Incidental Mutation 'R0690:Col2a1'
ID 218537
Institutional Source Beutler Lab
Gene Symbol Col2a1
Ensembl Gene ENSMUSG00000022483
Gene Name collagen, type II, alpha 1
Synonyms Rgsc413, M100413, Rgsc856, Col2a-1, M100856, Del1, Col2a, Col2, Lpk
MMRRC Submission 038875-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0690 (G1)
Quality Score 28
Status Validated
Chromosome 15
Chromosomal Location 97873483-97902525 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 97878073 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 954 (V954E)
Ref Sequence ENSEMBL: ENSMUSP00000085693 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023123] [ENSMUST00000088355] [ENSMUST00000131560]
AlphaFold P28481
Predicted Effect unknown
Transcript: ENSMUST00000023123
AA Change: V1022E
SMART Domains Protein: ENSMUSP00000023123
Gene: ENSMUSG00000022483
AA Change: V1022E

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
VWC 34 88 1.59e-21 SMART
Pfam:Collagen 115 175 1.3e-11 PFAM
Pfam:Collagen 199 260 7.2e-11 PFAM
Pfam:Collagen 258 317 1.3e-12 PFAM
Pfam:Collagen 312 377 4e-9 PFAM
low complexity region 395 411 N/A INTRINSIC
low complexity region 416 451 N/A INTRINSIC
internal_repeat_5 456 468 5.45e-5 PROSPERO
low complexity region 471 513 N/A INTRINSIC
internal_repeat_3 516 619 3.99e-13 PROSPERO
internal_repeat_1 524 567 1.6e-17 PROSPERO
low complexity region 621 633 N/A INTRINSIC
low complexity region 636 655 N/A INTRINSIC
low complexity region 659 687 N/A INTRINSIC
low complexity region 696 753 N/A INTRINSIC
internal_repeat_5 756 768 5.45e-5 PROSPERO
low complexity region 783 804 N/A INTRINSIC
Pfam:Collagen 852 918 1.1e-8 PFAM
Pfam:Collagen 876 941 1.9e-9 PFAM
Pfam:Collagen 900 966 2.4e-9 PFAM
Pfam:Collagen 983 1049 2.1e-10 PFAM
low complexity region 1062 1081 N/A INTRINSIC
Pfam:Collagen 1101 1172 3.4e-9 PFAM
Pfam:Collagen 1158 1218 1.3e-9 PFAM
COLFI 1252 1487 3.06e-184 SMART
Predicted Effect unknown
Transcript: ENSMUST00000088355
AA Change: V954E
SMART Domains Protein: ENSMUSP00000085693
Gene: ENSMUSG00000022483
AA Change: V954E

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:Collagen 47 107 1.2e-11 PFAM
Pfam:Collagen 131 192 7.2e-11 PFAM
Pfam:Collagen 190 249 1.3e-12 PFAM
low complexity region 262 314 N/A INTRINSIC
Pfam:Collagen 327 405 3.5e-7 PFAM
Pfam:Collagen 361 429 7.6e-10 PFAM
internal_repeat_3 448 551 1.3e-13 PROSPERO
internal_repeat_7 454 466 2.86e-5 PROSPERO
internal_repeat_1 456 499 4.05e-18 PROSPERO
internal_repeat_6 481 504 1.7e-5 PROSPERO
low complexity region 553 565 N/A INTRINSIC
low complexity region 568 587 N/A INTRINSIC
low complexity region 591 619 N/A INTRINSIC
low complexity region 628 685 N/A INTRINSIC
internal_repeat_4 688 712 8.3e-12 PROSPERO
low complexity region 715 736 N/A INTRINSIC
low complexity region 747 784 N/A INTRINSIC
Pfam:Collagen 808 878 9.8e-9 PFAM
Pfam:Collagen 832 898 2.1e-9 PFAM
Pfam:Collagen 916 979 7.2e-10 PFAM
Pfam:Collagen 937 1005 2.1e-8 PFAM
Pfam:Collagen 973 1049 6e-7 PFAM
Pfam:Collagen 1030 1094 1.5e-10 PFAM
Pfam:Collagen 1088 1150 1.4e-9 PFAM
COLFI 1184 1419 3.06e-184 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131560
SMART Domains Protein: ENSMUSP00000116951
Gene: ENSMUSG00000022483

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
VWC 34 88 1.59e-21 SMART
low complexity region 109 132 N/A INTRINSIC
Meta Mutation Damage Score 0.2885 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 97% (87/90)
MGI Phenotype FUNCTION: This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mutations in this locus affect cartilage development. Homozygotes die perinatally with anomalies such as shortened limbs without epiphiseal growth plates, cleft palate and persistence of notochord. Heterozygotes are dwarfed with reduced cartilage matrix. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,860,634 (GRCm39) probably benign Het
Abi3 T C 11: 95,724,460 (GRCm39) probably benign Het
Adam2 T C 14: 66,295,095 (GRCm39) N250S probably damaging Het
Agbl4 T A 4: 111,514,585 (GRCm39) I532K probably benign Het
Agrn T G 4: 156,258,910 (GRCm39) E905A probably damaging Het
Ahi1 A G 10: 20,846,742 (GRCm39) probably benign Het
Aifm2 A G 10: 61,562,231 (GRCm39) N89S probably benign Het
Arsj C T 3: 126,231,833 (GRCm39) T193I probably damaging Het
Ascc2 T A 11: 4,632,933 (GRCm39) V702E probably damaging Het
Avpr1b T C 1: 131,528,019 (GRCm39) S181P probably damaging Het
Bcl7a G A 5: 123,490,003 (GRCm39) V56I possibly damaging Het
Cd160 T A 3: 96,713,102 (GRCm39) D54V probably damaging Het
Celsr2 C A 3: 108,322,293 (GRCm39) R173M probably damaging Het
Cfap57 A G 4: 118,426,924 (GRCm39) probably benign Het
Cfap69 G A 5: 5,713,951 (GRCm39) T27I probably damaging Het
Chaf1b T C 16: 93,696,905 (GRCm39) probably benign Het
Cldn8 C T 16: 88,359,527 (GRCm39) V133M probably damaging Het
Col6a4 T C 9: 105,905,386 (GRCm39) probably benign Het
Col6a6 T C 9: 105,586,685 (GRCm39) M1779V probably benign Het
Coq8b A G 7: 26,941,674 (GRCm39) E253G probably benign Het
Ctse T C 1: 131,602,516 (GRCm39) probably benign Het
Cyp2c29 T A 19: 39,298,170 (GRCm39) N238K probably benign Het
Dcaf1 T A 9: 106,723,848 (GRCm39) probably benign Het
Dcc A T 18: 71,942,275 (GRCm39) probably benign Het
Dkk1 A G 19: 30,526,745 (GRCm39) F12S probably benign Het
Dnah6 A G 6: 73,106,457 (GRCm39) V1760A probably benign Het
Fam117b G A 1: 59,997,512 (GRCm39) S288N possibly damaging Het
Fam216a A T 5: 122,505,709 (GRCm39) M110K probably damaging Het
Frem3 T A 8: 81,340,581 (GRCm39) I958N possibly damaging Het
Gab1 T A 8: 81,526,745 (GRCm39) N118Y probably damaging Het
Gda T A 19: 21,387,251 (GRCm39) I251L probably benign Het
Gli2 C A 1: 118,772,190 (GRCm39) R505L probably damaging Het
Gm5093 A T 17: 46,750,664 (GRCm39) I121N possibly damaging Het
Gpnmb C T 6: 49,024,949 (GRCm39) S327L probably benign Het
Gpr156 T A 16: 37,812,503 (GRCm39) Y280N probably damaging Het
Gria4 A G 9: 4,427,071 (GRCm39) Y790H probably damaging Het
Guf1 C A 5: 69,723,695 (GRCm39) probably null Het
H6pd T C 4: 150,067,030 (GRCm39) E452G possibly damaging Het
Herc1 T A 9: 66,294,120 (GRCm39) Y487* probably null Het
Ifi30 T A 8: 71,217,593 (GRCm39) probably benign Het
Klf13 G A 7: 63,587,819 (GRCm39) A159V possibly damaging Het
Med11 T A 11: 70,344,052 (GRCm39) M124K possibly damaging Het
Myom3 A G 4: 135,515,737 (GRCm39) probably benign Het
Nat2 A T 8: 67,954,456 (GRCm39) I189F probably damaging Het
Nhlrc4 C G 17: 26,162,658 (GRCm39) G30R probably damaging Het
Nkx3-2 G A 5: 41,919,470 (GRCm39) R173C probably damaging Het
Nox3 T C 17: 3,745,839 (GRCm39) N23S probably damaging Het
Npr2 A T 4: 43,646,991 (GRCm39) Y708F probably damaging Het
Nsun2 A G 13: 69,777,661 (GRCm39) N409S probably benign Het
Nucb2 T C 7: 116,135,086 (GRCm39) probably benign Het
Or13a26 T C 7: 140,284,700 (GRCm39) F179L possibly damaging Het
Or5be3 A G 2: 86,864,226 (GRCm39) F113S probably damaging Het
Or8b12 T C 9: 37,657,513 (GRCm39) F28L probably benign Het
Orai2 A T 5: 136,190,453 (GRCm39) V52D probably damaging Het
Pcyox1 A T 6: 86,371,424 (GRCm39) M154K probably damaging Het
Pik3r4 C A 9: 105,531,175 (GRCm39) T492K possibly damaging Het
Pmpca T A 2: 26,281,109 (GRCm39) Y150N probably damaging Het
Ppp1r12b G T 1: 134,803,820 (GRCm39) S446R probably damaging Het
Ptpdc1 A G 13: 48,740,381 (GRCm39) I289T probably benign Het
Pyroxd2 A G 19: 42,716,081 (GRCm39) probably benign Het
Qrfpr G A 3: 36,243,708 (GRCm39) T131M probably damaging Het
Rab33b A G 3: 51,400,838 (GRCm39) Y104C probably damaging Het
Rad54l G T 4: 115,956,947 (GRCm39) probably benign Het
Rad9a A T 19: 4,247,359 (GRCm39) probably null Het
Slc1a5 A T 7: 16,520,829 (GRCm39) M233L probably benign Het
Slc47a2 C T 11: 61,233,330 (GRCm39) V67I possibly damaging Het
Slco1a5 T A 6: 142,214,004 (GRCm39) Y39F probably benign Het
Slfn5 T C 11: 82,852,229 (GRCm39) V785A probably damaging Het
Sp6 C T 11: 96,912,370 (GRCm39) P28S possibly damaging Het
Sptbn5 A G 2: 119,893,156 (GRCm39) probably null Het
Sry ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTG Y: 2,662,944 (GRCm39) probably benign Het
St8sia1 A G 6: 142,774,980 (GRCm39) W200R probably damaging Het
Stxbp1 C A 2: 32,690,707 (GRCm39) probably benign Het
Syne1 A G 10: 4,983,138 (GRCm39) probably benign Het
Thbs3 T A 3: 89,127,472 (GRCm39) I371N possibly damaging Het
Tll1 C T 8: 64,527,324 (GRCm39) S399N probably damaging Het
Tmem209 A C 6: 30,505,833 (GRCm39) C114G probably null Het
Tmem25 C T 9: 44,706,811 (GRCm39) probably benign Het
Tmem8b T C 4: 43,674,562 (GRCm39) I282T possibly damaging Het
Trdmt1 T A 2: 13,549,391 (GRCm39) H18L probably benign Het
Trim63 A G 4: 134,043,716 (GRCm39) T60A probably benign Het
Trpv2 T C 11: 62,475,502 (GRCm39) probably null Het
Ubr2 A T 17: 47,249,579 (GRCm39) I1591K probably damaging Het
Use1 A T 8: 71,819,709 (GRCm39) probably benign Het
Zfp850 A T 7: 27,684,642 (GRCm39) C35S possibly damaging Het
Other mutations in Col2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Col2a1 APN 15 97,874,054 (GRCm39) missense unknown
IGL01286:Col2a1 APN 15 97,892,759 (GRCm39) missense unknown
IGL01369:Col2a1 APN 15 97,875,707 (GRCm39) missense unknown
IGL01747:Col2a1 APN 15 97,889,273 (GRCm39) splice site probably benign
IGL02086:Col2a1 APN 15 97,884,618 (GRCm39) splice site probably null
IGL02549:Col2a1 APN 15 97,875,680 (GRCm39) missense unknown
IGL03289:Col2a1 APN 15 97,878,762 (GRCm39) missense unknown
IGL03369:Col2a1 APN 15 97,879,923 (GRCm39) missense unknown
Foreseen UTSW 15 97,874,674 (GRCm39) missense unknown
FR4304:Col2a1 UTSW 15 97,886,862 (GRCm39) splice site probably null
FR4340:Col2a1 UTSW 15 97,886,862 (GRCm39) splice site probably null
FR4342:Col2a1 UTSW 15 97,886,862 (GRCm39) splice site probably null
FR4589:Col2a1 UTSW 15 97,886,862 (GRCm39) splice site probably null
LCD18:Col2a1 UTSW 15 97,886,862 (GRCm39) splice site probably null
R0124:Col2a1 UTSW 15 97,896,743 (GRCm39) missense unknown
R0227:Col2a1 UTSW 15 97,874,636 (GRCm39) missense unknown
R1434:Col2a1 UTSW 15 97,877,532 (GRCm39) missense probably damaging 0.96
R1473:Col2a1 UTSW 15 97,880,789 (GRCm39) splice site probably benign
R1577:Col2a1 UTSW 15 97,877,083 (GRCm39) missense probably damaging 1.00
R1598:Col2a1 UTSW 15 97,877,131 (GRCm39) missense probably damaging 0.99
R1837:Col2a1 UTSW 15 97,894,522 (GRCm39) splice site probably benign
R2153:Col2a1 UTSW 15 97,885,461 (GRCm39) missense unknown
R2965:Col2a1 UTSW 15 97,873,976 (GRCm39) missense unknown
R2966:Col2a1 UTSW 15 97,873,976 (GRCm39) missense unknown
R3710:Col2a1 UTSW 15 97,888,788 (GRCm39) splice site probably benign
R3838:Col2a1 UTSW 15 97,898,462 (GRCm39) intron probably benign
R3838:Col2a1 UTSW 15 97,886,857 (GRCm39) missense unknown
R4112:Col2a1 UTSW 15 97,881,582 (GRCm39) missense probably benign 0.18
R4417:Col2a1 UTSW 15 97,896,466 (GRCm39) missense unknown
R4656:Col2a1 UTSW 15 97,874,057 (GRCm39) missense unknown
R4960:Col2a1 UTSW 15 97,874,030 (GRCm39) missense unknown
R5008:Col2a1 UTSW 15 97,877,550 (GRCm39) missense probably benign 0.28
R5435:Col2a1 UTSW 15 97,898,391 (GRCm39) intron probably benign
R5473:Col2a1 UTSW 15 97,885,370 (GRCm39) missense unknown
R6042:Col2a1 UTSW 15 97,898,451 (GRCm39) intron probably benign
R6118:Col2a1 UTSW 15 97,896,448 (GRCm39) missense unknown
R6183:Col2a1 UTSW 15 97,886,671 (GRCm39) missense unknown
R6187:Col2a1 UTSW 15 97,886,671 (GRCm39) missense unknown
R6401:Col2a1 UTSW 15 97,883,773 (GRCm39) missense unknown
R6550:Col2a1 UTSW 15 97,874,674 (GRCm39) missense unknown
R6568:Col2a1 UTSW 15 97,875,157 (GRCm39) missense unknown
R6988:Col2a1 UTSW 15 97,902,335 (GRCm39) missense unknown
R7060:Col2a1 UTSW 15 97,874,022 (GRCm39) missense unknown
R7069:Col2a1 UTSW 15 97,896,469 (GRCm39) missense unknown
R7167:Col2a1 UTSW 15 97,898,337 (GRCm39) missense unknown
R7294:Col2a1 UTSW 15 97,885,168 (GRCm39) splice site probably null
R7392:Col2a1 UTSW 15 97,878,032 (GRCm39) nonsense probably null
R7491:Col2a1 UTSW 15 97,874,040 (GRCm39) missense not run
R7583:Col2a1 UTSW 15 97,874,065 (GRCm39) missense unknown
R7665:Col2a1 UTSW 15 97,874,581 (GRCm39) missense unknown
R7872:Col2a1 UTSW 15 97,898,458 (GRCm39) nonsense probably null
R8177:Col2a1 UTSW 15 97,874,654 (GRCm39) missense unknown
R8306:Col2a1 UTSW 15 97,888,849 (GRCm39) critical splice acceptor site probably null
R9343:Col2a1 UTSW 15 97,877,775 (GRCm39) missense probably damaging 0.99
R9458:Col2a1 UTSW 15 97,876,242 (GRCm39) missense unknown
Z1177:Col2a1 UTSW 15 97,896,226 (GRCm39) missense unknown
Z1177:Col2a1 UTSW 15 97,881,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCACTTCTGCCCAACTGAGAC -3'
(R):5'- AGCCGCACAGAATGGACTCAATG -3'

Sequencing Primer
(F):5'- CCTCAAGATCATCCTGCCAC -3'
(R):5'- GGCTCAAAACTCTTAACTGGGTG -3'
Posted On 2014-08-18