Incidental Mutation 'R2032:Vmn1r78'
ID 221349
Institutional Source Beutler Lab
Gene Symbol Vmn1r78
Ensembl Gene ENSMUSG00000061602
Gene Name vomeronasal 1 receptor 78
Synonyms V1rg7
MMRRC Submission 040039-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2032 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 11886391-11887332 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 11887210 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 274 (I274L)
Ref Sequence ENSEMBL: ENSMUSP00000154797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]
AlphaFold K7N608
Predicted Effect probably benign
Transcript: ENSMUST00000078039
AA Change: I274L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I274L

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 5.7e-8 PFAM
Pfam:V1R 12 301 1.5e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209489
Predicted Effect probably benign
Transcript: ENSMUST00000228244
AA Change: I274L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000228664
AA Change: I274L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 G A 17: 24,585,056 (GRCm39) probably benign Het
Abca7 C T 10: 79,844,071 (GRCm39) T1359M probably damaging Het
Acox2 A G 14: 8,246,400 (GRCm38) S464P probably benign Het
Adgrf1 C T 17: 43,622,166 (GRCm39) T801I probably damaging Het
Akap11 T A 14: 78,747,477 (GRCm39) I1637L possibly damaging Het
Akap12 C A 10: 4,306,673 (GRCm39) A1161D possibly damaging Het
Ankrd36 T A 11: 5,578,616 (GRCm39) V635D possibly damaging Het
Ankrd44 C T 1: 54,762,168 (GRCm39) probably null Het
Atl2 A G 17: 80,203,373 (GRCm39) V28A probably benign Het
Atxn3 A T 12: 101,908,453 (GRCm39) L133* probably null Het
Bmp2 T C 2: 133,403,216 (GRCm39) S256P probably benign Het
Ccdc121rt3 G A 5: 112,502,978 (GRCm39) T242I possibly damaging Het
Ccdc138 T A 10: 58,348,984 (GRCm39) Y177N possibly damaging Het
Ccdc168 C A 1: 44,100,900 (GRCm39) C66F possibly damaging Het
Cdcp3 G A 7: 130,844,781 (GRCm39) G674E probably damaging Het
Cep164 C T 9: 45,682,898 (GRCm39) V931M probably damaging Het
Cfhr4 T A 1: 139,660,993 (GRCm39) probably benign Het
CK137956 T C 4: 127,839,069 (GRCm39) T450A probably benign Het
Col23a1 G A 11: 51,450,835 (GRCm39) G215D unknown Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dennd6a T C 14: 26,325,904 (GRCm39) M5T probably benign Het
Dnajc6 T G 4: 101,471,435 (GRCm39) I284S probably benign Het
Dolpp1 C T 2: 30,282,453 (GRCm39) A2V probably damaging Het
Eml2 C T 7: 18,936,480 (GRCm39) T711I probably benign Het
Evi5l T C 8: 4,260,622 (GRCm39) D1065G probably damaging Het
Fam110b G T 4: 5,799,460 (GRCm39) A293S probably benign Het
Fap A G 2: 62,372,581 (GRCm39) V266A probably benign Het
Fgf10 A T 13: 118,852,131 (GRCm39) Y71F probably damaging Het
Gm3443 G T 19: 21,533,164 (GRCm39) G43C probably damaging Het
Gpr146 T C 5: 139,364,902 (GRCm39) probably benign Het
Hif3a A T 7: 16,785,104 (GRCm39) L172H probably damaging Het
Mas1 T C 17: 13,061,457 (GRCm39) probably benign Het
Nlrp5 G A 7: 23,120,937 (GRCm39) R717Q probably damaging Het
Nop14 A G 5: 34,817,283 (GRCm39) V36A possibly damaging Het
Or10v5 C T 19: 11,805,664 (GRCm39) C242Y probably damaging Het
Or51a39 A T 7: 102,363,083 (GRCm39) I179N probably benign Het
Or7a41 T A 10: 78,871,163 (GRCm39) F178I possibly damaging Het
Parp4 T A 14: 56,866,553 (GRCm39) I1039K possibly damaging Het
Pate12 T C 9: 36,344,195 (GRCm39) probably null Het
Pold2 A T 11: 5,826,757 (GRCm39) I59N probably benign Het
Prr36 T C 8: 4,264,304 (GRCm39) probably benign Het
Pyroxd2 T C 19: 42,716,088 (GRCm39) probably benign Het
Recql C T 6: 142,313,009 (GRCm39) G403R probably damaging Het
Serpina3m T A 12: 104,355,928 (GRCm39) D198E probably benign Het
Sik2 A T 9: 50,906,947 (GRCm39) Y93N probably damaging Het
Slc27a3 C T 3: 90,294,704 (GRCm39) R389H probably damaging Het
Slc29a1 A T 17: 45,897,035 (GRCm39) M417K probably damaging Het
Syt13 A G 2: 92,783,746 (GRCm39) K339E probably damaging Het
Tmem237 A T 1: 59,148,265 (GRCm39) H163Q probably benign Het
Tram2 C T 1: 21,074,180 (GRCm39) G253R probably null Het
Trpv1 A G 11: 73,129,211 (GRCm39) T43A probably benign Het
Ugt2b34 A G 5: 87,039,131 (GRCm39) I510T probably damaging Het
Vmn1r224 C A 17: 20,639,658 (GRCm39) D78E probably benign Het
Wdfy4 C T 14: 32,868,946 (GRCm39) V361I probably benign Het
Zpbp2 A T 11: 98,445,534 (GRCm39) K165N probably damaging Het
Other mutations in Vmn1r78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Vmn1r78 APN 7 11,887,165 (GRCm39) missense probably benign 0.10
IGL02019:Vmn1r78 APN 7 11,886,634 (GRCm39) missense probably damaging 0.99
IGL02143:Vmn1r78 APN 7 11,886,407 (GRCm39) missense probably benign
IGL02154:Vmn1r78 APN 7 11,886,472 (GRCm39) missense probably benign 0.22
IGL02290:Vmn1r78 APN 7 11,887,082 (GRCm39) missense probably damaging 1.00
IGL03012:Vmn1r78 APN 7 11,887,291 (GRCm39) missense probably benign 0.32
IGL03256:Vmn1r78 APN 7 11,886,725 (GRCm39) missense probably damaging 1.00
IGL03373:Vmn1r78 APN 7 11,887,270 (GRCm39) missense possibly damaging 0.86
IGL03384:Vmn1r78 APN 7 11,887,136 (GRCm39) missense possibly damaging 0.94
R0016:Vmn1r78 UTSW 7 11,887,279 (GRCm39) missense probably benign 0.02
R1445:Vmn1r78 UTSW 7 11,886,508 (GRCm39) missense possibly damaging 0.64
R1748:Vmn1r78 UTSW 7 11,887,250 (GRCm39) missense probably damaging 1.00
R2017:Vmn1r78 UTSW 7 11,887,270 (GRCm39) missense possibly damaging 0.86
R2198:Vmn1r78 UTSW 7 11,886,487 (GRCm39) missense probably benign 0.06
R4330:Vmn1r78 UTSW 7 11,886,386 (GRCm39) splice site probably null
R4564:Vmn1r78 UTSW 7 11,886,485 (GRCm39) missense probably damaging 1.00
R4769:Vmn1r78 UTSW 7 11,886,725 (GRCm39) missense probably damaging 1.00
R4801:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4802:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R5648:Vmn1r78 UTSW 7 11,886,693 (GRCm39) missense possibly damaging 0.92
R6561:Vmn1r78 UTSW 7 11,886,826 (GRCm39) missense probably damaging 1.00
R6869:Vmn1r78 UTSW 7 11,886,676 (GRCm39) missense probably benign 0.01
R6945:Vmn1r78 UTSW 7 11,886,832 (GRCm39) missense probably benign 0.01
R7793:Vmn1r78 UTSW 7 11,887,241 (GRCm39) missense probably benign 0.01
R7954:Vmn1r78 UTSW 7 11,887,227 (GRCm39) nonsense probably null
R8698:Vmn1r78 UTSW 7 11,886,539 (GRCm39) missense probably benign 0.06
R8830:Vmn1r78 UTSW 7 11,887,118 (GRCm39) missense probably damaging 0.98
R9624:Vmn1r78 UTSW 7 11,886,410 (GRCm39) missense probably benign
Z1088:Vmn1r78 UTSW 7 11,886,641 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGGTGAGTGTCCTCTACAG -3'
(R):5'- GACTGCAGTCTTAGCATTCTACAATAG -3'

Sequencing Primer
(F):5'- GTGAGTGTCCTCTACAGACACAAG -3'
(R):5'- CTTAGCATTCTACAATAGATACAGGG -3'
Posted On 2014-08-25