,012,893 (GRCm39)	S591T	probably damaging	Het
Slc12a6	C	T	2: 112,185,503 (GRCm39)	T924I	possibly damaging	Het
Sln	T	A	9: 53,760,785 (GRCm39)	I10N	probably benign	Het
St3gal3	A	T	4: 117,797,268 (GRCm39)	M309K	probably damaging	Het
Tgtp2	A	G	11: 48,949,919 (GRCm39)	S218P	probably damaging	Het
Tha1	C	T	11: 117,760,179 (GRCm39)		probably benign	Het
Tmem102	A	G	11: 69,695,225 (GRCm39)	V249A	probably benign	Het
Top3b	G	A	16: 16,702,166 (GRCm39)	E268K	possibly damaging	Het
Trip4	T	C	9: 65,746,307 (GRCm39)	S530G	possibly damaging	Het
Tut1	T	A	19: 8,936,677 (GRCm39)	V167E	probably damaging	Het
Tut4	A	T	4: 108,412,903 (GRCm39)	S1535C	probably damaging	Het
Ube2u	A	T	4: 100,338,833 (GRCm39)	M33L	probably benign	Het
Unc79	T	C	12: 102,957,621 (GRCm39)	I12T	probably damaging	Het
Unc79	A	T	12: 103,041,178 (GRCm39)	D737V	probably benign	Het
Vmn1r26	A	G	6: 57,985,286 (GRCm39)	V301A	probably benign	Het
Vmn1r86	A	G	7: 12,836,621 (GRCm39)	V35A	possibly damaging	Het
Vmn2r98	A	C	17: 19,286,680 (GRCm39)	N393H	possibly damaging	Het
Vps13b	T	G	15: 35,878,835 (GRCm39)	S2945A	probably damaging	Het
Whrn	C	T	4: 63,353,666 (GRCm39)	R367H	possibly damaging	Het
Zfp235	A	T	7: 23,839,771 (GRCm39)	L133F	probably damaging	Het
Zfp74	T	C	7: 29,635,136 (GRCm39)	T191A	probably benign	Het
Zfp943	A	T	17: 22,211,979 (GRCm39)	K355I	probably damaging	Het
Zranb1	T	G	7: 132,584,458 (GRCm39)	S601R	probably damaging	Het
Zscan29	A	T	2: 121,000,289 (GRCm39)		probably null	Het

Other mutations in Syne2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00329:Syne2	APN	12	76,078,474 (GRCm39)	unclassified	probably benign
IGL00595:Syne2	APN	12	75,972,420 (GRCm39)	missense	possibly damaging	0.76
IGL00672:Syne2	APN	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
IGL00781:Syne2	APN	12	76,070,836 (GRCm39)	missense	probably benign	0.00
IGL00823:Syne2	APN	12	76,036,016 (GRCm39)	missense	probably damaging	0.98
IGL01014:Syne2	APN	12	75,952,051 (GRCm39)	missense	probably damaging	0.99
IGL01074:Syne2	APN	12	76,078,361 (GRCm39)	nonsense	probably null
IGL01074:Syne2	APN	12	76,033,785 (GRCm39)	missense	probably benign	0.00
IGL01324:Syne2	APN	12	76,090,526 (GRCm39)	missense	probably damaging	1.00
IGL01325:Syne2	APN	12	75,973,288 (GRCm39)	missense	probably benign	0.01
IGL01331:Syne2	APN	12	75,976,027 (GRCm39)	splice site	probably benign
IGL01338:Syne2	APN	12	76,107,000 (GRCm39)	missense	possibly damaging	0.55
IGL01373:Syne2	APN	12	76,033,881 (GRCm39)	missense	probably damaging	1.00
IGL01446:Syne2	APN	12	76,088,149 (GRCm39)	missense	probably damaging	1.00
IGL01556:Syne2	APN	12	76,134,589 (GRCm39)	missense	probably damaging	1.00
IGL01585:Syne2	APN	12	75,995,834 (GRCm39)	critical splice acceptor site	probably null
IGL01629:Syne2	APN	12	76,051,377 (GRCm39)	missense	possibly damaging	0.49
IGL01686:Syne2	APN	12	75,956,110 (GRCm39)	missense	probably benign
IGL01935:Syne2	APN	12	75,972,087 (GRCm39)	missense	probably damaging	1.00
IGL01941:Syne2	APN	12	76,013,994 (GRCm39)	missense	probably benign	0.01
IGL01956:Syne2	APN	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
IGL01967:Syne2	APN	12	75,988,077 (GRCm39)	missense	probably damaging	1.00
IGL01990:Syne2	APN	12	76,101,707 (GRCm39)	missense	probably damaging	1.00
IGL02000:Syne2	APN	12	76,062,419 (GRCm39)	missense	probably damaging	0.99
IGL02063:Syne2	APN	12	76,098,874 (GRCm39)	missense	probably damaging	0.96
IGL02069:Syne2	APN	12	75,974,186 (GRCm39)	missense	probably benign	0.13
IGL02120:Syne2	APN	12	75,993,480 (GRCm39)	missense	probably damaging	1.00
IGL02222:Syne2	APN	12	75,999,617 (GRCm39)	missense	probably damaging	0.96
IGL02223:Syne2	APN	12	76,155,079 (GRCm39)	missense	probably benign	0.00
IGL02321:Syne2	APN	12	75,965,773 (GRCm39)	missense	possibly damaging	0.58
IGL02488:Syne2	APN	12	76,012,512 (GRCm39)	missense	probably benign	0.24
IGL02491:Syne2	APN	12	76,118,953 (GRCm39)	missense	probably benign	0.10
IGL02525:Syne2	APN	12	76,147,777 (GRCm39)	missense	probably damaging	0.99
IGL02578:Syne2	APN	12	76,069,053 (GRCm39)	missense	possibly damaging	0.76
IGL02615:Syne2	APN	12	76,143,768 (GRCm39)	missense	probably damaging	1.00
IGL02702:Syne2	APN	12	76,144,698 (GRCm39)	missense	probably damaging	1.00
IGL02726:Syne2	APN	12	76,062,356 (GRCm39)	missense	probably damaging	0.99
IGL02795:Syne2	APN	12	76,013,323 (GRCm39)	missense	probably damaging	0.99
IGL02803:Syne2	APN	12	76,078,320 (GRCm39)	missense	probably damaging	1.00
IGL02814:Syne2	APN	12	75,992,150 (GRCm39)	missense	possibly damaging	0.64
IGL03013:Syne2	APN	12	75,976,111 (GRCm39)	missense	probably benign	0.00
IGL03131:Syne2	APN	12	76,104,264 (GRCm39)	missense	probably damaging	1.00
IGL03152:Syne2	APN	12	76,012,486 (GRCm39)	missense	probably benign	0.12
IGL03216:Syne2	APN	12	75,989,735 (GRCm39)	splice site	probably benign
IGL03228:Syne2	APN	12	76,026,686 (GRCm39)	missense	probably benign	0.01
IGL03259:Syne2	APN	12	76,035,853 (GRCm39)	missense	probably benign	0.05
IGL03374:Syne2	APN	12	76,121,360 (GRCm39)	missense	possibly damaging	0.66
IGL03375:Syne2	APN	12	75,972,209 (GRCm39)	missense	possibly damaging	0.57
3-1:Syne2	UTSW	12	75,977,406 (GRCm39)	missense	probably benign	0.02
B5639:Syne2	UTSW	12	75,976,564 (GRCm39)	missense	probably benign
K3955:Syne2	UTSW	12	75,977,439 (GRCm39)	missense	probably damaging	1.00
P0026:Syne2	UTSW	12	75,926,994 (GRCm39)	splice site	probably benign
PIT4514001:Syne2	UTSW	12	76,151,789 (GRCm39)	missense	probably damaging	0.99
R0089:Syne2	UTSW	12	76,010,650 (GRCm39)	missense	probably damaging	1.00
R0110:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0113:Syne2	UTSW	12	76,080,496 (GRCm39)	missense	probably damaging	1.00
R0113:Syne2	UTSW	12	75,977,352 (GRCm39)	missense	probably damaging	1.00
R0141:Syne2	UTSW	12	75,988,072 (GRCm39)	missense	probably damaging	1.00
R0211:Syne2	UTSW	12	76,144,731 (GRCm39)	missense	probably damaging	1.00
R0219:Syne2	UTSW	12	76,088,778 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0279:Syne2	UTSW	12	76,142,387 (GRCm39)	missense	probably damaging	1.00
R0319:Syne2	UTSW	12	76,110,936 (GRCm39)	missense	probably damaging	0.99
R0325:Syne2	UTSW	12	76,009,415 (GRCm39)	missense	probably benign	0.00
R0329:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0330:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0361:Syne2	UTSW	12	75,965,384 (GRCm39)	missense	probably benign	0.22
R0363:Syne2	UTSW	12	76,118,981 (GRCm39)	missense	probably damaging	0.98
R0367:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R0371:Syne2	UTSW	12	75,980,619 (GRCm39)	missense	probably damaging	1.00
R0374:Syne2	UTSW	12	75,968,000 (GRCm39)	nonsense	probably null
R0388:Syne2	UTSW	12	76,033,749 (GRCm39)	missense	probably benign	0.41
R0411:Syne2	UTSW	12	76,106,358 (GRCm39)	splice site	probably null
R0432:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R0469:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0492:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0496:Syne2	UTSW	12	76,085,714 (GRCm39)	missense	possibly damaging	0.80
R0504:Syne2	UTSW	12	76,080,365 (GRCm39)	splice site	probably benign
R0505:Syne2	UTSW	12	76,146,238 (GRCm39)	missense	probably damaging	1.00
R0510:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0518:Syne2	UTSW	12	76,155,636 (GRCm39)	critical splice acceptor site	probably null
R0539:Syne2	UTSW	12	76,070,895 (GRCm39)	missense	possibly damaging	0.69
R0552:Syne2	UTSW	12	75,977,778 (GRCm39)	missense	probably benign	0.00
R0557:Syne2	UTSW	12	75,976,075 (GRCm39)	missense	probably benign	0.04
R0567:Syne2	UTSW	12	75,937,004 (GRCm39)	missense	probably damaging	0.98
R0599:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0602:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0608:Syne2	UTSW	12	76,010,587 (GRCm39)	missense	probably damaging	1.00
R0614:Syne2	UTSW	12	75,959,127 (GRCm39)	splice site	probably null
R0636:Syne2	UTSW	12	75,977,757 (GRCm39)	missense	possibly damaging	0.75
R0647:Syne2	UTSW	12	75,934,977 (GRCm39)	missense	probably benign
R0654:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0658:Syne2	UTSW	12	76,141,110 (GRCm39)	missense	probably damaging	1.00
R0666:Syne2	UTSW	12	75,969,787 (GRCm39)	missense	probably damaging	0.99
R0707:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0714:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0841:Syne2	UTSW	12	76,121,209 (GRCm39)	splice site	probably benign
R0848:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0848:Syne2	UTSW	12	76,144,733 (GRCm39)	frame shift	probably null
R1077:Syne2	UTSW	12	76,088,809 (GRCm39)	missense	possibly damaging	0.94
R1103:Syne2	UTSW	12	76,156,609 (GRCm39)	missense	probably benign	0.00
R1144:Syne2	UTSW	12	76,013,298 (GRCm39)	missense	probably benign	0.04
R1194:Syne2	UTSW	12	75,981,287 (GRCm39)	missense	probably damaging	1.00
R1247:Syne2	UTSW	12	76,014,264 (GRCm39)	missense	probably benign	0.39
R1276:Syne2	UTSW	12	75,987,963 (GRCm39)	critical splice acceptor site	probably null
R1343:Syne2	UTSW	12	76,080,417 (GRCm39)	missense	probably damaging	1.00
R1442:Syne2	UTSW	12	75,993,489 (GRCm39)	missense	probably damaging	1.00
R1448:Syne2	UTSW	12	76,098,952 (GRCm39)	missense	possibly damaging	0.56
R1448:Syne2	UTSW	12	76,067,099 (GRCm39)	splice site	probably null
R1522:Syne2	UTSW	12	76,150,557 (GRCm39)	missense	probably damaging	0.98
R1528:Syne2	UTSW	12	76,012,874 (GRCm39)	missense	probably benign	0.00
R1636:Syne2	UTSW	12	76,051,506 (GRCm39)	missense	probably benign	0.01
R1637:Syne2	UTSW	12	76,042,776 (GRCm39)	missense	probably damaging	1.00
R1650:Syne2	UTSW	12	75,951,033 (GRCm39)	nonsense	probably null
R1654:Syne2	UTSW	12	76,147,868 (GRCm39)	missense	possibly damaging	0.56
R1714:Syne2	UTSW	12	76,101,713 (GRCm39)	missense	probably benign	0.26
R1750:Syne2	UTSW	12	76,099,579 (GRCm39)	missense	probably damaging	1.00
R1772:Syne2	UTSW	12	75,985,503 (GRCm39)	missense	probably benign	0.19
R1797:Syne2	UTSW	12	76,010,557 (GRCm39)	missense	probably benign	0.00
R1830:Syne2	UTSW	12	76,156,636 (GRCm39)	missense	probably damaging	1.00
R1837:Syne2	UTSW	12	76,014,434 (GRCm39)	missense	probably damaging	0.99
R1908:Syne2	UTSW	12	76,141,053 (GRCm39)	critical splice acceptor site	probably null
R1913:Syne2	UTSW	12	75,946,020 (GRCm39)	missense	possibly damaging	0.60
R1944:Syne2	UTSW	12	76,121,318 (GRCm39)	missense	probably damaging	1.00
R1950:Syne2	UTSW	12	75,999,644 (GRCm39)	missense	probably benign
R2018:Syne2	UTSW	12	76,121,353 (GRCm39)	missense	probably damaging	1.00
R2037:Syne2	UTSW	12	76,072,343 (GRCm39)	missense	probably benign	0.04
R2067:Syne2	UTSW	12	75,935,116 (GRCm39)	critical splice donor site	probably null
R2073:Syne2	UTSW	12	76,062,353 (GRCm39)	missense	possibly damaging	0.54
R2099:Syne2	UTSW	12	76,026,747 (GRCm39)	missense	probably benign	0.06
R2102:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R2134:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2135:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2157:Syne2	UTSW	12	76,141,230 (GRCm39)	missense	probably damaging	1.00
R2173:Syne2	UTSW	12	76,147,763 (GRCm39)	splice site	probably benign
R2248:Syne2	UTSW	12	76,143,678 (GRCm39)	missense	probably damaging	1.00
R2276:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2277:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2278:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2279:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2483:Syne2	UTSW	12	76,142,311 (GRCm39)	missense	probably damaging	1.00
R2877:Syne2	UTSW	12	76,047,605 (GRCm39)	missense	probably benign	0.00
R2884:Syne2	UTSW	12	76,010,533 (GRCm39)	missense	probably benign	0.00
R3119:Syne2	UTSW	12	75,956,058 (GRCm39)	missense	probably benign	0.01
R3499:Syne2	UTSW	12	76,101,752 (GRCm39)	splice site	probably null
R3827:Syne2	UTSW	12	76,033,805 (GRCm39)	missense	probably benign	0.02
R3847:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3849:Syne2	UTSW	12	76,092,839 (GRCm39)	nonsense	probably null
R3850:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3859:Syne2	UTSW	12	75,976,558 (GRCm39)	missense	possibly damaging	0.55
R3861:Syne2	UTSW	12	76,013,253 (GRCm39)	missense	probably damaging	0.98
R4078:Syne2	UTSW	12	76,082,398 (GRCm39)	missense	probably damaging	1.00
R4116:Syne2	UTSW	12	75,977,853 (GRCm39)	missense	probably damaging	1.00
R4326:Syne2	UTSW	12	75,999,516 (GRCm39)	missense	probably damaging	1.00
R4335:Syne2	UTSW	12	76,074,866 (GRCm39)	missense	probably damaging	1.00
R4410:Syne2	UTSW	12	76,141,167 (GRCm39)	missense	probably damaging	1.00
R4412:Syne2	UTSW	12	76,152,834 (GRCm39)	missense	probably benign	0.01
R4444:Syne2	UTSW	12	76,069,804 (GRCm39)	missense	probably damaging	1.00
R4595:Syne2	UTSW	12	76,013,845 (GRCm39)	missense	possibly damaging	0.88
R4604:Syne2	UTSW	12	76,014,484 (GRCm39)	missense	probably damaging	0.99
R4606:Syne2	UTSW	12	76,036,027 (GRCm39)	missense	probably damaging	1.00
R4651:Syne2	UTSW	12	76,036,013 (GRCm39)	missense	probably damaging	0.99
R4656:Syne2	UTSW	12	76,078,147 (GRCm39)	missense	probably damaging	1.00
R4675:Syne2	UTSW	12	75,996,075 (GRCm39)	missense	probably damaging	1.00
R4790:Syne2	UTSW	12	76,067,165 (GRCm39)	missense	probably benign	0.19
R4791:Syne2	UTSW	12	75,956,018 (GRCm39)	missense	possibly damaging	0.96
R4799:Syne2	UTSW	12	75,945,941 (GRCm39)	missense	probably benign	0.04
R4836:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4880:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4881:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4899:Syne2	UTSW	12	75,900,875 (GRCm39)	missense	probably benign	0.03
R4934:Syne2	UTSW	12	75,946,046 (GRCm39)	missense	probably benign	0.14
R4981:Syne2	UTSW	12	75,987,993 (GRCm39)	missense	probably damaging	0.98
R4996:Syne2	UTSW	12	75,990,724 (GRCm39)	missense	possibly damaging	0.87
R5056:Syne2	UTSW	12	75,955,905 (GRCm39)	unclassified	probably benign
R5066:Syne2	UTSW	12	76,013,325 (GRCm39)	missense	probably benign	0.05
R5095:Syne2	UTSW	12	75,999,600 (GRCm39)	missense	probably damaging	0.99
R5151:Syne2	UTSW	12	76,090,484 (GRCm39)	missense	probably benign	0.06
R5193:Syne2	UTSW	12	76,141,194 (GRCm39)	missense	probably damaging	1.00
R5267:Syne2	UTSW	12	75,985,515 (GRCm39)	missense	possibly damaging	0.74
R5288:Syne2	UTSW	12	76,146,112 (GRCm39)	missense	possibly damaging	0.94
R5402:Syne2	UTSW	12	76,106,213 (GRCm39)	missense	probably damaging	0.98
R5434:Syne2	UTSW	12	76,018,649 (GRCm39)	missense	probably damaging	1.00
R5441:Syne2	UTSW	12	76,035,917 (GRCm39)	missense	possibly damaging	0.75
R5488:Syne2	UTSW	12	75,934,946 (GRCm39)	missense	probably benign	0.13
R5497:Syne2	UTSW	12	75,927,163 (GRCm39)	missense	probably benign	0.19
R5506:Syne2	UTSW	12	75,985,495 (GRCm39)	missense	probably benign	0.01
R5509:Syne2	UTSW	12	75,968,018 (GRCm39)	missense	probably damaging	1.00
R5518:Syne2	UTSW	12	75,991,944 (GRCm39)	missense	possibly damaging	0.88
R5561:Syne2	UTSW	12	76,141,232 (GRCm39)	nonsense	probably null
R5581:Syne2	UTSW	12	75,991,859 (GRCm39)	missense	probably benign	0.01
R5625:Syne2	UTSW	12	76,141,886 (GRCm39)	missense	probably benign	0.06
R5642:Syne2	UTSW	12	75,965,306 (GRCm39)	missense	probably damaging	1.00
R5665:Syne2	UTSW	12	76,154,991 (GRCm39)	critical splice donor site	probably null
R5666:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5670:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5691:Syne2	UTSW	12	76,074,630 (GRCm39)	frame shift	probably null
R5696:Syne2	UTSW	12	76,040,919 (GRCm39)	missense	probably benign	0.00
R5720:Syne2	UTSW	12	76,014,441 (GRCm39)	missense	probably benign	0.03
R5739:Syne2	UTSW	12	76,044,239 (GRCm39)	missense	possibly damaging	0.53
R5840:Syne2	UTSW	12	75,927,065 (GRCm39)	splice site	probably null
R5846:Syne2	UTSW	12	76,074,898 (GRCm39)	missense	probably benign	0.01
R5850:Syne2	UTSW	12	76,144,749 (GRCm39)	missense	probably damaging	1.00
R5889:Syne2	UTSW	12	76,119,026 (GRCm39)	nonsense	probably null
R5912:Syne2	UTSW	12	75,955,721 (GRCm39)	critical splice donor site	probably null
R5931:Syne2	UTSW	12	76,055,639 (GRCm39)	missense	probably benign	0.37
R5985:Syne2	UTSW	12	76,012,933 (GRCm39)	missense	probably damaging	0.96
R5988:Syne2	UTSW	12	75,976,191 (GRCm39)	critical splice donor site	probably null
R5990:Syne2	UTSW	12	76,070,918 (GRCm39)	missense	probably benign	0.10
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6132:Syne2	UTSW	12	75,991,921 (GRCm39)	missense	probably benign	0.14
R6136:Syne2	UTSW	12	75,952,099 (GRCm39)	missense	probably benign	0.24
R6229:Syne2	UTSW	12	75,967,994 (GRCm39)	missense	probably benign	0.00
R6252:Syne2	UTSW	12	76,016,210 (GRCm39)	missense	probably benign	0.39
R6271:Syne2	UTSW	12	75,937,155 (GRCm39)	missense	probably damaging	1.00
R6320:Syne2	UTSW	12	76,108,424 (GRCm39)	missense	probably damaging	0.96
R6339:Syne2	UTSW	12	76,035,927 (GRCm39)	missense	probably benign	0.34
R6380:Syne2	UTSW	12	76,151,754 (GRCm39)	missense	probably damaging	0.98
R6394:Syne2	UTSW	12	76,037,269 (GRCm39)	missense	probably benign	0.09
R6419:Syne2	UTSW	12	76,143,740 (GRCm39)	missense	probably damaging	1.00
R6426:Syne2	UTSW	12	75,969,857 (GRCm39)	missense	probably null	0.97
R6434:Syne2	UTSW	12	76,088,230 (GRCm39)	missense	probably damaging	0.99
R6437:Syne2	UTSW	12	76,037,188 (GRCm39)	missense	possibly damaging	0.87
R6466:Syne2	UTSW	12	75,990,675 (GRCm39)	missense	probably damaging	0.97
R6501:Syne2	UTSW	12	76,074,621 (GRCm39)	splice site	probably null
R6552:Syne2	UTSW	12	75,937,015 (GRCm39)	missense	possibly damaging	0.89
R6744:Syne2	UTSW	12	76,121,221 (GRCm39)	missense	probably damaging	1.00
R6810:Syne2	UTSW	12	75,989,659 (GRCm39)	missense	probably benign	0.00
R6831:Syne2	UTSW	12	76,013,568 (GRCm39)	missense	probably benign	0.39
R6861:Syne2	UTSW	12	75,956,040 (GRCm39)	missense	probably damaging	1.00
R6875:Syne2	UTSW	12	76,082,404 (GRCm39)	missense	probably damaging	0.99
R6892:Syne2	UTSW	12	76,009,302 (GRCm39)	missense	probably damaging	0.98
R6899:Syne2	UTSW	12	76,142,503 (GRCm39)	splice site	probably null
R6906:Syne2	UTSW	12	76,042,760 (GRCm39)	missense	possibly damaging	0.93
R6909:Syne2	UTSW	12	76,110,969 (GRCm39)	missense	probably benign	0.04
R6925:Syne2	UTSW	12	75,900,906 (GRCm39)	missense	possibly damaging	0.58
R6949:Syne2	UTSW	12	76,012,771 (GRCm39)	missense	probably benign	0.00
R6952:Syne2	UTSW	12	75,974,205 (GRCm39)	missense	possibly damaging	0.76
R6996:Syne2	UTSW	12	76,074,786 (GRCm39)	missense	probably damaging	0.99
R7080:Syne2	UTSW	12	76,099,501 (GRCm39)	missense	probably benign	0.00
R7083:Syne2	UTSW	12	75,990,662 (GRCm39)	missense	probably damaging	1.00
R7090:Syne2	UTSW	12	75,989,125 (GRCm39)	missense	probably benign
R7144:Syne2	UTSW	12	76,052,152 (GRCm39)	missense	probably benign	0.03
R7154:Syne2	UTSW	12	76,106,231 (GRCm39)	missense	possibly damaging	0.63
R7177:Syne2	UTSW	12	76,018,654 (GRCm39)	nonsense	probably null
R7190:Syne2	UTSW	12	76,113,361 (GRCm39)	missense	probably benign	0.01
R7206:Syne2	UTSW	12	76,051,531 (GRCm39)	missense	probably benign	0.02
R7208:Syne2	UTSW	12	76,078,172 (GRCm39)	splice site	probably null
R7230:Syne2	UTSW	12	75,980,674 (GRCm39)	missense	probably benign	0.12
R7260:Syne2	UTSW	12	75,991,853 (GRCm39)	missense	probably damaging	1.00
R7272:Syne2	UTSW	12	76,095,417 (GRCm39)	missense	probably benign	0.00
R7296:Syne2	UTSW	12	76,149,810 (GRCm39)	missense	probably benign	0.00
R7322:Syne2	UTSW	12	76,030,798 (GRCm39)	missense	probably damaging	1.00
R7329:Syne2	UTSW	12	76,013,758 (GRCm39)	missense	probably benign	0.01
R7332:Syne2	UTSW	12	76,014,529 (GRCm39)	critical splice donor site	probably null
R7381:Syne2	UTSW	12	75,973,263 (GRCm39)	missense	probably benign	0.11
R7401:Syne2	UTSW	12	76,014,155 (GRCm39)	missense	probably damaging	0.98
R7403:Syne2	UTSW	12	75,962,020 (GRCm39)	missense	not run
R7429:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7429:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7430:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7430:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7438:Syne2	UTSW	12	76,062,337 (GRCm39)	missense	probably benign	0.04
R7447:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R7466:Syne2	UTSW	12	76,092,960 (GRCm39)	missense	possibly damaging	0.92
R7493:Syne2	UTSW	12	76,012,654 (GRCm39)	missense	probably benign	0.00
R7502:Syne2	UTSW	12	76,141,100 (GRCm39)	missense	probably damaging	1.00
R7543:Syne2	UTSW	12	75,953,616 (GRCm39)	missense	possibly damaging	0.93
R7569:Syne2	UTSW	12	75,974,164 (GRCm39)	missense	probably benign	0.00
R7599:Syne2	UTSW	12	76,013,145 (GRCm39)	missense	probably benign	0.04
R7618:Syne2	UTSW	12	75,992,108 (GRCm39)	missense	probably benign	0.01
R7639:Syne2	UTSW	12	75,981,273 (GRCm39)	missense	probably damaging	1.00
R7698:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R7702:Syne2	UTSW	12	76,037,161 (GRCm39)	missense	probably benign	0.16
R7737:Syne2	UTSW	12	75,989,622 (GRCm39)	missense	probably damaging	1.00
R7742:Syne2	UTSW	12	76,106,209 (GRCm39)	missense	probably benign	0.02
R7753:Syne2	UTSW	12	76,085,697 (GRCm39)	missense	probably benign	0.43
R7755:Syne2	UTSW	12	76,044,181 (GRCm39)	missense	probably benign	0.19
R7757:Syne2	UTSW	12	76,108,553 (GRCm39)	missense	possibly damaging	0.87
R7790:Syne2	UTSW	12	75,975,877 (GRCm39)	splice site	probably null
R7808:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7809:Syne2	UTSW	12	76,014,230 (GRCm39)	missense	probably benign	0.00
R7811:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7834:Syne2	UTSW	12	76,014,021 (GRCm39)	missense	probably benign	0.00
R7853:Syne2	UTSW	12	76,078,278 (GRCm39)	missense	probably damaging	1.00
R7867:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7896:Syne2	UTSW	12	76,082,397 (GRCm39)	missense	probably damaging	0.99
R7903:Syne2	UTSW	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
R7944:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7945:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7963:Syne2	UTSW	12	76,067,174 (GRCm39)	missense	probably benign	0.38
R7996:Syne2	UTSW	12	76,051,441 (GRCm39)	missense	probably damaging	1.00
R7998:Syne2	UTSW	12	76,134,632 (GRCm39)	missense	probably damaging	1.00
R8010:Syne2	UTSW	12	75,977,512 (GRCm39)	missense	probably benign	0.39
R8016:Syne2	UTSW	12	75,989,681 (GRCm39)	missense	probably benign	0.19
R8140:Syne2	UTSW	12	75,959,127 (GRCm39)	missense	possibly damaging	0.63
R8141:Syne2	UTSW	12	76,108,442 (GRCm39)	missense	possibly damaging	0.66
R8206:Syne2	UTSW	12	76,062,365 (GRCm39)	missense	probably benign	0.03
R8258:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8259:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8320:Syne2	UTSW	12	76,150,604 (GRCm39)	missense	probably damaging	0.99
R8464:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8465:Syne2	UTSW	12	75,900,898 (GRCm39)	missense	possibly damaging	0.92
R8486:Syne2	UTSW	12	76,088,881 (GRCm39)	nonsense	probably null
R8488:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8511:Syne2	UTSW	12	76,055,647 (GRCm39)	missense	probably benign	0.03
R8540:Syne2	UTSW	12	76,141,148 (GRCm39)	missense	probably damaging	1.00
R8711:Syne2	UTSW	12	76,104,258 (GRCm39)	missense	probably damaging	1.00
R8722:Syne2	UTSW	12	75,972,095 (GRCm39)	missense	probably benign	0.04
R8827:Syne2	UTSW	12	76,095,357 (GRCm39)	missense	probably benign	0.00
R8867:Syne2	UTSW	12	75,989,620 (GRCm39)	missense	probably damaging	1.00
R8878:Syne2	UTSW	12	75,952,067 (GRCm39)	missense	probably benign
R8924:Syne2	UTSW	12	75,943,444 (GRCm39)	missense	probably damaging	0.97
R8966:Syne2	UTSW	12	76,146,197 (GRCm39)	missense	probably damaging	1.00
R9007:Syne2	UTSW	12	76,146,224 (GRCm39)	missense	possibly damaging	0.82
R9019:Syne2	UTSW	12	75,999,618 (GRCm39)	missense	possibly damaging	0.93
R9057:Syne2	UTSW	12	75,937,167 (GRCm39)	missense	probably damaging	1.00
R9067:Syne2	UTSW	12	75,950,994 (GRCm39)	missense	probably damaging	1.00
R9081:Syne2	UTSW	12	76,016,290 (GRCm39)	nonsense	probably null
R9091:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9123:Syne2	UTSW	12	76,040,838 (GRCm39)	missense	probably damaging	1.00
R9147:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9148:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9163:Syne2	UTSW	12	76,009,349 (GRCm39)	missense	possibly damaging	0.88
R9192:Syne2	UTSW	12	76,156,703 (GRCm39)	missense	probably damaging	1.00
R9248:Syne2	UTSW	12	76,154,230 (GRCm39)	intron	probably benign
R9270:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9292:Syne2	UTSW	12	75,997,823 (GRCm39)	missense	probably benign
R9397:Syne2	UTSW	12	76,040,849 (GRCm39)	missense	possibly damaging	0.59
R9454:Syne2	UTSW	12	76,141,844 (GRCm39)	nonsense	probably null
R9454:Syne2	UTSW	12	76,067,275 (GRCm39)	missense	probably damaging	0.99
R9478:Syne2	UTSW	12	76,154,387 (GRCm39)	missense	probably damaging	0.96
R9492:Syne2	UTSW	12	75,995,839 (GRCm39)	missense	possibly damaging	0.77
R9573:Syne2	UTSW	12	75,927,134 (GRCm39)	missense	probably damaging	1.00
R9611:Syne2	UTSW	12	76,080,460 (GRCm39)	missense	probably benign	0.05
R9623:Syne2	UTSW	12	75,986,760 (GRCm39)	missense	probably benign	0.12
R9647:Syne2	UTSW	12	76,151,875 (GRCm39)	missense	possibly damaging	0.55
R9652:Syne2	UTSW	12	76,101,620 (GRCm39)	missense	probably benign	0.00
R9667:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R9701:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
R9794:Syne2	UTSW	12	76,047,617 (GRCm39)	missense	probably benign	0.04
R9802:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
X0019:Syne2	UTSW	12	76,020,061 (GRCm39)	missense	probably benign	0.41
X0026:Syne2	UTSW	12	76,147,790 (GRCm39)	missense	possibly damaging	0.78
X0061:Syne2	UTSW	12	75,974,285 (GRCm39)	critical splice donor site	probably null
X0066:Syne2	UTSW	12	76,143,701 (GRCm39)	missense	probably damaging	1.00
Z1176:Syne2	UTSW	12	76,087,157 (GRCm39)	missense	possibly damaging	0.48
Z1176:Syne2	UTSW	12	76,014,315 (GRCm39)	missense	probably benign	0.01
Z1177:Syne2	UTSW	12	76,020,197 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,110,912 (GRCm39)	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- AGGATGTCCTGAACGATGC -3'
(R):5'- CATTCAAATTTCCTCTGATGTGCAC -3'

Sequencing Primer
(F):5'- CCTGAACGATGCTTATGACAGTGC -3'
(R):5'- GTGCACATTCATTATAAAGACCAAC -3'

Posted On

2014-08-01