Incidental Mutation 'R2025:Rapgef4'
| ID |
220374 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef4
|
| Ensembl Gene |
ENSMUSG00000049044 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 4 |
| Synonyms |
5730402K07Rik, 6330581N18Rik, Epac2, cAMP-GEFII, 1300003D15Rik |
| MMRRC Submission |
040034-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.648)
|
| Stock # |
R2025 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
71811584-72087818 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72073083 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 790
(T790A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028525
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028525]
[ENSMUST00000090826]
[ENSMUST00000102698]
|
| AlphaFold |
Q9EQZ6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028525
AA Change: T790A
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000028525
Gene: ENSMUSG00000049044
AA Change: T790A
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
72 |
147 |
3.43e-27 |
SMART |
|
low complexity region
|
158 |
167 |
N/A |
INTRINSIC |
|
cNMP
|
212 |
331 |
4.02e-15 |
SMART |
|
RasGEFN
|
351 |
486 |
3.61e-7 |
SMART |
|
Blast:RasGEF
|
534 |
607 |
1e-33 |
BLAST |
|
RasGEF
|
624 |
866 |
8.09e-105 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090826
AA Change: T934A
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000088336
Gene: ENSMUSG00000049044
AA Change: T934A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
13 |
N/A |
INTRINSIC |
|
cNMP
|
43 |
162 |
4.62e-15 |
SMART |
|
DEP
|
216 |
291 |
3.43e-27 |
SMART |
|
low complexity region
|
302 |
311 |
N/A |
INTRINSIC |
|
cNMP
|
356 |
475 |
4.02e-15 |
SMART |
|
RasGEFN
|
495 |
630 |
3.61e-7 |
SMART |
|
Blast:RasGEF
|
678 |
751 |
2e-33 |
BLAST |
|
RasGEF
|
768 |
1010 |
8.09e-105 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102698
AA Change: T916A
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000099759
Gene: ENSMUSG00000049044
AA Change: T916A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
13 |
N/A |
INTRINSIC |
|
cNMP
|
43 |
162 |
4.62e-15 |
SMART |
|
DEP
|
198 |
273 |
3.43e-27 |
SMART |
|
low complexity region
|
284 |
293 |
N/A |
INTRINSIC |
|
cNMP
|
338 |
457 |
4.02e-15 |
SMART |
|
RasGEFN
|
477 |
612 |
3.61e-7 |
SMART |
|
Blast:RasGEF
|
660 |
733 |
2e-33 |
BLAST |
|
RasGEF
|
750 |
992 |
8.09e-105 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132792
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146970
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153887
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis. Mice homozygous for a knock-out allele exhibit impaired isoproterenol-induced SR calcium leak and arrhythmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
C |
14: 118,790,737 (GRCm39) |
M757V |
probably benign |
Het |
| Abitram |
T |
A |
4: 56,805,916 (GRCm39) |
I138N |
probably damaging |
Het |
| Acan |
T |
G |
7: 78,750,970 (GRCm39) |
S1914A |
probably benign |
Het |
| Axin2 |
T |
A |
11: 108,833,904 (GRCm39) |
V617D |
probably damaging |
Het |
| Bhlhe22 |
A |
G |
3: 18,109,975 (GRCm39) |
S342G |
probably benign |
Het |
| Cald1 |
AAGAGAGAGAGAGAG |
AAGAGAGAGAGAG |
6: 34,723,108 (GRCm39) |
|
probably null |
Het |
| Ccdc34 |
A |
G |
2: 109,862,731 (GRCm39) |
K179E |
possibly damaging |
Het |
| Clasp1 |
A |
G |
1: 118,432,629 (GRCm39) |
T208A |
probably damaging |
Het |
| Crabp1 |
C |
T |
9: 54,675,752 (GRCm39) |
R112* |
probably null |
Het |
| Cstdc1 |
T |
C |
2: 148,624,148 (GRCm39) |
F41L |
probably damaging |
Het |
| D130040H23Rik |
A |
G |
8: 69,755,525 (GRCm39) |
N310S |
probably benign |
Het |
| Dalrd3 |
T |
C |
9: 108,448,284 (GRCm39) |
I278T |
probably benign |
Het |
| Dbp |
C |
A |
7: 45,357,700 (GRCm39) |
D89E |
probably benign |
Het |
| Dennd2c |
A |
G |
3: 103,039,005 (GRCm39) |
D51G |
possibly damaging |
Het |
| Dido1 |
A |
T |
2: 180,330,974 (GRCm39) |
L158* |
probably null |
Het |
| Disp1 |
G |
T |
1: 182,869,767 (GRCm39) |
F884L |
probably damaging |
Het |
| Dmrtb1 |
T |
C |
4: 107,540,782 (GRCm39) |
D193G |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,950,133 (GRCm39) |
D1984G |
probably damaging |
Het |
| Dpf2 |
T |
C |
19: 5,952,781 (GRCm39) |
Y218C |
possibly damaging |
Het |
| Dsg4 |
C |
T |
18: 20,599,693 (GRCm39) |
Q770* |
probably null |
Het |
| Efemp1 |
A |
T |
11: 28,864,696 (GRCm39) |
Y250F |
possibly damaging |
Het |
| Erbin |
A |
T |
13: 103,966,703 (GRCm39) |
I1249N |
probably benign |
Het |
| F5 |
A |
G |
1: 164,037,044 (GRCm39) |
K1928E |
probably benign |
Het |
| Fhip1b |
A |
G |
7: 105,038,143 (GRCm39) |
V260A |
probably damaging |
Het |
| Gdf11 |
T |
A |
10: 128,727,314 (GRCm39) |
I81F |
probably damaging |
Het |
| Gm10518 |
T |
A |
1: 179,631,483 (GRCm39) |
|
probably benign |
Het |
| Grb10 |
G |
C |
11: 11,920,576 (GRCm39) |
S14* |
probably null |
Het |
| Greb1l |
A |
T |
18: 10,515,221 (GRCm39) |
Y562F |
possibly damaging |
Het |
| Gtf2ird1 |
T |
C |
5: 134,392,788 (GRCm39) |
E789G |
probably damaging |
Het |
| Hook3 |
T |
C |
8: 26,528,126 (GRCm39) |
E588G |
probably damaging |
Het |
| Hpx |
A |
G |
7: 105,244,311 (GRCm39) |
S266P |
probably damaging |
Het |
| Hs6st3 |
A |
G |
14: 120,106,801 (GRCm39) |
D403G |
probably damaging |
Het |
| Igf2bp1 |
A |
G |
11: 95,864,996 (GRCm39) |
V151A |
possibly damaging |
Het |
| Itga11 |
C |
T |
9: 62,670,093 (GRCm39) |
T739I |
probably damaging |
Het |
| Kalrn |
T |
C |
16: 34,010,106 (GRCm39) |
I702V |
probably damaging |
Het |
| Kif2b |
C |
T |
11: 91,468,172 (GRCm39) |
S37N |
probably damaging |
Het |
| Kng2 |
T |
A |
16: 22,819,325 (GRCm39) |
D237V |
probably benign |
Het |
| Krtap27-1 |
C |
A |
16: 88,468,173 (GRCm39) |
V124L |
possibly damaging |
Het |
| Lig4 |
A |
T |
8: 10,022,436 (GRCm39) |
L448Q |
probably damaging |
Het |
| Macf1 |
C |
T |
4: 123,265,711 (GRCm39) |
A4821T |
probably damaging |
Het |
| Msh5 |
T |
A |
17: 35,251,768 (GRCm39) |
I431F |
possibly damaging |
Het |
| Ndufa10 |
A |
G |
1: 92,367,614 (GRCm39) |
Y339H |
probably damaging |
Het |
| Nin |
T |
A |
12: 70,076,782 (GRCm39) |
Q1091L |
probably damaging |
Het |
| Nom1 |
A |
C |
5: 29,651,849 (GRCm39) |
D729A |
probably damaging |
Het |
| Or52e8 |
C |
A |
7: 104,624,451 (GRCm39) |
G247V |
probably benign |
Het |
| P2ry14 |
A |
T |
3: 59,022,866 (GRCm39) |
V207E |
probably damaging |
Het |
| Pdss2 |
A |
T |
10: 43,269,871 (GRCm39) |
N238I |
possibly damaging |
Het |
| Pkn1 |
A |
G |
8: 84,398,007 (GRCm39) |
V795A |
probably damaging |
Het |
| Pla2g6 |
A |
C |
15: 79,170,964 (GRCm39) |
L804R |
probably damaging |
Het |
| Poglut1 |
A |
T |
16: 38,358,267 (GRCm39) |
|
probably null |
Het |
| Prkcz |
A |
T |
4: 155,374,167 (GRCm39) |
V83D |
probably damaging |
Het |
| Prss50 |
T |
C |
9: 110,690,328 (GRCm39) |
F157S |
probably benign |
Het |
| Psors1c2 |
A |
G |
17: 35,845,099 (GRCm39) |
|
probably benign |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
| Rab7 |
G |
A |
6: 87,981,161 (GRCm39) |
L174F |
probably damaging |
Het |
| Rb1cc1 |
G |
T |
1: 6,315,533 (GRCm39) |
V503L |
probably damaging |
Het |
| Sbf1 |
T |
A |
15: 89,186,933 (GRCm39) |
E815V |
probably damaging |
Het |
| Setd3 |
T |
A |
12: 108,126,526 (GRCm39) |
E104V |
probably damaging |
Het |
| Slc39a5 |
A |
T |
10: 128,234,279 (GRCm39) |
L208Q |
probably damaging |
Het |
| Slc39a5 |
G |
T |
10: 128,234,280 (GRCm39) |
L208M |
probably damaging |
Het |
| Slc3a1 |
T |
G |
17: 85,340,273 (GRCm39) |
Y232D |
probably damaging |
Het |
| Slc8a1 |
T |
A |
17: 81,956,541 (GRCm39) |
S166C |
probably damaging |
Het |
| Stard9 |
T |
A |
2: 120,532,879 (GRCm39) |
D3045E |
probably benign |
Het |
| Stk4 |
C |
A |
2: 163,938,751 (GRCm39) |
D206E |
probably damaging |
Het |
| Syn3 |
T |
C |
10: 86,302,846 (GRCm39) |
D103G |
probably damaging |
Het |
| Tbc1d30 |
T |
A |
10: 121,115,051 (GRCm39) |
Y369F |
probably benign |
Het |
| Tenm2 |
G |
T |
11: 35,938,091 (GRCm39) |
