Incidental Mutation 'R2011:Vmn1r59'
ID 219685
Institutional Source Beutler Lab
Gene Symbol Vmn1r59
Ensembl Gene ENSMUSG00000074401
Gene Name vomeronasal 1 receptor 59
Synonyms V1rd10
MMRRC Submission 040020-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R2011 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 5456826-5457758 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 5457283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 159 (D159V)
Ref Sequence ENSEMBL: ENSMUSP00000073768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074132]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000074132
AA Change: D159V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: D159V

DomainStartEndE-ValueType
Pfam:TAS2R 1 289 2e-14 PFAM
Pfam:7tm_1 20 279 1.9e-6 PFAM
Pfam:V1R 31 287 3e-16 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 107 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd6 A T 14: 8,042,742 (GRCm38) T100S probably benign Het
Adam6a T C 12: 113,508,998 (GRCm39) I457T probably benign Het
Aff3 T C 1: 38,246,996 (GRCm39) N863S probably benign Het
Agk C A 6: 40,353,168 (GRCm39) D177E probably benign Het
Alg9 C T 9: 50,699,500 (GRCm39) A209V probably damaging Het
Arl6 A T 16: 59,444,676 (GRCm39) I51K probably damaging Het
Bpi A T 2: 158,103,272 (GRCm39) H89L probably damaging Het
C1qtnf1 T A 11: 118,339,110 (GRCm39) F260Y probably benign Het
Cblc T A 7: 19,518,747 (GRCm39) D452V probably benign Het
Ccar1 T C 10: 62,612,473 (GRCm39) T231A probably benign Het
Ccdc112 A G 18: 46,420,499 (GRCm39) L417P probably damaging Het
Ccdc34 G A 2: 109,874,649 (GRCm39) R336Q possibly damaging Het
CK137956 A G 4: 127,844,829 (GRCm39) S305P probably benign Het
Clip2 T C 5: 134,531,969 (GRCm39) D612G probably damaging Het
Col28a1 T C 6: 8,059,360 (GRCm39) T692A probably benign Het
Copg2 A T 6: 30,793,676 (GRCm39) probably null Het
Ctnna2 T A 6: 76,950,774 (GRCm39) I566F possibly damaging Het
Cux2 C T 5: 121,999,389 (GRCm39) D1184N probably benign Het
Dclk3 A G 9: 111,297,422 (GRCm39) E322G probably benign Het
Ddx41 A T 13: 55,681,906 (GRCm39) probably null Het
Dnaaf2 G A 12: 69,243,559 (GRCm39) P107S probably damaging Het
Eif2ak4 A G 2: 118,261,428 (GRCm39) E578G probably damaging Het
Exd1 A G 2: 119,359,144 (GRCm39) probably benign Het
Fat2 G A 11: 55,173,583 (GRCm39) P2377S probably damaging Het
Fbxl18 T C 5: 142,858,214 (GRCm39) T741A probably benign Het
Fgr C A 4: 132,724,832 (GRCm39) A311E probably damaging Het
Fmo4 T C 1: 162,626,458 (GRCm39) T363A probably damaging Het
Fsbp T C 4: 11,584,006 (GRCm39) V235A probably benign Het
Gm1110 T A 9: 26,805,554 (GRCm39) H366L probably benign Het
Gm43302 T C 5: 105,438,846 (GRCm39) N14S probably damaging Het
Gm5422 A G 10: 31,124,764 (GRCm39) noncoding transcript Het
Gm57858 A T 3: 36,064,827 (GRCm39) C515* probably null Het
Gpr21 A G 2: 37,407,547 (GRCm39) E31G probably damaging Het
Gucy1b2 G T 14: 62,646,207 (GRCm39) N560K probably damaging Het
Hmcn1 T C 1: 150,553,085 (GRCm39) Q2535R probably benign Het
Hnrnpm A T 17: 33,883,598 (GRCm39) N264K probably damaging Het
Hyal6 A T 6: 24,734,723 (GRCm39) I219L possibly damaging Het
Ifi211 A G 1: 173,735,169 (GRCm39) S87P probably damaging Het
Il17rb A T 14: 29,718,797 (GRCm39) C428* probably null Het
Iqca1 T C 1: 89,973,348 (GRCm39) N808S probably benign Het
Kcnu1 A G 8: 26,408,470 (GRCm39) I94V probably benign Het
Lrba A T 3: 86,217,324 (GRCm39) E517V probably damaging Het
Mcidas A G 13: 113,130,515 (GRCm39) E37G possibly damaging Het
Med23 T A 10: 24,755,653 (GRCm39) F83L possibly damaging Het
Micu2 T C 14: 58,191,590 (GRCm39) probably null Het
Mrgprx2 A T 7: 48,132,282 (GRCm39) C179S probably damaging Het
Myo6 A G 9: 80,215,004 (GRCm39) T1236A probably damaging Het
Myo7a A T 7: 97,703,915 (GRCm39) V1946E possibly damaging Het
Nek10 A T 14: 14,885,122 (GRCm38) Y695F probably damaging Het
Nr3c2 A T 8: 77,636,422 (GRCm39) I508F possibly damaging Het
Or11g27 T C 14: 50,771,141 (GRCm39) S91P probably damaging Het
Or14a260 A T 7: 85,984,955 (GRCm39) Y216* probably null Het
Or2ag13 T C 7: 106,472,634 (GRCm39) I273V probably benign Het
Or5w1b A T 2: 87,476,233 (GRCm39) I78N probably damaging Het
Or8k23 A T 2: 86,186,530 (GRCm39) H65Q possibly damaging Het
Or9s13 T C 1: 92,548,471 (GRCm39) V281A probably benign Het
Oxct1 T C 15: 4,183,243 (GRCm39) S485P probably benign Het
Oxt A G 2: 130,418,572 (GRCm39) D61G probably damaging Het
P2ry10 A C X: 106,146,241 (GRCm39) I59L probably damaging Het
Parp11 A G 6: 127,454,854 (GRCm39) N124S probably benign Het
Pcdh7 T A 5: 57,876,971 (GRCm39) N175K probably damaging Het
Pdgfrb T A 18: 61,194,566 (GRCm39) S114R probably benign Het
Pfdn5 A G 15: 102,234,956 (GRCm39) N54S possibly damaging Het
Phc2 T A 4: 128,617,378 (GRCm39) V468E probably benign Het
Piezo2 T C 18: 63,192,815 (GRCm39) T1605A probably damaging Het
Pik3cb A T 9: 98,987,632 (GRCm39) Y35* probably null Het
Piwil2 A T 14: 70,664,083 (GRCm39) M22K probably damaging Het
Plag1 A G 4: 3,904,889 (GRCm39) F101L probably damaging Het
Pomt2 A G 12: 87,158,173 (GRCm39) L680P possibly damaging Het
Ppp1r36 A G 12: 76,465,700 (GRCm39) probably null Het
Prkag2 C T 5: 25,076,052 (GRCm39) probably null Het
Prkg1 T C 19: 31,641,542 (GRCm39) D47G possibly damaging Het
Prl6a1 G A 13: 27,499,352 (GRCm39) G45D probably benign Het
Rbm20 G A 19: 53,847,859 (GRCm39) C1135Y probably damaging Het
Recql5 A T 11: 115,787,923 (GRCm39) N465K probably benign Het
Rlig1 T G 10: 100,419,820 (GRCm39) D58A probably damaging Het
Rtcb A T 10: 85,777,797 (GRCm39) I459N probably damaging Het
Rtp3 A T 9: 110,815,102 (GRCm39) probably benign Het
Rundc3b T A 5: 8,562,409 (GRCm39) probably null Het
Scube3 A G 17: 28,387,132 (GRCm39) T877A probably damaging Het
Sh2d4a A T 8: 68,799,394 (GRCm39) Q421L probably benign Het
Siglec1 A T 2: 130,925,277 (GRCm39) Y395N probably damaging Het
Slc6a1 G T 6: 114,284,731 (GRCm39) G263V probably damaging Het
Slco1c1 T A 6: 141,500,833 (GRCm39) F437L probably benign Het
Slco3a1 G A 7: 73,996,419 (GRCm39) A329V probably benign Het
Spag9 T A 11: 93,983,201 (GRCm39) L504* probably null Het
Spen A T 4: 141,200,640 (GRCm39) N2662K probably damaging Het
Sptb G C 12: 76,679,246 (GRCm39) R70G possibly damaging Het
Stk3 A G 15: 35,072,644 (GRCm39) S136P probably damaging Het
Synj1 A T 16: 90,735,584 (GRCm39) F1456L probably damaging Het
Tbx5 T C 5: 119,979,971 (GRCm39) probably null Het
Tchh G A 3: 93,354,268 (GRCm39) R1236Q unknown Het
Timd4 C A 11: 46,710,857 (GRCm39) T253K possibly damaging Het
Tmc6 A G 11: 117,660,232 (GRCm39) Y669H probably damaging Het
Tmem151a C T 19: 5,132,966 (GRCm39) R80H probably benign Het
Tpgs1 T C 10: 79,511,722 (GRCm39) L288P probably damaging Het
Trhde T C 10: 114,334,698 (GRCm39) I659V probably benign Het
Trpm7 A T 2: 126,665,917 (GRCm39) Y896* probably null Het
Ttc5 C A 14: 51,019,007 (GRCm39) E37* probably null Het
Uvrag A G 7: 98,589,096 (GRCm39) probably null Het
Vmn2r78 G A 7: 86,604,287 (GRCm39) V822M possibly damaging Het
Vnn1 C A 10: 23,770,869 (GRCm39) Y32* probably null Het
Wrn A G 8: 33,726,432 (GRCm39) V1380A probably benign Het
Zc3h14 A C 12: 98,746,527 (GRCm39) S579R possibly damaging Het
Zfp277 G A 12: 40,367,217 (GRCm39) Q480* probably null Het
Zfp456 G A 13: 67,514,993 (GRCm39) Q238* probably null Het
Zranb3 T A 1: 128,019,638 (GRCm39) T35S probably benign Het
Other mutations in Vmn1r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01684:Vmn1r59 APN 7 5,457,299 (GRCm39) missense probably benign 0.12
IGL02035:Vmn1r59 APN 7 5,457,208 (GRCm39) missense possibly damaging 0.87
IGL02039:Vmn1r59 APN 7 5,457,380 (GRCm39) missense probably benign 0.23
IGL02812:Vmn1r59 APN 7 5,457,176 (GRCm39) missense probably damaging 1.00
R0033:Vmn1r59 UTSW 7 5,457,433 (GRCm39) missense probably benign 0.08
R0115:Vmn1r59 UTSW 7 5,457,115 (GRCm39) missense probably benign 0.07
R1164:Vmn1r59 UTSW 7 5,457,410 (GRCm39) missense probably benign 0.00
R1629:Vmn1r59 UTSW 7 5,457,466 (GRCm39) missense probably damaging 1.00
R1845:Vmn1r59 UTSW 7 5,457,553 (GRCm39) missense probably benign 0.03
R1969:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R1970:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R1971:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R3712:Vmn1r59 UTSW 7 5,457,637 (GRCm39) missense probably damaging 0.99
R4580:Vmn1r59 UTSW 7 5,457,136 (GRCm39) missense probably damaging 0.98
R4593:Vmn1r59 UTSW 7 5,457,686 (GRCm39) missense possibly damaging 0.46
R4697:Vmn1r59 UTSW 7 5,457,451 (GRCm39) missense probably damaging 1.00
R4856:Vmn1r59 UTSW 7 5,457,532 (GRCm39) missense possibly damaging 0.92
R4873:Vmn1r59 UTSW 7 5,457,108 (GRCm39) missense probably benign
R4875:Vmn1r59 UTSW 7 5,457,108 (GRCm39) missense probably benign
R4925:Vmn1r59 UTSW 7 5,457,115 (GRCm39) missense probably benign 0.07
R5319:Vmn1r59 UTSW 7 5,457,209 (GRCm39) missense probably damaging 0.99
R6239:Vmn1r59 UTSW 7 5,457,539 (GRCm39) missense probably damaging 1.00
R6533:Vmn1r59 UTSW 7 5,457,463 (GRCm39) missense probably benign 0.00
R6912:Vmn1r59 UTSW 7 5,457,599 (GRCm39) missense probably benign 0.01
R7023:Vmn1r59 UTSW 7 5,457,477 (GRCm39) missense probably benign 0.37
R7205:Vmn1r59 UTSW 7 5,457,725 (GRCm39) missense probably damaging 1.00
R7374:Vmn1r59 UTSW 7 5,457,160 (GRCm39) missense probably damaging 0.99
R7390:Vmn1r59 UTSW 7 5,456,986 (GRCm39) missense possibly damaging 0.59
R7776:Vmn1r59 UTSW 7 5,457,634 (GRCm39) missense probably damaging 0.97
R8306:Vmn1r59 UTSW 7 5,456,966 (GRCm39) missense probably benign 0.01
R8473:Vmn1r59 UTSW 7 5,457,064 (GRCm39) missense possibly damaging 0.84
R8499:Vmn1r59 UTSW 7 5,457,750 (GRCm39) missense probably benign 0.00
R8523:Vmn1r59 UTSW 7 5,457,053 (GRCm39) missense probably damaging 1.00
R8706:Vmn1r59 UTSW 7 5,457,715 (GRCm39) missense possibly damaging 0.83
R9104:Vmn1r59 UTSW 7 5,457,166 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGACCACCAGCATCAGGATG -3'
(R):5'- TCAGCACCTACCAGTTTGTC -3'

Sequencing Primer
(F):5'- CTGCTCTGGTCTCAGCATGG -3'
(R):5'- CACTGTTGTTCCTGGTACCTGG -3'
Posted On 2014-08-25