Incidental Mutation 'R2027:Vmn2r97'
| ID |
220868 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
040035-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R2027 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19149944 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 444
(I444N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000156141
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000168710
AA Change: I444N
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: I444N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000232219
AA Change: I444N
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232325
|
| Meta Mutation Damage Score |
0.0869 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.7%
|
| Validation Efficiency |
100% (70/70) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A4gnt |
T |
C |
9: 99,502,254 (GRCm39) |
V138A |
possibly damaging |
Het |
| Aatk |
A |
G |
11: 119,900,143 (GRCm39) |
S1291P |
probably damaging |
Het |
| Adgrv1 |
C |
T |
13: 81,743,301 (GRCm39) |
V67M |
probably damaging |
Het |
| Apoa4 |
G |
A |
9: 46,154,298 (GRCm39) |
V300M |
probably damaging |
Het |
| Bcl2a1d |
A |
T |
9: 88,613,438 (GRCm39) |
V112E |
possibly damaging |
Het |
| Bltp1 |
T |
A |
3: 37,102,110 (GRCm39) |
|
probably benign |
Het |
| Cabp2 |
T |
A |
19: 4,137,126 (GRCm39) |
M166K |
probably damaging |
Het |
| Camsap1 |
A |
G |
2: 25,828,538 (GRCm39) |
V1062A |
possibly damaging |
Het |
| Cap1 |
T |
G |
4: 122,756,686 (GRCm39) |
|
probably benign |
Het |
| Caprin2 |
A |
G |
6: 148,779,385 (GRCm39) |
Y141H |
probably damaging |
Het |
| Card11 |
T |
C |
5: 140,892,522 (GRCm39) |
Y181C |
probably damaging |
Het |
| Ccdc107 |
T |
C |
4: 43,495,874 (GRCm39) |
V259A |
probably benign |
Het |
| Ccn4 |
A |
G |
15: 66,789,258 (GRCm39) |
E248G |
possibly damaging |
Het |
| Chd9 |
A |
G |
8: 91,634,619 (GRCm39) |
|
probably benign |
Het |
| Cibar1 |
T |
A |
4: 12,171,216 (GRCm39) |
D79V |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,553,075 (GRCm39) |
|
probably null |
Het |
| Cuzd1 |
T |
C |
7: 130,921,820 (GRCm39) |
T61A |
possibly damaging |
Het |
| Dbp |
C |
A |
7: 45,357,700 (GRCm39) |
D89E |
probably benign |
Het |
| Dhps |
A |
T |
8: 85,799,240 (GRCm39) |
N140Y |
probably damaging |
Het |
| Dido1 |
A |
T |
2: 180,330,974 (GRCm39) |
L158* |
probably null |
Het |
| Dnah9 |
T |
G |
11: 65,846,164 (GRCm39) |
N2958T |
probably benign |
Het |
| Dpp8 |
T |
A |
9: 64,986,056 (GRCm39) |
Y849N |
probably damaging |
Het |
| Dsg2 |
A |
G |
18: 20,716,061 (GRCm39) |
|
probably benign |
Het |
| Efemp1 |
A |
T |
11: 28,864,696 (GRCm39) |
Y250F |
possibly damaging |
Het |
| Faxc |
T |
C |
4: 21,958,439 (GRCm39) |
|
probably benign |
Het |
| Frem3 |
G |
T |
8: 81,421,966 (GRCm39) |
C2122F |
possibly damaging |
Het |
| Gan |
T |
C |
8: 117,914,238 (GRCm39) |
|
probably null |
Het |
| Gnl1 |
A |
G |
17: 36,293,850 (GRCm39) |
N274D |
probably benign |
Het |
| Hook3 |
T |
C |
8: 26,528,126 (GRCm39) |
E588G |
probably damaging |
Het |
| Itpr1 |
C |
A |
6: 108,363,814 (GRCm39) |
S812Y |
possibly damaging |
Het |
| Kbtbd3 |
C |
T |
9: 4,317,075 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
C |
T |
4: 123,265,711 (GRCm39) |
A4821T |
probably damaging |
Het |
| Mepe |
T |
C |
5: 104,474,957 (GRCm39) |
S13P |
possibly damaging |
Het |
| Msantd5f6 |
A |
G |
4: 73,321,295 (GRCm39) |
I154T |
possibly damaging |
Het |
| Myh11 |
A |
G |
16: 14,050,532 (GRCm39) |
Y478H |
probably damaging |
Het |
| Myo7b |
A |
G |
18: 32,118,013 (GRCm39) |
V871A |
probably benign |
Het |
| Nckap1 |
A |
T |
2: 80,365,862 (GRCm39) |
M466K |
probably damaging |
Het |
| Nup155 |
A |
T |
15: 8,187,244 (GRCm39) |
H1391L |
probably damaging |
Het |
| Or4k6 |
A |
G |
14: 50,475,406 (GRCm39) |
I312T |
probably benign |
Het |
| Or52r1b |
A |
T |
7: 102,690,731 (GRCm39) |
H15L |
probably benign |
Het |
| Or5aq1b |
T |
A |
2: 86,901,897 (GRCm39) |
N194Y |
possibly damaging |
Het |
| Or5m13 |
A |
C |
2: 85,749,114 (GRCm39) |
S282R |
probably damaging |
Het |
| Or9k2 |
A |
G |
10: 129,998,604 (GRCm39) |
I197T |
probably benign |
Het |
| Or9s23 |
A |
T |
1: 92,501,489 (GRCm39) |
T199S |
probably damaging |
Het |
| Otof |
T |
C |
5: 30,578,358 (GRCm39) |
T97A |
probably benign |
Het |
| Peli2 |
G |
A |
14: 48,493,602 (GRCm39) |
E275K |
probably benign |
Het |
| Pik3c2a |
T |
C |
7: 115,950,057 (GRCm39) |
Y1320C |
probably damaging |
Het |
| Pkn1 |
A |
G |
8: 84,398,007 (GRCm39) |
V795A |
probably damaging |
Het |
| Pramel5 |
A |
G |
4: 143,998,274 (GRCm39) |
L323P |
probably damaging |
Het |
| Prr5 |
A |
T |
15: 84,585,580 (GRCm39) |
R183W |
probably damaging |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Rabgef1 |
A |
G |
5: 130,237,620 (GRCm39) |
D231G |
possibly damaging |
Het |
| Rbp3 |
C |
T |
14: 33,677,975 (GRCm39) |
T641M |
probably damaging |
Het |
| Rc3h1 |
C |
T |
1: 160,782,507 (GRCm39) |
P662L |
probably benign |
Het |
| Rpl7a-ps5 |
G |
T |
17: 58,146,090 (GRCm39) |
Q47K |
probably benign |
Het |
| Sclt1 |
G |
A |
3: 41,685,323 (GRCm39) |
T45I |
probably benign |
Het |
| Slc22a17 |
A |
G |
14: 55,145,543 (GRCm39) |
I202T |
probably damaging |
Het |
| Slc25a13 |
A |
G |
6: 6,073,487 (GRCm39) |
L457S |
probably damaging |
Het |
| Slc44a3 |
T |
C |
3: 121,257,059 (GRCm39) |
|
probably benign |
Het |
| Slc7a9 |
G |
A |
7: 35,153,562 (GRCm39) |
V188M |
probably damaging |
Het |
| Spata31d1e |
A |
G |
13: 59,890,401 (GRCm39) |
M55T |
possibly damaging |
Het |
| Tmem161a |
T |
A |
8: 70,630,170 (GRCm39) |
F119I |
probably damaging |
Het |
| Tmem240 |
A |
G |
4: 155,819,892 (GRCm39) |
D32G |
possibly damaging |
Het |
| Tmtc4 |
T |
C |
14: 123,158,677 (GRCm39) |
N682S |
probably benign |
Het |
| Uqcrc1 |
G |
A |
9: 108,776,083 (GRCm39) |
V262M |
probably benign |
Het |
| Vmn1r87 |
G |
A |
7: 12,865,823 (GRCm39) |
R155C |
probably damaging |
Het |
| Vmn2r100 |
A |
T |
17: 19,742,334 (GRCm39) |
Q236L |
probably benign |
Het |
| Yif1a |
A |
T |
19: 5,139,900 (GRCm39) |
H115L |
probably damaging |
Het |
| Zfp280b |
T |
C |
10: 75,874,328 (GRCm39) |
L69S |
probably damaging |
Het |
| Zfp579 |
C |
A |
7: 4,996,520 (GRCm39) |
E464* |
probably null |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TATTTGATGTGGCCATGAATGCAG -3'
(R):5'- CCATAATAAGGCTGCAAAGCTAG -3'
Sequencing Primer
(F):5'- TGTGGCCATGAATGCAGAAAGC -3'
(R):5'- GGCTGCAAAGCTAGATATTGATG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation