Incidental Mutation 'R1975:Or5ac21'
ID 221645
Institutional Source Beutler Lab
Gene Symbol Or5ac21
Ensembl Gene ENSMUSG00000068182
Gene Name olfactory receptor family 5 subfamily AC member 21
Synonyms GA_x54KRFPKG5P-55517445-55518365, Olfr203, MOR182-5
MMRRC Submission 039988-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R1975 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 59123518-59124438 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59124091 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 193 (S193P)
Ref Sequence ENSEMBL: ENSMUSP00000086719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089305] [ENSMUST00000201687] [ENSMUST00000215893]
AlphaFold L7N205
Predicted Effect probably damaging
Transcript: ENSMUST00000089305
AA Change: S193P

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000086719
Gene: ENSMUSG00000068182
AA Change: S193P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1e-46 PFAM
Pfam:7tm_1 41 290 7.6e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000201687
AA Change: S192P

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000144622
Gene: ENSMUSG00000048810
AA Change: S192P

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 3.4e-46 PFAM
Pfam:7tm_1 40 289 1.4e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215893
AA Change: S192P

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency 96% (71/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 T C 5: 121,742,322 (GRCm39) T429A probably benign Het
Afmid A C 11: 117,727,300 (GRCm39) I275L probably benign Het
Aimp1 A C 3: 132,382,860 (GRCm39) D5E possibly damaging Het
Aldob G A 4: 49,538,171 (GRCm39) A319V probably benign Het
Ankar C T 1: 72,697,600 (GRCm39) V1068I possibly damaging Het
Ccr2 C T 9: 123,906,830 (GRCm39) S370L probably benign Het
Chrnb4 A G 9: 54,942,102 (GRCm39) Y391H probably damaging Het
Clip1 A G 5: 123,761,281 (GRCm39) M873T possibly damaging Het
Cspg4 G C 9: 56,797,762 (GRCm39) G1409R probably damaging Het
Dnah17 A T 11: 117,987,362 (GRCm39) L1320* probably null Het
Dock4 T C 12: 40,829,641 (GRCm39) probably benign Het
Eml4 T C 17: 83,717,622 (GRCm39) S65P probably benign Het
Fblim1 A T 4: 141,312,175 (GRCm39) D183E probably damaging Het
Foxn1 T C 11: 78,256,763 (GRCm39) probably benign Het
Gm973 A T 1: 59,601,930 (GRCm39) T515S possibly damaging Het
Hdac7 G A 15: 97,704,386 (GRCm39) Q495* probably null Het
Hipk3 T C 2: 104,301,518 (GRCm39) I225V probably benign Het
Hrc A T 7: 44,985,638 (GRCm39) D263V probably damaging Het
Hs6st3 T C 14: 119,375,888 (GRCm39) I21T probably benign Het
Il15ra A G 2: 11,728,334 (GRCm39) T133A possibly damaging Het
Krt78 T C 15: 101,854,603 (GRCm39) *1069W probably null Het
Lama3 T A 18: 12,586,920 (GRCm39) M761K probably damaging Het
Lonp1 T C 17: 56,922,068 (GRCm39) T771A possibly damaging Het
Macf1 T C 4: 123,383,005 (GRCm39) T1320A probably damaging Het
Mark3 A T 12: 111,581,875 (GRCm39) I115L probably damaging Het
Mcph1 T G 8: 18,739,081 (GRCm39) probably benign Het
Med23 T A 10: 24,786,664 (GRCm39) N923K probably benign Het
Msrb2 T G 2: 19,398,032 (GRCm39) Y97D probably damaging Het
Muc6 C T 7: 141,234,368 (GRCm39) G708S probably damaging Het
Mylk T C 16: 34,700,673 (GRCm39) probably null Het
Nfrkb T A 9: 31,325,980 (GRCm39) V1141E possibly damaging Het
Obscn T C 11: 58,958,555 (GRCm39) E3675G probably damaging Het
Or11h7 T A 14: 50,890,821 (GRCm39) N42K probably damaging Het
Or2l5 G A 16: 19,333,586 (GRCm39) P267S probably damaging Het
Or2t6 A T 14: 14,175,446 (GRCm38) V212E probably damaging Het
Or51aa2 A T 7: 103,188,201 (GRCm39) F80Y probably damaging Het
Or52z14 A G 7: 103,253,219 (GRCm39) probably null Het
Or8k21 C G 2: 86,145,498 (GRCm39) G44A probably damaging Het
Pan2 T C 10: 128,156,282 (GRCm39) V1171A probably damaging Het
Pdgfc C T 3: 81,116,552 (GRCm39) T302I probably damaging Het
Pkhd1l1 G T 15: 44,393,109 (GRCm39) V1815F probably damaging Het
Pnpt1 A G 11: 29,091,256 (GRCm39) I337V probably benign Het
Psma8 T G 18: 14,864,033 (GRCm39) probably null Het
Rbl2 T C 8: 91,812,090 (GRCm39) S220P probably benign Het
Rere T A 4: 150,700,190 (GRCm39) D1091E probably damaging Het
Rpa1 A G 11: 75,197,002 (GRCm39) C540R probably damaging Het
Sema3d T A 5: 12,613,285 (GRCm39) V454E probably damaging Het
Sema3d T C 5: 12,634,965 (GRCm39) V677A probably benign Het
Sgk2 A G 2: 162,846,080 (GRCm39) N207S probably benign Het
Sirpb1a T C 3: 15,444,141 (GRCm39) I370V probably benign Het
Slc22a19 A G 19: 7,661,224 (GRCm39) probably benign Het
Slc26a1 T A 5: 108,820,338 (GRCm39) D287V probably damaging Het
Slc36a4 T A 9: 15,645,506 (GRCm39) V311D probably damaging Het
Slco1b2 A T 6: 141,628,951 (GRCm39) Y551F probably damaging Het
Slco2a1 T A 9: 102,956,653 (GRCm39) Y488* probably null Het
Stab2 A C 10: 86,732,360 (GRCm39) probably null Het
Strn T C 17: 78,999,928 (GRCm39) probably null Het
Tbxas1 A G 6: 38,925,575 (GRCm39) probably benign Het
Thumpd3 A G 6: 113,032,838 (GRCm39) N192S possibly damaging Het
Tns3 T A 11: 8,385,738 (GRCm39) I1386F probably benign Het
Treml4 T A 17: 48,579,821 (GRCm39) V219E probably damaging Het
Triobp T C 15: 78,850,908 (GRCm39) V354A probably benign Het
Tspan8 A G 10: 115,680,035 (GRCm39) I217V probably benign Het
Tub G A 7: 108,627,042 (GRCm39) G314R possibly damaging Het
Ube3b C T 5: 114,537,926 (GRCm39) T339M possibly damaging Het
Vmn2r43 A G 7: 8,258,550 (GRCm39) I221T possibly damaging Het
Vmn2r5 C T 3: 64,411,642 (GRCm39) E309K probably damaging Het
Zfp110 C T 7: 12,582,429 (GRCm39) T359I probably benign Het
Zfp322a A T 13: 23,541,074 (GRCm39) C223S probably damaging Het
Zfp512b G A 2: 181,228,878 (GRCm39) R696* probably null Het
Other mutations in Or5ac21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02003:Or5ac21 APN 16 59,123,996 (GRCm39) missense probably damaging 0.99
IGL02294:Or5ac21 APN 16 59,123,975 (GRCm39) missense probably damaging 1.00
IGL02412:Or5ac21 APN 16 59,123,555 (GRCm39) missense probably damaging 1.00
IGL02899:Or5ac21 APN 16 59,123,649 (GRCm39) missense probably damaging 1.00
R0792:Or5ac21 UTSW 16 59,124,352 (GRCm39) missense probably damaging 0.99
R1551:Or5ac21 UTSW 16 59,123,766 (GRCm39) missense probably benign 0.03
R1701:Or5ac21 UTSW 16 59,123,651 (GRCm39) missense probably benign 0.23
R2272:Or5ac21 UTSW 16 59,123,807 (GRCm39) missense possibly damaging 0.55
R5199:Or5ac21 UTSW 16 59,124,103 (GRCm39) missense probably benign
R5843:Or5ac21 UTSW 16 59,123,724 (GRCm39) missense probably damaging 1.00
R5928:Or5ac21 UTSW 16 59,123,521 (GRCm39) missense probably damaging 1.00
R6708:Or5ac21 UTSW 16 59,124,416 (GRCm39) missense probably damaging 1.00
R6747:Or5ac21 UTSW 16 59,124,004 (GRCm39) missense probably benign 0.03
R6894:Or5ac21 UTSW 16 59,124,142 (GRCm39) missense probably damaging 0.98
R7324:Or5ac21 UTSW 16 59,123,611 (GRCm39) missense probably benign
R7380:Or5ac21 UTSW 16 59,124,391 (GRCm39) missense probably damaging 1.00
R7612:Or5ac21 UTSW 16 59,123,990 (GRCm39) missense probably damaging 1.00
R7775:Or5ac21 UTSW 16 59,123,614 (GRCm39) missense probably damaging 1.00
R8010:Or5ac21 UTSW 16 59,123,867 (GRCm39) missense probably damaging 1.00
R8408:Or5ac21 UTSW 16 59,124,418 (GRCm39) nonsense probably null
R8424:Or5ac21 UTSW 16 59,123,772 (GRCm39) missense possibly damaging 0.60
R8746:Or5ac21 UTSW 16 59,123,973 (GRCm39) missense probably benign 0.03
Z1176:Or5ac21 UTSW 16 59,123,532 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CGCTATGTAGCCATATGCAATCC -3'
(R):5'- CCAGGGCTCACGTACATAAAG -3'

Sequencing Primer
(F):5'- CTATCTTGTGGTGATGTCCAACAGAG -3'
(R):5'- TCACGTACATAAAGAAGAGAGTTCC -3'
Posted On 2014-08-25