Mutagenetix > Incidental Mutation

Incidental Mutation 'R2048:Mycbp2'

222269

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2, E3 ubiquitin protein ligase

Synonyms

Phr1, Pam, C130061D10Rik

MMRRC Submission

040055-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2048 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103350847-103584250 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 103469960 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124601 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000159855

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000160758

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Meta Mutation Damage Score

0.9596

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

98% (52/53)

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam10	A	G	9: 70,647,357 (GRCm39)	D19G	possibly damaging	Het
Adhfe1	A	G	1: 9,633,778 (GRCm39)	K342R	probably benign	Het
Adk	A	G	14: 21,368,244 (GRCm39)	N223S	probably damaging	Het
Aff4	A	G	11: 53,289,212 (GRCm39)	S454G	probably benign	Het
Ahnak	T	A	19: 8,984,420 (GRCm39)	N1901K	probably damaging	Het
Camsap1	T	C	2: 25,819,755 (GRCm39)	T1578A	probably benign	Het
Ccdc63	A	C	5: 122,268,350 (GRCm39)		probably null	Het
Ceacam1	G	T	7: 25,176,113 (GRCm39)	S27Y	probably benign	Het
Cit	T	C	5: 116,024,872 (GRCm39)		probably null	Het
Cntn4	A	G	6: 106,414,825 (GRCm39)		probably benign	Het
Cyp2d26	A	G	15: 82,676,928 (GRCm39)		probably benign	Het
Cyp3a13	A	T	5: 137,908,237 (GRCm39)	V204E	probably damaging	Het
Cyp51	G	A	5: 4,136,636 (GRCm39)		probably benign	Het
Dipk1a	T	C	5: 108,057,886 (GRCm39)	D179G	probably damaging	Het
Epb41l4b	T	G	4: 57,142,866 (GRCm39)	E96D	probably benign	Het
Epg5	A	G	18: 78,067,202 (GRCm39)	E2221G	probably damaging	Het
Fbxo21	T	A	5: 118,146,169 (GRCm39)	N597K	probably damaging	Het
Fpr-rs4	CAGGAA	CA	17: 18,242,596 (GRCm39)		probably null	Het
Fsip1	C	A	2: 118,072,197 (GRCm39)	E195D	probably damaging	Het
Gm10152	T	C	7: 144,317,049 (GRCm39)	F35L	unknown	Het
Gtpbp6	A	C	5: 110,254,931 (GRCm39)	V87G	probably damaging	Het
Hal	A	G	10: 93,327,002 (GRCm39)	T176A	probably damaging	Het
Il12rb2	G	T	6: 67,337,529 (GRCm39)	N117K	probably benign	Het
Kalrn	A	G	16: 34,072,680 (GRCm39)	V734A	probably benign	Het
Klf7	A	G	1: 64,117,913 (GRCm39)	V228A	possibly damaging	Het
Kng1	A	G	16: 22,877,354 (GRCm39)	Y54C	probably damaging	Het
Lpcat2	T	G	8: 93,596,471 (GRCm39)	N169K	possibly damaging	Het
Magohb	A	T	6: 131,266,385 (GRCm39)	S40R	probably damaging	Het
Mgam	A	G	6: 40,633,363 (GRCm39)	D186G	possibly damaging	Het
Myh15	A	G	16: 48,975,928 (GRCm39)	D1332G	probably damaging	Het
Myh9	G	A	15: 77,655,332 (GRCm39)	T1208M	possibly damaging	Het
Ncor2	C	T	5: 125,161,996 (GRCm39)	R426H	unknown	Het
Nradd	T	C	9: 110,450,697 (GRCm39)	E160G	probably benign	Het
Or10u4	G	A	10: 129,801,861 (GRCm39)	S230L	probably damaging	Het
Or2a54	T	A	6: 43,093,312 (GRCm39)	M212K	probably benign	Het
Otog	A	T	7: 45,937,063 (GRCm39)	T1591S	probably damaging	Het
Oxsr1	A	G	9: 119,076,140 (GRCm39)	S389P	probably benign	Het
Pde3a	A	G	6: 141,434,732 (GRCm39)		probably benign	Het
Pi4k2b	A	T	5: 52,905,773 (GRCm39)	I105L	probably benign	Het
Pilrb1	T	C	5: 137,853,153 (GRCm39)	R217G	possibly damaging	Het
Poteg	A	T	8: 27,946,774 (GRCm39)	I159L	probably benign	Het
Ppargc1a	A	G	5: 51,705,858 (GRCm39)	F75S	probably damaging	Het
Ptk2b	T	G	14: 66,409,954 (GRCm39)	D466A	probably benign	Het
Ptpn21	A	G	12: 98,655,785 (GRCm39)	V394A	possibly damaging	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,229,114 (GRCm39)		probably benign	Het
Shisa3	G	A	5: 67,768,651 (GRCm39)	E184K	possibly damaging	Het
Slc4a2	A	G	5: 24,636,557 (GRCm39)	H283R	probably damaging	Het
Slc9a3	A	G	13: 74,311,860 (GRCm39)	S603G	probably damaging	Het
Tas2r124	A	G	6: 132,731,858 (GRCm39)	I56V	possibly damaging	Het
Tbcd	G	T	11: 121,431,762 (GRCm39)	C470F	probably damaging	Het
Thsd1	A	G	8: 22,749,333 (GRCm39)	R674G	probably benign	Het
Zbtb11	T	A	16: 55,818,372 (GRCm39)	C599S	probably damaging	Het
Zfp541	A	G	7: 15,812,252 (GRCm39)	R302G	possibly damaging	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,460,486 (GRCm39)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,393,244 (GRCm39)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,438,788 (GRCm39)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,432,057 (GRCm39)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,364,189 (GRCm39)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,528,719 (GRCm39)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,466,820 (GRCm39)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,410,078 (GRCm39)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,359,983 (GRCm39)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,392,946 (GRCm39)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,466,928 (GRCm39)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,378,305 (GRCm39)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,528,723 (GRCm39)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,365,415 (GRCm39)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,372,640 (GRCm39)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,425,937 (GRCm39)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,380,647 (GRCm39)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,392,343 (GRCm39)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,461,802 (GRCm39)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,479,643 (GRCm39)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,551,811 (GRCm39)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,522,709 (GRCm39)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,442,621 (GRCm39)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,457,560 (GRCm39)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,392,697 (GRCm39)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,351,678 (GRCm39)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,367,428 (GRCm39)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,414,715 (GRCm39)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,441,805 (GRCm39)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,536,212 (GRCm39)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,392,889 (GRCm39)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,536,134 (GRCm39)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,426,025 (GRCm39)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
compost	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
decompose	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
moulder	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,461,898 (GRCm39)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,389,578 (GRCm39)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,394,070 (GRCm39)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,551,761 (GRCm39)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,394,103 (GRCm39)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,372,569 (GRCm39)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,419,895 (GRCm39)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,433,827 (GRCm39)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,432,024 (GRCm39)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,412,230 (GRCm39)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,457,449 (GRCm39)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,513,293 (GRCm39)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,500,129 (GRCm39)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,422,271 (GRCm39)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,378,353 (GRCm39)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,412,262 (GRCm39)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,437,588 (GRCm39)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,357,999 (GRCm39)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,446,218 (GRCm39)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,393,334 (GRCm39)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,536,303 (GRCm39)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,441,825 (GRCm39)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,470,033 (GRCm39)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,407,287 (GRCm39)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,464,947 (GRCm39)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,461,852 (GRCm39)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1751:Mycbp2	UTSW	14	103,485,841 (GRCm39)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,485,841 (GRCm39)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,419,855 (GRCm39)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,393,150 (GRCm39)	missense	possibly damaging	0.94
R1916:Mycbp2	UTSW	14	103,422,319 (GRCm39)	missense	probably damaging	1.00
R1944:Mycbp2	UTSW	14	103,466,840 (GRCm39)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,383,407 (GRCm39)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,485,839 (GRCm39)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,497,675 (GRCm39)	missense	probably damaging	1.00
R2061:Mycbp2	UTSW	14	103,524,696 (GRCm39)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,457,512 (GRCm39)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,438,666 (GRCm39)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,383,378 (GRCm39)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,407,291 (GRCm39)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,407,295 (GRCm39)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,500,185 (GRCm39)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,381,774 (GRCm39)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,412,386 (GRCm39)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,437,554 (GRCm39)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,368,681 (GRCm39)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,392,691 (GRCm39)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,534,794 (GRCm39)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,446,179 (GRCm39)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,437,550 (GRCm39)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,372,553 (GRCm39)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,466,866 (GRCm39)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,393,850 (GRCm39)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,371,224 (GRCm39)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,434,721 (GRCm39)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,412,233 (GRCm39)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,364,149 (GRCm39)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,441,936 (GRCm39)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,532,688 (GRCm39)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,376,161 (GRCm39)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,389,593 (GRCm39)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,485,893 (GRCm39)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,360,881 (GRCm39)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,524,664 (GRCm39)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,372,702 (GRCm39)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,371,225 (GRCm39)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,425,938 (GRCm39)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,393,094 (GRCm39)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,583,733 (GRCm39)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,414,749 (GRCm39)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,426,027 (GRCm39)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,457,380 (GRCm39)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,466,873 (GRCm39)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,448,731 (GRCm39)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,383,382 (GRCm39)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,524,675 (GRCm39)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,497,821 (GRCm39)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,393,946 (GRCm39)	missense	probably benign	0.21
R5038:Mycbp2	UTSW	14	103,534,375 (GRCm39)	missense	probably damaging	1.00
R5044:Mycbp2	UTSW	14	103,376,671 (GRCm39)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,583,650 (GRCm39)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,583,757 (GRCm39)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,423,119 (GRCm39)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,479,868 (GRCm39)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,543,697 (GRCm39)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,438,837 (GRCm39)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,437,562 (GRCm39)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,479,615 (GRCm39)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,411,250 (GRCm39)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,532,673 (GRCm39)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,520,081 (GRCm39)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,372,679 (GRCm39)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,380,203 (GRCm39)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,528,769 (GRCm39)	missense	probably damaging	0.98
R5590:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	1.00
R5592:Mycbp2	UTSW	14	103,432,113 (GRCm39)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,426,051 (GRCm39)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,426,044 (GRCm39)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,407,346 (GRCm39)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,528,778 (GRCm39)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,520,101 (GRCm39)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,357,955 (GRCm39)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,385,986 (GRCm39)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,371,410 (GRCm39)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,361,839 (GRCm39)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,364,120 (GRCm39)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,394,159 (GRCm39)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,372,582 (GRCm39)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,460,482 (GRCm39)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,513,323 (GRCm39)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,522,836 (GRCm39)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,392,945 (GRCm39)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,536,183 (GRCm39)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,384,453 (GRCm39)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,497,665 (GRCm39)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,392,862 (GRCm39)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,500,176 (GRCm39)	missense	possibly damaging	0.93
R6329:Mycbp2	UTSW	14	103,393,288 (GRCm39)	missense	probably benign	0.00
R6439:Mycbp2	UTSW	14	103,392,911 (GRCm39)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,373,993 (GRCm39)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,380,317 (GRCm39)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,429,003 (GRCm39)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,376,845 (GRCm39)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,497,630 (GRCm39)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,522,703 (GRCm39)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,392,342 (GRCm39)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,444,117 (GRCm39)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,412,417 (GRCm39)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,393,534 (GRCm39)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,360,039 (GRCm39)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,391,513 (GRCm39)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,520,115 (GRCm39)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,497,636 (GRCm39)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,371,282 (GRCm39)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,452,773 (GRCm39)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,393,733 (GRCm39)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,446,345 (GRCm39)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,434,679 (GRCm39)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,358,027 (GRCm39)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,434,793 (GRCm39)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,513,829 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,480,564 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,389,627 (GRCm39)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,526,180 (GRCm39)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,434,690 (GRCm39)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,583,701 (GRCm39)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,450,059 (GRCm39)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,429,045 (GRCm39)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,429,055 (GRCm39)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,485,840 (GRCm39)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,364,533 (GRCm39)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,376,851 (GRCm39)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,414,729 (GRCm39)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,384,267 (GRCm39)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,393,741 (GRCm39)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,393,582 (GRCm39)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,437,621 (GRCm39)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,392,674 (GRCm39)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,452,898 (GRCm39)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,367,400 (GRCm39)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,436,110 (GRCm39)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,392,640 (GRCm39)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,372,701 (GRCm39)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,398,111 (GRCm39)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,376,250 (GRCm39)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,446,267 (GRCm39)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,392,895 (GRCm39)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,450,155 (GRCm39)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,460,586 (GRCm39)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,466,871 (GRCm39)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,393,781 (GRCm39)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,361,857 (GRCm39)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,446,232 (GRCm39)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,551,752 (GRCm39)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,479,796 (GRCm39)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,469,974 (GRCm39)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,434,753 (GRCm39)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,425,960 (GRCm39)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,497,642 (GRCm39)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,497,705 (GRCm39)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,372,697 (GRCm39)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,433,817 (GRCm39)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,371,474 (GRCm39)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,448,749 (GRCm39)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,434,852 (GRCm39)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,520,229 (GRCm39)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,551,806 (GRCm39)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,384,378 (GRCm39)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,583,685 (GRCm39)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,394,073 (GRCm39)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,407,309 (GRCm39)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,372,559 (GRCm39)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,364,499 (GRCm39)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- TTGCCAAGTTGTGTACCTGG -3'
(R):5'- AGGTTAGTTATACTGGACATGCAC -3'

Sequencing Primer
(F):5'- GCCAAGTTGTGTACCTGGTATAG -3'
(R):5'- AATTGGGTCCTGATGGAG -3'

Posted On

2014-08-25