Incidental Mutation 'R0707:Cdc14a'
ID 218350
Institutional Source Beutler Lab
Gene Symbol Cdc14a
Ensembl Gene ENSMUSG00000033502
Gene Name CDC14 cell division cycle 14A
Synonyms A830059A17Rik, CDC14a1, CDC14A2, Cdc14
MMRRC Submission 038890-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R0707 (G1)
Quality Score 72
Status Validated
Chromosome 3
Chromosomal Location 116066202-116222390 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 116087362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090464] [ENSMUST00000106491]
AlphaFold Q6GQT0
Predicted Effect probably benign
Transcript: ENSMUST00000090464
SMART Domains Protein: ENSMUSP00000087950
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 13 153 1.6e-66 PFAM
Pfam:Y_phosphatase 210 324 1.1e-7 PFAM
Pfam:DSPc 214 328 1.8e-14 PFAM
low complexity region 539 558 N/A INTRINSIC
low complexity region 573 595 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106491
SMART Domains Protein: ENSMUSP00000102100
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 12 121 9.5e-44 PFAM
Pfam:Y_phosphatase 160 274 6.4e-8 PFAM
Pfam:DSPc 160 280 2.8e-14 PFAM
low complexity region 490 509 N/A INTRINSIC
low complexity region 524 546 N/A INTRINSIC
Meta Mutation Damage Score 0.0634 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 A G 4: 106,617,329 (GRCm39) F259S probably damaging Het
Aldh16a1 T A 7: 44,793,931 (GRCm39) probably benign Het
Ankrd24 A T 10: 81,478,547 (GRCm39) probably benign Het
Arhgap5 T C 12: 52,564,951 (GRCm39) S641P probably damaging Het
Arpp21 A C 9: 111,986,824 (GRCm39) S242R probably benign Het
Bpifb5 A G 2: 154,070,820 (GRCm39) T204A probably benign Het
Bud31 A G 5: 145,083,265 (GRCm39) Y77C probably damaging Het
Ccdc65 G A 15: 98,607,095 (GRCm39) V101I possibly damaging Het
Ccr7 T A 11: 99,036,809 (GRCm39) T38S probably damaging Het
Ces2f C T 8: 105,677,618 (GRCm39) H208Y possibly damaging Het
Chst1 C A 2: 92,443,964 (GRCm39) N145K possibly damaging Het
Clock A G 5: 76,374,976 (GRCm39) V731A possibly damaging Het
Cog6 C T 3: 52,921,283 (GRCm39) V108I possibly damaging Het
Cplane1 T A 15: 8,287,805 (GRCm39) N2881K unknown Het
Crtc2 T A 3: 90,170,804 (GRCm39) F626I probably damaging Het
Dicer1 A T 12: 104,673,144 (GRCm39) F792I probably damaging Het
Dnajc13 T C 9: 104,049,781 (GRCm39) K1780R probably benign Het
Dph5 A C 3: 115,708,782 (GRCm39) N155H probably benign Het
Dscam T C 16: 96,626,982 (GRCm39) probably null Het
Etl4 C A 2: 20,810,382 (GRCm39) probably benign Het
Flt3l T C 7: 44,785,450 (GRCm39) S9G probably benign Het
Fmnl2 A G 2: 52,944,498 (GRCm39) E159G possibly damaging Het
Fryl A G 5: 73,240,715 (GRCm39) I1295T probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gatad2b T A 3: 90,263,489 (GRCm39) S529T probably benign Het
Herc6 G A 6: 57,639,347 (GRCm39) G905E possibly damaging Het
Hhip T A 8: 80,724,884 (GRCm39) N296I probably damaging Het
Hmgcr A T 13: 96,787,151 (GRCm39) probably benign Het
Kalrn T G 16: 33,830,951 (GRCm39) N723H possibly damaging Het
Mroh5 T A 15: 73,662,588 (GRCm39) Y242F possibly damaging Het
Msh3 T A 13: 92,483,848 (GRCm39) K258* probably null Het
Myo1a T C 10: 127,555,732 (GRCm39) probably benign Het
Nlrp4f C T 13: 65,342,317 (GRCm39) E443K probably benign Het
Nupr2 A G 5: 129,937,533 (GRCm39) Y34C probably damaging Het
Ociad1 T C 5: 73,452,255 (GRCm39) probably benign Het
Or1af1 A T 2: 37,110,208 (GRCm39) K236* probably null Het
Or5af2 T A 11: 58,708,577 (GRCm39) L248M probably damaging Het
Or5b3 A T 19: 13,388,784 (GRCm39) M284L probably benign Het
Or5p5 A G 7: 107,414,331 (GRCm39) D182G probably damaging Het
Or6ae1 T C 7: 139,742,002 (GRCm39) N287S probably damaging Het
P2ry12 C A 3: 59,124,908 (GRCm39) V256F probably damaging Het
Pcdhb22 T A 18: 37,651,904 (GRCm39) I124N probably damaging Het
Pcnt A G 10: 76,256,375 (GRCm39) F622L probably damaging Het
Pfas A T 11: 68,888,863 (GRCm39) N361K probably benign Het
Plod2 T G 9: 92,487,480 (GRCm39) L600V possibly damaging Het
Pole T C 5: 110,446,854 (GRCm39) Y631H probably damaging Het
Proser1 T C 3: 53,386,197 (GRCm39) L693P probably damaging Het
Ptprd A G 4: 75,875,476 (GRCm39) Y1195H probably damaging Het
Rbm27 T A 18: 42,459,091 (GRCm39) probably null Het
Ric8a A G 7: 140,437,886 (GRCm39) probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rimkla C T 4: 119,335,177 (GRCm39) V69M probably damaging Het
Scfd1 A T 12: 51,459,360 (GRCm39) K307M probably damaging Het
Sh2b2 A G 5: 136,261,117 (GRCm39) F33S probably damaging Het
Smg7 T G 1: 152,746,508 (GRCm39) probably null Het
Srebf1 T C 11: 60,094,942 (GRCm39) T486A probably benign Het
Strn3 G A 12: 51,657,187 (GRCm39) T642I probably damaging Het
Syne2 T C 12: 76,028,837 (GRCm39) probably null Het
Syne3 A G 12: 104,935,619 (GRCm39) L53P probably damaging Het
Tcea1 T A 1: 4,950,569 (GRCm39) probably benign Het
Tmem30b T C 12: 73,592,942 (GRCm39) N58D probably benign Het
Tnpo1 A G 13: 98,991,954 (GRCm39) Y641H probably damaging Het
Trim25 A T 11: 88,890,564 (GRCm39) T84S probably benign Het
Trip4 A T 9: 65,746,286 (GRCm39) F537I possibly damaging Het
Uaca G A 9: 60,755,900 (GRCm39) probably benign Het
Ugt2b34 T A 5: 87,040,758 (GRCm39) Y388F possibly damaging Het
Vmn2r71 T C 7: 85,268,640 (GRCm39) V281A probably benign Het
Vps13d A T 4: 144,882,502 (GRCm39) D1030E probably damaging Het
Vps8 C A 16: 21,261,107 (GRCm39) F82L probably damaging Het
Zfp296 A G 7: 19,313,661 (GRCm39) D172G probably benign Het
Zfp977 C A 7: 42,229,958 (GRCm39) C189F probably damaging Het
Other mutations in Cdc14a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Cdc14a APN 3 116,088,493 (GRCm39) nonsense probably null
IGL01062:Cdc14a APN 3 116,068,361 (GRCm39) splice site probably benign
IGL01584:Cdc14a APN 3 116,186,474 (GRCm39) nonsense probably null
IGL03084:Cdc14a APN 3 116,142,101 (GRCm39) critical splice donor site probably null
IGL03237:Cdc14a APN 3 116,198,275 (GRCm39) intron probably benign
IGL03296:Cdc14a APN 3 116,090,807 (GRCm39) missense probably benign 0.02
PIT4131001:Cdc14a UTSW 3 116,122,310 (GRCm39) missense possibly damaging 0.66
R0782:Cdc14a UTSW 3 116,115,785 (GRCm39) missense probably damaging 1.00
R0835:Cdc14a UTSW 3 116,122,171 (GRCm39) missense probably benign 0.12
R1363:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R1507:Cdc14a UTSW 3 116,087,646 (GRCm39) missense possibly damaging 0.47
R1545:Cdc14a UTSW 3 116,087,373 (GRCm39) critical splice donor site probably null
R1795:Cdc14a UTSW 3 116,092,122 (GRCm39) missense possibly damaging 0.81
R1797:Cdc14a UTSW 3 116,115,843 (GRCm39) missense probably damaging 1.00
R1830:Cdc14a UTSW 3 116,216,296 (GRCm39) nonsense probably null
R4229:Cdc14a UTSW 3 116,087,413 (GRCm39) missense probably damaging 0.99
R4655:Cdc14a UTSW 3 116,122,136 (GRCm39) missense probably damaging 1.00
R4769:Cdc14a UTSW 3 116,088,399 (GRCm39) critical splice donor site probably null
R4870:Cdc14a UTSW 3 116,217,109 (GRCm39) missense probably benign 0.30
R4980:Cdc14a UTSW 3 116,186,506 (GRCm39) nonsense probably null
R6228:Cdc14a UTSW 3 116,144,862 (GRCm39) missense probably damaging 1.00
R6248:Cdc14a UTSW 3 116,101,843 (GRCm39) missense probably benign 0.01
R6402:Cdc14a UTSW 3 116,142,108 (GRCm39) missense probably damaging 1.00
R6749:Cdc14a UTSW 3 116,090,807 (GRCm39) missense possibly damaging 0.68
R6852:Cdc14a UTSW 3 116,122,325 (GRCm39) missense possibly damaging 0.94
R6996:Cdc14a UTSW 3 116,122,355 (GRCm39) missense probably damaging 1.00
R7185:Cdc14a UTSW 3 116,087,676 (GRCm39) missense probably benign
R7783:Cdc14a UTSW 3 116,198,236 (GRCm39) missense probably damaging 1.00
R7896:Cdc14a UTSW 3 116,088,482 (GRCm39) missense probably benign 0.00
R7991:Cdc14a UTSW 3 116,101,887 (GRCm39) missense probably benign 0.01
R8049:Cdc14a UTSW 3 116,087,577 (GRCm39) missense probably benign 0.33
R9163:Cdc14a UTSW 3 116,122,213 (GRCm39) missense possibly damaging 0.95
R9434:Cdc14a UTSW 3 116,217,092 (GRCm39) missense probably benign
R9526:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R9662:Cdc14a UTSW 3 116,088,484 (GRCm39) missense probably damaging 0.99
R9781:Cdc14a UTSW 3 116,122,274 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAATGTAGCGCATGGACAGTTGCAC -3'
(R):5'- TTCTTGAATGGCAGCACCCAGACAC -3'

Sequencing Primer
(F):5'- TGGACAGTTGCACAACACAG -3'
(R):5'- cagaagcagcaacagcaac -3'
Posted On 2014-08-01