Incidental Mutation 'R2013:Vmn2r102'
| ID |
222446 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
040022-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2013 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19897006 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 118
(T118A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171741
AA Change: T118A
PolyPhen 2
Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: T118A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700122O11Rik |
T |
G |
17: 48,347,723 (GRCm39) |
T194P |
possibly damaging |
Het |
| 4921504E06Rik |
T |
A |
2: 19,545,124 (GRCm39) |
M110L |
probably benign |
Het |
| Acad9 |
T |
G |
3: 36,127,737 (GRCm39) |
I113R |
probably damaging |
Het |
| Adam34l |
T |
C |
8: 44,079,442 (GRCm39) |
S261G |
possibly damaging |
Het |
| Adamts6 |
A |
T |
13: 104,450,812 (GRCm39) |
I332F |
probably damaging |
Het |
| Adcy8 |
C |
T |
15: 64,639,727 (GRCm39) |
G678S |
probably benign |
Het |
| Afg3l2 |
C |
T |
18: 67,564,842 (GRCm39) |
V211I |
probably damaging |
Het |
| Ahnak |
T |
C |
19: 8,991,937 (GRCm39) |
I4407T |
probably damaging |
Het |
| Alpl |
G |
T |
4: 137,482,458 (GRCm39) |
H79N |
probably benign |
Het |
| Apc |
A |
G |
18: 34,448,644 (GRCm39) |
I1813V |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,525,908 (GRCm39) |
M540T |
probably damaging |
Het |
| Blm |
T |
C |
7: 80,152,147 (GRCm39) |
E600G |
probably damaging |
Het |
| Btbd8 |
T |
C |
5: 107,658,655 (GRCm39) |
W1742R |
probably damaging |
Het |
| Cadps |
T |
A |
14: 12,522,337 (GRCm38) |
D609V |
probably damaging |
Het |
| Ccdc69 |
C |
T |
11: 54,941,983 (GRCm39) |
M174I |
probably benign |
Het |
| Cdk13 |
A |
T |
13: 17,913,748 (GRCm39) |
L877* |
probably null |
Het |
| Cdk14 |
T |
C |
5: 5,143,047 (GRCm39) |
Y228C |
probably damaging |
Het |
| Dip2c |
C |
T |
13: 9,617,882 (GRCm39) |
Q426* |
probably null |
Het |
| Dsp |
A |
G |
13: 38,375,434 (GRCm39) |
N1073S |
probably damaging |
Het |
| Epyc |
T |
C |
10: 97,511,655 (GRCm39) |
I216T |
probably damaging |
Het |
| Erbin |
A |
G |
13: 103,994,041 (GRCm39) |
S300P |
probably damaging |
Het |
| Ercc3 |
A |
G |
18: 32,381,482 (GRCm39) |
T433A |
probably benign |
Het |
| Exoc4 |
A |
G |
6: 33,243,026 (GRCm39) |
T80A |
probably damaging |
Het |
| Foxm1 |
T |
A |
6: 128,352,465 (GRCm39) |
|
probably null |
Het |
| Gaa |
A |
G |
11: 119,175,409 (GRCm39) |
|
probably null |
Het |
| H2-Q4 |
A |
G |
17: 35,599,526 (GRCm39) |
E203G |
probably damaging |
Het |
| Helt |
T |
C |
8: 46,745,355 (GRCm39) |
D214G |
probably damaging |
Het |
| Hlcs |
A |
G |
16: 94,063,599 (GRCm39) |
V487A |
probably benign |
Het |
| Hmmr |
A |
T |
11: 40,619,259 (GRCm39) |
S74T |
possibly damaging |
Het |
| Hspa9 |
A |
T |
18: 35,079,701 (GRCm39) |
Y243N |
probably damaging |
Het |
| Htt |
T |
G |
5: 35,010,215 (GRCm39) |
L1556R |
probably damaging |
Het |
| Ift80 |
T |
C |
3: 68,898,117 (GRCm39) |
K73E |
possibly damaging |
Het |
| Il6st |
G |
A |
13: 112,635,423 (GRCm39) |
A551T |
probably null |
Het |
| Kdm5a |
T |
C |
6: 120,408,951 (GRCm39) |
S1545P |
probably benign |
Het |
| Lef1 |
T |
A |
3: 130,905,236 (GRCm39) |
I39N |
probably damaging |
Het |
| Lmo2 |
T |
C |
2: 103,811,407 (GRCm39) |
Y147H |
probably damaging |
Het |
| Lrp6 |
A |
G |
6: 134,457,337 (GRCm39) |
|
probably null |
Het |
| Macf1 |
T |
C |
4: 123,577,807 (GRCm39) |
D59G |
probably damaging |
Het |
| Maged1 |
T |
C |
X: 93,580,523 (GRCm39) |
Y636C |
possibly damaging |
Het |
| Mamdc4 |
T |
A |
2: 25,453,584 (GRCm39) |
D1195V |
probably damaging |
Het |
| Mob3b |
A |
G |
4: 35,083,922 (GRCm39) |
V89A |
probably benign |
Het |
| Mogs |
C |
T |
6: 83,094,631 (GRCm39) |
R483* |
probably null |
Het |
| Mybphl |
A |
C |
3: 108,282,718 (GRCm39) |
T203P |
probably benign |
Het |
| Myo15a |
A |
G |
11: 60,385,057 (GRCm39) |
T1720A |
probably damaging |
Het |
| Myo16 |
T |
A |
8: 10,552,796 (GRCm39) |
F945I |
probably damaging |
Het |
| Nbeal2 |
G |
A |
9: 110,463,139 (GRCm39) |
L1309F |
probably benign |
Het |
| Nes |
A |
G |
3: 87,883,985 (GRCm39) |
Q748R |
possibly damaging |
Het |
| Nhsl1 |
A |
T |
10: 18,387,340 (GRCm39) |
R205W |
probably damaging |
Het |
| Nlrc3 |
A |
C |
16: 3,782,974 (GRCm39) |
L161R |
probably damaging |
Het |
| Npy2r |
T |
A |
3: 82,448,487 (GRCm39) |
D96V |
probably damaging |
Het |
| Or4d11 |
T |
A |
19: 12,013,518 (GRCm39) |
E196V |
probably damaging |
Het |
| Or5w18 |
T |
G |
2: 87,632,847 (GRCm39) |
V38G |
probably damaging |
Het |
| Pappa2 |
C |
T |
1: 158,662,498 (GRCm39) |
C1159Y |
probably damaging |
Het |
| Phf21a |
T |
C |
2: 92,058,828 (GRCm39) |
|
probably null |
Het |
| Pik3c2a |
T |
A |
7: 115,950,166 (GRCm39) |
|
probably null |
Het |
| Psg22 |
A |
T |
7: 18,453,560 (GRCm39) |
Y85F |
possibly damaging |
Het |
| Pttg1ip2 |
T |
A |
5: 5,505,964 (GRCm39) |
I106L |
probably benign |
Het |
| Qtrt2 |
A |
G |
16: 43,689,455 (GRCm39) |
I181T |
probably damaging |
Het |
| Sash1 |
A |
T |
10: 8,605,177 (GRCm39) |
V1071D |
probably benign |
Het |
| Scn10a |
A |
T |
9: 119,442,802 (GRCm39) |
I1481N |
probably damaging |
Het |
| Slc15a1 |
G |
A |
14: 121,713,399 (GRCm39) |
A376V |
possibly damaging |
Het |
| Slc25a46 |
A |
T |
18: 31,742,778 (GRCm39) |
H29Q |
probably benign |
Het |
| Slit2 |
T |
C |
5: 48,459,832 (GRCm39) |
C1354R |
probably damaging |
Het |
| Ssu2 |
C |
T |
6: 112,360,902 (GRCm39) |
E52K |
possibly damaging |
Het |
| Taar7e |
A |
T |
10: 23,913,732 (GRCm39) |
H74L |
possibly damaging |
Het |
| Tcte1 |
A |
T |
17: 45,852,237 (GRCm39) |
N490I |
probably benign |
Het |
| Tent4b |
T |
A |
8: 88,972,223 (GRCm39) |
|
probably null |
Het |
| Tpst2 |
G |
T |
5: 112,455,880 (GRCm39) |
G140C |
probably damaging |
Het |
| Trip11 |
A |
T |
12: 101,803,981 (GRCm39) |
F1634I |
probably damaging |
Het |
| Trpm2 |
A |
G |
10: 77,761,600 (GRCm39) |
F1017L |
probably damaging |
Het |
| Utp18 |
A |
G |
11: 93,766,948 (GRCm39) |
V253A |
possibly damaging |
Het |
| Vmn2r14 |
T |
C |
5: 109,369,109 (GRCm39) |
T155A |
probably benign |
Het |
| Vmn2r19 |
T |
A |
6: 123,292,954 (GRCm39) |
M332K |
probably benign |
Het |
| Vmn2r71 |
T |
A |
7: 85,269,845 (GRCm39) |
M452K |
probably benign |
Het |
| Vmn2r79 |
T |
G |
7: 86,653,289 (GRCm39) |
L518R |
possibly damaging |
Het |
| Vps13b |
T |
C |
15: 35,607,288 (GRCm39) |
S1074P |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,835,078 (GRCm39) |
S2757P |
probably damaging |
Het |
| Wdr33 |
C |
A |
18: 32,022,029 (GRCm39) |
Q860K |
unknown |
Het |
| Zfp423 |
T |
A |
8: 88,509,025 (GRCm39) |
I440F |
probably benign |
Het |
| Zup1 |
A |
G |
10: 33,805,820 (GRCm39) |
V437A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TAAGGTAAAGGAGCTTACCTAAACC -3'
(R):5'- ACAATCCAAATTTTCTCACCTGTGG -3'
Sequencing Primer
(F):5'- AGGAGCTTACCTAAACCTATTTACC -3'
(R):5'- CCTGTGGAAATTTAAAAAGTTGAAGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation