Incidental Mutation 'R1959:Trpm1'
| ID |
218153 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
039973-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1959 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 63879978 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 661
(L661Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146140
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000205348]
[ENSMUST00000206277]
[ENSMUST00000206263]
[ENSMUST00000206314]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000085222
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: L777Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107525
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000103149
Gene: ENSMUSG00000030523
AA Change: L777Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
876 |
1138 |
7.6e-22 |
PFAM |
|
transmembrane domain
|
1156 |
1173 |
N/A |
INTRINSIC |
|
Pfam:TRPM_tetra
|
1230 |
1285 |
9.4e-28 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138074
AA Change: L201Q
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138609
AA Change: C79S
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205939
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206000
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206277
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206263
AA Change: L661Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Meta Mutation Damage Score |
0.4440 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 130 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc1 |
T |
C |
16: 14,214,257 (GRCm39) |
Y191H |
probably damaging |
Het |
| Aco1 |
T |
C |
4: 40,167,193 (GRCm39) |
|
probably null |
Het |
| Adap1 |
A |
G |
5: 139,259,096 (GRCm39) |
Y364H |
probably benign |
Het |
| Add2 |
T |
C |
6: 86,073,738 (GRCm39) |
F209S |
probably damaging |
Het |
| Adgb |
A |
T |
10: 10,270,993 (GRCm39) |
D883E |
probably benign |
Het |
| Anapc1 |
C |
A |
2: 128,475,335 (GRCm39) |
R1381S |
probably benign |
Het |
| Aoah |
A |
G |
13: 20,978,564 (GRCm39) |
M1V |
probably null |
Het |
| Arap1 |
C |
A |
7: 101,022,222 (GRCm39) |
A8E |
probably damaging |
Het |
| Arhgap10 |
A |
G |
8: 78,136,255 (GRCm39) |
F319S |
possibly damaging |
Het |
| Btrc |
T |
G |
19: 45,515,782 (GRCm39) |
I480S |
probably damaging |
Het |
| Cabin1 |
A |
T |
10: 75,570,924 (GRCm39) |
V784E |
possibly damaging |
Het |
| Card9 |
T |
A |
2: 26,244,885 (GRCm39) |
|
probably null |
Het |
| Cdk18 |
A |
G |
1: 132,045,559 (GRCm39) |
I238T |
possibly damaging |
Het |
| Clec12a |
A |
C |
6: 129,327,444 (GRCm39) |
T21P |
possibly damaging |
Het |
| Commd3 |
A |
T |
2: 18,678,774 (GRCm39) |
I70F |
probably benign |
Het |
| Cspg5 |
G |
A |
9: 110,080,094 (GRCm39) |
V340M |
probably damaging |
Het |
| Cyb5r4 |
G |
A |
9: 86,937,902 (GRCm39) |
S307N |
possibly damaging |
Het |
| Cyp26c1 |
T |
A |
19: 37,675,825 (GRCm39) |
F230I |
probably damaging |
Het |
| Ddx11 |
A |
G |
17: 66,437,723 (GRCm39) |
M150V |
probably benign |
Het |
