Mutagenetix > Incidental Mutation

Incidental Mutation 'R1971:Dnah17'

220938

Institutional Source

Beutler Lab

Gene Symbol

Dnah17

Ensembl Gene

ENSMUSG00000033987

Gene Name

dynein, axonemal, heavy chain 17

Synonyms

Dnahcl1, LOC382552, 2810003K23Rik, Dnahc17

MMRRC Submission

039984-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1971 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

117912549-118021460 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to C at 117995361 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Glutamic Acid at position 996 (Q996E)

Ref Sequence

ENSEMBL: ENSMUSP00000120542 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084803] [ENSMUST00000106308] [ENSMUST00000132685]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000084803
AA Change: Q996E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000081864
Gene: ENSMUSG00000033987
AA Change: Q996E

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	183	766	8.5e-142	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1260	1673	5.8e-135	PFAM
Pfam:AAA_6	1793	2023	6e-161	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	7.8e-13	PFAM
Pfam:AAA_7	2400	2671	1.1e-171	PFAM
Pfam:AAA_8	2748	3015	4.9e-166	PFAM
Pfam:MT	3027	3370	3.4e-214	PFAM
Pfam:AAA_9	3388	3615	2.4e-144	PFAM
Pfam:Dynein_heavy	3742	4452	N/A	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106308
AA Change: Q996E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101915
Gene: ENSMUSG00000033987
AA Change: Q996E

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	184	764	1.7e-152	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1262	1671	4.1e-132	PFAM
Pfam:AAA_6	1793	2023	7e-149	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	2.5e-11	PFAM
Pfam:AAA_7	2400	2671	4.4e-169	PFAM
Pfam:AAA_8	2748	3015	7.1e-163	PFAM
Pfam:MT	3027	3370	1.1e-210	PFAM
Pfam:AAA_9	3392	3614	1e-84	PFAM
Pfam:Dynein_heavy	3748	4479	3.5e-230	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000132685
AA Change: Q996E

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000120542
Gene: ENSMUSG00000033987
AA Change: Q996E

Domain	Start	End	E-Value	Type
Pfam:DHC_N2	279	688	3.1e-132	PFAM
Pfam:AAA_6	811	1041	5.3e-149	PFAM
low complexity region	1110	1122	N/A	INTRINSIC
Blast:AAA	1123	1354	1e-104	BLAST
Pfam:AAA_7	1452	1671	8.9e-134	PFAM
Pfam:AAA_8	1763	2030	5.4e-163	PFAM
Pfam:MT	2042	2168	6.8e-52	PFAM
Pfam:MT	2163	2412	8.2e-149	PFAM
Pfam:AAA_9	2434	2656	7.9e-85	PFAM
Pfam:Dynein_heavy	2790	3457	2.6e-209	PFAM
Pfam:Dynein_heavy	3460	3569	4.6e-17	PFAM

Meta Mutation Damage Score

0.1051

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

99% (115/116)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001O22Rik	A	T	2: 30,686,566 (GRCm39)	I242N	probably benign	Het
2510009E07Rik	G	T	16: 21,472,048 (GRCm39)	Y217*	probably null	Het
4931429L15Rik	C	T	9: 46,220,086 (GRCm39)	V149M	probably benign	Het
Abcg8	G	T	17: 85,002,587 (GRCm39)		probably benign	Het
Acox1	A	G	11: 116,089,087 (GRCm39)	F77S	probably benign	Het
Adgrb3	G	T	1: 25,586,525 (GRCm39)	H389Q	probably benign	Het
Ak7	A	G	12: 105,692,504 (GRCm39)	N186S	probably damaging	Het
Apobr	A	G	7: 126,185,397 (GRCm39)	T303A	probably benign	Het
Arnt	C	T	3: 95,355,704 (GRCm39)	S16L	possibly damaging	Het
Bcl9l	T	C	9: 44,419,996 (GRCm39)		probably null	Het
Bco2	T	C	9: 50,457,284 (GRCm39)	D86G	probably damaging	Het
Bmpr1b	T	A	3: 141,563,333 (GRCm39)	I204F	probably damaging	Het
Bpifb5	C	A	2: 154,072,264 (GRCm39)	Q324K	probably benign	Het
Cacna2d2	G	A	9: 107,389,205 (GRCm39)	V223I	probably damaging	Het
Capn3	A	G	2: 120,311,228 (GRCm39)	D105G	possibly damaging	Het
Ccdc40	G	T	11: 119,153,901 (GRCm39)		probably null	Het
Ccdc83	T	A	7: 89,893,362 (GRCm39)	S132C	probably damaging	Het
Ckap2l	A	G	2: 129,127,342 (GRCm39)	S279P	possibly damaging	Het
Cldn12	C	A	5: 5,558,137 (GRCm39)	A97S	probably benign	Het
Clec2l	T	G	6: 38,640,309 (GRCm39)	S47A	probably benign	Het
Csnk1d	C	A	11: 120,863,274 (GRCm39)	R222M	possibly damaging	Het
Ctnna1	T	A	18: 35,287,580 (GRCm39)	D96E	probably benign	Het
D630045J12Rik	T	C	6: 38,145,078 (GRCm39)	D1316G	probably damaging	Het
Ddx4	C	T	13: 112,736,547 (GRCm39)	V608I	probably damaging	Het
Dmtf1	T	C	5: 9,198,989 (GRCm39)	E48G	probably benign	Het
Dnah9	G	C	11: 65,739,197 (GRCm39)	N4180K	probably damaging	Het
Dpf3	T	A	12: 83,371,809 (GRCm39)		probably null	Het
Drd2	T	C	9: 49,318,359 (GRCm39)	F434L	probably damaging	Het
En1	A	G	1: 120,534,742 (GRCm39)	T344A	unknown	Het
Eri3	A	G	4: 117,421,964 (GRCm39)	T81A	probably benign	Het
Fam20a	T	C	11: 109,576,237 (GRCm39)	Y174C	probably damaging	Het
Fam234a	G	C	17: 26,435,629 (GRCm39)		probably null	Het
Fam76a	A	T	4: 132,631,294 (GRCm39)	I217N	probably damaging	Het
Fancm	T	A	12: 65,148,466 (GRCm39)	S694T	probably benign	Het
Fcgbpl1	C	A	7: 27,830,937 (GRCm39)	A50E	possibly damaging	Het
Foxo3	A	G	10: 42,073,258 (GRCm39)	S420P	probably benign	Het
Foxp4	C	T	17: 48,186,796 (GRCm39)	R378Q	unknown	Het
Gm136	T	G	4: 34,755,986 (GRCm39)	D9A	probably benign	Het
Gstt2	G	T	10: 75,668,499 (GRCm39)	T116N	probably benign	Het
Hs3st6	A	G	17: 24,972,267 (GRCm39)	T70A	probably benign	Het
Hspa14	A	G	2: 3,490,804 (GRCm39)	V461A	possibly damaging	Het
Itih5	A	T	2: 10,243,379 (GRCm39)	D372V	probably damaging	Het
Kcna2	A	T	3: 107,012,140 (GRCm39)	R240S	probably damaging	Het
Kctd18	T	C	1: 58,006,779 (GRCm39)	I24V	probably benign	Het
Lap3	T	C	5: 45,663,508 (GRCm39)		probably benign	Het
Lcp1	T	C	14: 75,437,946 (GRCm39)	S119P	probably damaging	Het
Lig3	G	C	11: 82,686,544 (GRCm39)	D642H	probably benign	Het
Lpin1	A	T	12: 16,630,724 (GRCm39)	L58H	probably damaging	Het
Map4k5	G	T	12: 69,873,102 (GRCm39)	P468Q	possibly damaging	Het
Med31	G	A	11: 72,106,244 (GRCm39)		probably benign	Het
Mki67	A	T	7: 135,315,688 (GRCm39)		probably null	Het
Mrc1	G	A	2: 14,249,103 (GRCm39)		probably null	Het
Msh3	A	G	13: 92,359,784 (GRCm39)	I16T	probably damaging	Het
Msh3	T	A	13: 92,386,328 (GRCm39)		probably benign	Het
Mst1r	A	T	9: 107,790,411 (GRCm39)	I675F	probably benign	Het
Myb	A	C	10: 21,016,555 (GRCm39)	S652A	probably benign	Het
Myh2	G	T	11: 67,080,004 (GRCm39)	S1099I	possibly damaging	Het
Myl6b	A	G	10: 128,330,512 (GRCm39)	V181A	probably damaging	Het
Myt1l	A	T	12: 29,877,091 (GRCm39)	K247N	unknown	Het
Nanos2	G	T	7: 18,721,629 (GRCm39)	V34L	probably benign	Het
Nav1	T	C	1: 135,460,091 (GRCm39)	T411A	probably benign	Het
Nedd9	T	A	13: 41,492,424 (GRCm39)	I23F	probably damaging	Het
Nes	G	A	3: 87,885,634 (GRCm39)	V1254I	possibly damaging	Het
Nol6	A	G	4: 41,119,542 (GRCm39)	F588S	probably damaging	Het
Numa1	C	T	7: 101,658,529 (GRCm39)	A1605V	probably damaging	Het
Ofd1	T	C	X: 165,210,210 (GRCm39)	Y205C	probably benign	Het
Olr1	T	C	6: 129,470,498 (GRCm39)	E223G	probably benign	Het
Or1e30	T	A	11: 73,678,616 (GRCm39)	M284K	probably damaging	Het
Or2ag12	T	A	7: 106,276,877 (GRCm39)	N272I	probably damaging	Het
Or4c118	A	T	2: 88,975,078 (GRCm39)	C96*	probably null	Het
Or51k2	A	T	7: 103,596,150 (GRCm39)	I126F	probably damaging	Het
Or51l4	C	T	7: 103,404,527 (GRCm39)	W88*	probably null	Het
Pate6	T	A	9: 35,700,309 (GRCm39)	H92L	probably benign	Het
Pclo	A	G	5: 14,763,487 (GRCm39)	T3987A	unknown	Het
Pik3cg	A	T	12: 32,242,152 (GRCm39)	V986D	probably damaging	Het
Pitpnm1	T	A	19: 4,162,450 (GRCm39)	D1093E	probably damaging	Het
Ppp1r12b	T	C	1: 134,793,651 (GRCm39)	D571G	probably benign	Het
Rfx1	A	G	8: 84,822,126 (GRCm39)	E875G	probably damaging	Het
Rnf145	T	A	11: 44,439,642 (GRCm39)	I146N	probably damaging	Het
Rttn	G	A	18: 89,108,557 (GRCm39)	R1587H	probably benign	Het
Safb	A	G	17: 56,912,821 (GRCm39)	H883R	probably benign	Het
Sdhb	A	G	4: 140,700,260 (GRCm39)	D120G	possibly damaging	Het
Serpine3	A	G	14: 62,902,533 (GRCm39)	N48S	probably damaging	Het
Sgms1	T	A	19: 32,137,357 (GRCm39)	I70L	probably benign	Het
Slc1a7	G	T	4: 107,825,782 (GRCm39)	D14Y	probably benign	Het
Smtnl2	C	T	11: 72,302,183 (GRCm39)	A93T	probably benign	Het
Srpra	T	C	9: 35,124,834 (GRCm39)		probably null	Het
Taf6l	A	G	19: 8,752,866 (GRCm39)		probably null	Het
Tbc1d10b	A	T	7: 126,807,036 (GRCm39)	V167E	probably benign	Het
Tbc1d9	G	A	8: 83,976,139 (GRCm39)	R566H	probably damaging	Het
Tenm3	A	G	8: 48,689,348 (GRCm39)	Y2080H	probably damaging	Het
Tex14	A	G	11: 87,402,431 (GRCm39)	N506S	probably damaging	Het
Thada	G	T	17: 84,617,470 (GRCm39)	P1349T	probably damaging	Het
Tjp1	G	T	7: 64,973,826 (GRCm39)	T476K	probably damaging	Het
Tlr11	A	T	14: 50,598,691 (GRCm39)	T226S	probably benign	Het
Tmem131	G	A	1: 36,843,680 (GRCm39)	Q1394*	probably null	Het
Tmem161a	C	T	8: 70,629,559 (GRCm39)	R58W	probably damaging	Het
Tmem219	T	C	7: 126,496,422 (GRCm39)	S13G	probably benign	Het
Trp53bp1	T	C	2: 121,035,517 (GRCm39)	Y47C	probably damaging	Het
Ttn	T	A	2: 76,731,922 (GRCm39)		probably benign	Het
Ush1g	A	G	11: 115,209,280 (GRCm39)	S305P	probably damaging	Het
Usp37	A	T	1: 74,479,127 (GRCm39)	Y948*	probably null	Het
Vav1	A	T	17: 57,634,697 (GRCm39)	Y805F	probably damaging	Het
Vmn1r59	A	T	7: 5,457,038 (GRCm39)	Y241N	probably damaging	Het
Vmn2r2	T	A	3: 64,034,121 (GRCm39)	Y467F	probably damaging	Het
Vps35l	A	C	7: 118,374,557 (GRCm39)	R352S	probably damaging	Het
Vps54	C	A	11: 21,242,051 (GRCm39)	L389I	probably damaging	Het
Vwa8	G	T	14: 79,162,694 (GRCm39)		probably benign	Het
Wdr19	G	T	5: 65,398,503 (GRCm39)		probably benign	Het
Wnt2b	A	T	3: 104,861,933 (GRCm39)		probably benign	Het
Xirp2	A	G	2: 67,342,039 (GRCm39)	R1427G	possibly damaging	Het
Ylpm1	T	C	12: 85,087,560 (GRCm39)	S1115P	probably damaging	Het
Zfp946	T	A	17: 22,674,406 (GRCm39)	C387S	probably damaging	Het

Other mutations in Dnah17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Dnah17	APN	11	117,979,040 (GRCm39)	missense	possibly damaging	0.81
IGL00531:Dnah17	APN	11	117,933,999 (GRCm39)	missense	probably damaging	0.97
IGL00764:Dnah17	APN	11	117,987,311 (GRCm39)	missense	probably damaging	0.99
IGL00795:Dnah17	APN	11	117,984,460 (GRCm39)	missense	probably benign	0.35
IGL00823:Dnah17	APN	11	117,937,987 (GRCm39)	missense	probably benign	0.22
IGL01145:Dnah17	APN	11	117,937,999 (GRCm39)	missense	possibly damaging	0.63
IGL01433:Dnah17	APN	11	117,940,760 (GRCm39)	missense	probably damaging	1.00
IGL01454:Dnah17	APN	11	117,949,223 (GRCm39)	missense	probably damaging	1.00
IGL01545:Dnah17	APN	11	118,010,394 (GRCm39)	missense	probably damaging	1.00
IGL01548:Dnah17	APN	11	117,989,438 (GRCm39)	missense	probably benign	0.21
IGL01557:Dnah17	APN	11	117,964,512 (GRCm39)	missense	probably damaging	0.98
IGL01632:Dnah17	APN	11	117,924,707 (GRCm39)	missense	probably damaging	1.00
IGL01636:Dnah17	APN	11	117,931,882 (GRCm39)	missense	probably benign	0.03
IGL01672:Dnah17	APN	11	117,932,986 (GRCm39)	missense	probably damaging	0.97
IGL01822:Dnah17	APN	11	117,972,819 (GRCm39)	missense	probably damaging	1.00
IGL01869:Dnah17	APN	11	117,943,502 (GRCm39)	missense	probably benign	0.09
IGL01916:Dnah17	APN	11	118,016,114 (GRCm39)	missense	probably benign	0.00
IGL02131:Dnah17	APN	11	117,963,734 (GRCm39)	missense	probably damaging	1.00
IGL02154:Dnah17	APN	11	118,015,087 (GRCm39)	missense	probably benign	0.01
IGL02220:Dnah17	APN	11	117,963,793 (GRCm39)	nonsense	probably null
IGL02454:Dnah17	APN	11	117,971,593 (GRCm39)	missense	probably damaging	0.98
IGL02458:Dnah17	APN	11	117,927,176 (GRCm39)	missense	probably damaging	1.00
IGL02588:Dnah17	APN	11	117,916,479 (GRCm39)	missense	possibly damaging	0.95
IGL02865:Dnah17	APN	11	117,964,374 (GRCm39)	missense	probably damaging	1.00
IGL02881:Dnah17	APN	11	117,932,944 (GRCm39)	missense	probably damaging	1.00
IGL02952:Dnah17	APN	11	117,979,094 (GRCm39)	missense	probably benign	0.03
IGL03382:Dnah17	APN	11	117,972,769 (GRCm39)	missense	probably damaging	1.00
IGL03389:Dnah17	APN	11	117,985,805 (GRCm39)	missense	probably damaging	1.00
ergos	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
watt	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
PIT4280001:Dnah17	UTSW	11	117,989,408 (GRCm39)	missense	possibly damaging	0.85
R0004:Dnah17	UTSW	11	117,950,918 (GRCm39)	missense	possibly damaging	0.90
R0112:Dnah17	UTSW	11	117,965,260 (GRCm39)	missense	possibly damaging	0.82
R0116:Dnah17	UTSW	11	117,949,132 (GRCm39)	missense	probably benign	0.01
R0157:Dnah17	UTSW	11	118,017,997 (GRCm39)	missense	probably benign
R0320:Dnah17	UTSW	11	117,943,500 (GRCm39)	missense	possibly damaging	0.56
R0362:Dnah17	UTSW	11	117,989,365 (GRCm39)	missense	probably benign	0.10
R0382:Dnah17	UTSW	11	118,019,822 (GRCm39)	missense	probably damaging	1.00
R0383:Dnah17	UTSW	11	117,958,373 (GRCm39)	missense	probably benign
R0400:Dnah17	UTSW	11	117,972,904 (GRCm39)	missense	probably damaging	1.00
R0420:Dnah17	UTSW	11	117,930,765 (GRCm39)	missense	probably damaging	1.00
R0483:Dnah17	UTSW	11	117,937,950 (GRCm39)	missense	probably benign
R0533:Dnah17	UTSW	11	118,001,363 (GRCm39)	missense	possibly damaging	0.50
R0562:Dnah17	UTSW	11	117,963,726 (GRCm39)	missense	probably damaging	1.00
R0564:Dnah17	UTSW	11	117,973,807 (GRCm39)	missense	probably damaging	1.00
R0604:Dnah17	UTSW	11	118,012,297 (GRCm39)	missense	probably benign	0.00
R0608:Dnah17	UTSW	11	117,981,575 (GRCm39)	nonsense	probably null
R0614:Dnah17	UTSW	11	117,961,394 (GRCm39)	splice site	probably benign
R0632:Dnah17	UTSW	11	117,958,508 (GRCm39)	splice site	probably benign
R0831:Dnah17	UTSW	11	117,951,097 (GRCm39)	missense	probably damaging	0.99
R0838:Dnah17	UTSW	11	117,950,930 (GRCm39)	missense	probably damaging	1.00
R0879:Dnah17	UTSW	11	117,947,661 (GRCm39)	splice site	probably benign
R1061:Dnah17	UTSW	11	117,943,514 (GRCm39)	missense	possibly damaging	0.51
R1190:Dnah17	UTSW	11	117,933,001 (GRCm39)	missense	probably damaging	1.00
R1293:Dnah17	UTSW	11	118,017,963 (GRCm39)	critical splice donor site	probably null
R1297:Dnah17	UTSW	11	118,012,192 (GRCm39)	splice site	probably benign
R1332:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1336:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1364:Dnah17	UTSW	11	118,016,432 (GRCm39)	splice site	probably benign
R1418:Dnah17	UTSW	11	117,964,849 (GRCm39)	missense	probably damaging	0.98
R1432:Dnah17	UTSW	11	117,914,153 (GRCm39)	missense	probably damaging	1.00
R1497:Dnah17	UTSW	11	118,005,059 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah17	UTSW	11	117,991,879 (GRCm39)	missense	probably benign
R1506:Dnah17	UTSW	11	118,016,213 (GRCm39)	missense	possibly damaging	0.53
R1512:Dnah17	UTSW	11	117,985,841 (GRCm39)	missense	probably benign
R1567:Dnah17	UTSW	11	118,016,811 (GRCm39)	missense	probably damaging	1.00
R1597:Dnah17	UTSW	11	117,994,324 (GRCm39)	splice site	probably benign
R1665:Dnah17	UTSW	11	118,012,321 (GRCm39)	splice site	probably benign
R1703:Dnah17	UTSW	11	117,917,575 (GRCm39)	missense	probably damaging	1.00
R1716:Dnah17	UTSW	11	117,923,424 (GRCm39)	missense	probably benign	0.00
R1727:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1727:Dnah17	UTSW	11	117,961,315 (GRCm39)	missense	probably damaging	0.98
R1728:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1784:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1852:Dnah17	UTSW	11	118,012,742 (GRCm39)	missense	probably damaging	0.97
R1869:Dnah17	UTSW	11	117,938,015 (GRCm39)	nonsense	probably null
R1886:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	possibly damaging	0.62
R1893:Dnah17	UTSW	11	117,957,794 (GRCm39)	missense	probably benign	0.00
R1954:Dnah17	UTSW	11	117,915,557 (GRCm39)	missense	probably damaging	1.00
R1969:Dnah17	UTSW	11	117,995,361 (GRCm39)	missense	probably benign	0.00
R1975:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1977:Dnah17	UTSW	11	118,003,417 (GRCm39)	missense	possibly damaging	0.52
R2055:Dnah17	UTSW	11	117,958,357 (GRCm39)	missense	probably benign	0.00
R2115:Dnah17	UTSW	11	118,010,628 (GRCm39)	missense	probably benign	0.00
R2132:Dnah17	UTSW	11	117,924,573 (GRCm39)	missense	probably damaging	0.98
R2200:Dnah17	UTSW	11	117,993,235 (GRCm39)	splice site	probably benign
R2277:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2279:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2400:Dnah17	UTSW	11	118,017,210 (GRCm39)	critical splice acceptor site	probably null
R2402:Dnah17	UTSW	11	118,016,800 (GRCm39)	missense	probably benign	0.10
R2497:Dnah17	UTSW	11	117,977,850 (GRCm39)	splice site	probably null
R2923:Dnah17	UTSW	11	117,984,373 (GRCm39)	missense	probably damaging	1.00
R3121:Dnah17	UTSW	11	117,931,912 (GRCm39)	missense	probably damaging	1.00
R3236:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3237:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3498:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3499:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3746:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3749:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3762:Dnah17	UTSW	11	117,995,352 (GRCm39)	missense	probably benign	0.00
R3826:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3828:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3829:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3877:Dnah17	UTSW	11	117,915,533 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3900:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3911:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3913:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3930:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3931:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3969:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3970:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R4056:Dnah17	UTSW	11	117,961,364 (GRCm39)	missense	probably benign	0.05
R4113:Dnah17	UTSW	11	118,003,420 (GRCm39)	missense	possibly damaging	0.50
R4295:Dnah17	UTSW	11	118,009,598 (GRCm39)	missense	probably damaging	1.00
R4324:Dnah17	UTSW	11	117,985,039 (GRCm39)	missense	probably benign	0.01
R4412:Dnah17	UTSW	11	117,964,509 (GRCm39)	missense	probably damaging	1.00
R4413:Dnah17	UTSW	11	117,915,994 (GRCm39)	missense	probably benign	0.00
R4422:Dnah17	UTSW	11	117,972,799 (GRCm39)	missense	possibly damaging	0.91
R4552:Dnah17	UTSW	11	117,943,769 (GRCm39)	missense	possibly damaging	0.79
R4669:Dnah17	UTSW	11	117,965,119 (GRCm39)	missense	probably benign	0.02
R4677:Dnah17	UTSW	11	118,010,640 (GRCm39)	missense	probably damaging	1.00
R4716:Dnah17	UTSW	11	117,964,474 (GRCm39)	missense	probably benign	0.02
R4832:Dnah17	UTSW	11	117,917,606 (GRCm39)	missense	probably damaging	1.00
R4868:Dnah17	UTSW	11	117,999,038 (GRCm39)	missense	probably benign	0.03
R4897:Dnah17	UTSW	11	117,969,419 (GRCm39)	missense	probably damaging	1.00
R4928:Dnah17	UTSW	11	117,918,259 (GRCm39)	missense	probably damaging	1.00
R4937:Dnah17	UTSW	11	117,932,980 (GRCm39)	missense	probably damaging	1.00
R4957:Dnah17	UTSW	11	117,965,124 (GRCm39)	missense	probably benign	0.44
R5008:Dnah17	UTSW	11	118,001,403 (GRCm39)	missense	probably benign	0.01
R5016:Dnah17	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
R5027:Dnah17	UTSW	11	117,993,365 (GRCm39)	missense	probably benign	0.01
R5133:Dnah17	UTSW	11	118,007,939 (GRCm39)	missense	probably benign	0.00
R5140:Dnah17	UTSW	11	117,977,771 (GRCm39)	missense	probably damaging	1.00
R5146:Dnah17	UTSW	11	118,005,005 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah17	UTSW	11	117,918,293 (GRCm39)	missense	probably damaging	1.00
R5153:Dnah17	UTSW	11	117,973,800 (GRCm39)	nonsense	probably null
R5192:Dnah17	UTSW	11	117,925,185 (GRCm39)	missense	possibly damaging	0.96
R5315:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5317:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5335:Dnah17	UTSW	11	118,003,340 (GRCm39)	missense	probably damaging	1.00
R5379:Dnah17	UTSW	11	118,008,029 (GRCm39)	intron	probably benign
R5396:Dnah17	UTSW	11	118,018,108 (GRCm39)	missense	probably benign
R5418:Dnah17	UTSW	11	117,985,810 (GRCm39)	missense	probably benign	0.04
R5534:Dnah17	UTSW	11	117,943,596 (GRCm39)	missense	possibly damaging	0.83
R5539:Dnah17	UTSW	11	117,964,486 (GRCm39)	missense	probably benign	0.03
R5594:Dnah17	UTSW	11	117,934,055 (GRCm39)	splice site	probably null
R5634:Dnah17	UTSW	11	117,943,752 (GRCm39)	splice site	probably null
R5696:Dnah17	UTSW	11	117,991,882 (GRCm39)	missense	probably benign	0.44
R5802:Dnah17	UTSW	11	117,927,272 (GRCm39)	missense	possibly damaging	0.79
R5826:Dnah17	UTSW	11	117,925,193 (GRCm39)	missense	probably damaging	1.00
R5873:Dnah17	UTSW	11	117,947,723 (GRCm39)	missense	probably benign	0.01
R5898:Dnah17	UTSW	11	118,005,039 (GRCm39)	missense	probably benign	0.00
R5934:Dnah17	UTSW	11	117,931,928 (GRCm39)	missense	probably benign
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6113:Dnah17	UTSW	11	118,017,101 (GRCm39)	missense	probably damaging	1.00
R6117:Dnah17	UTSW	11	118,010,397 (GRCm39)	missense	probably benign	0.00
R6137:Dnah17	UTSW	11	117,916,480 (GRCm39)	missense	probably damaging	1.00
R6173:Dnah17	UTSW	11	117,930,772 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6258:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6278:Dnah17	UTSW	11	118,017,116 (GRCm39)	missense	probably damaging	0.99
R6298:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	probably benign	0.00
R6300:Dnah17	UTSW	11	117,925,136 (GRCm39)	missense	probably damaging	1.00
R6302:Dnah17	UTSW	11	118,019,981 (GRCm39)	missense	probably benign	0.09
R6363:Dnah17	UTSW	11	118,001,331 (GRCm39)	missense	probably benign
R6381:Dnah17	UTSW	11	118,020,011 (GRCm39)	missense	probably benign	0.08
R6418:Dnah17	UTSW	11	118,020,023 (GRCm39)	missense	probably damaging	0.99
R6660:Dnah17	UTSW	11	117,991,014 (GRCm39)	missense	probably benign
R6803:Dnah17	UTSW	11	118,016,198 (GRCm39)	missense	probably benign	0.00
R6820:Dnah17	UTSW	11	117,959,826 (GRCm39)	missense	probably damaging	0.99
R6885:Dnah17	UTSW	11	117,981,598 (GRCm39)	missense	possibly damaging	0.47
R6921:Dnah17	UTSW	11	117,932,310 (GRCm39)	missense	probably damaging	0.98
R6932:Dnah17	UTSW	11	117,950,905 (GRCm39)	missense	possibly damaging	0.95
R6954:Dnah17	UTSW	11	117,957,258 (GRCm39)	missense	probably damaging	1.00
R7000:Dnah17	UTSW	11	117,916,528 (GRCm39)	critical splice acceptor site	probably null
R7007:Dnah17	UTSW	11	118,009,697 (GRCm39)	missense	possibly damaging	0.92
R7048:Dnah17	UTSW	11	117,936,944 (GRCm39)	missense	possibly damaging	0.80
R7056:Dnah17	UTSW	11	118,016,212 (GRCm39)	missense	probably benign
R7131:Dnah17	UTSW	11	117,970,484 (GRCm39)	missense	probably benign	0.14
R7143:Dnah17	UTSW	11	117,976,956 (GRCm39)	missense	probably damaging	1.00
R7146:Dnah17	UTSW	11	117,972,936 (GRCm39)	missense	probably damaging	0.98
R7147:Dnah17	UTSW	11	117,985,755 (GRCm39)	missense	probably benign	0.31
R7172:Dnah17	UTSW	11	117,931,957 (GRCm39)	nonsense	probably null
R7183:Dnah17	UTSW	11	118,020,014 (GRCm39)	missense	probably benign
R7297:Dnah17	UTSW	11	117,994,182 (GRCm39)	missense	probably damaging	0.98
R7297:Dnah17	UTSW	11	117,946,556 (GRCm39)	critical splice donor site	probably null
R7367:Dnah17	UTSW	11	118,006,022 (GRCm39)	missense	probably benign
R7398:Dnah17	UTSW	11	117,971,550 (GRCm39)	missense	probably damaging	0.96
R7426:Dnah17	UTSW	11	117,981,543 (GRCm39)	missense	probably null	0.79
R7524:Dnah17	UTSW	11	118,012,307 (GRCm39)	missense	probably benign	0.03
R7529:Dnah17	UTSW	11	117,940,692 (GRCm39)	critical splice donor site	probably null
R7615:Dnah17	UTSW	11	118,001,373 (GRCm39)	nonsense	probably null
R7681:Dnah17	UTSW	11	117,916,012 (GRCm39)	missense	probably damaging	1.00
R7702:Dnah17	UTSW	11	118,012,304 (GRCm39)	missense	possibly damaging	0.64
R7702:Dnah17	UTSW	11	117,916,466 (GRCm39)	missense	probably benign	0.00
R7713:Dnah17	UTSW	11	117,915,997 (GRCm39)	missense	probably benign	0.02
R7809:Dnah17	UTSW	11	117,995,462 (GRCm39)	missense	probably benign	0.09
R7842:Dnah17	UTSW	11	117,970,508 (GRCm39)	critical splice acceptor site	probably null
R7935:Dnah17	UTSW	11	118,018,048 (GRCm39)	missense	probably benign	0.20
R7951:Dnah17	UTSW	11	118,009,592 (GRCm39)	missense	possibly damaging	0.64
R8070:Dnah17	UTSW	11	117,915,497 (GRCm39)	missense	probably damaging	0.97
R8098:Dnah17	UTSW	11	117,941,193 (GRCm39)	missense	probably damaging	1.00
R8101:Dnah17	UTSW	11	118,016,744 (GRCm39)	missense	probably benign
R8177:Dnah17	UTSW	11	118,019,753 (GRCm39)	missense	possibly damaging	0.60
R8343:Dnah17	UTSW	11	118,005,021 (GRCm39)	missense	probably benign
R8350:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8393:Dnah17	UTSW	11	117,947,855 (GRCm39)	missense	probably damaging	1.00
R8401:Dnah17	UTSW	11	117,915,485 (GRCm39)	missense	probably damaging	0.96
R8418:Dnah17	UTSW	11	117,994,284 (GRCm39)	missense	probably benign	0.01
R8450:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8546:Dnah17	UTSW	11	118,015,101 (GRCm39)	missense	probably benign	0.00
R8697:Dnah17	UTSW	11	117,976,985 (GRCm39)	missense	possibly damaging	0.96
R8710:Dnah17	UTSW	11	117,932,973 (GRCm39)	missense	probably damaging	1.00
R8713:Dnah17	UTSW	11	117,979,028 (GRCm39)	missense	probably damaging	1.00
R8722:Dnah17	UTSW	11	117,961,283 (GRCm39)	nonsense	probably null
R8797:Dnah17	UTSW	11	117,992,201 (GRCm39)	missense	probably benign	0.00
R8953:Dnah17	UTSW	11	118,016,238 (GRCm39)	splice site	probably benign
R8965:Dnah17	UTSW	11	117,915,492 (GRCm39)	missense	probably damaging	1.00
R8976:Dnah17	UTSW	11	117,917,666 (GRCm39)	missense	probably damaging	1.00
R9090:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9128:Dnah17	UTSW	11	117,937,004 (GRCm39)	missense	possibly damaging	0.76
R9134:Dnah17	UTSW	11	117,978,972 (GRCm39)	missense	probably damaging	1.00
R9245:Dnah17	UTSW	11	118,016,503 (GRCm39)	missense	probably benign	0.02
R9251:Dnah17	UTSW	11	118,012,618 (GRCm39)	missense	probably benign	0.03
R9271:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9367:Dnah17	UTSW	11	118,012,212 (GRCm39)	missense	possibly damaging	0.93
R9367:Dnah17	UTSW	11	117,987,464 (GRCm39)	missense	possibly damaging	0.95
R9381:Dnah17	UTSW	11	117,914,219 (GRCm39)	missense	probably benign
R9405:Dnah17	UTSW	11	118,009,737 (GRCm39)	missense	probably benign
R9449:Dnah17	UTSW	11	117,987,452 (GRCm39)	missense	probably benign	0.07
R9517:Dnah17	UTSW	11	117,915,440 (GRCm39)	missense	possibly damaging	0.76
R9588:Dnah17	UTSW	11	118,012,783 (GRCm39)	missense	probably benign	0.00
R9629:Dnah17	UTSW	11	117,979,804 (GRCm39)	missense	probably damaging	1.00
R9654:Dnah17	UTSW	11	117,927,156 (GRCm39)	critical splice donor site	probably null
R9655:Dnah17	UTSW	11	117,971,649 (GRCm39)	missense	possibly damaging	0.94
R9662:Dnah17	UTSW	11	117,925,166 (GRCm39)	missense	probably damaging	0.97
R9686:Dnah17	UTSW	11	117,979,048 (GRCm39)	missense	possibly damaging	0.46
R9689:Dnah17	UTSW	11	117,963,731 (GRCm39)	missense	probably damaging	1.00
R9706:Dnah17	UTSW	11	118,017,026 (GRCm39)	missense	probably damaging	1.00
X0058:Dnah17	UTSW	11	117,973,751 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah17	UTSW	11	118,017,992 (GRCm39)	missense	probably benign	0.01
Z1177:Dnah17	UTSW	11	117,977,786 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah17	UTSW	11	117,969,389 (GRCm39)	missense	possibly damaging	0.91
Z1177:Dnah17	UTSW	11	118,017,968 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TTCAAATCAGGCCTGTGGGG -3'
(R):5'- AGGATGCTCTTCCAGGTCTG -3'

Sequencing Primer
(F):5'- GGGAGGGGGTCGTCTAC -3'
(R):5'- CTGTCTCTCATGAAGGCAAATGAC -3'

Posted On

2014-08-25