Incidental Mutation 'R1984:Or11g24'
ID 220373
Institutional Source Beutler Lab
Gene Symbol Or11g24
Ensembl Gene ENSMUSG00000057903
Gene Name olfactory receptor family 11 subfamily G member 24
Synonyms GA_x6K02T2PMLR-6121675-6122604, MOR106-2, Olfr739
MMRRC Submission 039996-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R1984 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50661978-50662907 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50662848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 291 (I291L)
Ref Sequence ENSEMBL: ENSMUSP00000150559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]
AlphaFold E9Q1P0
Predicted Effect possibly damaging
Transcript: ENSMUST00000075261
AA Change: I291L

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: I291L

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.1e-53 PFAM
Pfam:7tm_1 43 292 1.9e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216949
AA Change: I291L

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A T 6: 124,324,778 (GRCm39) L81H probably damaging Het
Abca8b A G 11: 109,868,667 (GRCm39) C166R probably damaging Het
Adgrv1 T A 13: 81,671,868 (GRCm39) E2242D probably damaging Het
Agap1 T C 1: 89,694,045 (GRCm39) S448P probably benign Het
Aldh1a2 T C 9: 71,160,334 (GRCm39) L120P probably damaging Het
Alkbh2 T C 5: 114,262,115 (GRCm39) N205S probably benign Het
Anapc1 C A 2: 128,511,608 (GRCm39) G493C possibly damaging Het
Aox3 A T 1: 58,192,220 (GRCm39) I497F possibly damaging Het
Atp2b1 T C 10: 98,850,354 (GRCm39) S826P possibly damaging Het
Atp8b4 T A 2: 126,164,928 (GRCm39) R1129S probably damaging Het
Bche T A 3: 73,609,159 (GRCm39) Q89L probably benign Het
Bche G T 3: 73,609,160 (GRCm39) Q89K probably benign Het
Bcl9 T C 3: 97,121,050 (GRCm39) K171E probably damaging Het
Cacna1b A T 2: 24,538,998 (GRCm39) Y1488N probably damaging Het
Dock8 A G 19: 25,098,545 (GRCm39) N623S probably null Het
Dok6 T C 18: 89,578,234 (GRCm39) E61G probably damaging Het
Duxf4 T A 10: 58,071,785 (GRCm39) Q143L possibly damaging Het
Esf1 A T 2: 139,990,806 (GRCm39) D559E possibly damaging Het
F11r A G 1: 171,289,438 (GRCm39) I254V probably benign Het
Fkrp A G 7: 16,545,802 (GRCm39) V20A probably benign Het
Fscb T C 12: 64,521,457 (GRCm39) E3G unknown Het
Hdlbp A G 1: 93,358,840 (GRCm39) I237T probably damaging Het
Hfm1 A T 5: 107,046,442 (GRCm39) D481E probably damaging Het
Hspa4l T C 3: 40,714,833 (GRCm39) V156A probably damaging Het
Igfn1 A G 1: 135,889,782 (GRCm39) S2422P probably benign Het
Il23r T A 6: 67,467,652 (GRCm39) probably null Het
Il24 G A 1: 130,810,268 (GRCm39) T196I probably benign Het
Isg15 T C 4: 156,284,250 (GRCm39) I93V probably benign Het
Kcna6 T C 6: 126,715,473 (GRCm39) E472G probably benign Het
Kif21b G A 1: 136,075,284 (GRCm39) D166N probably damaging Het
Lilrb4b A T 10: 51,357,831 (GRCm39) Q80L possibly damaging Het
Lrrc69 T C 4: 14,708,669 (GRCm39) E225G possibly damaging Het
Marchf6 A T 15: 31,469,792 (GRCm39) L726Q probably damaging Het
Megf6 G T 4: 154,352,124 (GRCm39) G1210C probably damaging Het
Msh2 C T 17: 88,026,724 (GRCm39) T740I probably damaging Het
Myh14 T C 7: 44,288,446 (GRCm39) Y514C probably damaging Het
Myorg C A 4: 41,497,501 (GRCm39) A710S possibly damaging Het
Nedd1 T C 10: 92,550,022 (GRCm39) T88A possibly damaging Het
Nfkb1 G A 3: 135,321,110 (GRCm39) T215I possibly damaging Het
Obox1 A T 7: 15,289,135 (GRCm39) I17L probably benign Het
Palb2 A C 7: 121,726,303 (GRCm39) H522Q probably damaging Het
Pde4c C T 8: 71,177,191 (GRCm39) T6M probably damaging Het
Plekhg1 A G 10: 3,908,181 (GRCm39) K97E probably damaging Het
Plod3 A G 5: 137,019,707 (GRCm39) probably null Het
Plppr3 A T 10: 79,703,294 (GRCm39) Y63* probably null Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Qrich1 T C 9: 108,411,246 (GRCm39) V257A probably damaging Het
Rpl14 A G 9: 120,401,253 (GRCm39) D32G possibly damaging Het
Senp8 A G 9: 59,644,721 (GRCm39) V132A possibly damaging Het
Serac1 A G 17: 6,095,964 (GRCm39) probably null Het
Sh2d3c T A 2: 32,639,256 (GRCm39) C295* probably null Het
Stab1 A G 14: 30,872,605 (GRCm39) F1142L probably benign Het
Stam2 T C 2: 52,599,638 (GRCm39) T257A possibly damaging Het
Tedc2 T A 17: 24,435,291 (GRCm39) E366V probably damaging Het
Tedc2 C A 17: 24,435,292 (GRCm39) E366* probably null Het
Tg A G 15: 66,554,691 (GRCm39) E702G probably benign Het
Tgif2lx2 A T X: 117,337,690 (GRCm39) K218* probably null Het
Tpp1 C A 7: 105,400,905 (GRCm39) V41L probably benign Het
Tulp3 A T 6: 128,303,769 (GRCm39) S277T probably benign Het
Zfp407 C T 18: 84,577,898 (GRCm39) A1072T probably benign Het
Zfp683 T C 4: 133,784,766 (GRCm39) F338L probably damaging Het
Other mutations in Or11g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Or11g24 APN 14 50,662,018 (GRCm39) missense possibly damaging 0.88
IGL02430:Or11g24 APN 14 50,662,608 (GRCm39) missense probably benign
IGL02603:Or11g24 APN 14 50,662,657 (GRCm39) missense probably damaging 1.00
IGL02959:Or11g24 APN 14 50,662,389 (GRCm39) missense possibly damaging 0.76
IGL03154:Or11g24 APN 14 50,662,080 (GRCm39) missense probably benign 0.00
R0455:Or11g24 UTSW 14 50,662,359 (GRCm39) missense possibly damaging 0.45
R3160:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R3161:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R3162:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R4821:Or11g24 UTSW 14 50,662,206 (GRCm39) missense possibly damaging 0.96
R4880:Or11g24 UTSW 14 50,662,758 (GRCm39) missense possibly damaging 0.90
R5047:Or11g24 UTSW 14 50,662,696 (GRCm39) missense probably damaging 1.00
R5384:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5385:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5386:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5640:Or11g24 UTSW 14 50,662,111 (GRCm39) missense probably benign 0.18
R5809:Or11g24 UTSW 14 50,662,905 (GRCm39) makesense probably null
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6229:Or11g24 UTSW 14 50,662,662 (GRCm39) missense probably benign 0.38
R6614:Or11g24 UTSW 14 50,662,546 (GRCm39) missense probably benign 0.00
R7308:Or11g24 UTSW 14 50,662,722 (GRCm39) missense possibly damaging 0.57
R7443:Or11g24 UTSW 14 50,662,507 (GRCm39) missense probably damaging 1.00
R7699:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7700:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7851:Or11g24 UTSW 14 50,662,827 (GRCm39) missense probably damaging 0.99
R8397:Or11g24 UTSW 14 50,662,137 (GRCm39) missense probably damaging 1.00
R8906:Or11g24 UTSW 14 50,662,291 (GRCm39) missense probably damaging 1.00
R9393:Or11g24 UTSW 14 50,662,255 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTTCCTTCAAGAGATGGACAA -3'
(R):5'- CTCTGACAACTATTGCCCTATTCA -3'

Sequencing Primer
(F):5'- GTATCTGAGCCCAACATC -3'
(R):5'- GGGATGTCTACAGCTTCATCTGAAAG -3'
Posted On 2014-08-25