Incidental Mutation 'R2010:Evi5'
ID 219455
Institutional Source Beutler Lab
Gene Symbol Evi5
Ensembl Gene ENSMUSG00000011831
Gene Name ecotropic viral integration site 5
Synonyms NB4S
MMRRC Submission 040019-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2010 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 107892661-108022973 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to A at 107961411 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114845 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112642] [ENSMUST00000124034] [ENSMUST00000128723] [ENSMUST00000138111]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000112642
SMART Domains Protein: ENSMUSP00000108261
Gene: ENSMUSG00000011831

DomainStartEndE-ValueType
low complexity region 51 80 N/A INTRINSIC
Blast:TBC 81 157 2e-16 BLAST
TBC 160 371 7.92e-91 SMART
internal_repeat_1 450 477 8.83e-6 PROSPERO
internal_repeat_1 494 521 8.83e-6 PROSPERO
coiled coil region 555 717 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124034
SMART Domains Protein: ENSMUSP00000121761
Gene: ENSMUSG00000011831

DomainStartEndE-ValueType
low complexity region 7 36 N/A INTRINSIC
Blast:TBC 37 113 3e-17 BLAST
TBC 116 327 7.92e-91 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124590
Predicted Effect probably null
Transcript: ENSMUST00000128723
SMART Domains Protein: ENSMUSP00000114845
Gene: ENSMUSG00000011831

DomainStartEndE-ValueType
low complexity region 7 36 N/A INTRINSIC
Blast:TBC 37 113 2e-16 BLAST
TBC 116 327 7.92e-91 SMART
internal_repeat_1 466 493 2.66e-6 PROSPERO
internal_repeat_1 510 537 2.66e-6 PROSPERO
coiled coil region 571 660 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132482
Predicted Effect probably benign
Transcript: ENSMUST00000138111
SMART Domains Protein: ENSMUSP00000119196
Gene: ENSMUSG00000011831

DomainStartEndE-ValueType
low complexity region 7 36 N/A INTRINSIC
Blast:TBC 37 113 3e-17 BLAST
TBC 116 327 7.92e-91 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155897
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810062G17Rik G A 3: 36,535,955 (GRCm39) G74S unknown Het
Aimp1 A T 3: 132,373,253 (GRCm39) L229Q probably benign Het
Arhgef6 T C X: 56,344,865 (GRCm39) T52A possibly damaging Het
Aste1 C A 9: 105,280,701 (GRCm39) H25Q probably damaging Het
Atp13a1 G A 8: 70,244,010 (GRCm39) G36R possibly damaging Het
Bahcc1 T C 11: 120,163,604 (GRCm39) V634A probably damaging Het
Bltp1 T G 3: 36,982,700 (GRCm39) N788K probably benign Het
C1s1 A T 6: 124,514,353 (GRCm39) Y168N probably damaging Het
Camsap2 T C 1: 136,202,606 (GRCm39) S612G probably damaging Het
Cdh23 C A 10: 60,150,006 (GRCm39) R2611L probably damaging Het
Cfap20dc A T 14: 8,511,021 (GRCm38) F464L probably damaging Het
Cilp2 A G 8: 70,334,344 (GRCm39) Y885H probably damaging Het
Dhrs3 C T 4: 144,653,758 (GRCm39) T227I possibly damaging Het
Dnah2 A T 11: 69,349,184 (GRCm39) probably null Het
Dnah3 T G 7: 119,694,400 (GRCm39) M1L probably benign Het
Ehbp1l1 A G 19: 5,769,311 (GRCm39) I664T probably benign Het
Eif4e C T 3: 138,261,219 (GRCm39) T171I probably benign Het
Elfn1 C T 5: 139,959,071 (GRCm39) R692W probably damaging Het
Eps8l3 T A 3: 107,786,688 (GRCm39) M1K probably null Het
Fancd2 A T 6: 113,570,252 (GRCm39) D1401V probably damaging Het
Fat2 G A 11: 55,144,653 (GRCm39) R4074C probably damaging Het
Fkbp4 A T 6: 128,412,765 (GRCm39) V55E probably benign Het
Fnip1 A G 11: 54,373,329 (GRCm39) D180G probably damaging Het
Galc A G 12: 98,220,489 (GRCm39) F126S possibly damaging Het
Gdf7 C T 12: 8,351,729 (GRCm39) V69M unknown Het
Glis2 A G 16: 4,426,575 (GRCm39) E22G probably damaging Het
H2bc3 G A 13: 23,931,111 (GRCm39) V112M possibly damaging Het
Hps4 T A 5: 112,517,342 (GRCm39) V243E probably damaging Het
Ighe T A 12: 113,235,108 (GRCm39) I351F unknown Het
Irak4 A T 15: 94,449,687 (GRCm39) R55S probably damaging Het
Itpr2 G A 6: 146,129,022 (GRCm39) probably null Het
Katnip A G 7: 125,472,128 (GRCm39) I1544M possibly damaging Het
Kirrel3 T C 9: 34,850,494 (GRCm39) Y41H probably damaging Het
Krr1 A G 10: 111,811,474 (GRCm39) E56G possibly damaging Het
Lgi1 G A 19: 38,289,683 (GRCm39) V250I probably damaging Het
Lipf A G 19: 33,950,946 (GRCm39) N306D probably benign Het
Lman2l C T 1: 36,484,262 (GRCm39) W18* probably null Het
Lztfl1 T A 9: 123,531,251 (GRCm39) N239I possibly damaging Het
Mief1 T C 15: 80,132,126 (GRCm39) S66P possibly damaging Het
Mmp8 C A 9: 7,567,535 (GRCm39) S465* probably null Het
Muc2 A T 7: 141,287,444 (GRCm39) T208S probably damaging Het
Myh8 A T 11: 67,187,990 (GRCm39) K921* probably null Het
Myh9 T C 15: 77,656,147 (GRCm39) E1121G probably benign Het
Nbn T C 4: 15,969,393 (GRCm39) S213P probably damaging Het
Nol10 A G 12: 17,466,102 (GRCm39) E499G probably benign Het
Nxn T C 11: 76,289,627 (GRCm39) E87G probably damaging Het
Or14c40 A G 7: 86,313,811 (GRCm39) T314A probably benign Het
Or51f2 T A 7: 102,526,892 (GRCm39) C188* probably null Het
Or8g23 T C 9: 38,971,395 (GRCm39) H189R probably benign Het
Pds5b CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 5: 150,698,819 (GRCm39) probably benign Het
Pigk A G 3: 152,472,151 (GRCm39) I354M probably damaging Het
Pigl T A 11: 62,349,508 (GRCm39) C75S probably damaging Het
Pm20d1 T A 1: 131,739,852 (GRCm39) I400N probably benign Het
Prkg2 T A 5: 99,172,664 (GRCm39) H17L probably benign Het
Psmd1 T A 1: 86,003,719 (GRCm39) L168Q probably damaging Het
Rab3gap2 A T 1: 185,010,478 (GRCm39) H1136L possibly damaging Het
Rb1 T C 14: 73,532,433 (GRCm39) T134A probably benign Het
Rims1 T C 1: 22,367,220 (GRCm39) E1024G probably damaging Het
Rrp12 A G 19: 41,861,376 (GRCm39) V977A probably benign Het
Rusc2 C T 4: 43,415,212 (GRCm39) P173S probably benign Het
Selenov A T 7: 27,987,447 (GRCm39) D310E probably damaging Het
Serpina3f T A 12: 104,183,582 (GRCm39) L148Q probably damaging Het
Slc10a1 C T 12: 81,007,221 (GRCm39) V187I probably benign Het
Spsb2 A G 6: 124,787,339 (GRCm39) K258E probably damaging Het
Tas2r105 A C 6: 131,664,365 (GRCm39) V21G probably benign Het
Tmem229b-ps T A 10: 53,351,295 (GRCm39) noncoding transcript Het
Tnrc6a C G 7: 122,770,269 (GRCm39) H686Q probably benign Het
Trpc2 T A 7: 101,743,780 (GRCm39) F715L probably benign Het
Ube2t T A 1: 134,897,036 (GRCm39) I56N probably benign Het
Ubr4 T C 4: 139,207,963 (GRCm39) Y4915H possibly damaging Het
Usp32 T A 11: 84,930,830 (GRCm39) E533D probably damaging Het
Vipr2 T G 12: 116,086,430 (GRCm39) probably null Het
Vmn1r15 A G 6: 57,235,269 (GRCm39) T46A probably benign Het
Vmn1r203 T G 13: 22,708,617 (GRCm39) S133A possibly damaging Het
Vmn1r215 T G 13: 23,260,378 (GRCm39) N139K probably damaging Het
Vmn1r232 C T 17: 21,133,601 (GRCm39) R333H probably benign Het
Wdr20rt C A 12: 65,273,988 (GRCm39) H311N possibly damaging Het
Zranb1 T C 7: 132,568,425 (GRCm39) probably null Het
Other mutations in Evi5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01142:Evi5 APN 5 107,963,477 (GRCm39) missense probably benign 0.05
IGL01458:Evi5 APN 5 107,963,513 (GRCm39) missense probably damaging 1.00
IGL01615:Evi5 APN 5 107,912,573 (GRCm39) missense probably damaging 1.00
IGL01939:Evi5 APN 5 107,964,790 (GRCm39) unclassified probably benign
IGL02170:Evi5 APN 5 107,969,750 (GRCm39) missense probably benign 0.45
IGL02539:Evi5 APN 5 107,963,531 (GRCm39) missense probably benign 0.09
IGL02655:Evi5 APN 5 107,961,446 (GRCm39) missense probably benign 0.36
IGL03040:Evi5 APN 5 107,969,672 (GRCm39) missense probably damaging 1.00
IGL03058:Evi5 APN 5 107,896,017 (GRCm39) missense probably damaging 0.98
R0125:Evi5 UTSW 5 107,943,638 (GRCm39) missense probably benign 0.06
R0172:Evi5 UTSW 5 107,938,328 (GRCm39) missense probably benign
R0334:Evi5 UTSW 5 107,968,401 (GRCm39) missense probably damaging 0.97
R0335:Evi5 UTSW 5 107,960,277 (GRCm39) missense probably benign 0.06
R0526:Evi5 UTSW 5 107,969,614 (GRCm39) missense probably benign 0.44
R0579:Evi5 UTSW 5 107,969,575 (GRCm39) missense probably benign 0.36
R0585:Evi5 UTSW 5 107,961,402 (GRCm39) unclassified probably benign
R1123:Evi5 UTSW 5 107,968,444 (GRCm39) missense probably benign 0.02
R1618:Evi5 UTSW 5 107,946,984 (GRCm39) splice site probably benign
R1699:Evi5 UTSW 5 107,966,786 (GRCm39) missense probably damaging 1.00
R1772:Evi5 UTSW 5 107,943,707 (GRCm39) missense probably benign 0.32
R1969:Evi5 UTSW 5 107,896,230 (GRCm39) missense probably benign 0.04
R1977:Evi5 UTSW 5 107,947,005 (GRCm39) nonsense probably null
R3736:Evi5 UTSW 5 107,966,849 (GRCm39) missense probably damaging 0.98
R5047:Evi5 UTSW 5 107,969,740 (GRCm39) missense probably damaging 1.00
R5252:Evi5 UTSW 5 107,943,618 (GRCm39) missense probably benign
R5350:Evi5 UTSW 5 107,963,544 (GRCm39) missense probably benign 0.08
R5552:Evi5 UTSW 5 107,966,855 (GRCm39) missense probably damaging 1.00
R5594:Evi5 UTSW 5 107,968,317 (GRCm39) missense possibly damaging 0.84
R5895:Evi5 UTSW 5 107,968,302 (GRCm39) missense probably damaging 1.00
R6334:Evi5 UTSW 5 107,968,387 (GRCm39) nonsense probably null
R6364:Evi5 UTSW 5 107,989,979 (GRCm39) missense probably damaging 1.00
R6838:Evi5 UTSW 5 107,990,027 (GRCm39) missense possibly damaging 0.94
R6861:Evi5 UTSW 5 107,896,184 (GRCm39) missense probably benign 0.00
R7032:Evi5 UTSW 5 107,936,147 (GRCm39) missense probably benign 0.14
R7386:Evi5 UTSW 5 107,957,689 (GRCm39) splice site probably null
R7844:Evi5 UTSW 5 108,022,860 (GRCm39) missense probably benign 0.00
R8248:Evi5 UTSW 5 107,966,753 (GRCm39) critical splice donor site probably null
R8298:Evi5 UTSW 5 107,964,731 (GRCm39) missense possibly damaging 0.53
R9081:Evi5 UTSW 5 107,963,571 (GRCm39) missense probably benign 0.44
R9431:Evi5 UTSW 5 107,990,150 (GRCm39) missense probably damaging 1.00
R9533:Evi5 UTSW 5 107,957,566 (GRCm39) missense probably damaging 1.00
R9612:Evi5 UTSW 5 107,943,578 (GRCm39) missense probably benign 0.00
R9634:Evi5 UTSW 5 107,964,663 (GRCm39) missense probably benign 0.01
R9765:Evi5 UTSW 5 107,947,120 (GRCm39) missense probably benign
X0018:Evi5 UTSW 5 107,966,753 (GRCm39) critical splice donor site probably null
X0027:Evi5 UTSW 5 107,912,628 (GRCm39) missense probably damaging 0.98
Z1177:Evi5 UTSW 5 107,896,245 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GACGGAGAGCAACTTCAGTC -3'
(R):5'- CAGTTATGCCTCGAGGAGAAG -3'

Sequencing Primer
(F):5'- AGACAGGGTTTCTCTGTATAGCCC -3'
(R):5'- AGAATCAGAGATATGCCTGCCTCTG -3'
Posted On 2014-08-25