Incidental Mutation 'R2012:Vmn2r93'
ID 220056
Institutional Source Beutler Lab
Gene Symbol Vmn2r93
Ensembl Gene ENSMUSG00000079698
Gene Name vomeronasal 2, receptor 93
Synonyms EG627132
MMRRC Submission 040021-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R2012 (G1)
Quality Score 151
Status Not validated
Chromosome 17
Chromosomal Location 18518543-18546703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18536840 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 508 (I508V)
Ref Sequence ENSEMBL: ENSMUSP00000155900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]
AlphaFold L7N1Z9
Predicted Effect probably benign
Transcript: ENSMUST00000079206
AA Change: I508V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: I508V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 453 5.9e-40 PFAM
Pfam:NCD3G 509 562 2.6e-21 PFAM
Pfam:7tm_3 594 830 1.5e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231879
Predicted Effect probably benign
Transcript: ENSMUST00000231938
AA Change: I508V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 109 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A T 5: 8,167,634 (GRCm39) S675R probably damaging Het
Akap5 A T 12: 76,376,122 (GRCm39) H518L possibly damaging Het
Ankfn1 T C 11: 89,296,423 (GRCm39) D102G probably damaging Het
Aox3 A T 1: 58,177,391 (GRCm39) Y202F probably benign Het
Arhgef37 G A 18: 61,637,427 (GRCm39) L412F possibly damaging Het
B4galt3 C T 1: 171,100,118 (GRCm39) P121L probably damaging Het
BC034090 C T 1: 155,097,178 (GRCm39) R640Q probably damaging Het
Bhmt A T 13: 93,761,900 (GRCm39) Y128N probably damaging Het
Bin3 A G 14: 70,372,222 (GRCm39) E173G probably damaging Het
C1qtnf1 T A 11: 118,339,110 (GRCm39) F260Y probably benign Het
Ccdc14 G T 16: 34,511,092 (GRCm39) G22V possibly damaging Het
Ccnc A T 4: 21,741,955 (GRCm39) I135L possibly damaging Het
Chd3 T C 11: 69,239,878 (GRCm39) D1650G probably benign Het
Cherp A C 8: 73,228,613 (GRCm39) N14K probably damaging Het
Clint1 C T 11: 45,784,919 (GRCm39) T306I possibly damaging Het
Cyb5r1 T A 1: 134,335,315 (GRCm39) Y85N probably damaging Het
D830013O20Rik A G 12: 73,418,162 (GRCm39) noncoding transcript Het
Dapk1 A T 13: 60,869,671 (GRCm39) K304N probably damaging Het
Dnah6 T A 6: 73,044,449 (GRCm39) N3169Y probably damaging Het
Dync2h1 A T 9: 7,169,589 (GRCm39) I296K probably benign Het
Elp2 A T 18: 24,764,515 (GRCm39) T621S probably benign Het
Eml6 G T 11: 29,781,128 (GRCm39) Q635K possibly damaging Het
Exph5 G A 9: 53,278,466 (GRCm39) M192I possibly damaging Het
Fmnl2 A G 2: 52,995,549 (GRCm39) E424G probably damaging Het
Gas6 C T 8: 13,518,266 (GRCm39) V523M probably damaging Het
Ggn A T 7: 28,873,188 (GRCm39) probably null Het
Gimap8 A G 6: 48,633,287 (GRCm39) T369A probably damaging Het
Grm5 T C 7: 87,724,080 (GRCm39) I790T probably damaging Het
Gtpbp6 G A 5: 110,252,790 (GRCm39) A354V probably damaging Het
Habp4 G A 13: 64,317,995 (GRCm39) probably null Het
Has2 A G 15: 56,531,264 (GRCm39) W484R probably damaging Het
Herc4 G T 10: 63,079,817 (GRCm39) probably benign Het
Igf2 C A 7: 142,208,136 (GRCm39) E106D probably damaging Het
Il17rb A T 14: 29,718,797 (GRCm39) C428* probably null Het
Ipo11 A T 13: 107,056,130 (GRCm39) N47K probably benign Het
Itga4 T G 2: 79,108,138 (GRCm39) S197A probably damaging Het
Itpr1 T A 6: 108,417,497 (GRCm39) M1788K probably benign Het
Kbtbd3 C T 9: 4,330,919 (GRCm39) T431I probably benign Het
Kif5a A T 10: 127,075,044 (GRCm39) V523E probably benign Het
Klhl41 A T 2: 69,513,840 (GRCm39) D573V possibly damaging Het
Kndc1 C A 7: 139,501,196 (GRCm39) H828Q possibly damaging Het
Leng8 T A 7: 4,146,609 (GRCm39) V407D probably damaging Het
Mamdc2 C T 19: 23,288,215 (GRCm39) E608K probably benign Het
Mcf2 T A X: 59,122,574 (GRCm39) R850S probably damaging Het
Mmp2 A G 8: 93,576,831 (GRCm39) N618S probably benign Het
Morn5 A T 2: 35,942,950 (GRCm39) M17L probably benign Het
Nme8 T C 13: 19,881,053 (GRCm39) N26S probably damaging Het
Nostrin C A 2: 68,975,111 (GRCm39) probably null Het
Npy4r T A 14: 33,869,154 (GRCm39) I45F possibly damaging Het
Or13a21 T A 7: 139,999,024 (GRCm39) I221F probably damaging Het
Or1j11 A G 2: 36,311,931 (GRCm39) I174V probably benign Het
Or2aj5 C T 16: 19,424,881 (GRCm39) C179Y probably benign Het
Or2w1 T A 13: 21,317,659 (GRCm39) M238K probably benign Het
Or2w3b T C 11: 58,623,214 (GRCm39) Y259C possibly damaging Het
Or4a70 A G 2: 89,324,342 (GRCm39) F105L probably benign Het
Or5d36 A G 2: 87,901,063 (GRCm39) V221A probably benign Het
Oxt A G 2: 130,418,572 (GRCm39) D61G probably damaging Het
Patl1 T C 19: 11,917,181 (GRCm39) L676P probably damaging Het
Pcdhb20 G A 18: 37,638,127 (GRCm39) G218R probably damaging Het
Pdgfrb T A 18: 61,194,566 (GRCm39) S114R probably benign Het
Pfdn5 A G 15: 102,234,956 (GRCm39) N54S possibly damaging Het
Phldb1 G T 9: 44,639,333 (GRCm39) T15N possibly damaging Het
Pink1 A C 4: 138,045,316 (GRCm39) S253A probably null Het
Plag1 A T 4: 3,904,870 (GRCm39) L107Q probably damaging Het
Pld5 C A 1: 175,791,579 (GRCm39) V476L probably benign Het
Pramel28 A T 4: 143,692,637 (GRCm39) D121E probably benign Het
Prrt2 C T 7: 126,618,581 (GRCm39) A295T probably damaging Het
Ptgs1 A G 2: 36,127,668 (GRCm39) I76V probably benign Het
Ptprz1 A G 6: 23,001,026 (GRCm39) T1039A probably benign Het
Rbm20 G A 19: 53,847,859 (GRCm39) C1135Y probably damaging Het
Recql5 A T 11: 115,787,923 (GRCm39) N465K probably benign Het
Rgs12 A G 5: 35,187,872 (GRCm39) S510G probably benign Het
Satb1 G A 17: 52,089,816 (GRCm39) Q344* probably null Het
Sdr16c5 A G 4: 3,996,244 (GRCm39) I283T probably benign Het
Serpinb3c T C 1: 107,199,574 (GRCm39) S316G possibly damaging Het
Siglec1 A T 2: 130,925,277 (GRCm39) Y395N probably damaging Het
Simc1 A G 13: 54,651,701 (GRCm39) I5V probably benign Het
Slc27a2 T C 2: 126,395,535 (GRCm39) V154A probably damaging Het
Slc27a5 A G 7: 12,731,634 (GRCm39) L119S probably damaging Het
Slc35g2 T A 9: 100,435,120 (GRCm39) T184S possibly damaging Het
Slc4a7 C T 14: 14,733,727 (GRCm38) R46* probably null Het
Smcr8 T C 11: 60,669,010 (GRCm39) F53L probably damaging Het
Spag9 T A 11: 93,983,201 (GRCm39) L504* probably null Het
Spata31d1a A G 13: 59,850,370 (GRCm39) I586T possibly damaging Het
Spata31d1c A T 13: 65,183,041 (GRCm39) E194D possibly damaging Het
Spats2 A G 15: 99,076,375 (GRCm39) E151G probably damaging Het
Sugp2 T A 8: 70,695,861 (GRCm39) L278Q possibly damaging Het
Sult2a7 T A 7: 14,207,322 (GRCm39) probably benign Het
Syde2 G T 3: 145,694,163 (GRCm39) G137V possibly damaging Het
Synj1 A T 16: 90,735,584 (GRCm39) F1456L probably damaging Het
Szt2 A G 4: 118,220,862 (GRCm39) probably benign Het
Timd4 C A 11: 46,710,857 (GRCm39) T253K possibly damaging Het
Tlr3 G T 8: 45,855,823 (GRCm39) T119N possibly damaging Het
Tmc6 A G 11: 117,660,232 (GRCm39) Y669H probably damaging Het
Tmem221 T C 8: 72,008,458 (GRCm39) E194G probably benign Het
Tmem232 C A 17: 65,807,167 (GRCm39) V9F probably benign Het
Tpm1 G A 9: 66,941,247 (GRCm39) Q135* probably null Het
Trank1 A G 9: 111,194,096 (GRCm39) T707A probably benign Het
Trpm7 A T 2: 126,665,917 (GRCm39) Y896* probably null Het
Tuba4a A T 1: 75,192,983 (GRCm39) Y210* probably null Het
Tut7 A G 13: 59,959,352 (GRCm39) V372A probably damaging Het
Vegfa T G 17: 46,336,284 (GRCm39) I279L probably benign Het
Vmn2r54 T A 7: 12,349,804 (GRCm39) T593S probably damaging Het
Vps33a G T 5: 123,669,244 (GRCm39) probably null Het
Wasl T A 6: 24,624,360 (GRCm39) N231I probably damaging Het
Zbtb39 A G 10: 127,578,703 (GRCm39) N426D probably benign Het
Zeb2 T G 2: 44,887,962 (GRCm39) H350P probably damaging Het
Zfp112 T C 7: 23,824,725 (GRCm39) F231S possibly damaging Het
Zfp180 T C 7: 23,803,943 (GRCm39) S121P probably benign Het
Other mutations in Vmn2r93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Vmn2r93 APN 17 18,546,504 (GRCm39) missense probably damaging 1.00
IGL01326:Vmn2r93 APN 17 18,536,906 (GRCm39) missense possibly damaging 0.92
IGL01328:Vmn2r93 APN 17 18,545,819 (GRCm39) missense probably benign 0.00
IGL01360:Vmn2r93 APN 17 18,525,510 (GRCm39) missense possibly damaging 0.71
IGL01382:Vmn2r93 APN 17 18,533,578 (GRCm39) nonsense probably null
IGL01463:Vmn2r93 APN 17 18,525,150 (GRCm39) missense probably damaging 1.00
IGL02057:Vmn2r93 APN 17 18,546,032 (GRCm39) missense probably damaging 1.00
IGL02257:Vmn2r93 APN 17 18,545,770 (GRCm39) unclassified probably benign
IGL02686:Vmn2r93 APN 17 18,533,526 (GRCm39) missense possibly damaging 0.89
IGL02720:Vmn2r93 APN 17 18,525,296 (GRCm39) missense probably damaging 1.00
IGL03328:Vmn2r93 APN 17 18,525,220 (GRCm39) missense probably damaging 1.00
PIT4576001:Vmn2r93 UTSW 17 18,533,473 (GRCm39) missense probably benign
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0488:Vmn2r93 UTSW 17 18,546,311 (GRCm39) missense probably damaging 1.00
R0667:Vmn2r93 UTSW 17 18,546,503 (GRCm39) missense probably damaging 1.00
R0668:Vmn2r93 UTSW 17 18,518,667 (GRCm39) missense probably benign 0.00
R0850:Vmn2r93 UTSW 17 18,525,279 (GRCm39) missense possibly damaging 0.93
R0924:Vmn2r93 UTSW 17 18,524,443 (GRCm39) missense probably benign
R0947:Vmn2r93 UTSW 17 18,524,343 (GRCm39) missense probably benign 0.06
R1124:Vmn2r93 UTSW 17 18,518,710 (GRCm39) missense probably benign 0.00
R1584:Vmn2r93 UTSW 17 18,525,413 (GRCm39) missense possibly damaging 0.84
R1943:Vmn2r93 UTSW 17 18,546,063 (GRCm39) missense probably benign 0.04
R2018:Vmn2r93 UTSW 17 18,546,324 (GRCm39) missense probably damaging 1.00
R2196:Vmn2r93 UTSW 17 18,525,428 (GRCm39) missense probably damaging 1.00
R2373:Vmn2r93 UTSW 17 18,518,665 (GRCm39) missense probably benign
R2864:Vmn2r93 UTSW 17 18,546,323 (GRCm39) missense probably damaging 1.00
R4276:Vmn2r93 UTSW 17 18,525,092 (GRCm39) missense possibly damaging 0.47
R4446:Vmn2r93 UTSW 17 18,524,312 (GRCm39) missense possibly damaging 0.93
R4537:Vmn2r93 UTSW 17 18,525,194 (GRCm39) missense possibly damaging 0.86
R4674:Vmn2r93 UTSW 17 18,525,255 (GRCm39) missense probably benign 0.34
R4726:Vmn2r93 UTSW 17 18,536,960 (GRCm39) missense probably damaging 1.00
R4936:Vmn2r93 UTSW 17 18,524,327 (GRCm39) missense possibly damaging 0.95
R4984:Vmn2r93 UTSW 17 18,533,389 (GRCm39) splice site probably null
R5111:Vmn2r93 UTSW 17 18,546,326 (GRCm39) missense probably damaging 0.99
R5749:Vmn2r93 UTSW 17 18,518,546 (GRCm39) missense probably benign 0.06
R5918:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R5921:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R6091:Vmn2r93 UTSW 17 18,545,958 (GRCm39) missense probably benign 0.06
R6283:Vmn2r93 UTSW 17 18,524,366 (GRCm39) missense probably benign 0.02
R6680:Vmn2r93 UTSW 17 18,536,920 (GRCm39) nonsense probably null
R6876:Vmn2r93 UTSW 17 18,525,450 (GRCm39) missense probably benign 0.00
R6963:Vmn2r93 UTSW 17 18,536,849 (GRCm39) missense probably damaging 1.00
R6996:Vmn2r93 UTSW 17 18,524,903 (GRCm39) missense probably damaging 1.00
R7027:Vmn2r93 UTSW 17 18,533,548 (GRCm39) missense probably benign 0.01
R7034:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7036:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7246:Vmn2r93 UTSW 17 18,546,012 (GRCm39) missense possibly damaging 0.89
R7258:Vmn2r93 UTSW 17 18,525,403 (GRCm39) missense probably benign 0.32
R7323:Vmn2r93 UTSW 17 18,533,497 (GRCm39) nonsense probably null
R7325:Vmn2r93 UTSW 17 18,524,249 (GRCm39) missense probably benign 0.01
R7390:Vmn2r93 UTSW 17 18,525,329 (GRCm39) missense probably damaging 1.00
R7427:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7428:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7448:Vmn2r93 UTSW 17 18,546,248 (GRCm39) missense probably benign 0.19
R7453:Vmn2r93 UTSW 17 18,533,580 (GRCm39) missense probably benign 0.10
R7562:Vmn2r93 UTSW 17 18,518,731 (GRCm39) missense probably benign 0.01
R7662:Vmn2r93 UTSW 17 18,525,631 (GRCm39) missense probably benign 0.00
R7682:Vmn2r93 UTSW 17 18,525,583 (GRCm39) missense probably benign 0.03
R7704:Vmn2r93 UTSW 17 18,536,910 (GRCm39) missense probably benign 0.01
R7772:Vmn2r93 UTSW 17 18,533,482 (GRCm39) missense probably damaging 0.99
R7957:Vmn2r93 UTSW 17 18,545,954 (GRCm39) nonsense probably null
R8276:Vmn2r93 UTSW 17 18,525,649 (GRCm39) critical splice donor site probably null
R8290:Vmn2r93 UTSW 17 18,524,291 (GRCm39) missense probably damaging 1.00
R8362:Vmn2r93 UTSW 17 18,546,353 (GRCm39) missense probably benign 0.02
R8376:Vmn2r93 UTSW 17 18,525,230 (GRCm39) missense probably damaging 1.00
R8870:Vmn2r93 UTSW 17 18,525,320 (GRCm39) missense possibly damaging 0.91
R8925:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8927:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8954:Vmn2r93 UTSW 17 18,546,252 (GRCm39) missense probably damaging 0.99
R9038:Vmn2r93 UTSW 17 18,524,471 (GRCm39) missense probably benign
R9131:Vmn2r93 UTSW 17 18,546,143 (GRCm39) missense probably damaging 0.99
R9205:Vmn2r93 UTSW 17 18,524,281 (GRCm39) missense probably damaging 1.00
R9530:Vmn2r93 UTSW 17 18,518,562 (GRCm39) missense probably damaging 0.96
Z1088:Vmn2r93 UTSW 17 18,546,665 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r93 UTSW 17 18,525,600 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGTCTTTGTCATGGCCAATG -3'
(R):5'- GATGGTGCTGAATTGTGACATTAAC -3'

Sequencing Primer
(F):5'- GGCCAATGTCAAATTTCTGCCAG -3'
(R):5'- CTGCACAAGGAGTGCAAT -3'
Posted On 2014-08-25