Incidental Mutation 'R2012:Dapk1'
| ID |
220018 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
040021-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2012 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 60869671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 304
(K304N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044083
AA Change: K304N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: K304N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077453
AA Change: K304N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: K304N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224340
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226059
AA Change: K304N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam22 |
A |
T |
5: 8,167,634 (GRCm39) |
S675R |
probably damaging |
Het |
| Akap5 |
A |
T |
12: 76,376,122 (GRCm39) |
H518L |
possibly damaging |
Het |
| Ankfn1 |
T |
C |
11: 89,296,423 (GRCm39) |
D102G |
probably damaging |
Het |
| Aox3 |
A |
T |
1: 58,177,391 (GRCm39) |
Y202F |
probably benign |
Het |
| Arhgef37 |
G |
A |
18: 61,637,427 (GRCm39) |
L412F |
possibly damaging |
Het |
| B4galt3 |
C |
T |
1: 171,100,118 (GRCm39) |
P121L |
probably damaging |
Het |
| BC034090 |
C |
T |
1: 155,097,178 (GRCm39) |
R640Q |
probably damaging |
Het |
| Bhmt |
A |
T |
13: 93,761,900 (GRCm39) |
Y128N |
probably damaging |
Het |
| Bin3 |
A |
G |
14: 70,372,222 (GRCm39) |
E173G |
probably damaging |
Het |
| C1qtnf1 |
T |
A |
11: 118,339,110 (GRCm39) |
F260Y |
probably benign |
Het |
| Ccdc14 |
G |
T |
16: 34,511,092 (GRCm39) |
G22V |
possibly damaging |
Het |
| Ccnc |
A |
T |
4: 21,741,955 (GRCm39) |
I135L |
possibly damaging |
Het |
| Chd3 |
T |
C |
11: 69,239,878 (GRCm39) |
D1650G |
probably benign |
Het |
| Cherp |
A |
C |
8: 73,228,613 (GRCm39) |
N14K |
probably damaging |
Het |
| Clint1 |
C |
T |
11: 45,784,919 (GRCm39) |
T306I |
possibly damaging |
Het |
| Cyb5r1 |
T |
A |
1: 134,335,315 (GRCm39) |
Y85N |
probably damaging |
Het |
| D830013O20Rik |
A |
G |
12: 73,418,162 (GRCm39) |
|
noncoding transcript |
Het |
| Dnah6 |
T |
A |
6: 73,044,449 (GRCm39) |
N3169Y |
probably damaging |
Het |
| Dync2h1 |
A |
T |
9: 7,169,589 (GRCm39) |
I296K |
probably benign |
Het |
| Elp2 |
A |
T |
18: 24,764,515 (GRCm39) |
T621S |
probably benign |
Het |
| Eml6 |
G |
T |
11: 29,781,128 (GRCm39) |
Q635K |
possibly damaging |
Het |
| Exph5 |
G |
A |
9: 53,278,466 (GRCm39) |
M192I |
possibly damaging |
Het |
| Fmnl2 |
A |
G |
2: 52,995,549 (GRCm39) |
E424G |
probably damaging |
Het |
| Gas6 |
C |
T |
8: 13,518,266 (GRCm39) |
V523M |
probably damaging |
Het |
| Ggn |
A |
T |
7: 28,873,188 (GRCm39) |
|
probably null |
Het |
| Gimap8 |
A |
G |
6: 48,633,287 (GRCm39) |
T369A |
probably damaging |
Het |
| Grm5 |
T |
C |
7: 87,724,080 (GRCm39) |
I790T |
probably damaging |
Het |
| Gtpbp6 |
G |
A |
5: 110,252,790 (GRCm39) |
A354V |
probably damaging |
Het |
| Habp4 |
G |
A |
13: 64,317,995 (GRCm39) |
|
probably null |
Het |
| Has2 |
A |
G |
15: 56,531,264 (GRCm39) |
W484R |
probably damaging |
Het |
| Herc4 |
G |
T |
10: 63,079,817 (GRCm39) |
|
probably benign |
Het |
| Igf2 |
C |
A |
7: 142,208,136 (GRCm39) |
E106D |
probably damaging |
Het |
| Il17rb |
A |
T |
14: 29,718,797 (GRCm39) |
C428* |
probably null |
Het |
| Ipo11 |
A |
T |
13: 107,056,130 (GRCm39) |
N47K |
probably benign |
Het |
| Itga4 |
T |
G |
2: 79,108,138 (GRCm39) |
S197A |
probably damaging |
Het |
| Itpr1 |
T |
A |
6: 108,417,497 (GRCm39) |
M1788K |
probably benign |
Het |
| Kbtbd3 |
C |
T |
9: 4,330,919 (GRCm39) |
T431I |
probably benign |
Het |
| Kif5a |
A |
T |
10: 127,075,044 (GRCm39) |
V523E |
probably benign |
Het |
| Klhl41 |
A |
T |
2: 69,513,840 (GRCm39) |
D573V |
possibly damaging |
Het |
| Kndc1 |
C |
A |
7: 139,501,196 (GRCm39) |
H828Q |
possibly damaging |
Het |
| Leng8 |
T |
A |
7: 4,146,609 (GRCm39) |
V407D |
probably damaging |
Het |
| Mamdc2 |
C |
T |
19: 23,288,215 (GRCm39) |
E608K |
probably benign |
Het |
| Mcf2 |
T |
A |
X: 59,122,574 (GRCm39) |
R850S |
probably damaging |
Het |
| Mmp2 |
A |
G |
8: 93,576,831 (GRCm39) |
N618S |
probably benign |
Het |
| Morn5 |
A |
T |
2: 35,942,950 (GRCm39) |
M17L |
probably benign |
Het |
| Nme8 |
T |
C |
13: 19,881,053 (GRCm39) |
N26S |
probably damaging |
Het |
| Nostrin |
C |
A |
2: 68,975,111 (GRCm39) |
|
probably null |
Het |
| Npy4r |
T |
A |
14: 33,869,154 (GRCm39) |
I45F |
possibly damaging |
Het |
| Or13a21 |
T |
A |
7: 139,999,024 (GRCm39) |
I221F |
probably damaging |
Het |
| Or1j11 |
A |
G |
2: 36,311,931 (GRCm39) |
I174V |
probably benign |
Het |
| Or2aj5 |
C |
T |
16: 19,424,881 (GRCm39) |
C179Y |
probably benign |
Het |
| Or2w1 |
T |
A |
13: 21,317,659 (GRCm39) |
M238K |
probably benign |
Het |
| Or2w3b |
T |
C |
11: 58,623,214 (GRCm39) |
Y259C |
possibly damaging |
Het |
| Or4a70 |
A |
G |
2: 89,324,342 (GRCm39) |
F105L |
probably benign |
Het |
| Or5d36 |
A |
G |
2: 87,901,063 (GRCm39) |
V221A |
probably benign |
Het |
| Oxt |
A |
G |
2: 130,418,572 (GRCm39) |
D61G |
probably damaging |
Het |
| Patl1 |
T |
C |
19: 11,917,181 (GRCm39) |
L676P |
probably damaging |
Het |
| Pcdhb20 |
G |
A |
18: 37,638,127 (GRCm39) |
G218R |
probably damaging |
Het |
| Pdgfrb |
T |
A |
18: 61,194,566 (GRCm39) |
S114R |
probably benign |
Het |
| Pfdn5 |
A |
G |
15: 102,234,956 (GRCm39) |
N54S |
possibly damaging |
Het |
| Phldb1 |
G |
T |
9: 44,639,333 (GRCm39) |
T15N |
possibly damaging |
Het |
| Pink1 |
A |
C |
4: 138,045,316 (GRCm39) |
S253A |
probably null |
Het |
| Plag1 |
A |
T |
4: 3,904,870 (GRCm39) |
L107Q |
probably damaging |
Het |
| Pld5 |
C |
A |
1: 175,791,579 (GRCm39) |
V476L |
probably benign |
Het |
| Pramel28 |
A |
T |
4: 143,692,637 (GRCm39) |
D121E |
probably benign |
Het |
| Prrt2 |
C |
T |
7: 126,618,581 (GRCm39) |
A295T |
probably damaging |
Het |
| Ptgs1 |
A |
G |
2: 36,127,668 (GRCm39) |
I76V |
probably benign |
Het |
| Ptprz1 |
A |
G |
6: 23,001,026 (GRCm39) |
T1039A |
probably benign |
Het |
| Rbm20 |
G |
A |
19: 53,847,859 (GRCm39) |
C1135Y |
probably damaging |
Het |
| Recql5 |
A |
T |
11: 115,787,923 (GRCm39) |
N465K |
probably benign |
Het |
| Rgs12 |
A |
G |
5: 35,187,872 (GRCm39) |
S510G |
probably benign |
Het |
| Satb1 |
G |
A |
17: 52,089,816 (GRCm39) |
Q344* |
probably null |
Het |
| Sdr16c5 |
A |
G |
4: 3,996,244 (GRCm39) |
I283T |
probably benign |
Het |
| Serpinb3c |
T |
C |
1: 107,199,574 (GRCm39) |
S316G |
possibly damaging |
Het |
| Siglec1 |
A |
T |
2: 130,925,277 (GRCm39) |
Y395N |
probably damaging |
Het |
| Simc1 |
A |
G |
13: 54,651,701 (GRCm39) |
I5V |
probably benign |
Het |
| Slc27a2 |
T |
C |
2: 126,395,535 (GRCm39) |
V154A |
probably damaging |
Het |
| Slc27a5 |
A |
G |
7: 12,731,634 (GRCm39) |
L119S |
probably damaging |
Het |
| Slc35g2 |
T |
A |
9: 100,435,120 (GRCm39) |
T184S |
possibly damaging |
Het |
| Slc4a7 |
C |
T |
14: 14,733,727 (GRCm38) |
R46* |
probably null |
Het |
| Smcr8 |
T |
C |
11: 60,669,010 (GRCm39) |
F53L |
probably damaging |
Het |
| Spag9 |
T |
A |
11: 93,983,201 (GRCm39) |
L504* |
probably null |
Het |
| Spata31d1a |
A |
G |
13: 59,850,370 (GRCm39) |
I586T |
possibly damaging |
Het |
| Spata31d1c |
A |
T |
13: 65,183,041 (GRCm39) |
E194D |
possibly damaging |
Het |
| Spats2 |
A |
G |
15: 99,076,375 (GRCm39) |
E151G |
probably damaging |
Het |
| Sugp2 |
T |
A |
8: 70,695,861 (GRCm39) |
L278Q |
possibly damaging |
Het |
| Sult2a7 |
T |
A |
7: 14,207,322 (GRCm39) |
|
probably benign |
Het |
| Syde2 |
G |
T |
3: 145,694,163 (GRCm39) |
G137V |
possibly damaging |
Het |
| Synj1 |
A |
T |
16: 90,735,584 (GRCm39) |
F1456L |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,220,862 (GRCm39) |
|
probably benign |
Het |
| Timd4 |
C |
A |
11: 46,710,857 (GRCm39) |
T253K |
possibly damaging |
Het |
| Tlr3 |
G |
T |
8: 45,855,823 (GRCm39) |
T119N |
possibly damaging |
Het |
| Tmc6 |
A |
G |
11: 117,660,232 (GRCm39) |
Y669H |
probably damaging |
Het |
| Tmem221 |
T |
C |
8: 72,008,458 (GRCm39) |
E194G |
probably benign |
Het |
| Tmem232 |
C |
A |
17: 65,807,167 (GRCm39) |
V9F |
probably benign |
Het |
| Tpm1 |
G |
A |
9: 66,941,247 (GRCm39) |
Q135* |
probably null |
Het |
| Trank1 |
A |
G |
9: 111,194,096 (GRCm39) |
T707A |
probably benign |
Het |
| Trpm7 |
A |
T |
2: 126,665,917 (GRCm39) |
Y896* |
probably null |
Het |
| Tuba4a |
A |
T |
1: 75,192,983 (GRCm39) |
Y210* |
probably null |
Het |
| Tut7 |
A |
G |
13: 59,959,352 (GRCm39) |
V372A |
probably damaging |
Het |
| Vegfa |
T |
G |
17: 46,336,284 (GRCm39) |
I279L |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,349,804 (GRCm39) |
T593S |
probably damaging |
Het |
| Vmn2r93 |
A |
G |
17: 18,536,840 (GRCm39) |
I508V |
probably benign |
Het |
| Vps33a |
G |
T |
5: 123,669,244 (GRCm39) |
|
probably null |
Het |
| Wasl |
T |
A |
6: 24,624,360 (GRCm39) |
N231I |
probably damaging |
Het |
| Zbtb39 |
A |
G |
10: 127,578,703 (GRCm39) |
N426D |
probably benign |
Het |
| Zeb2 |
T |
G |
2: 44,887,962 (GRCm39) |
H350P |
probably damaging |
Het |
| Zfp112 |
T |
C |
7: 23,824,725 (GRCm39) |
F231S |
possibly damaging |
Het |
| Zfp180 |
T |
C |
7: 23,803,943 (GRCm39) |
S121P |
probably benign |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATAGGGAGTGTGTAAGCCTTTCAG -3'
(R):5'- AGAGCACGCAAAATGACATTTC -3'
Sequencing Primer
(F):5'- TGTAAGCCTTTCAGAGTGATAAGG -3'
(R):5'- CACTGAAATATGGTTTATGCTTGTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation