Incidental Mutation 'R1967:Epha5'
| ID |
219042 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Epha5
|
| Ensembl Gene |
ENSMUSG00000029245 |
| Gene Name |
Eph receptor A5 |
| Synonyms |
Rek7, Cek7, Els1, Ehk1, Hek7, bsk |
| MMRRC Submission |
039980-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1967 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
84202620-84565241 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84564288 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 26
(V26A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109033
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053733]
[ENSMUST00000113398]
[ENSMUST00000113399]
[ENSMUST00000113401]
[ENSMUST00000113403]
[ENSMUST00000113406]
|
| AlphaFold |
Q60629 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000053733
AA Change: V26A
|
| SMART Domains |
Protein: ENSMUSP00000060646
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
413 |
511 |
2.1e-22 |
PFAM |
|
TyrKc
|
514 |
771 |
9.33e-138 |
SMART |
|
SAM
|
801 |
868 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113398
AA Change: V26A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000109025
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
359 |
439 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
465 |
563 |
8.4e-23 |
PFAM |
|
TyrKc
|
566 |
823 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
854 |
894 |
7.2e-11 |
PFAM |
|
Pfam:SAM_2
|
856 |
894 |
1.6e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113399
AA Change: V26A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000109026
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
3.4e-22 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
966 |
1006 |
2.9e-10 |
PFAM |
|
Pfam:SAM_2
|
968 |
1006 |
5.9e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113401
AA Change: V26A
PolyPhen 2
Score 0.235 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000109028
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
411 |
488 |
3.1e-30 |
PFAM |
|
TyrKc
|
491 |
748 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
779 |
819 |
1.7e-10 |
PFAM |
|
Pfam:SAM_2
|
781 |
819 |
3.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113403
AA Change: V26A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000109030
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
1.2e-25 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
SAM
|
965 |
1032 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113406
AA Change: V26A
PolyPhen 2
Score 0.235 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000109033
Gene: ENSMUSG00000029245
AA Change: V26A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
575 |
652 |
1.9e-30 |
PFAM |
|
TyrKc
|
655 |
912 |
9.33e-138 |
SMART |
|
SAM
|
942 |
1009 |
6.65e-23 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136775
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152573
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154804
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155469
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
A |
C |
15: 37,439,842 (GRCm39) |
|
probably benign |
Het |
| Abca6 |
T |
C |
11: 110,077,974 (GRCm39) |
I1278V |
probably benign |
Het |
| Adamts15 |
C |
T |
9: 30,832,605 (GRCm39) |
W310* |
probably null |
Het |
| Adamts6 |
T |
A |
13: 104,563,459 (GRCm39) |
C650* |
probably null |
Het |
| Akap3 |
G |
T |
6: 126,842,061 (GRCm39) |
G227C |
probably benign |
Het |
| Alox12e |
A |
T |
11: 70,208,682 (GRCm39) |
S457T |
probably benign |
Het |
| Angpt1 |
C |
A |
15: 42,301,703 (GRCm39) |
C435F |
probably damaging |
Het |
| Anxa9 |
T |
C |
3: 95,207,919 (GRCm39) |
Q207R |
probably benign |
Het |
| Aplnr |
A |
T |
2: 84,967,950 (GRCm39) |
D325V |
probably benign |
Het |
| Art2b |
A |
C |
7: 101,229,414 (GRCm39) |
F162V |
probably damaging |
Het |
| Atp13a4 |
A |
G |
16: 29,298,672 (GRCm39) |
S96P |
probably damaging |
Het |
| Bnc1 |
A |
T |
7: 81,623,384 (GRCm39) |
H614Q |
probably benign |
Het |
| C6 |
A |
G |
15: 4,789,302 (GRCm39) |
D249G |
probably damaging |
Het |
| Camta1 |
A |
T |
4: 151,173,430 (GRCm39) |
F977I |
probably damaging |
Het |
| Chil6 |
T |
C |
3: 106,298,470 (GRCm39) |
S188G |
possibly damaging |
Het |
| Cntrob |
A |
T |
11: 69,211,789 (GRCm39) |
L145Q |
probably damaging |
Het |
| Coro7 |
T |
C |
16: 4,452,753 (GRCm39) |
E306G |
probably damaging |
Het |
| Cplane1 |
T |
G |
15: 8,232,904 (GRCm39) |
V1141G |
probably benign |
Het |
| Cpq |
T |
C |
15: 33,497,348 (GRCm39) |
S363P |
possibly damaging |
Het |
| Ctc1 |
A |
G |
11: 68,918,688 (GRCm39) |
|
probably null |
Het |
| Defb43 |
T |
A |
14: 63,255,246 (GRCm39) |
N26K |
probably benign |
Het |
| Dennd1a |
T |
C |
2: 37,734,845 (GRCm39) |
T41A |
probably benign |
Het |
| Dnah11 |
A |
C |
12: 117,880,523 (GRCm39) |
Y3866D |
probably damaging |
Het |
| Eml6 |
A |
G |
11: 29,974,545 (GRCm39) |
L11P |
probably damaging |
Het |
| Fam13c |
A |
G |
10: 70,387,565 (GRCm39) |
D443G |
probably damaging |
Het |
| Fam227a |
G |
A |
15: 79,521,335 (GRCm39) |
L243F |
possibly damaging |
Het |
| Fat3 |
T |
G |
9: 15,879,591 (GRCm39) |
R3301S |
probably benign |
Het |
| Fbxw20 |
T |
C |
9: 109,046,578 (GRCm39) |
T461A |
probably benign |
Het |
| Fgf8 |
T |
A |
19: 45,730,007 (GRCm39) |
S61C |
probably damaging |
Het |
| Fgfrl1 |
A |
G |
5: 108,852,871 (GRCm39) |
E100G |
probably damaging |
Het |
| Gabra4 |
G |
A |
5: 71,729,412 (GRCm39) |
S456F |
possibly damaging |
Het |
| Gas6 |
T |
C |
8: 13,520,317 (GRCm39) |
E457G |
probably damaging |
Het |
| Gpr33 |
G |
A |
12: 52,070,991 (GRCm39) |
S16L |
probably benign |
Het |
| Greb1l |
A |
C |
18: 10,501,049 (GRCm39) |
N393T |
possibly damaging |
Het |
| Gtpbp4 |
T |
C |
13: 9,027,340 (GRCm39) |
K492E |
probably benign |
Het |
| Hsf2bp |
A |
T |
17: 32,206,378 (GRCm39) |
L251* |
probably null |
Het |
| Hyal5 |
A |
T |
6: 24,876,193 (GRCm39) |
Q22L |
possibly damaging |
Het |
| Itih1 |
A |
T |
14: 30,663,941 (GRCm39) |
V114E |
possibly damaging |
Het |
| Jak3 |
T |
A |
8: 72,134,179 (GRCm39) |
I427N |
probably damaging |
Het |
| Jcad |
T |
C |
18: 4,675,162 (GRCm39) |
S975P |
probably benign |
Het |
| Kcng4 |
A |
G |
8: 120,359,662 (GRCm39) |
V238A |
probably damaging |
Het |
| Klb |
A |
G |
5: 65,529,417 (GRCm39) |
D315G |
probably damaging |
Het |
| Klrh1 |
A |
T |
6: 129,752,798 (GRCm39) |
N2K |
possibly damaging |
Het |
| Krt5 |
T |
C |
15: 101,620,094 (GRCm39) |
N208D |
probably benign |
Het |
| Lmo7 |
T |
A |
14: 102,137,651 (GRCm39) |
H551Q |
probably benign |
Het |
| Lrp8 |
G |
T |
4: 107,717,168 (GRCm39) |
G732V |
probably damaging |
Het |
| Lrrc38 |
A |
G |
4: 143,096,553 (GRCm39) |
D288G |
unknown |
Het |
| Lrrc4b |
GAGAAG |
GAG |
7: 44,111,654 (GRCm39) |
|
probably benign |
Het |
| Mas1 |
A |
G |
17: 13,060,923 (GRCm39) |
Y167H |
probably benign |
Het |
| Mcm8 |
A |
C |
2: 132,684,662 (GRCm39) |
I759L |
probably benign |
Het |
| Med13l |
G |
A |
5: 118,899,387 (GRCm39) |
D2148N |
probably damaging |
Het |
| Muc20 |
A |
T |
16: 32,614,612 (GRCm39) |
I255K |
probably benign |
Het |
| Myh1 |
A |
G |
11: 67,104,273 (GRCm39) |
N980S |
probably benign |
Het |
| Nap1l4 |
T |
A |
7: 143,088,024 (GRCm39) |
Q178L |
probably damaging |
Het |
| Ncapg |
T |
A |
5: 45,857,252 (GRCm39) |
L988Q |
probably damaging |
Het |
| Ncf2 |
A |
T |
1: 152,706,123 (GRCm39) |
H245L |
probably damaging |
Het |
| Neurl4 |
A |
G |
11: 69,794,036 (GRCm39) |
E164G |
possibly damaging |
Het |
| Nf1 |
G |
A |
11: 79,303,571 (GRCm39) |
R416H |
probably damaging |
Het |
| Obscn |
G |
A |
11: 59,026,535 (GRCm39) |
Q223* |
probably null |
Het |
| Or10q1 |
T |
A |
19: 13,727,417 (GRCm39) |
*316R |
probably null |
Het |
| Or2o1 |
T |
C |
11: 49,051,675 (GRCm39) |
I278T |
probably benign |
Het |
| Pcdhb16 |
T |
A |
18: 37,612,715 (GRCm39) |
N558K |
probably damaging |
Het |
| Pcnx2 |
A |
T |
8: 126,542,422 (GRCm39) |
M1253K |
possibly damaging |
Het |
| Pla2g4a |
A |
G |
1: 149,797,832 (GRCm39) |
V22A |
probably damaging |
Het |
| Plppr5 |
G |
A |
3: 117,419,555 (GRCm39) |
|
probably null |
Het |
| Pnpla2 |
T |
C |
7: 141,039,345 (GRCm39) |
S353P |
probably benign |
Het |
| Pom121 |
A |
T |
5: 135,420,608 (GRCm39) |
L271Q |
unknown |
Het |
| Prepl |
A |
T |
17: 85,395,979 (GRCm39) |
M1K |
probably null |
Het |
| Prr14l |
A |
G |
5: 33,001,813 (GRCm39) |
|
probably benign |
Het |
| Psmc3 |
C |
A |
2: 90,888,189 (GRCm39) |
P325T |
probably benign |
Het |
| Psme2b |
A |
G |
11: 48,836,896 (GRCm39) |
V17A |
probably damaging |
Het |
| Ptpro |
A |
G |
6: 137,393,863 (GRCm39) |
I23V |
probably benign |
Het |
| Rab31 |
A |
G |
17: 66,079,499 (GRCm39) |
|
probably null |
Het |
| Ranbp6 |
T |
A |
19: 29,789,900 (GRCm39) |
K151* |
probably null |
Het |
| Rbm12b1 |
A |
T |
4: 12,146,304 (GRCm39) |
I759L |
probably benign |
Het |
| Rgs5 |
T |
C |
1: 169,504,425 (GRCm39) |
I25T |
probably benign |
Het |
| Rnf213 |
T |
C |
11: 119,371,721 (GRCm39) |
V4842A |
probably damaging |
Het |
| Rtl9 |
A |
T |
X: 141,886,037 (GRCm39) |
I1150F |
probably damaging |
Het |
| Scn1a |
A |
T |
2: 66,158,769 (GRCm39) |
W384R |
probably damaging |
Het |
| Sema5a |
C |
T |
15: 32,681,765 (GRCm39) |
P948L |
probably damaging |
Het |
| Slc26a3 |
G |
A |
12: 31,515,777 (GRCm39) |
R559Q |
probably damaging |
Het |
| Slc29a3 |
A |
G |
10: 60,552,243 (GRCm39) |
V267A |
probably benign |
Het |
| Spata22 |
A |
G |
11: 73,221,953 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
A |
1: 26,722,454 (GRCm39) |
I909L |
probably benign |
Het |
| Sptbn2 |
G |
T |
19: 4,795,327 (GRCm39) |
R1595L |
probably benign |
Het |
| Tfdp1 |
T |
C |
8: 13,423,039 (GRCm39) |
S315P |
possibly damaging |
Het |
| Tle1 |
A |
T |
4: 72,038,463 (GRCm39) |
V688E |
probably damaging |
Het |
| Tmem129 |
A |
T |
5: 33,812,665 (GRCm39) |
|
probably null |
Het |
| Tmprss11a |
G |
A |
5: 86,579,702 (GRCm39) |
T91I |
probably benign |
Het |
| Tnfsf14 |
A |
G |
17: 57,497,807 (GRCm39) |
Y142H |
probably damaging |
Het |
| Tph1 |
T |
C |
7: 46,311,538 (GRCm39) |
D68G |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,592,631 (GRCm39) |
S12507T |
probably damaging |
Het |
| Tubgcp2 |
T |
A |
7: 139,586,066 (GRCm39) |
M408L |
probably benign |
Het |
| Usp34 |
A |
T |
11: 23,314,503 (GRCm39) |
H815L |
probably benign |
Het |
| Usp6nl |
G |
A |
2: 6,446,330 (GRCm39) |
R746H |
probably benign |
Het |
| Utp20 |
A |
G |
10: 88,652,841 (GRCm39) |
S358P |
probably benign |
Het |
| Vmn2r118 |
G |
A |
17: 55,899,882 (GRCm39) |
T674I |
probably damaging |
Het |
| Vmn2r8 |
A |
T |
5: 108,950,249 (GRCm39) |
H199Q |
probably benign |
Het |
| Vmn2r9 |
A |
G |
5: 108,995,388 (GRCm39) |
V420A |
probably benign |
Het |
| Vmn2r99 |
A |
T |
17: 19,599,077 (GRCm39) |
T254S |
probably benign |
Het |
| Zbed5 |
A |
G |
5: 129,930,510 (GRCm39) |
H132R |
possibly damaging |
Het |
| Zfp568 |
A |
G |
7: 29,688,513 (GRCm39) |
E25G |
probably damaging |
Het |
| Zfp951 |
T |
A |
5: 104,964,866 (GRCm39) |
I67L |
possibly damaging |
Het |
|
| Other mutations in Epha5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00808:Epha5
|
APN |
5 |
84,254,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01084:Epha5
|
APN |
5 |
84,218,946 (GRCm39) |
nonsense |
probably null |
|
|
IGL01462:Epha5
|
APN |
5 |
84,219,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Epha5
|
APN |
5 |
84,534,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01998:Epha5
|
APN |
5 |
84,232,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02744:Epha5
|
APN |
5 |
84,255,848 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03076:Epha5
|
APN |
5 |
84,479,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03123:Epha5
|
APN |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03381:Epha5
|
APN |
5 |
84,479,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB001:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
BB011:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
PIT4544001:Epha5
|
UTSW |
5 |
84,479,471 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0004:Epha5
|
UTSW |
5 |
84,479,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0490:Epha5
|
UTSW |
5 |
84,255,833 (GRCm39) |
splice site |
probably benign |
|
|
R0545:Epha5
|
UTSW |
5 |
84,215,217 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0835:Epha5
|
UTSW |
5 |
84,534,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1102:Epha5
|
UTSW |
5 |
84,381,434 (GRCm39) |
splice site |
probably benign |
|
|
R1184:Epha5
|
UTSW |
5 |
84,219,134 (GRCm39) |
splice site |
probably null |
|
|
R1255:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1255:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1327:Epha5
|
UTSW |
5 |
84,254,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Epha5
|
UTSW |
5 |
84,381,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Epha5
|
UTSW |
5 |
84,479,674 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2187:Epha5
|
UTSW |
5 |
84,234,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2282:Epha5
|
UTSW |
5 |
84,298,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2899:Epha5
|
UTSW |
5 |
84,381,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3746:Epha5
|
UTSW |
5 |
84,206,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4454:Epha5
|
UTSW |
5 |
84,304,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Epha5
|
UTSW |
5 |
84,298,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4809:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4810:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4825:Epha5
|
UTSW |
5 |
84,381,699 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4833:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4961:Epha5
|
UTSW |
5 |
84,381,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Epha5
|
UTSW |
5 |
84,232,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4981:Epha5
|
UTSW |
5 |
84,298,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5149:Epha5
|
UTSW |
5 |
84,298,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5422:Epha5
|
UTSW |
5 |
84,479,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5575:Epha5
|
UTSW |
5 |
84,564,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5664:Epha5
|
UTSW |
5 |
84,479,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5801:Epha5
|
UTSW |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5821:Epha5
|
UTSW |
5 |
84,232,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Epha5
|
UTSW |
5 |
84,381,533 (GRCm39) |
nonsense |
probably null |
|
|
R5951:Epha5
|
UTSW |
5 |
84,479,051 (GRCm39) |
intron |
probably benign |
|
|
R5956:Epha5
|
UTSW |
5 |
84,298,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6127:Epha5
|
UTSW |
5 |
84,218,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6189:Epha5
|
UTSW |
5 |
84,385,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6240:Epha5
|
UTSW |
5 |
84,265,438 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6343:Epha5
|
UTSW |
5 |
84,254,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6463:Epha5
|
UTSW |
5 |
84,254,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6517:Epha5
|
UTSW |
5 |
84,304,360 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6622:Epha5
|
UTSW |
5 |
84,385,387 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6667:Epha5
|
UTSW |
5 |
84,219,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Epha5
|
UTSW |
5 |
84,254,557 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6757:Epha5
|
UTSW |
5 |
84,253,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Epha5
|
UTSW |
5 |
84,479,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Epha5
|
UTSW |
5 |
84,254,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Epha5
|
UTSW |
5 |
84,564,321 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7031:Epha5
|
UTSW |
5 |
84,290,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7213:Epha5
|
UTSW |
5 |
84,381,782 (GRCm39) |
splice site |
probably null |
|
|
R7728:Epha5
|
UTSW |
5 |
84,215,267 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7924:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7953:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8043:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8468:Epha5
|
UTSW |
5 |
84,290,275 (GRCm39) |
splice site |
probably null |
|
|
R8558:Epha5
|
UTSW |
5 |
84,206,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8796:Epha5
|
UTSW |
5 |
84,255,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9035:Epha5
|
UTSW |
5 |
84,255,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Epha5
|
UTSW |
5 |
84,218,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9244:Epha5
|
UTSW |
5 |
84,265,441 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9347:Epha5
|
UTSW |
5 |
84,479,731 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9355:Epha5
|
UTSW |
5 |
84,253,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9434:Epha5
|
UTSW |
5 |
84,479,227 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1088:Epha5
|
UTSW |
5 |
84,385,381 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Epha5
|
UTSW |
5 |
84,218,979 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGAGCGGGGATTTAGTCTC -3'
(R):5'- CATTTAGAGGGGTCGAGAGC -3'
Sequencing Primer
(F):5'- GGATTTAGTCTCCGCAGCG -3'
(R):5'- GTACAGGACCCCACCAGGAG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation