Incidental Mutation 'R2048:Zfp541'
ID 222226
Institutional Source Beutler Lab
Gene Symbol Zfp541
Ensembl Gene ENSMUSG00000078796
Gene Name zinc finger protein 541
Synonyms EG666528
MMRRC Submission 040055-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.750) question?
Stock # R2048 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 15795739-15830259 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 15812252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 302 (R302G)
Ref Sequence ENSEMBL: ENSMUSP00000148143 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108509] [ENSMUST00000209369] [ENSMUST00000210805]
AlphaFold Q0GGX2
Predicted Effect possibly damaging
Transcript: ENSMUST00000108509
AA Change: R302G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104149
Gene: ENSMUSG00000078796
AA Change: R302G

DomainStartEndE-ValueType
low complexity region 48 65 N/A INTRINSIC
ZnF_C2H2 140 162 2.24e-3 SMART
ZnF_C2H2 168 190 4.47e-3 SMART
ZnF_C2H2 196 221 2.36e-2 SMART
low complexity region 249 260 N/A INTRINSIC
low complexity region 362 374 N/A INTRINSIC
low complexity region 444 465 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 594 609 N/A INTRINSIC
low complexity region 659 670 N/A INTRINSIC
ZnF_C2H2 838 860 3.72e0 SMART
low complexity region 953 958 N/A INTRINSIC
ELM2 1065 1122 4.46e-14 SMART
SANT 1171 1219 8.38e-7 SMART
low complexity region 1252 1263 N/A INTRINSIC
ZnF_C2H2 1301 1323 1.01e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000209369
AA Change: R302G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000210805
AA Change: R302G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1341 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam10 A G 9: 70,647,357 (GRCm39) D19G possibly damaging Het
Adhfe1 A G 1: 9,633,778 (GRCm39) K342R probably benign Het
Adk A G 14: 21,368,244 (GRCm39) N223S probably damaging Het
Aff4 A G 11: 53,289,212 (GRCm39) S454G probably benign Het
Ahnak T A 19: 8,984,420 (GRCm39) N1901K probably damaging Het
Camsap1 T C 2: 25,819,755 (GRCm39) T1578A probably benign Het
Ccdc63 A C 5: 122,268,350 (GRCm39) probably null Het
Ceacam1 G T 7: 25,176,113 (GRCm39) S27Y probably benign Het
Cit T C 5: 116,024,872 (GRCm39) probably null Het
Cntn4 A G 6: 106,414,825 (GRCm39) probably benign Het
Cyp2d26 A G 15: 82,676,928 (GRCm39) probably benign Het
Cyp3a13 A T 5: 137,908,237 (GRCm39) V204E probably damaging Het
Cyp51 G A 5: 4,136,636 (GRCm39) probably benign Het
Dipk1a T C 5: 108,057,886 (GRCm39) D179G probably damaging Het
Epb41l4b T G 4: 57,142,866 (GRCm39) E96D probably benign Het
Epg5 A G 18: 78,067,202 (GRCm39) E2221G probably damaging Het
Fbxo21 T A 5: 118,146,169 (GRCm39) N597K probably damaging Het
Fpr-rs4 CAGGAA CA 17: 18,242,596 (GRCm39) probably null Het
Fsip1 C A 2: 118,072,197 (GRCm39) E195D probably damaging Het
Gm10152 T C 7: 144,317,049 (GRCm39) F35L unknown Het
Gtpbp6 A C 5: 110,254,931 (GRCm39) V87G probably damaging Het
Hal A G 10: 93,327,002 (GRCm39) T176A probably damaging Het
Il12rb2 G T 6: 67,337,529 (GRCm39) N117K probably benign Het
Kalrn A G 16: 34,072,680 (GRCm39) V734A probably benign Het
Klf7 A G 1: 64,117,913 (GRCm39) V228A possibly damaging Het
Kng1 A G 16: 22,877,354 (GRCm39) Y54C probably damaging Het
Lpcat2 T G 8: 93,596,471 (GRCm39) N169K possibly damaging Het
Magohb A T 6: 131,266,385 (GRCm39) S40R probably damaging Het
Mgam A G 6: 40,633,363 (GRCm39) D186G possibly damaging Het
Mycbp2 A G 14: 103,469,960 (GRCm39) probably null Het
Myh15 A G 16: 48,975,928 (GRCm39) D1332G probably damaging Het
Myh9 G A 15: 77,655,332 (GRCm39) T1208M possibly damaging Het
Ncor2 C T 5: 125,161,996 (GRCm39) R426H unknown Het
Nradd T C 9: 110,450,697 (GRCm39) E160G probably benign Het
Or10u4 G A 10: 129,801,861 (GRCm39) S230L probably damaging Het
Or2a54 T A 6: 43,093,312 (GRCm39) M212K probably benign Het
Otog A T 7: 45,937,063 (GRCm39) T1591S probably damaging Het
Oxsr1 A G 9: 119,076,140 (GRCm39) S389P probably benign Het
Pde3a A G 6: 141,434,732 (GRCm39) probably benign Het
Pi4k2b A T 5: 52,905,773 (GRCm39) I105L probably benign Het
Pilrb1 T C 5: 137,853,153 (GRCm39) R217G possibly damaging Het
Poteg A T 8: 27,946,774 (GRCm39) I159L probably benign Het
Ppargc1a A G 5: 51,705,858 (GRCm39) F75S probably damaging Het
Ptk2b T G 14: 66,409,954 (GRCm39) D466A probably benign Het
Ptpn21 A G 12: 98,655,785 (GRCm39) V394A possibly damaging Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Shisa3 G A 5: 67,768,651 (GRCm39) E184K possibly damaging Het
Slc4a2 A G 5: 24,636,557 (GRCm39) H283R probably damaging Het
Slc9a3 A G 13: 74,311,860 (GRCm39) S603G probably damaging Het
Tas2r124 A G 6: 132,731,858 (GRCm39) I56V possibly damaging Het
Tbcd G T 11: 121,431,762 (GRCm39) C470F probably damaging Het
Thsd1 A G 8: 22,749,333 (GRCm39) R674G probably benign Het
Zbtb11 T A 16: 55,818,372 (GRCm39) C599S probably damaging Het
Other mutations in Zfp541
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02162:Zfp541 APN 7 15,813,393 (GRCm39) missense possibly damaging 0.80
IGL02262:Zfp541 APN 7 15,813,620 (GRCm39) missense probably damaging 1.00
IGL02347:Zfp541 APN 7 15,817,390 (GRCm39) missense probably damaging 1.00
IGL02516:Zfp541 APN 7 15,816,918 (GRCm39) splice site probably null
R0101:Zfp541 UTSW 7 15,811,968 (GRCm39) missense probably damaging 1.00
R0412:Zfp541 UTSW 7 15,816,099 (GRCm39) missense possibly damaging 0.88
R0627:Zfp541 UTSW 7 15,829,607 (GRCm39) splice site probably benign
R0784:Zfp541 UTSW 7 15,816,917 (GRCm39) intron probably benign
R1083:Zfp541 UTSW 7 15,812,637 (GRCm39) missense probably benign 0.16
R1541:Zfp541 UTSW 7 15,812,437 (GRCm39) missense probably benign 0.04
R1575:Zfp541 UTSW 7 15,812,640 (GRCm39) missense possibly damaging 0.94
R1730:Zfp541 UTSW 7 15,811,898 (GRCm39) missense probably damaging 0.99
R1783:Zfp541 UTSW 7 15,811,898 (GRCm39) missense probably damaging 0.99
R1966:Zfp541 UTSW 7 15,812,996 (GRCm39) missense probably benign 0.02
R2022:Zfp541 UTSW 7 15,816,110 (GRCm39) missense probably damaging 1.00
R2436:Zfp541 UTSW 7 15,810,373 (GRCm39) missense possibly damaging 0.94
R3973:Zfp541 UTSW 7 15,806,147 (GRCm39) missense probably damaging 1.00
R4081:Zfp541 UTSW 7 15,806,060 (GRCm39) missense probably benign 0.16
R4589:Zfp541 UTSW 7 15,817,261 (GRCm39) missense probably benign 0.35
R4724:Zfp541 UTSW 7 15,815,612 (GRCm39) missense probably damaging 0.99
R4812:Zfp541 UTSW 7 15,813,035 (GRCm39) missense probably benign 0.01
R4817:Zfp541 UTSW 7 15,824,307 (GRCm39) missense probably damaging 1.00
R5232:Zfp541 UTSW 7 15,829,104 (GRCm39) missense probably damaging 1.00
R5331:Zfp541 UTSW 7 15,829,683 (GRCm39) missense probably damaging 1.00
R5551:Zfp541 UTSW 7 15,824,786 (GRCm39) missense probably damaging 1.00
R5976:Zfp541 UTSW 7 15,810,344 (GRCm39) missense probably benign 0.34
R6259:Zfp541 UTSW 7 15,829,451 (GRCm39) missense probably benign 0.02
R6523:Zfp541 UTSW 7 15,829,445 (GRCm39) missense probably damaging 1.00
R6826:Zfp541 UTSW 7 15,812,907 (GRCm39) missense probably damaging 0.96
R7319:Zfp541 UTSW 7 15,813,294 (GRCm39) missense probably benign 0.21
R7428:Zfp541 UTSW 7 15,826,793 (GRCm39) missense probably damaging 1.00
R7594:Zfp541 UTSW 7 15,810,311 (GRCm39) missense probably damaging 0.96
R7724:Zfp541 UTSW 7 15,805,919 (GRCm39) missense probably damaging 1.00
R8276:Zfp541 UTSW 7 15,813,009 (GRCm39) missense possibly damaging 0.87
R8433:Zfp541 UTSW 7 15,805,999 (GRCm39) missense probably benign 0.16
R9068:Zfp541 UTSW 7 15,812,376 (GRCm39) missense probably damaging 0.96
R9086:Zfp541 UTSW 7 15,824,329 (GRCm39) missense probably damaging 1.00
R9132:Zfp541 UTSW 7 15,816,966 (GRCm39) missense probably benign 0.45
R9261:Zfp541 UTSW 7 15,816,029 (GRCm39) missense possibly damaging 0.94
R9408:Zfp541 UTSW 7 15,806,139 (GRCm39) missense probably damaging 1.00
R9518:Zfp541 UTSW 7 15,813,036 (GRCm39) missense possibly damaging 0.80
R9621:Zfp541 UTSW 7 15,805,892 (GRCm39) missense possibly damaging 0.94
Z1088:Zfp541 UTSW 7 15,813,720 (GRCm39) missense probably benign 0.16
Z1176:Zfp541 UTSW 7 15,812,191 (GRCm39) missense probably damaging 1.00
Z1177:Zfp541 UTSW 7 15,816,092 (GRCm39) missense probably damaging 0.98
Z1177:Zfp541 UTSW 7 15,812,954 (GRCm39) missense probably benign 0.26
Z1177:Zfp541 UTSW 7 15,812,688 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGAAGGAGACTCCACCAGAAG -3'
(R):5'- CAACTCTGACTCTGGTGGATCG -3'

Sequencing Primer
(F):5'- TCCACCAGAAGAGGAGGCC -3'
(R):5'- ATCGGGGACACCATTCTCAG -3'
Posted On 2014-08-25