Incidental Mutation 'R0764:Angpt4'
ID 218490
Institutional Source Beutler Lab
Gene Symbol Angpt4
Ensembl Gene ENSMUSG00000027460
Gene Name angiopoietin 4
Synonyms
MMRRC Submission 038944-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0764 (G1)
Quality Score 198
Status Validated
Chromosome 2
Chromosomal Location 151753130-151787257 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to G at 151753204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000028955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028955]
AlphaFold Q9WVH6
Predicted Effect probably benign
Transcript: ENSMUST00000028955
SMART Domains Protein: ENSMUSP00000028955
Gene: ENSMUSG00000027460

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 86 95 N/A INTRINSIC
coiled coil region 181 239 N/A INTRINSIC
low complexity region 253 267 N/A INTRINSIC
FBG 292 507 2.23e-98 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.1%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: This gene is a member of the angiopoietin family of secreted growth factors comprising Angiopoietins-1, -2, and -3, all of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is also required for lymphangiogenesis. Family members bind TEK Receptor Tyrosine Kinase as multimeric clusters but their oligomerization properties differ from one another and this is thought to provide a mechanistic basis for their distinct physiologic roles. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A T 11: 109,950,772 (GRCm39) Y898N probably damaging Het
Acp4 T C 7: 43,901,738 (GRCm39) probably benign Het
Adipor2 T C 6: 119,334,215 (GRCm39) I332V probably benign Het
Ago3 T A 4: 126,248,885 (GRCm39) K555N possibly damaging Het
Ano5 G T 7: 51,187,590 (GRCm39) probably benign Het
Ap3b1 C T 13: 94,616,387 (GRCm39) probably benign Het
Cbl A T 9: 44,075,449 (GRCm39) C399S probably damaging Het
Cdkl2 C A 5: 92,168,136 (GRCm39) V353L probably benign Het
Celsr3 A G 9: 108,705,017 (GRCm39) Y500C probably damaging Het
Cep162 A G 9: 87,083,798 (GRCm39) S1242P probably damaging Het
Crhr1 C T 11: 104,050,152 (GRCm39) R66W probably damaging Het
Ddx49 T C 8: 70,749,907 (GRCm39) E170G probably benign Het
Fam193a T C 5: 34,600,685 (GRCm39) F305L probably damaging Het
Fam76a C T 4: 132,638,010 (GRCm39) G198R probably damaging Het
Gm43302 T A 5: 105,428,355 (GRCm39) I130F probably benign Het
Hectd4 T A 5: 121,424,832 (GRCm39) I745N possibly damaging Het
Ina T A 19: 47,012,087 (GRCm39) *502K probably null Het
Kdm1b A T 13: 47,222,079 (GRCm39) D506V possibly damaging Het
Lrrk2 A G 15: 91,659,249 (GRCm39) probably null Het
Ly6g2 T A 15: 75,092,572 (GRCm39) F97Y probably benign Het
Naip5 A T 13: 100,353,613 (GRCm39) D1215E probably benign Het
Neb A G 2: 52,106,879 (GRCm39) probably benign Het
Nectin2 T A 7: 19,483,096 (GRCm39) probably null Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or2aj5 G T 16: 19,425,182 (GRCm39) P79T probably damaging Het
Or4a71 A G 2: 89,358,340 (GRCm39) V138A probably benign Het
Osbp A G 19: 11,961,520 (GRCm39) probably benign Het
Otog A G 7: 45,949,918 (GRCm39) D2460G probably benign Het
Pcgf1 T C 6: 83,056,150 (GRCm39) C2R probably damaging Het
Per2 C T 1: 91,357,142 (GRCm39) V674M probably damaging Het
Pias3 C T 3: 96,608,611 (GRCm39) P218S probably damaging Het
Plod3 C T 5: 137,018,437 (GRCm39) probably benign Het
Purb C T 11: 6,425,661 (GRCm39) V76M probably damaging Het
Ranbp1 C A 16: 18,058,022 (GRCm39) E181* probably null Het
Rit2 T C 18: 31,286,754 (GRCm39) probably benign Het
Rnf103 C A 6: 71,486,566 (GRCm39) T399K probably damaging Het
Slc22a13 T C 9: 119,037,746 (GRCm39) probably null Het
Slc35f4 T A 14: 49,543,796 (GRCm39) probably benign Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Tnfrsf17 C T 16: 11,133,063 (GRCm39) T47M possibly damaging Het
Tram1 A G 1: 13,649,933 (GRCm39) I97T probably damaging Het
Ttc38 T C 15: 85,730,604 (GRCm39) probably benign Het
Zfp113 T A 5: 138,143,506 (GRCm39) Q248L probably damaging Het
Other mutations in Angpt4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02900:Angpt4 APN 2 151,753,391 (GRCm39) missense probably damaging 0.99
IGL03107:Angpt4 APN 2 151,785,342 (GRCm39) missense probably benign 0.08
IGL03343:Angpt4 APN 2 151,778,623 (GRCm39) missense probably damaging 1.00
R0034:Angpt4 UTSW 2 151,771,311 (GRCm39) missense probably benign 0.44
R0709:Angpt4 UTSW 2 151,776,434 (GRCm39) missense possibly damaging 0.46
R0853:Angpt4 UTSW 2 151,780,847 (GRCm39) missense probably damaging 1.00
R1796:Angpt4 UTSW 2 151,780,909 (GRCm39) missense probably damaging 1.00
R2091:Angpt4 UTSW 2 151,778,703 (GRCm39) splice site probably benign
R2184:Angpt4 UTSW 2 151,780,874 (GRCm39) missense probably damaging 1.00
R2901:Angpt4 UTSW 2 151,753,259 (GRCm39) missense unknown
R3014:Angpt4 UTSW 2 151,771,517 (GRCm39) missense probably benign 0.07
R4192:Angpt4 UTSW 2 151,785,238 (GRCm39) missense probably benign
R4440:Angpt4 UTSW 2 151,786,566 (GRCm39) missense probably damaging 1.00
R5059:Angpt4 UTSW 2 151,776,360 (GRCm39) missense probably damaging 1.00
R5326:Angpt4 UTSW 2 151,767,464 (GRCm39) critical splice donor site probably null
R6345:Angpt4 UTSW 2 151,771,354 (GRCm39) missense probably benign 0.00
R7232:Angpt4 UTSW 2 151,771,460 (GRCm39) missense possibly damaging 0.63
R7313:Angpt4 UTSW 2 151,767,326 (GRCm39) missense probably benign
R7456:Angpt4 UTSW 2 151,780,987 (GRCm39) missense probably damaging 1.00
R7598:Angpt4 UTSW 2 151,767,445 (GRCm39) missense possibly damaging 0.95
R7823:Angpt4 UTSW 2 151,753,286 (GRCm39) missense unknown
R8261:Angpt4 UTSW 2 151,769,084 (GRCm39) missense probably benign 0.00
R8682:Angpt4 UTSW 2 151,769,005 (GRCm39) missense probably benign 0.00
R8730:Angpt4 UTSW 2 151,771,467 (GRCm39) missense probably damaging 0.99
R8861:Angpt4 UTSW 2 151,767,373 (GRCm39) missense probably damaging 1.00
R9359:Angpt4 UTSW 2 151,780,892 (GRCm39) missense probably damaging 0.98
R9403:Angpt4 UTSW 2 151,780,892 (GRCm39) missense probably damaging 0.98
Predicted Primers
Posted On 2014-08-11