| Dennd4b |
A |
G |
3: 90,176,080 (GRCm39) |
Y190C |
probably damaging |
Het |
| Det1 |
A |
G |
7: 78,493,191 (GRCm39) |
V271A |
probably benign |
Het |
| Dgkd |
C |
A |
1: 87,857,549 (GRCm39) |
P754T |
possibly damaging |
Het |
| Dhx36 |
T |
C |
3: 62,386,806 (GRCm39) |
S649G |
probably benign |
Het |
| Dlgap5 |
A |
G |
14: 47,653,843 (GRCm39) |
I62T |
possibly damaging |
Het |
| Dmgdh |
A |
G |
13: 93,857,067 (GRCm39) |
M724V |
probably benign |
Het |
| Dnah7a |
A |
G |
1: 53,724,142 (GRCm39) |
S108P |
probably benign |
Het |
| Dock4 |
A |
T |
12: 40,760,797 (GRCm39) |
K495M |
probably damaging |
Het |
| Dse |
A |
G |
10: 34,036,202 (GRCm39) |
Y225H |
probably damaging |
Het |
| Emx1 |
G |
A |
6: 85,180,916 (GRCm39) |
R211K |
probably damaging |
Het |
| Ergic2 |
A |
G |
6: 148,100,852 (GRCm39) |
|
probably null |
Het |
| Fbxo27 |
G |
A |
7: 28,397,797 (GRCm39) |
C277Y |
possibly damaging |
Het |
| Fcrl1 |
T |
C |
3: 87,283,827 (GRCm39) |
I9T |
possibly damaging |
Het |
| Fjx1 |
T |
C |
2: 102,281,152 (GRCm39) |
E261G |
probably benign |
Het |
| Flacc1 |
A |
T |
1: 58,698,437 (GRCm39) |
V327D |
possibly damaging |
Het |
| Flnb |
C |
T |
14: 7,884,735 (GRCm38) |
Q445* |
probably null |
Het |
| Flrt2 |
G |
A |
12: 95,747,074 (GRCm39) |
V471I |
probably benign |
Het |
| Frmd4a |
G |
A |
2: 4,539,997 (GRCm39) |
V210M |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,821,894 (GRCm39) |
K5876E |
probably benign |
Het |
| Galnt10 |
T |
C |
11: 57,656,443 (GRCm39) |
L209P |
probably damaging |
Het |
| Gata5 |
A |
T |
2: 179,968,729 (GRCm39) |
S382T |
possibly damaging |
Het |
| Glt6d1 |
C |
A |
2: 25,684,425 (GRCm39) |
V194L |
probably damaging |
Het |
| Gm10803 |
T |
G |
2: 93,394,288 (GRCm39) |
V20G |
unknown |
Het |
| Gm44511 |
T |
G |
6: 128,797,234 (GRCm39) |
T52P |
probably damaging |
Het |
| Gpat4 |
A |
T |
8: 23,672,952 (GRCm39) |
L88Q |
possibly damaging |
Het |
| Gpr15 |
T |
A |
16: 58,538,370 (GRCm39) |
I240L |
probably benign |
Het |
| Hivep2 |
A |
T |
10: 14,008,453 (GRCm39) |
I1684F |
probably benign |
Het |
| Hmcn1 |
T |
C |
1: 150,525,427 (GRCm39) |
T3366A |
probably benign |
Het |
| Hnmt |
A |
G |
2: 23,893,894 (GRCm39) |
V200A |
possibly damaging |
Het |
| Hps6 |
A |
T |
19: 45,992,774 (GRCm39) |
H237L |
probably benign |
Het |
| Hspg2 |
C |
T |
4: 137,292,206 (GRCm39) |
P4033S |
probably damaging |
Het |
| Ift70b |
C |
T |
2: 75,767,443 (GRCm39) |
E437K |
probably benign |
Het |
| Irf9 |
T |
A |
14: 55,845,174 (GRCm39) |
S297T |
possibly damaging |
Het |
| Kdm3b |
T |
C |
18: 34,945,448 (GRCm39) |
V753A |
possibly damaging |
Het |
| Kif21a |
G |
A |
15: 90,855,051 (GRCm39) |
A703V |
probably damaging |
Het |
| Kif27 |
T |
G |
13: 58,440,937 (GRCm39) |
R1159S |
probably benign |
Het |
| Krtap4-16 |
A |
G |
11: 99,742,373 (GRCm39) |
V9A |
unknown |
Het |
| Lama2 |
G |
T |
10: 27,298,614 (GRCm39) |
P161T |
probably damaging |
Het |
| Ltbp4 |
G |
A |
7: 27,028,443 (GRCm39) |
P273L |
unknown |
Het |
| Lvrn |
T |
A |
18: 47,027,784 (GRCm39) |
S866R |
probably damaging |
Het |
| Med13 |
A |
G |
11: 86,189,805 (GRCm39) |
Y1035H |
probably damaging |
Het |
| Mertk |
T |
A |
2: 128,601,010 (GRCm39) |
N331K |
probably damaging |
Het |
| Mios |
T |
A |
6: 8,215,437 (GRCm39) |
F211Y |
probably benign |
Het |
| Mpeg1 |
G |
A |
19: 12,440,275 (GRCm39) |
V578M |
probably damaging |
Het |
| Mphosph9 |
A |
T |
5: 124,453,764 (GRCm39) |
S183T |
possibly damaging |
Het |
| Mrto4 |
A |
T |
4: 139,076,949 (GRCm39) |
I56N |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,416,374 (GRCm39) |
C3107R |
possibly damaging |
Het |
| Ncoa2 |
A |
G |
1: 13,230,476 (GRCm39) |
Y1023H |
probably damaging |
Het |
| Nlrp2 |
T |
C |
7: 5,330,737 (GRCm39) |
E553G |
probably damaging |
Het |
| Nlrp6 |
GAGAAGAAGAAGAAGAAGAAGA |
GAGAAGAAGAAGAAGAAGA |
7: 140,504,026 (GRCm39) |
|
probably benign |
Het |
| Nr2f1 |
T |
C |
13: 78,337,935 (GRCm39) |
T237A |
probably damaging |
Het |
| Nup205 |
C |
A |
6: 35,210,301 (GRCm39) |
Q1621K |
probably benign |
Het |
| Nup50l |
A |
G |
6: 96,142,250 (GRCm39) |
S265P |
possibly damaging |
Het |
| Nxpe2 |
T |
A |
9: 48,231,026 (GRCm39) |
S448C |
probably benign |
Het |
| Ogdh |
T |
A |
11: 6,296,638 (GRCm39) |
C498S |
possibly damaging |
Het |
| Oplah |
G |
A |
15: 76,181,664 (GRCm39) |
T1119I |
probably damaging |
Het |
| Or14a256 |
A |
T |
7: 86,265,639 (GRCm39) |
F71L |
probably benign |
Het |
| Or2ag15 |
T |
C |
7: 106,340,601 (GRCm39) |
E180G |
probably damaging |
Het |
| Or2d2 |
A |
T |
7: 106,727,717 (GRCm39) |
D294E |
possibly damaging |
Het |
| Or5ak24 |
T |
C |
2: 85,260,963 (GRCm39) |
D70G |
probably damaging |
Het |
| Or5d46 |
T |
C |
2: 88,170,545 (GRCm39) |
L212P |
probably damaging |
Het |
| Or6p1 |
A |
T |
1: 174,258,471 (GRCm39) |
K159M |
probably damaging |
Het |
| Or8s8 |
T |
C |
15: 98,354,634 (GRCm39) |
S148P |
probably damaging |
Het |
| Pcdhb9 |
T |
A |
18: 37,536,369 (GRCm39) |
Y788N |
probably damaging |
Het |
| Pcsk5 |
T |
C |
19: 17,410,782 (GRCm39) |
D1870G |
unknown |
Het |
| Pde6g |
A |
G |
11: 120,338,962 (GRCm39) |
L76P |
probably damaging |
Het |
| Peak1 |
A |
T |
9: 56,114,073 (GRCm39) |
Y593N |
probably damaging |
Het |
| Pfas |
C |
T |
11: 68,885,110 (GRCm39) |
G16R |
probably damaging |
Het |
| Pkd1l2 |
A |
T |
8: 117,769,970 (GRCm39) |
|
probably null |
Het |
| Pla2g3 |
C |
T |
11: 3,440,983 (GRCm39) |
T316I |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,530,788 (GRCm39) |
I489F |
probably damaging |
Het |
| Rere |
T |
G |
4: 150,553,247 (GRCm39) |
H146Q |
probably benign |
Het |
| Rundc1 |
A |
T |
11: 101,322,322 (GRCm39) |
Q272L |
probably damaging |
Het |
| Scml4 |
T |
C |
10: 42,832,017 (GRCm39) |
L305P |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,320,144 (GRCm39) |
H1431Q |
probably benign |
Het |
| Serpina1a |
G |
A |
12: 103,820,059 (GRCm39) |
Q373* |
probably null |
Het |
| Shank1 |
A |
T |
7: 43,974,801 (GRCm39) |
N377I |
unknown |
Het |
| Shc2 |
T |
C |
10: 79,462,625 (GRCm39) |
|
probably null |
Het |
| Slc22a29 |
C |
A |
19: 8,146,557 (GRCm39) |
R415M |
probably benign |
Het |
| Slc7a2 |
A |
T |
8: 41,368,002 (GRCm39) |
I589F |
probably damaging |
Het |
| Smim8 |
C |
T |
4: 34,771,316 (GRCm39) |
R26Q |
probably damaging |
Het |
| Smox |
C |
A |
2: 131,362,384 (GRCm39) |
A221D |
probably damaging |
Het |
| Sox5 |
A |
G |
6: 143,819,831 (GRCm39) |
S62P |
possibly damaging |
Het |
| Spg21 |
A |
C |
9: 65,391,774 (GRCm39) |
K240N |
probably damaging |
Het |
| Sv2c |
C |
T |
13: 96,113,153 (GRCm39) |
V599M |
probably damaging |
Het |
| Tanc2 |
T |
A |
11: 105,801,121 (GRCm39) |
H1112Q |
probably damaging |
Het |
| Tbata |
T |
C |
10: 61,011,623 (GRCm39) |
I58T |
possibly damaging |
Het |
| Tbc1d2 |
T |
G |
4: 46,606,419 (GRCm39) |
Y842S |
probably benign |
Het |
| Tctn1 |
A |
T |
5: 122,379,903 (GRCm39) |
|
probably null |
Het |
| Tenm1 |
T |
C |
X: 41,916,078 (GRCm39) |
D402G |
probably benign |
Het |
| Tfcp2l1 |
T |
C |
1: 118,597,119 (GRCm39) |
V400A |
probably benign |
Het |
| Tm9sf2 |
T |
A |
14: 122,363,576 (GRCm39) |
L99I |
probably benign |
Het |
| Top2a |
T |
C |
11: 98,886,803 (GRCm39) |
|
probably null |
Het |
| Traf7 |
C |
A |
17: 24,732,255 (GRCm39) |
G191C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,580,967 (GRCm39) |
I23309V |
probably benign |
Het |
| Usp50 |
T |
C |
2: 126,619,881 (GRCm39) |
K199E |
possibly damaging |
Het |
| Vmn1r218 |
T |
C |
13: 23,320,683 (GRCm39) |
F10S |
probably damaging |
Het |
| Vmn2r89 |
C |
A |
14: 51,694,897 (GRCm39) |
T459K |
probably benign |
Het |
| Vps13a |
T |
G |
19: 16,655,302 (GRCm39) |
S1909R |
possibly damaging |
Het |
| Vwa5b2 |
T |
C |
16: 20,420,941 (GRCm39) |
|
probably null |
Het |
| Vwa8 |
A |
G |
14: 79,219,800 (GRCm39) |
H516R |
possibly damaging |
Het |
| Wnk1 |
T |
C |
6: 119,946,208 (GRCm39) |
I648M |
probably damaging |
Het |
| Zfat |
G |
C |
15: 68,018,392 (GRCm39) |
P974R |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,259,158 (GRCm39) |
I1601K |
probably benign |
Het |
| Zfp239 |
A |
G |
6: 117,848,778 (GRCm39) |
K172R |
probably benign |
Het |
| Zfp335 |
C |
T |
2: 164,736,722 (GRCm39) |
G971D |
probably damaging |
Het |
| Zfp532 |
A |
T |
18: 65,757,563 (GRCm39) |
I499F |
probably damaging |
Het |
| Zfp647 |
T |
C |
15: 76,795,314 (GRCm39) |
T449A |
possibly damaging |
Het |
| Zfp938 |
C |
T |
10: 82,061,465 (GRCm39) |
G385D |
probably damaging |
Het |
| Zfp959 |
T |
G |
17: 56,204,404 (GRCm39) |
V147G |
probably damaging |
Het |
| Znfx1 |
A |
T |
2: 166,892,270 (GRCm39) |
C649S |
probably damaging |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
63,858,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
63,858,089 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
63,873,446 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGATTTTGGCCAGCTCGCTG -3'
(R):5'- GCTGCTCAGAATGCAATTTACAAC -3'
Sequencing Primer
(F):5'- CTGTGGAGCTGTTAGACCAGTCTTAC -3'
(R):5'- TGCAATTTACAACTCAAGCAAGGG -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation