Incidental Mutation 'R2009:Rnase2b'
ID 219388
Institutional Source Beutler Lab
Gene Symbol Rnase2b
Ensembl Gene ENSMUSG00000059606
Gene Name ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
Synonyms Ear5, mR5, murine ribonuclease 5
MMRRC Submission 040018-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R2009 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 51399717-51400475 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 51400347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 143 (T143A)
Ref Sequence ENSEMBL: ENSMUSP00000075074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075648]
AlphaFold O35292
Predicted Effect possibly damaging
Transcript: ENSMUST00000075648
AA Change: T143A

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000075074
Gene: ENSMUSG00000059606
AA Change: T143A

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
RNAse_Pc 27 155 1.26e-48 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts15 T A 9: 30,833,433 (GRCm39) D34V probably benign Het
Adgrf1 A T 17: 43,632,112 (GRCm39) R884* probably null Het
Adgrg7 T C 16: 56,582,236 (GRCm39) T301A probably benign Het
Arhgef17 A G 7: 100,530,988 (GRCm39) I1366T probably damaging Het
C1s2 A T 6: 124,612,048 (GRCm39) L112H probably damaging Het
C2cd6 A T 1: 59,042,391 (GRCm39) noncoding transcript Het
Cfap74 G A 4: 155,504,724 (GRCm39) R103H possibly damaging Het
Col7a1 A T 9: 108,797,943 (GRCm39) probably null Het
Dmp1 A G 5: 104,360,706 (GRCm39) S461G probably damaging Het
Eif4g2 A T 7: 110,673,405 (GRCm39) D753E probably benign Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Etv4 T C 11: 101,665,063 (GRCm39) D130G probably damaging Het
Gabbr2 A T 4: 46,734,119 (GRCm39) I533N probably damaging Het
Gne T C 4: 44,055,273 (GRCm39) E234G probably benign Het
Itga6 C A 2: 71,647,025 (GRCm39) N78K probably benign Het
Lap3 C T 5: 45,650,899 (GRCm39) T33M probably benign Het
Limd1 A G 9: 123,308,564 (GRCm39) S88G probably benign Het
Lrp1 G T 10: 127,380,385 (GRCm39) T3922K probably damaging Het
Map4k3 A G 17: 80,971,517 (GRCm39) probably benign Het
Mib1 T C 18: 10,812,118 (GRCm39) L263S probably damaging Het
Ncor1 T C 11: 62,216,427 (GRCm39) S1474G probably benign Het
Nkapl A C 13: 21,651,607 (GRCm39) S335R probably damaging Het
Nrg3 A G 14: 38,092,771 (GRCm39) S605P probably damaging Het
Or10x4 G T 1: 174,218,995 (GRCm39) R120L possibly damaging Het
Or52b3 A G 7: 102,204,151 (GRCm39) Y220C probably damaging Het
Patj G A 4: 98,344,406 (GRCm39) D577N probably damaging Het
Pfpl A C 19: 12,407,319 (GRCm39) K523N possibly damaging Het
Pik3c2a A C 7: 115,963,738 (GRCm39) L924R probably damaging Het
Pkd2l1 C A 19: 44,144,403 (GRCm39) R278L probably benign Het
Prss2 A T 6: 41,500,910 (GRCm39) I108F probably damaging Het
Sgk1 C T 10: 21,872,500 (GRCm39) R171W probably damaging Het
Sphk2 A T 7: 45,360,437 (GRCm39) H522Q probably damaging Het
Szt2 A G 4: 118,235,261 (GRCm39) probably null Het
Tmem88 C A 11: 69,288,602 (GRCm39) A106S probably damaging Het
Trappc14 C A 5: 138,259,191 (GRCm39) C434F probably damaging Het
Trim39 A G 17: 36,574,646 (GRCm39) L252S possibly damaging Het
Trim60 T A 8: 65,453,975 (GRCm39) E91D probably damaging Het
Trpm5 A G 7: 142,641,475 (GRCm39) I145T possibly damaging Het
Vmn2r107 A T 17: 20,595,729 (GRCm39) M761L probably benign Het
Wdr4 G A 17: 31,719,584 (GRCm39) probably benign Het
Wfs1 A T 5: 37,125,653 (GRCm39) S413T probably damaging Het
Wnt2 A T 6: 18,030,208 (GRCm39) W27R probably damaging Het
Zc3h3 A T 15: 75,651,158 (GRCm39) H687Q probably damaging Het
Zfp750 G A 11: 121,403,951 (GRCm39) P308L possibly damaging Het
Other mutations in Rnase2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02089:Rnase2b APN 14 51,400,240 (GRCm39) missense probably benign 0.04
IGL02947:Rnase2b APN 14 51,400,264 (GRCm39) missense probably damaging 1.00
R1358:Rnase2b UTSW 14 51,400,146 (GRCm39) missense probably damaging 1.00
R1359:Rnase2b UTSW 14 51,400,146 (GRCm39) missense probably damaging 1.00
R1361:Rnase2b UTSW 14 51,400,146 (GRCm39) missense probably damaging 1.00
R1466:Rnase2b UTSW 14 51,400,296 (GRCm39) nonsense probably null
R1466:Rnase2b UTSW 14 51,400,296 (GRCm39) nonsense probably null
R1912:Rnase2b UTSW 14 51,400,357 (GRCm39) missense probably damaging 1.00
R2307:Rnase2b UTSW 14 51,400,188 (GRCm39) missense probably benign 0.00
R3849:Rnase2b UTSW 14 51,400,205 (GRCm39) missense probably damaging 1.00
R4717:Rnase2b UTSW 14 51,400,174 (GRCm39) missense possibly damaging 0.65
R4994:Rnase2b UTSW 14 51,400,208 (GRCm39) missense possibly damaging 0.53
R7167:Rnase2b UTSW 14 51,400,222 (GRCm39) missense probably damaging 1.00
R8919:Rnase2b UTSW 14 51,400,347 (GRCm39) missense possibly damaging 0.69
R9490:Rnase2b UTSW 14 51,400,284 (GRCm39) missense probably benign 0.26
R9756:Rnase2b UTSW 14 51,400,302 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACAACTTTTGCTGATGTTGTCC -3'
(R):5'- TTTCAGCTAAAGTAAAGGAAGCCAG -3'

Sequencing Primer
(F):5'- GTGTGTGTCACAATCCACCCAAG -3'
(R):5'- CCAGGGATAGGTTTCATGAGGAC -3'
Posted On 2014-08-25