Y1527* |
probably null |
Het |
| Tfg |
T |
C |
16: 56,525,988 (GRCm39) |
K85R |
possibly damaging |
Het |
| Timp3 |
T |
C |
10: 86,136,749 (GRCm39) |
L11P |
probably damaging |
Het |
| Tmem144 |
A |
T |
3: 79,735,018 (GRCm39) |
|
probably null |
Het |
| Tmtc4 |
T |
C |
14: 123,158,677 (GRCm39) |
N682S |
probably benign |
Het |
| Tnks2 |
C |
T |
19: 36,843,466 (GRCm39) |
L464F |
probably damaging |
Het |
| Trank1 |
T |
C |
9: 111,221,107 (GRCm39) |
F2615L |
probably benign |
Het |
| Trio |
T |
C |
15: 27,744,223 (GRCm39) |
K2570E |
probably damaging |
Het |
| Trio |
T |
A |
15: 27,774,013 (GRCm39) |
D673V |
probably damaging |
Het |
| Ublcp1 |
A |
T |
11: 44,356,458 (GRCm39) |
C87S |
probably benign |
Het |
| Unc13a |
C |
T |
8: 72,092,412 (GRCm39) |
E1386K |
possibly damaging |
Het |
| Wdr41 |
C |
T |
13: 95,155,456 (GRCm39) |
H404Y |
probably damaging |
Het |
| Zfp280b |
T |
C |
10: 75,874,328 (GRCm39) |
L69S |
probably damaging |
Het |
| Zfp346 |
T |
C |
13: 55,280,121 (GRCm39) |
S282P |
probably damaging |
Het |
| Zfp579 |
C |
A |
7: 4,996,520 (GRCm39) |
E464* |
probably null |
Het |
| Zfp78 |
T |
A |
7: 6,378,513 (GRCm39) |
|
probably null |
Het |
| Zswim9 |
T |
C |
7: 13,003,292 (GRCm39) |
E186G |
probably damaging |
Het |
|
| Other mutations in Rapgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00467:Rapgef4
|
APN |
2 |
72,086,656 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL00858:Rapgef4
|
APN |
2 |
72,029,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01408:Rapgef4
|
APN |
2 |
72,005,185 (GRCm39) |
nonsense |
probably null |
|
|
IGL01673:Rapgef4
|
APN |
2 |
72,071,781 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01678:Rapgef4
|
APN |
2 |
72,072,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL01725:Rapgef4
|
APN |
2 |
72,005,218 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01871:Rapgef4
|
APN |
2 |
72,028,704 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01935:Rapgef4
|
APN |
2 |
72,064,467 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02001:Rapgef4
|
APN |
2 |
72,055,396 (GRCm39) |
splice site |
probably benign |
|
|
IGL02041:Rapgef4
|
APN |
2 |
72,029,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Rapgef4
|
APN |
2 |
72,010,405 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02410:Rapgef4
|
APN |
2 |
72,056,938 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02807:Rapgef4
|
APN |
2 |
72,035,993 (GRCm39) |
splice site |
probably benign |
|
|
IGL03066:Rapgef4
|
APN |
2 |
71,971,523 (GRCm39) |
splice site |
probably benign |
|
|
IGL03282:Rapgef4
|
APN |
2 |
72,036,096 (GRCm39) |
splice site |
probably benign |
|
|
IGL03291:Rapgef4
|
APN |
2 |
72,026,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0033:Rapgef4
|
UTSW |
2 |
71,967,675 (GRCm39) |
intron |
probably benign |
|
|
R0045:Rapgef4
|
UTSW |
2 |
72,029,122 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0045:Rapgef4
|
UTSW |
2 |
72,029,122 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0309:Rapgef4
|
UTSW |
2 |
72,056,374 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0398:Rapgef4
|
UTSW |
2 |
71,861,385 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0747:Rapgef4
|
UTSW |
2 |
72,053,417 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1216:Rapgef4
|
UTSW |
2 |
72,038,492 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1264:Rapgef4
|
UTSW |
2 |
71,861,449 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1302:Rapgef4
|
UTSW |
2 |
71,875,504 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1460:Rapgef4
|
UTSW |
2 |
71,861,520 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1483:Rapgef4
|
UTSW |
2 |
71,885,370 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1682:Rapgef4
|
UTSW |
2 |
72,056,912 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1768:Rapgef4
|
UTSW |
2 |
72,056,131 (GRCm39) |
splice site |
probably benign |
|
|
R1858:Rapgef4
|
UTSW |
2 |
71,861,408 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1860:Rapgef4
|
UTSW |
2 |
72,065,064 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1952:Rapgef4
|
UTSW |
2 |
72,038,471 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2128:Rapgef4
|
UTSW |
2 |
72,056,897 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2159:Rapgef4
|
UTSW |
2 |
72,005,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Rapgef4
|
UTSW |
2 |
71,875,533 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2883:Rapgef4
|
UTSW |
2 |
71,861,469 (GRCm39) |
missense |
probably benign |
|
|
R3015:Rapgef4
|
UTSW |
2 |
72,028,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4278:Rapgef4
|
UTSW |
2 |
72,028,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5256:Rapgef4
|
UTSW |
2 |
71,864,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5572:Rapgef4
|
UTSW |
2 |
71,864,464 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5574:Rapgef4
|
UTSW |
2 |
71,864,464 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5575:Rapgef4
|
UTSW |
2 |
71,864,464 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Rapgef4
|
UTSW |
2 |
72,073,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6007:Rapgef4
|
UTSW |
2 |
72,010,293 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6084:Rapgef4
|
UTSW |
2 |
72,026,622 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6192:Rapgef4
|
UTSW |
2 |
71,811,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6409:Rapgef4
|
UTSW |
2 |
72,008,581 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6683:Rapgef4
|
UTSW |
2 |
71,885,123 (GRCm39) |
intron |
probably benign |
|
|
R6774:Rapgef4
|
UTSW |
2 |
72,056,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6844:Rapgef4
|
UTSW |
2 |
72,064,970 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6999:Rapgef4
|
UTSW |
2 |
72,069,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7077:Rapgef4
|
UTSW |
2 |
72,071,820 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7138:Rapgef4
|
UTSW |
2 |
72,028,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7275:Rapgef4
|
UTSW |
2 |
72,038,445 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7352:Rapgef4
|
UTSW |
2 |
72,010,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7397:Rapgef4
|
UTSW |
2 |
72,036,010 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7508:Rapgef4
|
UTSW |
2 |
72,036,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7620:Rapgef4
|
UTSW |
2 |
72,059,422 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7703:Rapgef4
|
UTSW |
2 |
72,010,315 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7770:Rapgef4
|
UTSW |
2 |
72,028,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7814:Rapgef4
|
UTSW |
2 |
72,053,461 (GRCm39) |
missense |
probably benign |
|
|
R7868:Rapgef4
|
UTSW |
2 |
72,031,481 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8210:Rapgef4
|
UTSW |
2 |
72,056,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8967:Rapgef4
|
UTSW |
2 |
72,056,854 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9113:Rapgef4
|
UTSW |
2 |
71,861,493 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9157:Rapgef4
|
UTSW |
2 |
72,005,212 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9314:Rapgef4
|
UTSW |
2 |
72,064,983 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9552:Rapgef4
|
UTSW |
2 |
72,008,561 (GRCm39) |
missense |
probably benign |
|
|
R9578:Rapgef4
|
UTSW |
2 |
72,026,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9620:Rapgef4
|
UTSW |
2 |
72,036,051 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9665:Rapgef4
|
UTSW |
2 |
72,036,018 (GRCm39) |
missense |
probably benign |
0.17 |
|
X0062:Rapgef4
|
UTSW |
2 |
72,056,951 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCTCAGGTAAAGTGATTTGGAAAG -3'
(R):5'- AGACGGAGCCAATTTGAACC -3'
Sequencing Primer
(F):5'- GTGATTTGGAAAGTTAAACACCTAAC -3'
(R):5'- CGGAGCCAATTTGAACCAAATGTTTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation