Incidental Mutation 'R1971:Adgrb3'
| ID |
220768 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb3
|
| Ensembl Gene |
ENSMUSG00000033569 |
| Gene Name |
adhesion G protein-coupled receptor B3 |
| Synonyms |
Bai3, A830096D10Rik |
| MMRRC Submission |
039984-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.350)
|
| Stock # |
R1971 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
25106557-25868788 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 25586525 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 389
(H389Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116231
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041838]
[ENSMUST00000135518]
[ENSMUST00000146592]
[ENSMUST00000151309]
|
| AlphaFold |
Q80ZF8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041838
AA Change: H389Q
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000035612
Gene: ENSMUSG00000033569
AA Change: H389Q
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135518
AA Change: H389Q
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000119804
Gene: ENSMUSG00000033569
AA Change: H389Q
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146592
AA Change: H182Q
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000116759
Gene: ENSMUSG00000033569
AA Change: H182Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
TSP1
|
87 |
136 |
2.1e-12 |
SMART |
|
TSP1
|
141 |
191 |
7.97e-13 |
SMART |
|
TSP1
|
196 |
246 |
6.28e-11 |
SMART |
|
TSP1
|
251 |
301 |
1.48e-7 |
SMART |
|
HormR
|
303 |
369 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
379 |
603 |
2.5e-52 |
PFAM |
|
GPS
|
608 |
661 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
667 |
903 |
5.4e-66 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151309
AA Change: H389Q
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000116231
Gene: ENSMUSG00000033569
AA Change: H389Q
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:GAIN
|
589 |
794 |
1.1e-44 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
875 |
1143 |
2.7e-63 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189254
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
99% (115/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
A |
T |
2: 30,686,566 (GRCm39) |
I242N |
probably benign |
Het |
| 2510009E07Rik |
G |
T |
16: 21,472,048 (GRCm39) |
Y217* |
probably null |
Het |
| 4931429L15Rik |
C |
T |
9: 46,220,086 (GRCm39) |
V149M |
probably benign |
Het |
| Abcg8 |
G |
T |
17: 85,002,587 (GRCm39) |
|
probably benign |
Het |
| Acox1 |
A |
G |
11: 116,089,087 (GRCm39) |
F77S |
probably benign |
Het |
| Ak7 |
A |
G |
12: 105,692,504 (GRCm39) |
N186S |
probably damaging |
Het |
| Apobr |
A |
G |
7: 126,185,397 (GRCm39) |
T303A |
probably benign |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Bcl9l |
T |
C |
9: 44,419,996 (GRCm39) |
|
probably null |
Het |
| Bco2 |
T |
C |
9: 50,457,284 (GRCm39) |
D86G |
probably damaging |
Het |
| Bmpr1b |
T |
A |
3: 141,563,333 (GRCm39) |
I204F |
probably damaging |
Het |
| Bpifb5 |
C |
A |
2: 154,072,264 (GRCm39) |
Q324K |
probably benign |
Het |
| Cacna2d2 |
G |
A |
9: 107,389,205 (GRCm39) |
V223I |
probably damaging |
Het |
| Capn3 |
A |
G |
2: 120,311,228 (GRCm39) |
D105G |
possibly damaging |
Het |
| Ccdc40 |
G |
T |
11: 119,153,901 (GRCm39) |
|
probably null |
Het |
| Ccdc83 |
T |
A |
7: 89,893,362 (GRCm39) |
S132C |
probably damaging |
Het |
| Ckap2l |
A |
G |
2: 129,127,342 (GRCm39) |
S279P |
possibly damaging |
Het |
| Cldn12 |
C |
A |
5: 5,558,137 (GRCm39) |
A97S |
probably benign |
Het |
| Clec2l |
T |
G |
6: 38,640,309 (GRCm39) |
S47A |
probably benign |
Het |
| Csnk1d |
C |
A |
11: 120,863,274 (GRCm39) |
R222M |
possibly damaging |
Het |
| Ctnna1 |
T |
A |
18: 35,287,580 (GRCm39) |
D96E |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,145,078 (GRCm39) |
D1316G |
probably damaging |
Het |
| Ddx4 |
C |
T |
13: 112,736,547 (GRCm39) |
V608I |
probably damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,198,989 (GRCm39) |
E48G |
probably benign |
Het |
| Dnah17 |
G |
C |
11: 117,995,361 (GRCm39) |
Q996E |
probably benign |
Het |
| Dnah9 |
G |
C |
11: 65,739,197 (GRCm39) |
N4180K |
probably damaging |
Het |
| Dpf3 |
T |
A |
12: 83,371,809 (GRCm39) |
|
probably null |
Het |
| Drd2 |
T |
C |
9: 49,318,359 (GRCm39) |
F434L |
probably damaging |
Het |
| En1 |
A |
G |
1: 120,534,742 (GRCm39) |
T344A |
unknown |
Het |
| Eri3 |
A |
G |
4: 117,421,964 (GRCm39) |
T81A |
probably benign |
Het |
| Fam20a |
T |
C |
11: 109,576,237 (GRCm39) |
Y174C |
probably damaging |
Het |
| Fam234a |
G |
C |
17: 26,435,629 (GRCm39) |
|
probably null |
Het |
| Fam76a |
A |
T |
4: 132,631,294 (GRCm39) |
I217N |
probably damaging |
Het |
| Fancm |
T |
A |
12: 65,148,466 (GRCm39) |
S694T |
probably benign |
Het |
| Fcgbpl1 |
C |
A |
7: 27,830,937 (GRCm39) |
A50E |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,073,258 (GRCm39) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Gm136 |
T |
G |
4: 34,755,986 (GRCm39) |
D9A |
probably benign |
Het |
| Gstt2 |
G |
T |
10: 75,668,499 (GRCm39) |
T116N |
probably benign |
Het |
| Hs3st6 |
A |
G |
17: 24,972,267 (GRCm39) |
T70A |
probably benign |
Het |
| Hspa14 |
A |
G |
2: 3,490,804 (GRCm39) |
V461A |
possibly damaging |
Het |
| Itih5 |
A |
T |
2: 10,243,379 (GRCm39) |
D372V |
probably damaging |
Het |
| Kcna2 |
A |
T |
3: 107,012,140 (GRCm39) |
R240S |
probably damaging |
Het |
| Kctd18 |
T |
C |
1: 58,006,779 (GRCm39) |
I24V |
probably benign |
Het |
| Lap3 |
T |
C |
5: 45,663,508 (GRCm39) |
|
probably benign |
Het |
| Lcp1 |
T |
C |
14: 75,437,946 (GRCm39) |
S119P |
probably damaging |
Het |
| Lig3 |
G |
C |
11: 82,686,544 (GRCm39) |
D642H |
probably benign |
Het |
| Lpin1 |
A |
T |
12: 16,630,724 (GRCm39) |
L58H |
probably damaging |
Het |
| Map4k5 |
G |
T |
12: 69,873,102 (GRCm39) |
P468Q |
possibly damaging |
Het |
| Med31 |
G |
A |
11: 72,106,244 (GRCm39) |
|
probably benign |
Het |
| Mki67 |
A |
T |
7: 135,315,688 (GRCm39) |
|
probably null |
Het |
| Mrc1 |
G |
A |
2: 14,249,103 (GRCm39) |
|
probably null |
Het |
| Msh3 |
A |
G |
13: 92,359,784 (GRCm39) |
I16T |
probably damaging |
Het |
| Msh3 |
T |
A |
13: 92,386,328 (GRCm39) |
|
probably benign |
Het |
| Mst1r |
A |
T |
9: 107,790,411 (GRCm39) |
I675F |
probably benign |
Het |
| Myb |
A |
C |
10: 21,016,555 (GRCm39) |
S652A |
probably benign |
Het |
| Myh2 |
G |
T |
11: 67,080,004 (GRCm39) |
S1099I |
possibly damaging |
Het |
| Myl6b |
A |
G |
10: 128,330,512 (GRCm39) |
V181A |
probably damaging |
Het |
| Myt1l |
A |
T |
12: 29,877,091 (GRCm39) |
K247N |
unknown |
Het |
| Nanos2 |
G |
T |
7: 18,721,629 (GRCm39) |
V34L |
probably benign |
Het |
| Nav1 |
T |
C |
1: 135,460,091 (GRCm39) |
T411A |
probably benign |
Het |
| Nedd9 |
T |
A |
13: 41,492,424 (GRCm39) |
I23F |
probably damaging |
Het |
| Nes |
G |
A |
3: 87,885,634 (GRCm39) |
V1254I |
possibly damaging |
Het |
| Nol6 |
A |
G |
4: 41,119,542 (GRCm39) |
F588S |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 101,658,529 (GRCm39) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 165,210,210 (GRCm39) |
Y205C |
probably benign |
Het |
| Olr1 |
T |
C |
6: 129,470,498 (GRCm39) |
E223G |
probably benign |
Het |
| Or1e30 |
T |
A |
11: 73,678,616 (GRCm39) |
M284K |
probably damaging |
Het |
| Or2ag12 |
T |
A |
7: 106,276,877 (GRCm39) |
N272I |
probably damaging |
Het |
| Or4c118 |
A |
T |
2: 88,975,078 (GRCm39) |
C96* |
probably null |
Het |
| Or51k2 |
A |
T |
7: 103,596,150 (GRCm39) |
I126F |
probably damaging |
Het |
| Or51l4 |
C |
T |
7: 103,404,527 (GRCm39) |
W88* |
probably null |
Het |
| Pate6 |
T |
A |
9: 35,700,309 (GRCm39) |
H92L |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,763,487 (GRCm39) |
T3987A |
unknown |
Het |
| Pik3cg |
A |
T |
12: 32,242,152 (GRCm39) |
V986D |
probably damaging |
Het |
| Pitpnm1 |
T |
A |
19: 4,162,450 (GRCm39) |
D1093E |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,793,651 (GRCm39) |
D571G |
probably benign |
Het |
| Rfx1 |
A |
G |
8: 84,822,126 (GRCm39) |
E875G |
probably damaging |
Het |
| Rnf145 |
T |
A |
11: 44,439,642 (GRCm39) |
I146N |
probably damaging |
Het |
| Rttn |
G |
A |
18: 89,108,557 (GRCm39) |
R1587H |
probably benign |
Het |
| Safb |
A |
G |
17: 56,912,821 (GRCm39) |
H883R |
probably benign |
Het |
| Sdhb |
A |
G |
4: 140,700,260 (GRCm39) |
D120G |
possibly damaging |
Het |
| Serpine3 |
A |
G |
14: 62,902,533 (GRCm39) |
N48S |
probably damaging |
Het |
| Sgms1 |
T |
A |
19: 32,137,357 (GRCm39) |
I70L |
probably benign |
Het |
| Slc1a7 |
G |
T |
4: 107,825,782 (GRCm39) |
D14Y |
probably benign |
Het |
| Smtnl2 |
C |
T |
11: 72,302,183 (GRCm39) |
A93T |
probably benign |
Het |
| Srpra |
T |
C |
9: 35,124,834 (GRCm39) |
|
probably null |
Het |
| Taf6l |
A |
G |
19: 8,752,866 (GRCm39) |
|
probably null |
Het |
| Tbc1d10b |
A |
T |
7: 126,807,036 (GRCm39) |
V167E |
probably benign |
Het |
| Tbc1d9 |
G |
A |
8: 83,976,139 (GRCm39) |
R566H |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,689,348 (GRCm39) |
Y2080H |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,402,431 (GRCm39) |
N506S |
probably damaging |
Het |
| Thada |
G |
T |
17: 84,617,470 (GRCm39) |
P1349T |
probably damaging |
Het |
| Tjp1 |
G |
T |
7: 64,973,826 (GRCm39) |
T476K |
probably damaging |
Het |
| Tlr11 |
A |
T |
14: 50,598,691 (GRCm39) |
T226S |
probably benign |
Het |
| Tmem131 |
G |
A |
1: 36,843,680 (GRCm39) |
Q1394* |
probably null |
Het |
| Tmem161a |
C |
T |
8: 70,629,559 (GRCm39) |
R58W |
probably damaging |
Het |
| Tmem219 |
T |
C |
7: 126,496,422 (GRCm39) |
S13G |
probably benign |
Het |
| Trp53bp1 |
T |
C |
2: 121,035,517 (GRCm39) |
Y47C |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,731,922 (GRCm39) |
|
probably benign |
Het |
| Ush1g |
A |
G |
11: 115,209,280 (GRCm39) |
S305P |
probably damaging |
Het |
| Usp37 |
A |
T |
1: 74,479,127 (GRCm39) |
Y948* |
probably null |
Het |
| Vav1 |
A |
T |
17: 57,634,697 (GRCm39) |
Y805F |
probably damaging |
Het |
| Vmn1r59 |
A |
T |
7: 5,457,038 (GRCm39) |
Y241N |
probably damaging |
Het |
| Vmn2r2 |
T |
A |
3: 64,034,121 (GRCm39) |
Y467F |
probably damaging |
Het |
| Vps35l |
A |
C |
7: 118,374,557 (GRCm39) |
R352S |
probably damaging |
Het |
| Vps54 |
C |
A |
11: 21,242,051 (GRCm39) |
L389I |
probably damaging |
Het |
| Vwa8 |
G |
T |
14: 79,162,694 (GRCm39) |
|
probably benign |
Het |
| Wdr19 |
G |
T |
5: 65,398,503 (GRCm39) |
|
probably benign |
Het |
| Wnt2b |
A |
T |
3: 104,861,933 (GRCm39) |
|
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,342,039 (GRCm39) |
R1427G |
possibly damaging |
Het |
| Ylpm1 |
T |
C |
12: 85,087,560 (GRCm39) |
S1115P |
probably damaging |
Het |
| Zfp946 |
T |
A |
17: 22,674,406 (GRCm39) |
C387S |
probably damaging |
Het |
|
| Other mutations in Adgrb3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00164:Adgrb3
|
APN |
1 |
25,267,581 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00507:Adgrb3
|
APN |
1 |
25,113,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00828:Adgrb3
|
APN |
1 |
25,527,200 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01285:Adgrb3
|
APN |
1 |
25,132,868 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL01309:Adgrb3
|
APN |
1 |
25,151,352 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01540:Adgrb3
|
APN |
1 |
25,151,252 (GRCm39) |
splice site |
probably null |
|
|
IGL01608:Adgrb3
|
APN |
1 |
25,592,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01638:Adgrb3
|
APN |
1 |
25,598,832 (GRCm39) |
splice site |
probably benign |
|
|
IGL01657:Adgrb3
|
APN |
1 |
25,865,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01666:Adgrb3
|
APN |
1 |
25,499,832 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01712:Adgrb3
|
APN |
1 |
25,865,360 (GRCm39) |
missense |
probably benign |
|
|
IGL01767:Adgrb3
|
APN |
1 |
25,598,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01987:Adgrb3
|
APN |
1 |
25,140,512 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02201:Adgrb3
|
APN |
1 |
25,459,631 (GRCm39) |
splice site |
probably benign |
|
|
IGL02584:Adgrb3
|
APN |
1 |
25,544,065 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02685:Adgrb3
|
APN |
1 |
25,123,323 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02886:Adgrb3
|
APN |
1 |
25,543,991 (GRCm39) |
splice site |
probably null |
|
|
IGL02929:Adgrb3
|
APN |
1 |
25,592,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03153:Adgrb3
|
APN |
1 |
25,570,978 (GRCm39) |
nonsense |
probably null |
|
|
IGL03165:Adgrb3
|
APN |
1 |
25,133,475 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03227:Adgrb3
|
APN |
1 |
25,586,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03392:Adgrb3
|
APN |
1 |
25,543,529 (GRCm39) |
missense |
probably damaging |
0.99 |
|
schwach
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0007:Adgrb3
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0322:Adgrb3
|
UTSW |
1 |
25,260,829 (GRCm39) |
splice site |
probably benign |
|
|
R0442:Adgrb3
|
UTSW |
1 |
25,435,551 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0563:Adgrb3
|
UTSW |
1 |
25,586,635 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1168:Adgrb3
|
UTSW |
1 |
25,865,280 (GRCm39) |
missense |
probably benign |
|
|
R1252:Adgrb3
|
UTSW |
1 |
25,167,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Adgrb3
|
UTSW |
1 |
25,598,931 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1543:Adgrb3
|
UTSW |
1 |
25,527,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1577:Adgrb3
|
UTSW |
1 |
25,133,264 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1581:Adgrb3
|
UTSW |
1 |
25,133,153 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1583:Adgrb3
|
UTSW |
1 |
25,265,912 (GRCm39) |
splice site |
probably null |
|
|
R1653:Adgrb3
|
UTSW |
1 |
25,140,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1725:Adgrb3
|
UTSW |
1 |
25,865,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Adgrb3
|
UTSW |
1 |
25,267,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Adgrb3
|
UTSW |
1 |
25,571,658 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1838:Adgrb3
|
UTSW |
1 |
25,123,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Adgrb3
|
UTSW |
1 |
25,865,519 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2005:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2134:Adgrb3
|
UTSW |
1 |
25,133,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2142:Adgrb3
|
UTSW |
1 |
25,107,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Adgrb3
|
UTSW |
1 |
25,150,898 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3740:Adgrb3
|
UTSW |
1 |
25,865,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3877:Adgrb3
|
UTSW |
1 |
25,150,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4120:Adgrb3
|
UTSW |
1 |
25,133,388 (GRCm39) |
nonsense |
probably null |
|
|
R4344:Adgrb3
|
UTSW |
1 |
25,865,829 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4363:Adgrb3
|
UTSW |
1 |
25,151,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Adgrb3
|
UTSW |
1 |
25,870,108 (GRCm39) |
unclassified |
probably benign |
|
|
R4465:Adgrb3
|
UTSW |
1 |
25,133,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Adgrb3
|
UTSW |
1 |
25,150,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4554:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Adgrb3
|
UTSW |
1 |
25,865,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4713:Adgrb3
|
UTSW |
1 |
25,586,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4772:Adgrb3
|
UTSW |
1 |
25,570,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4890:Adgrb3
|
UTSW |
1 |
25,260,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5045:Adgrb3
|
UTSW |
1 |
25,113,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5061:Adgrb3
|
UTSW |
1 |
25,107,209 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5097:Adgrb3
|
UTSW |
1 |
25,865,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Adgrb3
|
UTSW |
1 |
25,133,033 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5241:Adgrb3
|
UTSW |
1 |
25,150,871 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5328:Adgrb3
|
UTSW |
1 |
25,133,356 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5372:Adgrb3
|
UTSW |
1 |
25,167,940 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5703:Adgrb3
|
UTSW |
1 |
25,459,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5747:Adgrb3
|
UTSW |
1 |
25,865,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5998:Adgrb3
|
UTSW |
1 |
25,470,582 (GRCm39) |
splice site |
probably null |
|
|
R6006:Adgrb3
|
UTSW |
1 |
25,865,612 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6077:Adgrb3
|
UTSW |
1 |
25,133,081 (GRCm39) |
nonsense |
probably null |
|
|
R6183:Adgrb3
|
UTSW |
1 |
25,133,451 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6190:Adgrb3
|
UTSW |
1 |
25,459,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6249:Adgrb3
|
UTSW |
1 |
25,471,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6310:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6450:Adgrb3
|
UTSW |
1 |
25,459,683 (GRCm39) |
missense |
probably benign |
|
|
R6678:Adgrb3
|
UTSW |
1 |
25,499,891 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6679:Adgrb3
|
UTSW |
1 |
25,170,377 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6685:Adgrb3
|
UTSW |
1 |
25,150,817 (GRCm39) |
nonsense |
probably null |
|
|
R6730:Adgrb3
|
UTSW |
1 |
25,133,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6805:Adgrb3
|
UTSW |
1 |
25,865,253 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6847:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6929:Adgrb3
|
UTSW |
1 |
25,150,852 (GRCm39) |
nonsense |
probably null |
|
|
R6953:Adgrb3
|
UTSW |
1 |
25,865,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7062:Adgrb3
|
UTSW |
1 |
25,865,166 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7244:Adgrb3
|
UTSW |
1 |
25,170,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7292:Adgrb3
|
UTSW |
1 |
25,570,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7325:Adgrb3
|
UTSW |
1 |
25,571,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7378:Adgrb3
|
UTSW |
1 |
25,571,000 (GRCm39) |
nonsense |
probably null |
|
|
R7489:Adgrb3
|
UTSW |
1 |
25,586,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7615:Adgrb3
|
UTSW |
1 |
25,137,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7623:Adgrb3
|
UTSW |
1 |
25,586,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Adgrb3
|
UTSW |
1 |
25,471,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7837:Adgrb3
|
UTSW |
1 |
25,167,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Adgrb3
|
UTSW |
1 |
25,459,637 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8152:Adgrb3
|
UTSW |
1 |
25,260,838 (GRCm39) |
splice site |
probably null |
|
|
R8161:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8225:Adgrb3
|
UTSW |
1 |
25,865,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8417:Adgrb3
|
UTSW |
1 |
25,527,134 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8694:Adgrb3
|
UTSW |
1 |
25,865,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8742:Adgrb3
|
UTSW |
1 |
25,265,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8886:Adgrb3
|
UTSW |
1 |
25,150,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8941:Adgrb3
|
UTSW |
1 |
25,133,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8958:Adgrb3
|
UTSW |
1 |
25,865,190 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8979:Adgrb3
|
UTSW |
1 |
25,527,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9064:Adgrb3
|
UTSW |
1 |
25,570,965 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9252:Adgrb3
|
UTSW |
1 |
25,865,496 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9401:Adgrb3
|
UTSW |
1 |
25,592,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Adgrb3
|
UTSW |
1 |
25,592,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrb3
|
UTSW |
1 |
25,170,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb3
|
UTSW |
1 |
25,132,995 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGACAAAGCCAAGGAAATTACCC -3'
(R):5'- ATACAGAACAAAGTCTTTGCCCTTG -3'
Sequencing Primer
(F):5'- GCCAAGGAAATTACCCTGTTTC -3'
(R):5'- GAACAAAGTCTTTGCCCTTGGTTCTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation