Incidental Mutation 'R2027:Or5m13'
ID 220742
Institutional Source Beutler Lab
Gene Symbol Or5m13
Ensembl Gene ENSMUSG00000058884
Gene Name olfactory receptor family 5 subfamily M member 13
Synonyms MOR196-5P, GA_x6K02T2Q125-47397266-47398205, Olfr1025, MOR196-6_p
MMRRC Submission 040035-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R2027 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85748271-85749097 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 85749114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 282 (S282R)
Ref Sequence ENSEMBL: ENSMUSP00000149785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056718] [ENSMUST00000188749] [ENSMUST00000213474] [ENSMUST00000217615] [ENSMUST00000219615]
AlphaFold A0A140T8K3
Predicted Effect probably benign
Transcript: ENSMUST00000056718
SMART Domains Protein: ENSMUSP00000049887
Gene: ENSMUSG00000042863

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-58 PFAM
Pfam:7tm_1 41 290 9e-25 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000076311
Gene: ENSMUSG00000058884
AA Change: S282R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-57 PFAM
Pfam:7tm_1 41 290 2.6e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000188749
AA Change: S282R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000139860
Gene: ENSMUSG00000058884
AA Change: S282R

DomainStartEndE-ValueType
low complexity region 26 40 N/A INTRINSIC
Pfam:7tm_1 41 290 5.7e-30 PFAM
Pfam:7tm_4 139 283 7.8e-48 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213474
AA Change: S282R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000217615
Predicted Effect probably benign
Transcript: ENSMUST00000219615
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt T C 9: 99,502,254 (GRCm39) V138A possibly damaging Het
Aatk A G 11: 119,900,143 (GRCm39) S1291P probably damaging Het
Adgrv1 C T 13: 81,743,301 (GRCm39) V67M probably damaging Het
Apoa4 G A 9: 46,154,298 (GRCm39) V300M probably damaging Het
Bcl2a1d A T 9: 88,613,438 (GRCm39) V112E possibly damaging Het
Bltp1 T A 3: 37,102,110 (GRCm39) probably benign Het
Cabp2 T A 19: 4,137,126 (GRCm39) M166K probably damaging Het
Camsap1 A G 2: 25,828,538 (GRCm39) V1062A possibly damaging Het
Cap1 T G 4: 122,756,686 (GRCm39) probably benign Het
Caprin2 A G 6: 148,779,385 (GRCm39) Y141H probably damaging Het
Card11 T C 5: 140,892,522 (GRCm39) Y181C probably damaging Het
Ccdc107 T C 4: 43,495,874 (GRCm39) V259A probably benign Het
Ccn4 A G 15: 66,789,258 (GRCm39) E248G possibly damaging Het
Chd9 A G 8: 91,634,619 (GRCm39) probably benign Het
Cibar1 T A 4: 12,171,216 (GRCm39) D79V probably damaging Het
Col12a1 T C 9: 79,553,075 (GRCm39) probably null Het
Cuzd1 T C 7: 130,921,820 (GRCm39) T61A possibly damaging Het
Dbp C A 7: 45,357,700 (GRCm39) D89E probably benign Het
Dhps A T 8: 85,799,240 (GRCm39) N140Y probably damaging Het
Dido1 A T 2: 180,330,974 (GRCm39) L158* probably null Het
Dnah9 T G 11: 65,846,164 (GRCm39) N2958T probably benign Het
Dpp8 T A 9: 64,986,056 (GRCm39) Y849N probably damaging Het
Dsg2 A G 18: 20,716,061 (GRCm39) probably benign Het
Efemp1 A T 11: 28,864,696 (GRCm39) Y250F possibly damaging Het
Faxc T C 4: 21,958,439 (GRCm39) probably benign Het
Frem3 G T 8: 81,421,966 (GRCm39) C2122F possibly damaging Het
Gan T C 8: 117,914,238 (GRCm39) probably null Het
Gnl1 A G 17: 36,293,850 (GRCm39) N274D probably benign Het
Hook3 T C 8: 26,528,126 (GRCm39) E588G probably damaging Het
Itpr1 C A 6: 108,363,814 (GRCm39) S812Y possibly damaging Het
Kbtbd3 C T 9: 4,317,075 (GRCm39) probably benign Het
Macf1 C T 4: 123,265,711 (GRCm39) A4821T probably damaging Het
Mepe T C 5: 104,474,957 (GRCm39) S13P possibly damaging Het
Msantd5f6 A G 4: 73,321,295 (GRCm39) I154T possibly damaging Het
Myh11 A G 16: 14,050,532 (GRCm39) Y478H probably damaging Het
Myo7b A G 18: 32,118,013 (GRCm39) V871A probably benign Het
Nckap1 A T 2: 80,365,862 (GRCm39) M466K probably damaging Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or4k6 A G 14: 50,475,406 (GRCm39) I312T probably benign Het
Or52r1b A T 7: 102,690,731 (GRCm39) H15L probably benign Het
Or5aq1b T A 2: 86,901,897 (GRCm39) N194Y possibly damaging Het
Or9k2 A G 10: 129,998,604 (GRCm39) I197T probably benign Het
Or9s23 A T 1: 92,501,489 (GRCm39) T199S probably damaging Het
Otof T C 5: 30,578,358 (GRCm39) T97A probably benign Het
Peli2 G A 14: 48,493,602 (GRCm39) E275K probably benign Het
Pik3c2a T C 7: 115,950,057 (GRCm39) Y1320C probably damaging Het
Pkn1 A G 8: 84,398,007 (GRCm39) V795A probably damaging Het
Pramel5 A G 4: 143,998,274 (GRCm39) L323P probably damaging Het
Prr5 A T 15: 84,585,580 (GRCm39) R183W probably damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rabgef1 A G 5: 130,237,620 (GRCm39) D231G possibly damaging Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rc3h1 C T 1: 160,782,507 (GRCm39) P662L probably benign Het
Rpl7a-ps5 G T 17: 58,146,090 (GRCm39) Q47K probably benign Het
Sclt1 G A 3: 41,685,323 (GRCm39) T45I probably benign Het
Slc22a17 A G 14: 55,145,543 (GRCm39) I202T probably damaging Het
Slc25a13 A G 6: 6,073,487 (GRCm39) L457S probably damaging Het
Slc44a3 T C 3: 121,257,059 (GRCm39) probably benign Het
Slc7a9 G A 7: 35,153,562 (GRCm39) V188M probably damaging Het
Spata31d1e A G 13: 59,890,401 (GRCm39) M55T possibly damaging Het
Tmem161a T A 8: 70,630,170 (GRCm39) F119I probably damaging Het
Tmem240 A G 4: 155,819,892 (GRCm39) D32G possibly damaging Het
Tmtc4 T C 14: 123,158,677 (GRCm39) N682S probably benign Het
Uqcrc1 G A 9: 108,776,083 (GRCm39) V262M probably benign Het
Vmn1r87 G A 7: 12,865,823 (GRCm39) R155C probably damaging Het
Vmn2r100 A T 17: 19,742,334 (GRCm39) Q236L probably benign Het
Vmn2r97 T A 17: 19,149,944 (GRCm39) I444N unknown Het
Yif1a A T 19: 5,139,900 (GRCm39) H115L probably damaging Het
Zfp280b T C 10: 75,874,328 (GRCm39) L69S probably damaging Het
Zfp579 C A 7: 4,996,520 (GRCm39) E464* probably null Het
Other mutations in Or5m13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Or5m13 APN 2 85,748,908 (GRCm39) missense probably benign 0.25
IGL02881:Or5m13 APN 2 85,748,460 (GRCm39) missense probably benign 0.00
R0097:Or5m13 UTSW 2 85,749,184 (GRCm39) missense probably benign 0.00
R0097:Or5m13 UTSW 2 85,749,184 (GRCm39) missense probably benign 0.00
R0324:Or5m13 UTSW 2 85,748,295 (GRCm39) missense probably benign 0.22
R0392:Or5m13 UTSW 2 85,749,106 (GRCm39) missense possibly damaging 0.81
R0765:Or5m13 UTSW 2 85,749,049 (GRCm39) missense probably damaging 0.99
R1199:Or5m13 UTSW 2 85,748,379 (GRCm39) missense probably benign 0.00
R1894:Or5m13 UTSW 2 85,748,599 (GRCm39) missense probably benign 0.28
R2141:Or5m13 UTSW 2 85,749,171 (GRCm39) missense probably null
R3871:Or5m13 UTSW 2 85,748,926 (GRCm39) splice site probably null
R4837:Or5m13 UTSW 2 85,748,748 (GRCm39) missense probably benign 0.00
R4945:Or5m13 UTSW 2 85,748,917 (GRCm39) missense possibly damaging 0.81
R5056:Or5m13 UTSW 2 85,748,480 (GRCm39) missense probably damaging 1.00
R5441:Or5m13 UTSW 2 85,748,934 (GRCm39) missense probably benign 0.01
R5960:Or5m13 UTSW 2 85,749,069 (GRCm39) missense probably benign 0.07
R6807:Or5m13 UTSW 2 85,748,382 (GRCm39) missense possibly damaging 0.48
R7320:Or5m13 UTSW 2 85,748,718 (GRCm39) missense probably benign 0.00
R8523:Or5m13 UTSW 2 85,748,407 (GRCm39) missense probably damaging 0.97
R8715:Or5m13 UTSW 2 85,748,273 (GRCm39) start codon destroyed probably null 0.81
R8734:Or5m13 UTSW 2 85,748,993 (GRCm39) nonsense probably null
R9275:Or5m13 UTSW 2 85,749,046 (GRCm39) missense probably benign 0.17
R9427:Or5m13 UTSW 2 85,748,704 (GRCm39) missense probably benign 0.00
R9728:Or5m13 UTSW 2 85,748,887 (GRCm39) missense possibly damaging 0.72
V1662:Or5m13 UTSW 2 85,748,938 (GRCm39) missense probably benign 0.10
Z1176:Or5m13 UTSW 2 85,748,845 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCGAATCCGTTCTGCAGAAG -3'
(R):5'- GCAATATGTCTGTGCAGCTTTAG -3'

Sequencing Primer
(F):5'- CGTTCTGCAGAAGGGAGGC -3'
(R):5'- ATGTCTGTGCAGCTTTAGAATTC -3'
Posted On 2014-08-25