Incidental Mutation 'R1970:Ddx60'
| ID |
219719 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ddx60
|
| Ensembl Gene |
ENSMUSG00000037921 |
| Gene Name |
DExD/H box helicase 60 |
| Synonyms |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
| MMRRC Submission |
039983-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.199)
|
| Stock # |
R1970 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
62381121-62490735 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 62425240 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 676
(H676L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091197
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070631]
[ENSMUST00000093485]
|
| AlphaFold |
E9PZQ1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000070631
AA Change: H675L
PolyPhen 2
Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000070741
Gene: ENSMUSG00000037921
AA Change: H675L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
364 |
376 |
N/A |
INTRINSIC |
|
DEXDc
|
758 |
949 |
1.05e-15 |
SMART |
|
Blast:DEXDc
|
1007 |
1132 |
4e-24 |
BLAST |
|
HELICc
|
1245 |
1328 |
4.35e-13 |
SMART |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1503 |
1584 |
1e-20 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000093485
AA Change: H676L
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000091197
Gene: ENSMUSG00000037921
AA Change: H676L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
99 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
364 |
376 |
N/A |
INTRINSIC |
|
DEXDc
|
759 |
950 |
1.05e-15 |
SMART |
|
Blast:DEXDc
|
1008 |
1133 |
4e-24 |
BLAST |
|
HELICc
|
1246 |
1329 |
4.35e-13 |
SMART |
|
low complexity region
|
1363 |
1374 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1504 |
1585 |
1e-20 |
BLAST |
|
| Meta Mutation Damage Score |
0.2040 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
97% (121/125) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal immunity to several viruses (IAV, EMCV, SINV) but increased susceptibility to VSV infection. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 121 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
A |
T |
17: 24,526,549 (GRCm39) |
H578Q |
probably benign |
Het |
| Abcc12 |
A |
G |
8: 87,253,910 (GRCm39) |
I958T |
probably benign |
Het |
| Abcg5 |
AATCATTTG |
AG |
17: 84,981,030 (GRCm39) |
|
probably null |
Het |
| Acap2 |
A |
G |
16: 30,952,345 (GRCm39) |
|
probably null |
Het |
| Adgrb1 |
T |
C |
15: 74,411,726 (GRCm39) |
|
probably benign |
Het |
| Akap6 |
T |
A |
12: 52,985,258 (GRCm39) |
V897E |
probably damaging |
Het |
| Als2 |
A |
T |
1: 59,254,328 (GRCm39) |
L343Q |
probably benign |
Het |
| Arhgap5 |
A |
G |
12: 52,589,376 (GRCm39) |
I1275M |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Bglap3 |
C |
T |
3: 88,284,300 (GRCm39) |
|
probably benign |
Het |
| Blnk |
T |
C |
19: 40,928,609 (GRCm39) |
|
probably benign |
Het |
| C1qtnf4 |
T |
C |
2: 90,720,003 (GRCm39) |
M92T |
probably damaging |
Het |
| Ccdc177 |
G |
A |
12: 80,805,486 (GRCm39) |
R263C |
unknown |
Het |
| Ccdc83 |
T |
A |
7: 89,893,362 (GRCm39) |
S132C |
probably damaging |
Het |
| Cdc7 |
A |
G |
5: 107,120,940 (GRCm39) |
|
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,632,817 (GRCm39) |
N178I |
probably benign |
Het |
| Col27a1 |
C |
T |
4: 63,191,354 (GRCm39) |
|
probably benign |
Het |
| Col5a1 |
A |
T |
2: 27,876,766 (GRCm39) |
M822L |
unknown |
Het |
| Coro7 |
T |
C |
16: 4,451,620 (GRCm39) |
I451V |
probably benign |
Het |
| Csmd3 |
T |
C |
15: 48,536,927 (GRCm39) |
T92A |
probably damaging |
Het |
| Ddc |
A |
G |
11: 11,765,292 (GRCm39) |
V460A |
possibly damaging |
Het |
| Ddx4 |
C |
T |
13: 112,736,547 (GRCm39) |
V608I |
probably damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,198,989 (GRCm39) |
E48G |
probably benign |
Het |
| Dpf3 |
T |
A |
12: 83,371,809 (GRCm39) |
|
probably null |
Het |
| Dydc2 |
A |
G |
14: 40,783,860 (GRCm39) |
C88R |
probably benign |
Het |
| Elovl4 |
A |
G |
9: 83,662,772 (GRCm39) |
Y163H |
probably damaging |
Het |
| Enpp2 |
T |
C |
15: 54,746,378 (GRCm39) |
D296G |
probably damaging |
Het |
| Fam83h |
G |
T |
15: 75,878,419 (GRCm39) |
|
probably benign |
Het |
| Fbf1 |
T |
A |
11: 116,042,317 (GRCm39) |
Q511L |
possibly damaging |
Het |
| Fhdc1 |
A |
T |
3: 84,362,158 (GRCm39) |
L323Q |
probably damaging |
Het |
| Fmnl2 |
T |
A |
2: 52,995,588 (GRCm39) |
V437D |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,073,258 (GRCm39) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Garem2 |
G |
T |
5: 30,322,172 (GRCm39) |
G844* |
probably null |
Het |
| Glmp |
T |
C |
3: 88,235,177 (GRCm39) |
L269S |
probably damaging |
Het |
| Gm9915 |
T |
C |
1: 42,269,881 (GRCm39) |
|
noncoding transcript |
Het |
| Gnb4 |
A |
T |
3: 32,652,290 (GRCm39) |
D27E |
probably damaging |
Het |
| Gnb5 |
A |
G |
9: 75,251,932 (GRCm39) |
|
probably null |
Het |
| Gpr161 |
T |
G |
1: 165,133,927 (GRCm39) |
V63G |
probably damaging |
Het |
| Gsk3a |
T |
A |
7: 24,929,146 (GRCm39) |
|
probably benign |
Het |
| Hapln2 |
T |
C |
3: 87,931,427 (GRCm39) |
|
probably null |
Het |
| Incenp |
G |
T |
19: 9,862,851 (GRCm39) |
T401N |
unknown |
Het |
| Kalrn |
A |
G |
16: 33,797,894 (GRCm39) |
|
probably null |
Het |
| Kcnq3 |
A |
G |
15: 65,900,472 (GRCm39) |
|
probably null |
Het |
| Kif21b |
T |
C |
1: 136,098,894 (GRCm39) |
V1394A |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,664,030 (GRCm39) |
C460R |
probably damaging |
Het |
| L3mbtl1 |
G |
A |
2: 162,801,492 (GRCm39) |
A291T |
probably damaging |
Het |
| Lcp1 |
T |
C |
14: 75,437,946 (GRCm39) |
S119P |
probably damaging |
Het |
| Ldhc |
A |
G |
7: 46,519,175 (GRCm39) |
I133V |
probably benign |
Het |
| Lmntd2 |
G |
A |
7: 140,791,972 (GRCm39) |
|
probably benign |
Het |
| Lpl |
A |
T |
8: 69,349,454 (GRCm39) |
K327* |
probably null |
Het |
| Lrp1b |
T |
C |
2: 40,765,081 (GRCm39) |
D2801G |
probably damaging |
Het |
| Mppe1 |
C |
A |
18: 67,362,843 (GRCm39) |
A131S |
probably benign |
Het |
| Msh3 |
T |
A |
13: 92,386,328 (GRCm39) |
|
probably benign |
Het |
| Msh5 |
A |
G |
17: 35,252,576 (GRCm39) |
I377T |
probably damaging |
Het |
| Myo1e |
T |
C |
9: 70,276,055 (GRCm39) |
F757L |
probably benign |
Het |
| Myof |
A |
T |
19: 37,934,082 (GRCm39) |
D955E |
probably damaging |
Het |
| Nckap1 |
C |
T |
2: 80,348,286 (GRCm39) |
S889N |
probably benign |
Het |
| Ncor2 |
T |
C |
5: 125,115,982 (GRCm39) |
D858G |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,153,917 (GRCm39) |
V2398D |
possibly damaging |
Het |
| Nefl |
C |
G |
14: 68,324,121 (GRCm39) |
T453R |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,444,787 (GRCm39) |
N371D |
probably benign |
Het |
| Nhsl3 |
A |
G |
4: 129,119,810 (GRCm39) |
|
probably benign |
Het |
| Nlrp4f |
T |
C |
13: 65,341,905 (GRCm39) |
Y580C |
probably damaging |
Het |
| Nme8 |
A |
C |
13: 19,836,492 (GRCm39) |
L228R |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 101,658,529 (GRCm39) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 165,210,210 (GRCm39) |
Y205C |
probably benign |
Het |
| Or2ag12 |
T |
A |
7: 106,276,877 (GRCm39) |
N272I |
probably damaging |
Het |
| Or2d3b |
G |
A |
7: 106,513,453 (GRCm39) |
G16D |
probably damaging |
Het |
| Or4k77 |
C |
T |
2: 111,199,421 (GRCm39) |
S148L |
probably benign |
Het |
| Or8g55 |
T |
A |
9: 39,785,234 (GRCm39) |
I221N |
probably damaging |
Het |
| Or8k3 |
T |
A |
2: 86,058,596 (GRCm39) |
T240S |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,763,487 (GRCm39) |
T3987A |
unknown |
Het |
| Pdgfrb |
G |
A |
18: 61,199,566 (GRCm39) |
|
probably benign |
Het |
| Pdxk |
G |
A |
10: 78,276,988 (GRCm39) |
T270I |
probably damaging |
Het |
| Pex5 |
T |
C |
6: 124,391,364 (GRCm39) |
E10G |
probably damaging |
Het |
| Pik3c2g |
T |
A |
6: 139,846,112 (GRCm39) |
|
probably null |
Het |
| Pkhd1 |
T |
A |
1: 20,451,747 (GRCm39) |
I2183F |
probably damaging |
Het |
| Plppr2 |
T |
C |
9: 21,852,422 (GRCm39) |
V102A |
probably damaging |
Het |
| Plxnd1 |
T |
C |
6: 115,939,478 (GRCm39) |
T1449A |
probably damaging |
Het |
| Pnkd |
T |
A |
1: 74,325,069 (GRCm39) |
|
probably null |
Het |
| Pom121l2 |
A |
G |
13: 22,167,642 (GRCm39) |
I638V |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,596,314 (GRCm39) |
|
probably null |
Het |
| Ranbp10 |
A |
G |
8: 106,513,340 (GRCm39) |
F191L |
probably damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,623,723 (GRCm39) |
L824P |
probably damaging |
Het |
| Rec8 |
T |
C |
14: 55,861,599 (GRCm39) |
L418P |
probably damaging |
Het |
| Rimbp2 |
T |
A |
5: 128,874,305 (GRCm39) |
N429Y |
probably damaging |
Het |
| Rpe65 |
C |
A |
3: 159,321,307 (GRCm39) |
T373K |
probably benign |
Het |
| Rpl35rt |
T |
G |
1: 156,194,017 (GRCm39) |
*124G |
probably null |
Het |
| Rrn3 |
T |
C |
16: 13,606,938 (GRCm39) |
S151P |
probably damaging |
Het |
| Scn7a |
A |
G |
2: 66,514,633 (GRCm39) |
V1047A |
possibly damaging |
Het |
| Scn9a |
G |
T |
2: 66,345,724 (GRCm39) |
P1123Q |
probably damaging |
Het |
| Secisbp2l |
T |
C |
2: 125,589,430 (GRCm39) |
D706G |
probably damaging |
Het |
| Serpina5 |
A |
T |
12: 104,070,116 (GRCm39) |
T338S |
probably benign |
Het |
| Sez6 |
G |
A |
11: 77,844,894 (GRCm39) |
|
probably null |
Het |
| Shisa4 |
C |
T |
1: 135,300,012 (GRCm39) |
G157D |
probably damaging |
Het |
| Slc1a7 |
G |
T |
4: 107,825,782 (GRCm39) |
D14Y |
probably benign |
Het |
| Slc25a11 |
A |
C |
11: 70,536,999 (GRCm39) |
L51V |
probably benign |
Het |
| Slit3 |
A |
G |
11: 35,521,668 (GRCm39) |
|
probably null |
Het |
| Spata13 |
G |
T |
14: 60,928,912 (GRCm39) |
G157W |
probably damaging |
Het |
| Spta1 |
T |
C |
1: 174,067,933 (GRCm39) |
V2120A |
possibly damaging |
Het |
| Srpra |
T |
C |
9: 35,124,834 (GRCm39) |
|
probably null |
Het |
| Syt6 |
A |
G |
3: 103,494,736 (GRCm39) |
I234V |
probably benign |
Het |
| Thada |
G |
T |
17: 84,617,470 (GRCm39) |
P1349T |
probably damaging |
Het |
| Tmem161a |
C |
T |
8: 70,629,559 (GRCm39) |
R58W |
probably damaging |
Het |
| Top3b |
A |
G |
16: 16,701,383 (GRCm39) |
I232V |
probably damaging |
Het |
| Tspan1 |
T |
A |
4: 116,020,826 (GRCm39) |
Q197L |
possibly damaging |
Het |
| Ttc28 |
A |
C |
5: 111,383,501 (GRCm39) |
Y1334S |
probably benign |
Het |
| Ubxn6 |
G |
T |
17: 56,380,077 (GRCm39) |
N28K |
possibly damaging |
Het |
| Uggt1 |
T |
C |
1: 36,190,862 (GRCm39) |
D1366G |
probably damaging |
Het |
| Ugp2 |
A |
G |
11: 21,278,942 (GRCm39) |
S415P |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,837,157 (GRCm39) |
S2796T |
probably damaging |
Het |
| Vipr2 |
T |
C |
12: 116,099,826 (GRCm39) |
V231A |
probably benign |
Het |
| Vmn1r176 |
T |
C |
7: 23,534,373 (GRCm39) |
N260S |
probably benign |
Het |
| Vmn1r59 |
A |
T |
7: 5,457,038 (GRCm39) |
Y241N |
probably damaging |
Het |
| Vmn2r67 |
A |
T |
7: 84,801,013 (GRCm39) |
Y308N |
probably benign |
Het |
| Vmn2r75 |
A |
T |
7: 85,797,470 (GRCm39) |
M781K |
probably damaging |
Het |
| Vwa3a |
A |
T |
7: 120,379,394 (GRCm39) |
I500F |
probably damaging |
Het |
| Zfp609 |
A |
G |
9: 65,702,559 (GRCm39) |
V31A |
probably damaging |
Het |
| Zfp689 |
G |
T |
7: 127,043,959 (GRCm39) |
Q224K |
probably damaging |
Het |
| Zfp81 |
A |
T |
17: 33,554,475 (GRCm39) |
L113H |
probably benign |
Het |
|
| Other mutations in Ddx60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Ddx60
|
APN |
8 |
62,411,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00915:Ddx60
|
APN |
8 |
62,440,465 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00931:Ddx60
|
APN |
8 |
62,422,617 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01023:Ddx60
|
APN |
8 |
62,395,548 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01313:Ddx60
|
APN |
8 |
62,435,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01615:Ddx60
|
APN |
8 |
62,416,774 (GRCm39) |
missense |
probably null |
0.81 |
|
IGL01733:Ddx60
|
APN |
8 |
62,436,899 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01779:Ddx60
|
APN |
8 |
62,470,857 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01900:Ddx60
|
APN |
8 |
62,453,743 (GRCm39) |
splice site |
probably benign |
|
|
IGL02110:Ddx60
|
APN |
8 |
62,470,281 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02302:Ddx60
|
APN |
8 |
62,428,866 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02468:Ddx60
|
APN |
8 |
62,411,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02569:Ddx60
|
APN |
8 |
62,477,985 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02622:Ddx60
|
APN |
8 |
62,395,470 (GRCm39) |
splice site |
probably null |
|
|
IGL02657:Ddx60
|
APN |
8 |
62,437,149 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02677:Ddx60
|
APN |
8 |
62,441,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Ddx60
|
APN |
8 |
62,432,375 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02806:Ddx60
|
APN |
8 |
62,409,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03137:Ddx60
|
APN |
8 |
62,441,117 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL03295:Ddx60
|
APN |
8 |
62,409,155 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03387:Ddx60
|
APN |
8 |
62,465,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03411:Ddx60
|
APN |
8 |
62,430,916 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Scatter
|
UTSW |
8 |
62,474,348 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
shotgun
|
UTSW |
8 |
62,490,101 (GRCm39) |
missense |
probably benign |
0.28 |
|
splay
|
UTSW |
8 |
62,474,343 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
G1Funyon:Ddx60
|
UTSW |
8 |
62,453,631 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4504001:Ddx60
|
UTSW |
8 |
62,411,147 (GRCm39) |
missense |
probably benign |
|
|
PIT4677001:Ddx60
|
UTSW |
8 |
62,425,288 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0090:Ddx60
|
UTSW |
8 |
62,395,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0266:Ddx60
|
UTSW |
8 |
62,486,527 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0325:Ddx60
|
UTSW |
8 |
62,436,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Ddx60
|
UTSW |
8 |
62,470,783 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0403:Ddx60
|
UTSW |
8 |
62,447,575 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Ddx60
|
UTSW |
8 |
62,422,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0561:Ddx60
|
UTSW |
8 |
62,470,828 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0844:Ddx60
|
UTSW |
8 |
62,440,395 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1119:Ddx60
|
UTSW |
8 |
62,395,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1428:Ddx60
|
UTSW |
8 |
62,411,193 (GRCm39) |
splice site |
probably benign |
|
|
R1778:Ddx60
|
UTSW |
8 |
62,427,210 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1840:Ddx60
|
UTSW |
8 |
62,422,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1964:Ddx60
|
UTSW |
8 |
62,401,903 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2101:Ddx60
|
UTSW |
8 |
62,393,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2174:Ddx60
|
UTSW |
8 |
62,470,234 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2174:Ddx60
|
UTSW |
8 |
62,409,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2198:Ddx60
|
UTSW |
8 |
62,411,097 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2332:Ddx60
|
UTSW |
8 |
62,490,125 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2338:Ddx60
|
UTSW |
8 |
62,465,470 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2379:Ddx60
|
UTSW |
8 |
62,490,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4010:Ddx60
|
UTSW |
8 |
62,409,178 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4010:Ddx60
|
UTSW |
8 |
62,407,569 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4133:Ddx60
|
UTSW |
8 |
62,425,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4282:Ddx60
|
UTSW |
8 |
62,447,427 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4382:Ddx60
|
UTSW |
8 |
62,402,012 (GRCm39) |
splice site |
probably null |
|
|
R4561:Ddx60
|
UTSW |
8 |
62,395,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4572:Ddx60
|
UTSW |
8 |
62,440,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4581:Ddx60
|
UTSW |
8 |
62,476,295 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4635:Ddx60
|
UTSW |
8 |
62,490,101 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4698:Ddx60
|
UTSW |
8 |
62,465,458 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Ddx60
|
UTSW |
8 |
62,432,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4858:Ddx60
|
UTSW |
8 |
62,474,348 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4964:Ddx60
|
UTSW |
8 |
62,432,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5120:Ddx60
|
UTSW |
8 |
62,398,940 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5187:Ddx60
|
UTSW |
8 |
62,427,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5222:Ddx60
|
UTSW |
8 |
62,437,192 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5400:Ddx60
|
UTSW |
8 |
62,463,036 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5500:Ddx60
|
UTSW |
8 |
62,403,485 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5514:Ddx60
|
UTSW |
8 |
62,411,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Ddx60
|
UTSW |
8 |
62,453,612 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5742:Ddx60
|
UTSW |
8 |
62,401,955 (GRCm39) |
missense |
probably benign |
|
|
R5772:Ddx60
|
UTSW |
8 |
62,401,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Ddx60
|
UTSW |
8 |
62,465,422 (GRCm39) |
nonsense |
probably null |
|
|
R5815:Ddx60
|
UTSW |
8 |
62,416,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5820:Ddx60
|
UTSW |
8 |
62,409,155 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5866:Ddx60
|
UTSW |
8 |
62,393,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5881:Ddx60
|
UTSW |
8 |
62,490,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5977:Ddx60
|
UTSW |
8 |
62,474,444 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6048:Ddx60
|
UTSW |
8 |
62,453,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6061:Ddx60
|
UTSW |
8 |
62,476,275 (GRCm39) |
missense |
probably null |
0.01 |
|
R6153:Ddx60
|
UTSW |
8 |
62,398,974 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6287:Ddx60
|
UTSW |
8 |
62,403,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6415:Ddx60
|
UTSW |
8 |
62,436,939 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6416:Ddx60
|
UTSW |
8 |
62,451,715 (GRCm39) |
missense |
probably benign |
|
|
R6416:Ddx60
|
UTSW |
8 |
62,430,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6660:Ddx60
|
UTSW |
8 |
62,409,273 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6694:Ddx60
|
UTSW |
8 |
62,490,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6715:Ddx60
|
UTSW |
8 |
62,436,924 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6720:Ddx60
|
UTSW |
8 |
62,453,723 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6937:Ddx60
|
UTSW |
8 |
62,490,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7153:Ddx60
|
UTSW |
8 |
62,441,142 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7274:Ddx60
|
UTSW |
8 |
62,393,142 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7409:Ddx60
|
UTSW |
8 |
62,411,612 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7464:Ddx60
|
UTSW |
8 |
62,393,708 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7670:Ddx60
|
UTSW |
8 |
62,428,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7904:Ddx60
|
UTSW |
8 |
62,430,924 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7992:Ddx60
|
UTSW |
8 |
62,407,569 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8124:Ddx60
|
UTSW |
8 |
62,436,945 (GRCm39) |
missense |
probably benign |
|
|
R8125:Ddx60
|
UTSW |
8 |
62,436,945 (GRCm39) |
missense |
probably benign |
|
|
R8126:Ddx60
|
UTSW |
8 |
62,436,945 (GRCm39) |
missense |
probably benign |
|
|
R8155:Ddx60
|
UTSW |
8 |
62,470,205 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8174:Ddx60
|
UTSW |
8 |
62,470,284 (GRCm39) |
splice site |
probably null |
|
|
R8192:Ddx60
|
UTSW |
8 |
62,431,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8271:Ddx60
|
UTSW |
8 |
62,393,142 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8301:Ddx60
|
UTSW |
8 |
62,453,631 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8304:Ddx60
|
UTSW |
8 |
62,451,803 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8319:Ddx60
|
UTSW |
8 |
62,395,669 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8374:Ddx60
|
UTSW |
8 |
62,427,205 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8401:Ddx60
|
UTSW |
8 |
62,409,277 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8487:Ddx60
|
UTSW |
8 |
62,427,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8804:Ddx60
|
UTSW |
8 |
62,411,640 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8826:Ddx60
|
UTSW |
8 |
62,398,990 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8829:Ddx60
|
UTSW |
8 |
62,393,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Ddx60
|
UTSW |
8 |
62,474,343 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8884:Ddx60
|
UTSW |
8 |
62,447,553 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8990:Ddx60
|
UTSW |
8 |
62,427,168 (GRCm39) |
nonsense |
probably null |
|
|
R9122:Ddx60
|
UTSW |
8 |
62,442,898 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9225:Ddx60
|
UTSW |
8 |
62,470,875 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9278:Ddx60
|
UTSW |
8 |
62,431,012 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9293:Ddx60
|
UTSW |
8 |
62,462,994 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9405:Ddx60
|
UTSW |
8 |
62,425,248 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9766:Ddx60
|
UTSW |
8 |
62,465,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0003:Ddx60
|
UTSW |
8 |
62,486,451 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
X0019:Ddx60
|
UTSW |
8 |
62,416,726 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Ddx60
|
UTSW |
8 |
62,453,622 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTGAGTAAGAGAGTAAGTGTC -3'
(R):5'- TGCAAACACAGCTCTTTTAGAAT -3'
Sequencing Primer
(F):5'- TGAGTAAGAGAGTAAGTGTCATGAAG -3'
(R):5'- TCCCCAAGAGAAGGTTGGTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation