Incidental Mutation 'R0137:Trp53i11'
ID 22001
Institutional Source Beutler Lab
Gene Symbol Trp53i11
Ensembl Gene ENSMUSG00000068735
Gene Name transformation related protein 53 inducible protein 11
Synonyms Tp53i11
MMRRC Submission 038422-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R0137 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 93017893-93032104 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to A at 93029696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028646] [ENSMUST00000090554] [ENSMUST00000111265] [ENSMUST00000111266] [ENSMUST00000150462]
AlphaFold Q4QQM4
Predicted Effect probably benign
Transcript: ENSMUST00000028646
SMART Domains Protein: ENSMUSP00000028646
Gene: ENSMUSG00000027217

DomainStartEndE-ValueType
Pfam:Tetraspannin 8 247 1.8e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000090554
SMART Domains Protein: ENSMUSP00000088042
Gene: ENSMUSG00000068735

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 188 8.5e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111265
SMART Domains Protein: ENSMUSP00000106896
Gene: ENSMUSG00000027217

DomainStartEndE-ValueType
Pfam:Tetraspannin 8 247 3.3e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111266
SMART Domains Protein: ENSMUSP00000106897
Gene: ENSMUSG00000068735

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 188 2.1e-89 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127173
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140172
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147377
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143164
Predicted Effect probably benign
Transcript: ENSMUST00000150462
SMART Domains Protein: ENSMUSP00000115918
Gene: ENSMUSG00000068735

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 87 1.5e-48 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 91.8%
Validation Efficiency 95% (94/99)
Allele List at MGI
Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik A T 8: 120,878,115 (GRCm39) H190L possibly damaging Het
Adap1 A G 5: 139,278,976 (GRCm39) probably benign Het
Adgra3 C T 5: 50,121,182 (GRCm39) probably benign Het
Adgre5 A T 8: 84,451,527 (GRCm39) V527E probably damaging Het
Anapc5 A T 5: 122,938,695 (GRCm39) Y360N probably damaging Het
Angptl6 C A 9: 20,789,683 (GRCm39) A70S probably benign Het
Ankdd1a C A 9: 65,417,610 (GRCm39) K137N probably null Het
Ccdc170 T C 10: 4,496,950 (GRCm39) probably benign Het
Ccdc51 A G 9: 108,920,698 (GRCm39) E195G probably damaging Het
Cdc37 A T 9: 21,053,426 (GRCm39) C204S possibly damaging Het
Cfap36 T C 11: 29,172,431 (GRCm39) probably benign Het
Col6a2 C A 10: 76,432,259 (GRCm39) G965C probably damaging Het
Csn1s2a G A 5: 87,926,826 (GRCm39) S53N possibly damaging Het
Dab2ip T C 2: 35,582,388 (GRCm39) probably null Het
Dhx58 A G 11: 100,587,823 (GRCm39) V578A probably damaging Het
Diaph1 G T 18: 38,024,902 (GRCm39) Q520K unknown Het
Eefsec C A 6: 88,274,631 (GRCm39) K444N probably benign Het
Eftud2 A T 11: 102,759,443 (GRCm39) H153Q possibly damaging Het
Eif5b T G 1: 38,058,324 (GRCm39) S209A probably benign Het
Exosc2 T A 2: 31,562,497 (GRCm39) Y46N probably damaging Het
F2 C T 2: 91,456,075 (GRCm39) G562D probably damaging Het
Fgf23 G A 6: 127,057,128 (GRCm39) G148D probably damaging Het
Fmnl3 G C 15: 99,220,619 (GRCm39) probably benign Het
Fstl5 G A 3: 76,614,786 (GRCm39) G179R probably damaging Het
Garre1 A T 7: 33,938,644 (GRCm39) W246R probably damaging Het
Gart T A 16: 91,422,282 (GRCm39) Q745L probably benign Het
Gmeb1 T A 4: 131,959,419 (GRCm39) M212L probably benign Het
Gpaa1 T C 15: 76,218,981 (GRCm39) Y548H probably damaging Het
Gpatch1 T C 7: 34,986,667 (GRCm39) E763G probably damaging Het
Grm8 T A 6: 27,762,389 (GRCm39) I279F probably damaging Het
Hcls1 T A 16: 36,771,536 (GRCm39) H147Q probably damaging Het
Hpcal1 A C 12: 17,836,389 (GRCm39) D73A probably damaging Het
Il22ra1 T C 4: 135,478,317 (GRCm39) S463P probably benign Het
Itgbl1 G A 14: 124,078,098 (GRCm39) probably null Het
Izumo3 G T 4: 92,035,437 (GRCm39) probably benign Het
Kcna5 A T 6: 126,510,346 (GRCm39) L594Q probably damaging Het
Kif13a A T 13: 46,918,079 (GRCm39) D409E probably benign Het
Kif9 A T 9: 110,314,106 (GRCm39) I39F probably damaging Het
Klri2 C T 6: 129,709,171 (GRCm39) R227H possibly damaging Het
Lamc3 G A 2: 31,798,628 (GRCm39) G445S probably damaging Het
Lctl A G 9: 64,024,980 (GRCm39) probably benign Het
Lrp4 T C 2: 91,325,327 (GRCm39) L1384P probably damaging Het
Mcm9 G A 10: 53,439,526 (GRCm39) S549L possibly damaging Het
Ms4a15 G A 19: 10,956,697 (GRCm39) probably benign Het
Mtor T C 4: 148,555,081 (GRCm39) V901A possibly damaging Het
Nckap1l A T 15: 103,390,391 (GRCm39) I721F probably benign Het
Nemp2 T C 1: 52,684,588 (GRCm39) V298A probably benign Het
Npc1l1 T A 11: 6,178,148 (GRCm39) K421* probably null Het
Npr1 C T 3: 90,363,244 (GRCm39) V879M probably damaging Het
Odad4 A G 11: 100,454,394 (GRCm39) E393G probably damaging Het
Or2ad1 A G 13: 21,326,336 (GRCm39) V297A possibly damaging Het
Or51q1c A G 7: 103,652,709 (GRCm39) T82A probably benign Het
Osgin1 A T 8: 120,169,219 (GRCm39) I39F possibly damaging Het
Phip G C 9: 82,809,244 (GRCm39) probably null Het
Pkdrej G T 15: 85,705,768 (GRCm39) P56Q possibly damaging Het
Plcxd2 A G 16: 45,800,889 (GRCm39) Y112H probably damaging Het
Plekha1 C T 7: 130,499,176 (GRCm39) T155M probably damaging Het
Prkdc T C 16: 15,558,196 (GRCm39) probably null Het
Prss1 A G 6: 41,439,495 (GRCm39) H76R probably damaging Het
Psg23 T C 7: 18,348,558 (GRCm39) D83G probably benign Het
Ptprd T A 4: 76,055,140 (GRCm39) Q196L probably benign Het
Ranbp3l A T 15: 9,063,067 (GRCm39) H292L probably damaging Het
Ranbp6 T C 19: 29,787,097 (GRCm39) E1085G probably benign Het
Rccd1 A G 7: 79,970,326 (GRCm39) V97A possibly damaging Het
Rchy1 T C 5: 92,105,458 (GRCm39) S48G probably benign Het
Rnmt G A 18: 68,446,771 (GRCm39) M265I probably benign Het
Robo3 A T 9: 37,336,640 (GRCm39) M376K probably benign Het
Rrp12 T C 19: 41,862,289 (GRCm39) D898G probably benign Het
Scg3 A T 9: 75,570,462 (GRCm39) probably benign Het
Sec31b A T 19: 44,522,821 (GRCm39) M57K probably damaging Het
Slc17a6 A C 7: 51,315,892 (GRCm39) I387L probably benign Het
Speer4a1 T A 5: 26,240,982 (GRCm39) Q170L possibly damaging Het
Srsf9 A G 5: 115,470,260 (GRCm39) D146G possibly damaging Het
Ss18 A G 18: 14,788,200 (GRCm39) M90T probably damaging Het
Syna A T 5: 134,588,314 (GRCm39) F212I possibly damaging Het
Tex54 A G 19: 8,718,221 (GRCm39) probably benign Het
Thsd1 A G 8: 22,733,055 (GRCm39) H34R probably damaging Het
Tmem143 T C 7: 45,547,086 (GRCm39) I84T probably benign Het
Trim50 T C 5: 135,395,487 (GRCm39) V281A probably damaging Het
Ttll4 C T 1: 74,718,851 (GRCm39) T234I possibly damaging Het
Ttyh1 A T 7: 4,127,719 (GRCm39) I136F possibly damaging Het
Ube2f T C 1: 91,189,976 (GRCm39) probably benign Het
Vcl T A 14: 21,037,083 (GRCm39) L227* probably null Het
Vmn1r222 A C 13: 23,416,974 (GRCm39) C80G probably damaging Het
Vps13b G T 15: 35,926,365 (GRCm39) A3889S probably benign Het
Vps8 T C 16: 21,323,136 (GRCm39) probably benign Het
Zbtb44 A G 9: 30,978,006 (GRCm39) Y422C probably damaging Het
Zfp180 A G 7: 23,805,158 (GRCm39) S526G possibly damaging Het
Zfp518a A C 19: 40,904,310 (GRCm39) E1413A probably damaging Het
Zfp629 T A 7: 127,210,858 (GRCm39) Y317F probably damaging Het
Zfp804b T C 5: 6,820,534 (GRCm39) E843G probably benign Het
Other mutations in Trp53i11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0011:Trp53i11 UTSW 2 93,029,698 (GRCm39) unclassified probably benign
R0011:Trp53i11 UTSW 2 93,029,698 (GRCm39) unclassified probably benign
R0148:Trp53i11 UTSW 2 93,028,080 (GRCm39) missense probably damaging 1.00
R0759:Trp53i11 UTSW 2 93,029,303 (GRCm39) missense possibly damaging 0.80
R4700:Trp53i11 UTSW 2 93,030,245 (GRCm39) missense probably damaging 1.00
R5451:Trp53i11 UTSW 2 93,030,200 (GRCm39) missense possibly damaging 0.85
R5466:Trp53i11 UTSW 2 93,029,728 (GRCm39) missense possibly damaging 0.51
R5626:Trp53i11 UTSW 2 93,029,723 (GRCm39) missense possibly damaging 0.95
R6709:Trp53i11 UTSW 2 93,030,163 (GRCm39) missense probably benign
R7889:Trp53i11 UTSW 2 93,029,244 (GRCm39) missense probably damaging 1.00
R9367:Trp53i11 UTSW 2 93,029,273 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- AGGGCTTTAGAAGCAATGTGAGCTG -3'
(R):5'- TAGGCTAGGCTGAATACCCTCGAC -3'

Sequencing Primer
(F):5'- AGAAGCAATGTGAGCTGTCTCTG -3'
(R):5'- CCTAGAAGTGCATCCTGAGTGTC -3'
Posted On 2013-04-12