Incidental Mutation 'R1971:Nav1'
| ID |
220781 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
039984-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.934)
|
| Stock # |
R1971 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 135460091 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 411
(T411A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040599
AA Change: T411A
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: T411A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067414
AA Change: T411A
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: T411A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190298
AA Change: T411A
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: T411A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.0593 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
99% (115/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
A |
T |
2: 30,686,566 (GRCm39) |
I242N |
probably benign |
Het |
| 2510009E07Rik |
G |
T |
16: 21,472,048 (GRCm39) |
Y217* |
probably null |
Het |
| 4931429L15Rik |
C |
T |
9: 46,220,086 (GRCm39) |
V149M |
probably benign |
Het |
| Abcg8 |
G |
T |
17: 85,002,587 (GRCm39) |
|
probably benign |
Het |
| Acox1 |
A |
G |
11: 116,089,087 (GRCm39) |
F77S |
probably benign |
Het |
| Adgrb3 |
G |
T |
1: 25,586,525 (GRCm39) |
H389Q |
probably benign |
Het |
| Ak7 |
A |
G |
12: 105,692,504 (GRCm39) |
N186S |
probably damaging |
Het |
| Apobr |
A |
G |
7: 126,185,397 (GRCm39) |
T303A |
probably benign |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Bcl9l |
T |
C |
9: 44,419,996 (GRCm39) |
|
probably null |
Het |
| Bco2 |
T |
C |
9: 50,457,284 (GRCm39) |
D86G |
probably damaging |
Het |
| Bmpr1b |
T |
A |
3: 141,563,333 (GRCm39) |
I204F |
probably damaging |
Het |
| Bpifb5 |
C |
A |
2: 154,072,264 (GRCm39) |
Q324K |
probably benign |
Het |
| Cacna2d2 |
G |
A |
9: 107,389,205 (GRCm39) |
V223I |
probably damaging |
Het |
| Capn3 |
A |
G |
2: 120,311,228 (GRCm39) |
D105G |
possibly damaging |
Het |
| Ccdc40 |
G |
T |
11: 119,153,901 (GRCm39) |
|
probably null |
Het |
| Ccdc83 |
T |
A |
7: 89,893,362 (GRCm39) |
S132C |
probably damaging |
Het |
| Ckap2l |
A |
G |
2: 129,127,342 (GRCm39) |
S279P |
possibly damaging |
Het |
| Cldn12 |
C |
A |
5: 5,558,137 (GRCm39) |
A97S |
probably benign |
Het |
| Clec2l |
T |
G |
6: 38,640,309 (GRCm39) |
S47A |
probably benign |
Het |
| Csnk1d |
C |
A |
11: 120,863,274 (GRCm39) |
R222M |
possibly damaging |
Het |
| Ctnna1 |
T |
A |
18: 35,287,580 (GRCm39) |
D96E |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,145,078 (GRCm39) |
D1316G |
probably damaging |
Het |
| Ddx4 |
C |
T |
13: 112,736,547 (GRCm39) |
V608I |
probably damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,198,989 (GRCm39) |
E48G |
probably benign |
Het |
| Dnah17 |
G |
C |
11: 117,995,361 (GRCm39) |
Q996E |
probably benign |
Het |
| Dnah9 |
G |
C |
11: 65,739,197 (GRCm39) |
N4180K |
probably damaging |
Het |
| Dpf3 |
T |
A |
12: 83,371,809 (GRCm39) |
|
probably null |
Het |
| Drd2 |
T |
C |
9: 49,318,359 (GRCm39) |
F434L |
probably damaging |
Het |
| En1 |
A |
G |
1: 120,534,742 (GRCm39) |
T344A |
unknown |
Het |
| Eri3 |
A |
G |
4: 117,421,964 (GRCm39) |
T81A |
probably benign |
Het |
| Fam20a |
T |
C |
11: 109,576,237 (GRCm39) |
Y174C |
probably damaging |
Het |
| Fam234a |
G |
C |
17: 26,435,629 (GRCm39) |
|
probably null |
Het |
| Fam76a |
A |
T |
4: 132,631,294 (GRCm39) |
I217N |
probably damaging |
Het |
| Fancm |
T |
A |
12: 65,148,466 (GRCm39) |
S694T |
probably benign |
Het |
| Fcgbpl1 |
C |
A |
7: 27,830,937 (GRCm39) |
A50E |
possibly damaging |
Het |
| Foxo3 |
A |
G |
10: 42,073,258 (GRCm39) |
S420P |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Gm136 |
T |
G |
4: 34,755,986 (GRCm39) |
D9A |
probably benign |
Het |
| Gstt2 |
G |
T |
10: 75,668,499 (GRCm39) |
T116N |
probably benign |
Het |
| Hs3st6 |
A |
G |
17: 24,972,267 (GRCm39) |
T70A |
probably benign |
Het |
| Hspa14 |
A |
G |
2: 3,490,804 (GRCm39) |
V461A |
possibly damaging |
Het |
| Itih5 |
A |
T |
2: 10,243,379 (GRCm39) |
D372V |
probably damaging |
Het |
| Kcna2 |
A |
T |
3: 107,012,140 (GRCm39) |
R240S |
probably damaging |
Het |
| Kctd18 |
T |
C |
1: 58,006,779 (GRCm39) |
I24V |
probably benign |
Het |
| Lap3 |
T |
C |
5: 45,663,508 (GRCm39) |
|
probably benign |
Het |
| Lcp1 |
T |
C |
14: 75,437,946 (GRCm39) |
S119P |
probably damaging |
Het |
| Lig3 |
G |
C |
11: 82,686,544 (GRCm39) |
D642H |
probably benign |
Het |
| Lpin1 |
A |
T |
12: 16,630,724 (GRCm39) |
L58H |
probably damaging |
Het |
| Map4k5 |
G |
T |
12: 69,873,102 (GRCm39) |
P468Q |
possibly damaging |
Het |
| Med31 |
G |
A |
11: 72,106,244 (GRCm39) |
|
probably benign |
Het |
| Mki67 |
A |
T |
7: 135,315,688 (GRCm39) |
|
probably null |
Het |
| Mrc1 |
G |
A |
2: 14,249,103 (GRCm39) |
|
probably null |
Het |
| Msh3 |
A |
G |
13: 92,359,784 (GRCm39) |
I16T |
probably damaging |
Het |
| Msh3 |
T |
A |
13: 92,386,328 (GRCm39) |
|
probably benign |
Het |
| Mst1r |
A |
T |
9: 107,790,411 (GRCm39) |
I675F |
probably benign |
Het |
| Myb |
A |
C |
10: 21,016,555 (GRCm39) |
S652A |
probably benign |
Het |
| Myh2 |
G |
T |
11: 67,080,004 (GRCm39) |
S1099I |
possibly damaging |
Het |
| Myl6b |
A |
G |
10: 128,330,512 (GRCm39) |
V181A |
probably damaging |
Het |
| Myt1l |
A |
T |
12: 29,877,091 (GRCm39) |
K247N |
unknown |
Het |
| Nanos2 |
G |
T |
7: 18,721,629 (GRCm39) |
V34L |
probably benign |
Het |
| Nedd9 |
T |
A |
13: 41,492,424 (GRCm39) |
I23F |
probably damaging |
Het |
| Nes |
G |
A |
3: 87,885,634 (GRCm39) |
V1254I |
possibly damaging |
Het |
| Nol6 |
A |
G |
4: 41,119,542 (GRCm39) |
F588S |
probably damaging |
Het |
| Numa1 |
C |
T |
7: 101,658,529 (GRCm39) |
A1605V |
probably damaging |
Het |
| Ofd1 |
T |
C |
X: 165,210,210 (GRCm39) |
Y205C |
probably benign |
Het |
| Olr1 |
T |
C |
6: 129,470,498 (GRCm39) |
E223G |
probably benign |
Het |
| Or1e30 |
T |
A |
11: 73,678,616 (GRCm39) |
M284K |
probably damaging |
Het |
| Or2ag12 |
T |
A |
7: 106,276,877 (GRCm39) |
N272I |
probably damaging |
Het |
| Or4c118 |
A |
T |
2: 88,975,078 (GRCm39) |
C96* |
probably null |
Het |
| Or51k2 |
A |
T |
7: 103,596,150 (GRCm39) |
I126F |
probably damaging |
Het |
| Or51l4 |
C |
T |
7: 103,404,527 (GRCm39) |
W88* |
probably null |
Het |
| Pate6 |
T |
A |
9: 35,700,309 (GRCm39) |
H92L |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,763,487 (GRCm39) |
T3987A |
unknown |
Het |
| Pik3cg |
A |
T |
12: 32,242,152 (GRCm39) |
V986D |
probably damaging |
Het |
| Pitpnm1 |
T |
A |
19: 4,162,450 (GRCm39) |
D1093E |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,793,651 (GRCm39) |
D571G |
probably benign |
Het |
| Rfx1 |
A |
G |
8: 84,822,126 (GRCm39) |
E875G |
probably damaging |
Het |
| Rnf145 |
T |
A |
11: 44,439,642 (GRCm39) |
I146N |
probably damaging |
Het |
| Rttn |
G |
A |
18: 89,108,557 (GRCm39) |
R1587H |
probably benign |
Het |
| Safb |
A |
G |
17: 56,912,821 (GRCm39) |
H883R |
probably benign |
Het |
| Sdhb |
A |
G |
4: 140,700,260 (GRCm39) |
D120G |
possibly damaging |
Het |
| Serpine3 |
A |
G |
14: 62,902,533 (GRCm39) |
N48S |
probably damaging |
Het |
| Sgms1 |
T |
A |
19: 32,137,357 (GRCm39) |
I70L |
probably benign |
Het |
| Slc1a7 |
G |
T |
4: 107,825,782 (GRCm39) |
D14Y |
probably benign |
Het |
| Smtnl2 |
C |
T |
11: 72,302,183 (GRCm39) |
A93T |
probably benign |
Het |
| Srpra |
T |
C |
9: 35,124,834 (GRCm39) |
|
probably null |
Het |
| Taf6l |
A |
G |
19: 8,752,866 (GRCm39) |
|
probably null |
Het |
| Tbc1d10b |
A |
T |
7: 126,807,036 (GRCm39) |
V167E |
probably benign |
Het |
| Tbc1d9 |
G |
A |
8: 83,976,139 (GRCm39) |
R566H |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,689,348 (GRCm39) |
Y2080H |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,402,431 (GRCm39) |
N506S |
probably damaging |
Het |
| Thada |
G |
T |
17: 84,617,470 (GRCm39) |
P1349T |
probably damaging |
Het |
| Tjp1 |
G |
T |
7: 64,973,826 (GRCm39) |
T476K |
probably damaging |
Het |
| Tlr11 |
A |
T |
14: 50,598,691 (GRCm39) |
T226S |
probably benign |
Het |
| Tmem131 |
G |
A |
1: 36,843,680 (GRCm39) |
Q1394* |
probably null |
Het |
| Tmem161a |
C |
T |
8: 70,629,559 (GRCm39) |
R58W |
probably damaging |
Het |
| Tmem219 |
T |
C |
7: 126,496,422 (GRCm39) |
S13G |
probably benign |
Het |
| Trp53bp1 |
T |
C |
2: 121,035,517 (GRCm39) |
Y47C |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,731,922 (GRCm39) |
|
probably benign |
Het |
| Ush1g |
A |
G |
11: 115,209,280 (GRCm39) |
S305P |
probably damaging |
Het |
| Usp37 |
A |
T |
1: 74,479,127 (GRCm39) |
Y948* |
probably null |
Het |
| Vav1 |
A |
T |
17: 57,634,697 (GRCm39) |
Y805F |
probably damaging |
Het |
| Vmn1r59 |
A |
T |
7: 5,457,038 (GRCm39) |
Y241N |
probably damaging |
Het |
| Vmn2r2 |
T |
A |
3: 64,034,121 (GRCm39) |
Y467F |
probably damaging |
Het |
| Vps35l |
A |
C |
7: 118,374,557 (GRCm39) |
R352S |
probably damaging |
Het |
| Vps54 |
C |
A |
11: 21,242,051 (GRCm39) |
L389I |
probably damaging |
Het |
| Vwa8 |
G |
T |
14: 79,162,694 (GRCm39) |
|
probably benign |
Het |
| Wdr19 |
G |
T |
5: 65,398,503 (GRCm39) |
|
probably benign |
Het |
| Wnt2b |
A |
T |
3: 104,861,933 (GRCm39) |
|
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,342,039 (GRCm39) |
R1427G |
possibly damaging |
Het |
| Ylpm1 |
T |
C |
12: 85,087,560 (GRCm39) |
S1115P |
probably damaging |
Het |
| Zfp946 |
T |
A |
17: 22,674,406 (GRCm39) |
C387S |
probably damaging |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGACCAATCAGCTCTTCCG -3'
(R):5'- TTGTTACGACAGCGATGACG -3'
Sequencing Primer
(F):5'- AATCAGCTCTTCCGTTTCCAG -3'
(R):5'- TGGTACATGCATGGCGAGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation