Incidental Mutation 'R1977:Dhrs2'
ID 221909
Institutional Source Beutler Lab
Gene Symbol Dhrs2
Ensembl Gene ENSMUSG00000022209
Gene Name dehydrogenase/reductase member 2
Synonyms 5430405K24Rik, SDR family
MMRRC Submission 039990-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1977 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 55459464-55478892 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 55472112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000129115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022820] [ENSMUST00000165432]
AlphaFold Q149L0
Predicted Effect probably null
Transcript: ENSMUST00000022820
AA Change: M1K

PolyPhen 2 Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000022820
Gene: ENSMUSG00000022209
AA Change: M1K

DomainStartEndE-ValueType
Pfam:adh_short 38 206 2.2e-31 PFAM
Pfam:KR 39 213 1.4e-11 PFAM
Pfam:adh_short_C2 43 279 2.8e-36 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000165432
AA Change: M1K

PolyPhen 2 Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000129115
Gene: ENSMUSG00000022209
AA Change: M1K

DomainStartEndE-ValueType
Pfam:adh_short 38 233 6.3e-52 PFAM
Pfam:KR 39 213 9.1e-12 PFAM
Pfam:adh_short_C2 43 279 1.8e-36 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency 99% (66/67)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf3 G T 8: 123,508,272 (GRCm39) C256F probably damaging Het
Adgra2 T A 8: 27,605,789 (GRCm39) V647D possibly damaging Het
AI593442 A T 9: 52,589,492 (GRCm39) S28R probably damaging Het
Akr1c21 G C 13: 4,624,211 (GRCm39) G22R probably damaging Het
Ampd3 T C 7: 110,402,369 (GRCm39) W458R probably damaging Het
Arhgap23 G T 11: 97,342,273 (GRCm39) R185L possibly damaging Het
Arhgap45 A T 10: 79,856,652 (GRCm39) I67F probably damaging Het
Asah1 A G 8: 41,796,554 (GRCm39) probably null Het
Atl2 A G 17: 80,160,019 (GRCm39) Y56H probably damaging Het
Carf A T 1: 60,185,295 (GRCm39) I447F probably damaging Het
Crmp1 A G 5: 37,433,627 (GRCm39) N162S probably damaging Het
Cyp2a5 A G 7: 26,535,347 (GRCm39) E103G probably benign Het
Cyp2c40 T C 19: 39,766,485 (GRCm39) D370G probably damaging Het
Dnah17 T C 11: 118,003,417 (GRCm39) E810G possibly damaging Het
E2f5 T A 3: 14,652,416 (GRCm39) I84N probably damaging Het
Eif2ak4 A T 2: 118,292,238 (GRCm39) K1185* probably null Het
Eif4ebp1 T A 8: 27,765,129 (GRCm39) M115K probably damaging Het
Evi5 A T 5: 107,947,005 (GRCm39) L505* probably null Het
Fbxw25 T A 9: 109,481,924 (GRCm39) Y254F possibly damaging Het
Gm7964 T A 7: 83,406,560 (GRCm39) F439Y possibly damaging Het
Gps1 A G 11: 120,676,652 (GRCm39) T124A probably damaging Het
Hopx T C 5: 77,265,463 (GRCm39) probably benign Het
Hoxd3 A G 2: 74,574,620 (GRCm39) S89G possibly damaging Het
Hrc A T 7: 44,985,638 (GRCm39) D263V probably damaging Het
Hs6st3 T C 14: 119,375,888 (GRCm39) I21T probably benign Het
Izumo4 A G 10: 80,538,955 (GRCm39) Y106C probably damaging Het
Lama2 A T 10: 26,866,796 (GRCm39) probably null Het
Lcorl A C 5: 45,932,762 (GRCm39) S123R probably null Het
Lgr4 A T 2: 109,842,273 (GRCm39) I729F probably damaging Het
Lonp1 T C 17: 56,922,068 (GRCm39) T771A possibly damaging Het
Matn3 T A 12: 9,011,110 (GRCm39) probably benign Het
Mdc1 T A 17: 36,161,822 (GRCm39) S912T probably benign Het
Mgam G A 6: 40,641,814 (GRCm39) V556I probably benign Het
Myom2 A T 8: 15,135,263 (GRCm39) I489F possibly damaging Het
Nfatc2 G A 2: 168,346,379 (GRCm39) T905I possibly damaging Het
Nme6 G A 9: 109,664,409 (GRCm39) R6Q probably damaging Het
Nr1h5 A G 3: 102,855,133 (GRCm39) S323P probably damaging Het
Nr4a3 C A 4: 48,056,539 (GRCm39) R364S probably damaging Het
Obox7 A T 7: 14,398,323 (GRCm39) D79V probably damaging Het
Or1ab2 G A 8: 72,863,698 (GRCm39) G96D probably benign Het
Or2a51 T A 6: 43,178,914 (GRCm39) V112D possibly damaging Het
Or2l5 G A 16: 19,333,586 (GRCm39) P267S probably damaging Het
Pan2 T C 10: 128,156,282 (GRCm39) V1171A probably damaging Het
Parp8 T A 13: 117,047,449 (GRCm39) I208F probably damaging Het
Pdgfc C T 3: 81,116,552 (GRCm39) T302I probably damaging Het
Pnpt1 A G 11: 29,091,256 (GRCm39) I337V probably benign Het
Polk T C 13: 96,625,736 (GRCm39) E436G probably damaging Het
Pramel7 A G 2: 87,321,465 (GRCm39) V190A probably benign Het
Rplp2 T C 7: 141,028,694 (GRCm39) probably benign Het
Sec23ip T A 7: 128,367,997 (GRCm39) S670T probably damaging Het
Sgk2 A G 2: 162,846,080 (GRCm39) N207S probably benign Het
Sh2d2a C T 3: 87,759,123 (GRCm39) Q242* probably null Het
Sh3pxd2b A C 11: 32,372,138 (GRCm39) N435T probably damaging Het
Slc36a4 T A 9: 15,645,506 (GRCm39) V311D probably damaging Het
Stx17 G A 4: 48,181,553 (GRCm39) V241M probably benign Het
Taok3 A T 5: 117,403,989 (GRCm39) K721N probably damaging Het
Tbxas1 A G 6: 38,925,575 (GRCm39) probably benign Het
Tmem87a G A 2: 120,204,985 (GRCm39) A377V probably benign Het
Topaz1 C T 9: 122,576,427 (GRCm39) T6M unknown Het
Tspan8 A G 10: 115,680,035 (GRCm39) I217V probably benign Het
Vmn2r125 A G 4: 156,707,162 (GRCm39) probably null Het
Vmn2r5 C T 3: 64,411,642 (GRCm39) E309K probably damaging Het
Wdr59 A T 8: 112,185,270 (GRCm39) C888S probably benign Het
Other mutations in Dhrs2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01747:Dhrs2 APN 14 55,472,120 (GRCm39) missense probably benign 0.00
IGL02510:Dhrs2 APN 14 55,473,532 (GRCm39) missense probably damaging 1.00
IGL02604:Dhrs2 APN 14 55,474,778 (GRCm39) missense possibly damaging 0.88
IGL02746:Dhrs2 APN 14 55,478,628 (GRCm39) missense probably damaging 1.00
IGL03060:Dhrs2 APN 14 55,474,775 (GRCm39) missense probably benign 0.06
R0179:Dhrs2 UTSW 14 55,477,933 (GRCm39) missense probably damaging 1.00
R0358:Dhrs2 UTSW 14 55,473,574 (GRCm39) missense probably damaging 0.99
R0755:Dhrs2 UTSW 14 55,472,247 (GRCm39) missense probably damaging 1.00
R1848:Dhrs2 UTSW 14 55,478,298 (GRCm39) missense probably benign
R3084:Dhrs2 UTSW 14 55,477,301 (GRCm39) missense probably benign 0.00
R3086:Dhrs2 UTSW 14 55,477,301 (GRCm39) missense probably benign 0.00
R3805:Dhrs2 UTSW 14 55,472,205 (GRCm39) missense probably benign 0.03
R3806:Dhrs2 UTSW 14 55,472,205 (GRCm39) missense probably benign 0.03
R4361:Dhrs2 UTSW 14 55,478,646 (GRCm39) missense probably damaging 0.99
R4754:Dhrs2 UTSW 14 55,476,205 (GRCm39) missense probably damaging 0.97
R4989:Dhrs2 UTSW 14 55,474,722 (GRCm39) missense probably damaging 1.00
R5307:Dhrs2 UTSW 14 55,473,601 (GRCm39) missense possibly damaging 0.71
R7561:Dhrs2 UTSW 14 55,474,698 (GRCm39) missense probably benign
R8245:Dhrs2 UTSW 14 55,478,637 (GRCm39) missense possibly damaging 0.94
R8296:Dhrs2 UTSW 14 55,477,928 (GRCm39) missense probably damaging 1.00
R8324:Dhrs2 UTSW 14 55,476,221 (GRCm39) missense probably damaging 1.00
R8782:Dhrs2 UTSW 14 55,473,538 (GRCm39) missense possibly damaging 0.94
R8923:Dhrs2 UTSW 14 55,478,309 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTGTCTCCCAGGCATCTTC -3'
(R):5'- TGGTAATGAGCCAGCCAATAC -3'

Sequencing Primer
(F):5'- GAGCACAGCCTGGTTACATACTATG -3'
(R):5'- GTAATGAGCCAGCCAATACTTCCAG -3'
Posted On 2014-08-25