Incidental Mutation 'R2025:Dido1'
| ID |
220386 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
040034-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R2025 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 180330974 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 158
(L158*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087517]
[ENSMUST00000103055]
[ENSMUST00000103056]
[ENSMUST00000103057]
[ENSMUST00000130986]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087517
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000103054
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103055
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099344
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103056
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000103057
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000130986
AA Change: L158*
|
| SMART Domains |
Protein: ENSMUSP00000119689
Gene: ENSMUSG00000038914
AA Change: L158*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9712 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
C |
14: 118,790,737 (GRCm39) |
M757V |
probably benign |
Het |
| Abitram |
T |
A |
4: 56,805,916 (GRCm39) |
I138N |
probably damaging |
Het |
| Acan |
T |
G |
7: 78,750,970 (GRCm39) |
S1914A |
probably benign |
Het |
| Axin2 |
T |
A |
11: 108,833,904 (GRCm39) |
V617D |
probably damaging |
Het |
| Bhlhe22 |
A |
G |
3: 18,109,975 (GRCm39) |
S342G |
probably benign |
Het |
| Cald1 |
AAGAGAGAGAGAGAG |
AAGAGAGAGAGAG |
6: 34,723,108 (GRCm39) |
|
probably null |
Het |
| Ccdc34 |
A |
G |
2: 109,862,731 (GRCm39) |
K179E |
possibly damaging |
Het |
| Clasp1 |
A |
G |
1: 118,432,629 (GRCm39) |
T208A |
probably damaging |
Het |
| Crabp1 |
C |
T |
9: 54,675,752 (GRCm39) |
R112* |
probably null |
Het |
| Cstdc1 |
T |
C |
2: 148,624,148 (GRCm39) |
F41L |
probably damaging |
Het |
| D130040H23Rik |
A |
G |
8: 69,755,525 (GRCm39) |
N310S |
probably benign |
Het |
| Dalrd3 |
T |
C |
9: 108,448,284 (GRCm39) |
I278T |
probably benign |
Het |
| Dbp |
C |
A |
7: 45,357,700 (GRCm39) |
D89E |
probably benign |
Het |
| Dennd2c |
A |
G |
3: 103,039,005 (GRCm39) |
D51G |
possibly damaging |
Het |
| Disp1 |
G |
T |
1: 182,869,767 (GRCm39) |
F884L |
probably damaging |
Het |
| Dmrtb1 |
T |
C |
4: 107,540,782 (GRCm39) |
D193G |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,950,133 (GRCm39) |
D1984G |
probably damaging |
Het |
| Dpf2 |
T |
C |
19: 5,952,781 (GRCm39) |
Y218C |
possibly damaging |
Het |
| Dsg4 |
C |
T |
18: 20,599,693 (GRCm39) |
Q770* |
probably null |
Het |
| Efemp1 |
A |
T |
11: 28,864,696 (GRCm39) |
Y250F |
possibly damaging |
Het |
| Erbin |
A |
T |
13: 103,966,703 (GRCm39) |
I1249N |
probably benign |
Het |
| F5 |
A |
G |
1: 164,037,044 (GRCm39) |
K1928E |
probably benign |
Het |
| Fhip1b |
A |
G |
7: 105,038,143 (GRCm39) |
V260A |
probably damaging |
Het |
| Gdf11 |
T |
A |
10: 128,727,314 (GRCm39) |
I81F |
probably damaging |
Het |
| Gm10518 |
T |
A |
1: 179,631,483 (GRCm39) |
|
probably benign |
Het |
| Grb10 |
G |
C |
11: 11,920,576 (GRCm39) |
S14* |
probably null |
Het |
| Greb1l |
A |
T |
18: 10,515,221 (GRCm39) |
Y562F |
possibly damaging |
Het |
| Gtf2ird1 |
T |
C |
5: 134,392,788 (GRCm39) |
E789G |
probably damaging |
Het |
| Hook3 |
T |
C |
8: 26,528,126 (GRCm39) |
E588G |
probably damaging |
Het |
| Hpx |
A |
G |
7: 105,244,311 (GRCm39) |
S266P |
probably damaging |
Het |
| Hs6st3 |
A |
G |
14: 120,106,801 (GRCm39) |
D403G |
probably damaging |
Het |
| Igf2bp1 |
A |
G |
11: 95,864,996 (GRCm39) |
V151A |
possibly damaging |
Het |
| Itga11 |
C |
T |
9: 62,670,093 (GRCm39) |
T739I |
probably damaging |
Het |
| Kalrn |
T |
C |
16: 34,010,106 (GRCm39) |
I702V |
probably damaging |
Het |
| Kif2b |
C |
T |
11: 91,468,172 (GRCm39) |
S37N |
probably damaging |
Het |
| Kng2 |
T |
A |
16: 22,819,325 (GRCm39) |
D237V |
probably benign |
Het |
| Krtap27-1 |
C |
A |
16: 88,468,173 (GRCm39) |
V124L |
possibly damaging |
Het |
| Lig4 |
A |
T |
8: 10,022,436 (GRCm39) |
L448Q |
probably damaging |
Het |
| Macf1 |
C |
T |
4: 123,265,711 (GRCm39) |
A4821T |
probably damaging |
Het |
| Msh5 |
T |
A |
17: 35,251,768 (GRCm39) |
I431F |
possibly damaging |
Het |
| Ndufa10 |
A |
G |
1: 92,367,614 (GRCm39) |
Y339H |
probably damaging |
Het |
| Nin |
T |
A |
12: 70,076,782 (GRCm39) |
Q1091L |
probably damaging |
Het |
| Nom1 |
A |
C |
5: 29,651,849 (GRCm39) |
D729A |
probably damaging |
Het |
| Or52e8 |
C |
A |
7: 104,624,451 (GRCm39) |
G247V |
probably benign |
Het |
| P2ry14 |
A |
T |
3: 59,022,866 (GRCm39) |
V207E |
probably damaging |
Het |
| Pdss2 |
A |
T |
10: 43,269,871 (GRCm39) |
N238I |
possibly damaging |
Het |
| Pkn1 |
A |
G |
8: 84,398,007 (GRCm39) |
V795A |
probably damaging |
Het |
| Pla2g6 |
A |
C |
15: 79,170,964 (GRCm39) |
L804R |
probably damaging |
Het |
| Poglut1 |
A |
T |
16: 38,358,267 (GRCm39) |
|
probably null |
Het |
| Prkcz |
A |
T |
4: 155,374,167 (GRCm39) |
V83D |
probably damaging |
Het |
| Prss50 |
T |
C |
9: 110,690,328 (GRCm39) |
F157S |
probably benign |
Het |
| Psors1c2 |
A |
G |
17: 35,845,099 (GRCm39) |
|
probably benign |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
| Rab7 |
G |
A |
6: 87,981,161 (GRCm39) |
L174F |
probably damaging |
Het |
| Rapgef4 |
A |
G |
2: 72,073,083 (GRCm39) |
T790A |
probably benign |
Het |
| Rb1cc1 |
G |
T |
1: 6,315,533 (GRCm39) |
V503L |
probably damaging |
Het |
| Sbf1 |
T |
A |
15: 89,186,933 (GRCm39) |
E815V |
probably damaging |
Het |
| Setd3 |
T |
A |
12: 108,126,526 (GRCm39) |
E104V |
probably damaging |
Het |
| Slc39a5 |
A |
T |
10: 128,234,279 (GRCm39) |
L208Q |
probably damaging |
Het |
| Slc39a5 |
G |
T |
10: 128,234,280 (GRCm39) |
L208M |
probably damaging |
Het |
| Slc3a1 |
T |
G |
17: 85,340,273 (GRCm39) |
Y232D |
probably damaging |
Het |
| Slc8a1 |
T |
A |
17: 81,956,541 (GRCm39) |
S166C |
probably damaging |
Het |
| Stard9 |
T |
A |
2: 120,532,879 (GRCm39) |
D3045E |
probably benign |
Het |
| Stk4 |
C |
A |
2: 163,938,751 (GRCm39) |
D206E |
probably damaging |
Het |
| Syn3 |
T |
C |
10: 86,302,846 (GRCm39) |
D103G |
probably damaging |
Het |
| Tbc1d30 |
T |
A |
10: 121,115,051 (GRCm39) |
Y369F |
probably benign |
Het |
| Tenm2 |
G |
T |
11: 35,938,091 (GRCm39) |
Y1527* |
probably null |
Het |
| Tfg |
T |
C |
16: 56,525,988 (GRCm39) |
K85R |
possibly damaging |
Het |
| Timp3 |
T |
C |
10: 86,136,749 (GRCm39) |
L11P |
probably damaging |
Het |
| Tmem144 |
A |
T |
3: 79,735,018 (GRCm39) |
|
probably null |
Het |
| Tmtc4 |
T |
C |
14: 123,158,677 (GRCm39) |
N682S |
probably benign |
Het |
| Tnks2 |
C |
T |
19: 36,843,466 (GRCm39) |
L464F |
probably damaging |
Het |
| Trank1 |
T |
C |
9: 111,221,107 (GRCm39) |
F2615L |
probably benign |
Het |
| Trio |
T |
C |
15: 27,744,223 (GRCm39) |
K2570E |
probably damaging |
Het |
| Trio |
T |
A |
15: 27,774,013 (GRCm39) |
D673V |
probably damaging |
Het |
| Ublcp1 |
A |
T |
11: 44,356,458 (GRCm39) |
C87S |
probably benign |
Het |
| Unc13a |
C |
T |
8: 72,092,412 (GRCm39) |
E1386K |
possibly damaging |
Het |
| Wdr41 |
C |
T |
13: 95,155,456 (GRCm39) |
H404Y |
probably damaging |
Het |
| Zfp280b |
T |
C |
10: 75,874,328 (GRCm39) |
L69S |
probably damaging |
Het |
| Zfp346 |
T |
C |
13: 55,280,121 (GRCm39) |
S282P |
probably damaging |
Het |
| Zfp579 |
C |
A |
7: 4,996,520 (GRCm39) |
E464* |
probably null |
Het |
| Zfp78 |
T |
A |
7: 6,378,513 (GRCm39) |
|
probably null |
Het |
| Zswim9 |
T |
C |
7: 13,003,292 (GRCm39) |
E186G |
probably damaging |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCATCTGTCTCTGACTGGGAC -3'
(R):5'- TGAGCCCACATCTTCCACAG -3'
Sequencing Primer
(F):5'- TCTCTGACTGGGACACTGGTC -3'
(R):5'- TTCCACAGTCACTGATGTGGAGAC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation