Incidental Mutation 'R2031:Serpinb6e'
ID 221273
Institutional Source Beutler Lab
Gene Symbol Serpinb6e
Ensembl Gene ENSMUSG00000069248
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms Gm11396, ovalbumin, SPI3B
MMRRC Submission 040038-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R2031 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 34016328-34027391 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 34021733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110275] [ENSMUST00000145221]
AlphaFold I7HJI3
Predicted Effect probably benign
Transcript: ENSMUST00000110275
SMART Domains Protein: ENSMUSP00000105904
Gene: ENSMUSG00000069248

DomainStartEndE-ValueType
SERPIN 65 429 4.43e-149 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145221
SMART Domains Protein: ENSMUSP00000117577
Gene: ENSMUSG00000069248

DomainStartEndE-ValueType
Pfam:Serpin 58 101 1.9e-9 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1b G T 5: 121,639,118 (GRCm39) N642K possibly damaging Het
Akap11 T A 14: 78,747,477 (GRCm39) I1637L possibly damaging Het
Aoc1l1 T C 6: 48,952,789 (GRCm39) V238A probably damaging Het
Arhgap28 G T 17: 68,203,111 (GRCm39) T114N probably damaging Het
Arid5b A G 10: 68,114,518 (GRCm39) probably null Het
Atp10a T A 7: 58,477,678 (GRCm39) C1292* probably null Het
Casp4 A G 9: 5,321,401 (GRCm39) S51G probably benign Het
Cast T C 13: 74,946,771 (GRCm39) probably null Het
Ccdc87 T C 19: 4,891,715 (GRCm39) F736L probably damaging Het
Cdon T C 9: 35,415,370 (GRCm39) S1203P probably damaging Het
Cep290 G A 10: 100,348,262 (GRCm39) probably null Het
Cep85 A G 4: 133,859,761 (GRCm39) V634A probably benign Het
Cpeb3 C T 19: 37,022,079 (GRCm39) R589H probably damaging Het
Crebrf T G 17: 26,961,895 (GRCm39) S331A probably damaging Het
Cul5 A G 9: 53,578,480 (GRCm39) V36A probably benign Het
Dock2 T A 11: 34,618,297 (GRCm39) probably benign Het
Dstyk G A 1: 132,380,929 (GRCm39) A475T probably damaging Het
Enpp6 C A 8: 47,506,649 (GRCm39) P151Q probably damaging Het
Fan1 A G 7: 64,004,172 (GRCm39) Y765H probably damaging Het
Hsfy2 A T 1: 56,675,476 (GRCm39) S354T probably benign Het
Ifi204 A C 1: 173,580,343 (GRCm39) F389C probably damaging Het
Ikbip T C 10: 90,932,474 (GRCm39) Y373H probably benign Het
Kbtbd11 C A 8: 15,078,021 (GRCm39) P207T possibly damaging Het
Krt73 A C 15: 101,707,199 (GRCm39) probably benign Het
Mfsd6 T A 1: 52,748,013 (GRCm39) Q284L probably benign Het
Mmp1b T A 9: 7,368,607 (GRCm39) D415V possibly damaging Het
Mrc1 A T 2: 14,326,584 (GRCm39) T1161S probably damaging Het
Ms4a18 A G 19: 10,991,014 (GRCm39) S27P probably benign Het
Muc6 G A 7: 141,218,313 (GRCm39) S2120F possibly damaging Het
Mycbp2 G T 14: 103,426,028 (GRCm39) R2366S probably damaging Het
Nfkbia A G 12: 55,537,937 (GRCm39) L172P probably damaging Het
Nrros C T 16: 31,962,975 (GRCm39) W311* probably null Het
Or1d2 A G 11: 74,255,777 (GRCm39) Y94C probably damaging Het
Or2ag15 A G 7: 106,341,105 (GRCm39) F12S probably damaging Het
Or4c107 A G 2: 88,789,643 (GRCm39) T278A probably benign Het
Or51f1e A G 7: 102,747,371 (GRCm39) Y141C probably damaging Het
Or5an10 A T 19: 12,275,740 (GRCm39) V252D probably damaging Het
Or5b112 T C 19: 13,319,770 (GRCm39) L216S probably benign Het
Parvb A T 15: 84,167,036 (GRCm39) Y117F probably benign Het
Plch2 A G 4: 155,127,484 (GRCm39) probably benign Het
Plxnb2 A T 15: 89,047,013 (GRCm39) C769* probably null Het
Plxnc1 G T 10: 94,779,529 (GRCm39) D304E probably benign Het
Prkg2 T C 5: 99,172,310 (GRCm39) D135G possibly damaging Het
Ptprb A G 10: 116,153,448 (GRCm39) D635G probably benign Het
Rapgef6 T G 11: 54,443,684 (GRCm39) V89G probably benign Het
Ror2 T A 13: 53,271,366 (GRCm39) T330S probably benign Het
Ros1 A G 10: 51,943,164 (GRCm39) V2050A possibly damaging Het
Skp2 C A 15: 9,113,786 (GRCm39) G376C probably damaging Het
Smarca4 T C 9: 21,597,358 (GRCm39) V1371A possibly damaging Het
Syvn1 G A 19: 6,100,560 (GRCm39) R317H probably damaging Het
Tdo2 T A 3: 81,876,812 (GRCm39) D139V probably damaging Het
Tmem130 A G 5: 144,689,236 (GRCm39) V135A possibly damaging Het
Tpr A T 1: 150,317,870 (GRCm39) Q2126L probably benign Het
Txlnb A G 10: 17,706,062 (GRCm39) M324V possibly damaging Het
Ubxn10 A G 4: 138,448,574 (GRCm39) M34T possibly damaging Het
Vmn2r95 T C 17: 18,659,717 (GRCm39) W154R possibly damaging Het
Other mutations in Serpinb6e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02501:Serpinb6e APN 13 34,016,785 (GRCm39) missense possibly damaging 0.46
IGL03174:Serpinb6e APN 13 34,020,463 (GRCm39) missense probably damaging 0.99
R0018:Serpinb6e UTSW 13 34,021,828 (GRCm39) missense probably damaging 1.00
R0145:Serpinb6e UTSW 13 34,025,043 (GRCm39) missense probably benign 0.30
R0592:Serpinb6e UTSW 13 34,025,057 (GRCm39) missense probably damaging 1.00
R0733:Serpinb6e UTSW 13 34,025,201 (GRCm39) missense probably benign
R1347:Serpinb6e UTSW 13 34,025,180 (GRCm39) missense possibly damaging 0.96
R1347:Serpinb6e UTSW 13 34,025,180 (GRCm39) missense possibly damaging 0.96
R1651:Serpinb6e UTSW 13 34,020,406 (GRCm39) missense probably benign 0.00
R1822:Serpinb6e UTSW 13 34,017,217 (GRCm39) missense probably damaging 0.96
R3740:Serpinb6e UTSW 13 34,022,943 (GRCm39) missense probably benign 0.09
R4549:Serpinb6e UTSW 13 34,017,214 (GRCm39) missense possibly damaging 0.92
R4658:Serpinb6e UTSW 13 34,025,299 (GRCm39) start gained probably benign
R5149:Serpinb6e UTSW 13 34,016,468 (GRCm39) missense probably damaging 0.99
R5736:Serpinb6e UTSW 13 34,016,753 (GRCm39) missense probably damaging 0.96
R6060:Serpinb6e UTSW 13 34,025,256 (GRCm39) missense possibly damaging 0.96
R6212:Serpinb6e UTSW 13 34,025,220 (GRCm39) missense probably damaging 0.99
R6335:Serpinb6e UTSW 13 34,021,805 (GRCm39) missense probably benign 0.44
R6818:Serpinb6e UTSW 13 34,016,337 (GRCm39) splice site probably null
R7089:Serpinb6e UTSW 13 34,016,698 (GRCm39) missense probably damaging 0.99
R7151:Serpinb6e UTSW 13 34,021,818 (GRCm39) missense probably damaging 1.00
R7263:Serpinb6e UTSW 13 34,022,923 (GRCm39) missense probably benign 0.03
R7528:Serpinb6e UTSW 13 34,016,474 (GRCm39) missense possibly damaging 0.57
R7944:Serpinb6e UTSW 13 34,016,588 (GRCm39) missense probably damaging 0.99
R8789:Serpinb6e UTSW 13 34,017,213 (GRCm39) missense probably damaging 1.00
R8792:Serpinb6e UTSW 13 34,022,942 (GRCm39) missense possibly damaging 0.59
R8794:Serpinb6e UTSW 13 34,024,977 (GRCm39) missense possibly damaging 0.54
R8944:Serpinb6e UTSW 13 34,017,261 (GRCm39) missense probably damaging 1.00
R8967:Serpinb6e UTSW 13 34,020,419 (GRCm39) missense possibly damaging 0.90
R8989:Serpinb6e UTSW 13 34,022,967 (GRCm39) missense possibly damaging 0.59
R9167:Serpinb6e UTSW 13 34,023,009 (GRCm39) missense possibly damaging 0.47
R9310:Serpinb6e UTSW 13 34,017,204 (GRCm39) missense probably benign
Z1177:Serpinb6e UTSW 13 34,025,221 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- ATCTGTGAGTGTTCCTGAATGC -3'
(R):5'- GGCTGTTGGCATTAATCACTTTC -3'

Sequencing Primer
(F):5'- GAGTGTTCCTGAATGCATGTG -3'
(R):5'- GGCATTAATCACTTTCATGGCTG -3'
Posted On 2014-08-25