Incidental Mutation 'R1987:Fn1'
ID 222582
Institutional Source Beutler Lab
Gene Symbol Fn1
Ensembl Gene ENSMUSG00000026193
Gene Name fibronectin 1
Synonyms Fn-1, Fn
MMRRC Submission 039999-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1987 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 71624679-71692359 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 71690784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 59 (H59R)
Ref Sequence ENSEMBL: ENSMUSP00000140471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055226] [ENSMUST00000186129] [ENSMUST00000186940] [ENSMUST00000190780] [ENSMUST00000188894] [ENSMUST00000187938] [ENSMUST00000188674] [ENSMUST00000189821] [ENSMUST00000186736]
AlphaFold P11276
Predicted Effect possibly damaging
Transcript: ENSMUST00000055226
AA Change: H59R

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000054499
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1264 1346 4.22e-9 SMART
FN3 1357 1437 9.6e-13 SMART
FN3 1448 1527 1.82e-13 SMART
FN3 1538 1617 6.69e-12 SMART
FN3 1632 1711 2.72e-12 SMART
FN3 1722 1801 8.9e-8 SMART
FN3 1812 1891 1.66e-7 SMART
FN3 1904 1983 4.92e-10 SMART
FN3 1993 2074 3.64e-13 SMART
low complexity region 2148 2165 N/A INTRINSIC
FN3 2193 2272 2.9e0 SMART
FN1 2296 2340 3.72e-19 SMART
FN1 2341 2383 2.49e-20 SMART
FN1 2385 2425 2.69e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000097699
SMART Domains Protein: ENSMUSP00000095305
Gene: ENSMUSG00000073652

DomainStartEndE-ValueType
low complexity region 40 67 N/A INTRINSIC
low complexity region 96 108 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125934
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126516
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127218
Predicted Effect probably damaging
Transcript: ENSMUST00000186129
AA Change: H59R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000141123
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1893 3.64e-13 SMART
low complexity region 1967 1984 N/A INTRINSIC
FN3 2012 2091 2.9e0 SMART
FN1 2115 2159 3.72e-19 SMART
FN1 2160 2202 2.49e-20 SMART
FN1 2204 2244 2.69e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186940
AA Change: H59R

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000140315
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 1.77e-11 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000190780
AA Change: H59R

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000140816
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1893 3.64e-13 SMART
low complexity region 1942 1959 N/A INTRINSIC
FN3 1987 2066 2.9e0 SMART
FN1 2090 2134 3.72e-19 SMART
FN1 2135 2177 2.49e-20 SMART
FN1 2179 2219 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000188894
AA Change: H59R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000140471
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1983 3.64e-13 SMART
low complexity region 2057 2074 N/A INTRINSIC
FN3 2102 2181 2.9e0 SMART
FN1 2205 2249 3.72e-19 SMART
FN1 2250 2292 2.49e-20 SMART
FN1 2294 2334 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000187938
AA Change: H59R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000140975
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1983 3.64e-13 SMART
low complexity region 2032 2049 N/A INTRINSIC
FN3 2077 2156 2.9e0 SMART
FN1 2180 2224 3.72e-19 SMART
FN1 2225 2267 2.49e-20 SMART
FN1 2269 2309 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000188674
AA Change: H59R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000140907
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 8.9e-8 SMART
FN3 1721 1800 1.66e-7 SMART
FN3 1813 1892 4.92e-10 SMART
FN3 1902 1981 6.79e-13 SMART
FN3 1983 2061 1.01e1 SMART
FN1 2085 2129 3.72e-19 SMART
FN1 2130 2172 2.49e-20 SMART
FN1 2174 2214 2.69e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000189821
AA Change: H59R

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000139702
Gene: ENSMUSG00000026193
AA Change: H59R

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
FN1 53 93 6.38e-18 SMART
FN1 98 141 6.04e-19 SMART
FN1 142 185 6.94e-19 SMART
FN1 187 231 3.47e-19 SMART
FN1 232 276 6.04e-19 SMART
FN1 308 347 5.91e-13 SMART
FN2 353 401 6.66e-30 SMART
FN2 413 461 5.05e-30 SMART
FN1 470 513 2.59e-18 SMART
FN1 518 560 1.68e-17 SMART
FN1 561 604 5.69e-15 SMART
FN3 609 688 3.79e-2 SMART
FN3 719 798 1.27e-3 SMART
FN3 810 888 7.92e-14 SMART
FN3 906 985 4.28e-10 SMART
FN3 996 1074 2.53e-12 SMART
FN3 1086 1160 1.31e-5 SMART
FN3 1173 1255 1.13e-9 SMART
FN3 1266 1346 9.6e-13 SMART
FN3 1357 1436 1.82e-13 SMART
FN3 1447 1526 6.69e-12 SMART
FN3 1541 1620 2.72e-12 SMART
FN3 1631 1710 1.66e-7 SMART
FN3 1723 1802 4.92e-10 SMART
FN3 1812 1891 6.79e-13 SMART
FN3 1893 1971 1.01e1 SMART
FN1 1995 2039 3.72e-19 SMART
FN1 2040 2082 2.49e-20 SMART
FN1 2084 2124 2.69e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186879
Predicted Effect probably benign
Transcript: ENSMUST00000186736
SMART Domains Protein: ENSMUSP00000140372
Gene: ENSMUSG00000026193

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
FN1 53 96 3.3e-21 SMART
FN1 98 142 1.7e-21 SMART
Pfam:fn1 143 160 1.2e-4 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mutants are defective in mesodermal function. Null mutants are embryonic lethal with major patterning and organizational defects. Conditional mutants live and show increased neuronal apoptosis and susceptibility to induced cerebral ischemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak A T 19: 8,992,615 (GRCm39) D4633V probably damaging Het
Akap6 T C 12: 53,187,578 (GRCm39) F1664S possibly damaging Het
Arhgef28 T C 13: 98,103,604 (GRCm39) M803V probably benign Het
Bltp1 T A 3: 37,008,134 (GRCm39) probably null Het
Bltp2 A T 11: 78,158,993 (GRCm39) Q433L probably damaging Het
Ccdc73 T A 2: 104,761,390 (GRCm39) L130* probably null Het
Ccdc73 A G 2: 104,829,504 (GRCm39) E1059G probably damaging Het
Ccer2 A C 7: 28,456,708 (GRCm39) S151R possibly damaging Het
Cep128 T A 12: 91,197,603 (GRCm39) H406L probably benign Het
Cep135 A G 5: 76,745,275 (GRCm39) D229G probably benign Het
Cpvl T A 6: 53,931,596 (GRCm39) D103V probably benign Het
Crppa T A 12: 36,571,995 (GRCm39) L301Q probably damaging Het
Cstdc6 C A 16: 36,142,194 (GRCm39) G61C probably damaging Het
Disp3 G A 4: 148,343,210 (GRCm39) A567V probably damaging Het
Dnah5 T C 15: 28,343,737 (GRCm39) I2379T probably damaging Het
Dnah6 T C 6: 73,072,027 (GRCm39) Y2433C probably damaging Het
Dock3 A G 9: 106,985,620 (GRCm39) I85T probably benign Het
Dock9 A C 14: 121,829,242 (GRCm39) S1380A probably benign Het
Erbin T C 13: 104,022,711 (GRCm39) T43A probably benign Het
Fastkd3 T C 13: 68,733,360 (GRCm39) V502A possibly damaging Het
Fsd2 A G 7: 81,209,407 (GRCm39) V145A possibly damaging Het
Fzr1 A G 10: 81,206,153 (GRCm39) V178A probably damaging Het
Gnpnat1 T C 14: 45,618,455 (GRCm39) R116G probably damaging Het
Grm7 T A 6: 110,891,472 (GRCm39) V235E probably damaging Het
Hdac4 A C 1: 91,862,367 (GRCm39) N1002K probably damaging Het
Hey1 C T 3: 8,729,957 (GRCm39) A167T probably benign Het
Hrnr A G 3: 93,239,911 (GRCm39) N3383S unknown Het
Ints2 A T 11: 86,108,626 (GRCm39) V907D probably benign Het
Jchain T A 5: 88,669,326 (GRCm39) Q109L probably damaging Het
Klhdc7a A T 4: 139,693,335 (GRCm39) Y537* probably null Het
Klra1 C T 6: 130,354,742 (GRCm39) S92N probably benign Het
Krt31 C T 11: 99,940,406 (GRCm39) G150S probably benign Het
Lrrc71 G A 3: 87,649,950 (GRCm39) T326M probably benign Het
Lrrn4 T C 2: 132,712,363 (GRCm39) T487A probably benign Het
Map4k5 T G 12: 69,889,686 (GRCm39) R198S probably damaging Het
Men1 G A 19: 6,388,867 (GRCm39) C354Y probably damaging Het
Ms4a18 A T 19: 10,991,019 (GRCm39) V25E probably damaging Het
Mutyh T A 4: 116,676,565 (GRCm39) S512R possibly damaging Het
Myh10 G T 11: 68,705,322 (GRCm39) A1947S possibly damaging Het
Nfasc T C 1: 132,538,624 (GRCm39) D427G probably damaging Het
Nlrp9c A G 7: 26,077,481 (GRCm39) M767T probably benign Het
Nrbp1 T C 5: 31,402,735 (GRCm39) L185P probably damaging Het
Pcdh9 G A 14: 94,125,741 (GRCm39) P143L probably damaging Het
Pcsk6 A T 7: 65,577,035 (GRCm39) M158L possibly damaging Het
Pkd1 G T 17: 24,795,566 (GRCm39) probably null Het
Plk4 A T 3: 40,760,252 (GRCm39) S383C possibly damaging Het
Plxna2 T C 1: 194,326,297 (GRCm39) L77P probably damaging Het
Pnpla6 A T 8: 3,592,370 (GRCm39) T1209S probably benign Het
Prdm2 A G 4: 142,859,079 (GRCm39) S1404P possibly damaging Het
Preb T C 5: 31,116,157 (GRCm39) D150G probably damaging Het
Prrt2 A G 7: 126,617,902 (GRCm39) V59A probably benign Het
Prss40 T C 1: 34,597,095 (GRCm39) N151S possibly damaging Het
Ptprt G T 2: 161,400,818 (GRCm39) A1053D probably damaging Het
Ptprt A G 2: 161,608,241 (GRCm39) V685A possibly damaging Het
Rfx4 C T 10: 84,731,952 (GRCm39) S549F possibly damaging Het
Rnaset2b T A 17: 7,263,876 (GRCm39) V87E probably benign Het
Rnf213 G A 11: 119,331,933 (GRCm39) E2381K probably damaging Het
Sectm1a A T 11: 120,960,506 (GRCm39) I103N probably damaging Het
Selp T A 1: 163,970,327 (GRCm39) L597Q probably damaging Het
Sema6a T C 18: 47,433,209 (GRCm39) D74G probably damaging Het
Serpinb9b T C 13: 33,213,542 (GRCm39) V33A probably benign Het
Setd1b A T 5: 123,285,769 (GRCm39) T272S unknown Het
Sgf29 G C 7: 126,248,649 (GRCm39) probably null Het
Slc4a10 C A 2: 62,098,548 (GRCm39) Q561K probably damaging Het
Slc4a5 T C 6: 83,250,214 (GRCm39) I649T possibly damaging Het
Slc5a7 A G 17: 54,600,863 (GRCm39) Y91H probably damaging Het
Styxl1 T C 5: 135,785,976 (GRCm39) Y23C probably damaging Het
Tbc1d24 A G 17: 24,425,846 (GRCm39) V490A possibly damaging Het
Tbpl2 A T 2: 23,984,744 (GRCm39) F133L probably benign Het
Tnfrsf22 T C 7: 143,192,126 (GRCm39) probably benign Het
Top2b A G 14: 16,398,916 (GRCm38) E512G probably damaging Het
Trgc3 C A 13: 19,445,164 (GRCm39) F37L probably damaging Het
Ttc17 T A 2: 94,194,690 (GRCm39) H561L probably benign Het
Ttll4 G T 1: 74,724,527 (GRCm39) V566L possibly damaging Het
Ubqlnl A G 7: 103,797,692 (GRCm39) Y602H probably benign Het
Vmn1r231 T A 17: 21,110,212 (GRCm39) E234D probably damaging Het
Wbp11 A G 6: 136,797,583 (GRCm39) S279P probably damaging Het
Wdr6 A G 9: 108,453,733 (GRCm39) L50P probably damaging Het
Zfp715 A C 7: 42,948,073 (GRCm39) I629S possibly damaging Het
Other mutations in Fn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Fn1 APN 1 71,692,032 (GRCm39) missense probably benign 0.28
IGL00402:Fn1 APN 1 71,680,322 (GRCm39) missense probably damaging 1.00
IGL00946:Fn1 APN 1 71,684,699 (GRCm39) splice site probably benign
IGL01311:Fn1 APN 1 71,667,299 (GRCm39) missense probably damaging 1.00
IGL01338:Fn1 APN 1 71,665,369 (GRCm39) missense probably damaging 0.98
IGL01353:Fn1 APN 1 71,626,098 (GRCm39) missense probably damaging 1.00
IGL01674:Fn1 APN 1 71,645,900 (GRCm39) missense probably damaging 1.00
IGL01701:Fn1 APN 1 71,669,012 (GRCm39) splice site probably benign
IGL01734:Fn1 APN 1 71,658,644 (GRCm39) missense probably damaging 1.00
IGL01788:Fn1 APN 1 71,652,996 (GRCm39) missense probably damaging 1.00
IGL02186:Fn1 APN 1 71,677,693 (GRCm39) missense probably damaging 1.00
IGL02398:Fn1 APN 1 71,657,829 (GRCm39) splice site probably null
IGL02425:Fn1 APN 1 71,680,302 (GRCm39) splice site probably benign
IGL02516:Fn1 APN 1 71,676,482 (GRCm39) missense possibly damaging 0.78
IGL02593:Fn1 APN 1 71,641,591 (GRCm39) missense probably benign
IGL02651:Fn1 APN 1 71,636,835 (GRCm39) missense possibly damaging 0.65
IGL02681:Fn1 APN 1 71,658,641 (GRCm39) missense probably damaging 1.00
IGL02890:Fn1 APN 1 71,637,531 (GRCm39) critical splice donor site probably null
IGL02929:Fn1 APN 1 71,634,821 (GRCm39) critical splice donor site probably null
IGL03036:Fn1 APN 1 71,668,932 (GRCm39) missense probably damaging 1.00
IGL03088:Fn1 APN 1 71,653,197 (GRCm39) splice site probably null
IGL03142:Fn1 APN 1 71,676,455 (GRCm39) missense probably damaging 1.00
IGL03172:Fn1 APN 1 71,680,421 (GRCm39) missense probably damaging 0.99
IGL03184:Fn1 APN 1 71,648,656 (GRCm39) missense probably benign 0.02
IGL03212:Fn1 APN 1 71,680,484 (GRCm39) nonsense probably null
IGL03246:Fn1 APN 1 71,663,455 (GRCm39) missense possibly damaging 0.89
IGL03367:Fn1 APN 1 71,636,712 (GRCm39) missense probably benign 0.27
depth UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
flooded UTSW 1 71,636,675 (GRCm39) missense probably benign 0.01
R0684_Fn1_062 UTSW 1 71,634,968 (GRCm39) splice site probably null
series UTSW 1 71,634,945 (GRCm39) missense probably damaging 1.00
PIT4514001:Fn1 UTSW 1 71,667,615 (GRCm39) missense probably benign 0.01
R0008:Fn1 UTSW 1 71,634,879 (GRCm39) missense probably damaging 0.98
R0112:Fn1 UTSW 1 71,648,812 (GRCm39) missense probably damaging 1.00
R0138:Fn1 UTSW 1 71,663,269 (GRCm39) missense possibly damaging 0.82
R0383:Fn1 UTSW 1 71,636,844 (GRCm39) missense probably damaging 0.99
R0386:Fn1 UTSW 1 71,634,945 (GRCm39) missense probably damaging 1.00
R0648:Fn1 UTSW 1 71,636,744 (GRCm39) missense possibly damaging 0.79
R0684:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R1054:Fn1 UTSW 1 71,625,373 (GRCm39) makesense probably null
R1183:Fn1 UTSW 1 71,625,404 (GRCm39) missense probably damaging 0.98
R1405:Fn1 UTSW 1 71,681,237 (GRCm39) missense probably damaging 1.00
R1405:Fn1 UTSW 1 71,681,237 (GRCm39) missense probably damaging 1.00
R1414:Fn1 UTSW 1 71,640,462 (GRCm39) splice site probably benign
R1677:Fn1 UTSW 1 71,636,814 (GRCm39) missense probably benign 0.00
R1773:Fn1 UTSW 1 71,676,542 (GRCm39) missense probably damaging 1.00
R1830:Fn1 UTSW 1 71,663,418 (GRCm39) missense probably damaging 1.00
R1989:Fn1 UTSW 1 71,690,784 (GRCm39) missense probably damaging 1.00
R2068:Fn1 UTSW 1 71,639,598 (GRCm39) missense probably damaging 1.00
R2113:Fn1 UTSW 1 71,665,323 (GRCm39) missense probably damaging 1.00
R2145:Fn1 UTSW 1 71,645,163 (GRCm39) missense probably damaging 1.00
R2246:Fn1 UTSW 1 71,667,694 (GRCm39) missense probably benign 0.10
R2273:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2274:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2275:Fn1 UTSW 1 71,653,102 (GRCm39) missense probably null 1.00
R2303:Fn1 UTSW 1 71,653,195 (GRCm39) critical splice acceptor site probably null
R2379:Fn1 UTSW 1 71,688,443 (GRCm39) nonsense probably null
R2382:Fn1 UTSW 1 71,687,278 (GRCm39) missense probably damaging 1.00
R2567:Fn1 UTSW 1 71,636,895 (GRCm39) nonsense probably null
R2864:Fn1 UTSW 1 71,641,578 (GRCm39) missense probably damaging 0.99
R3154:Fn1 UTSW 1 71,632,242 (GRCm39) missense probably damaging 1.00
R3837:Fn1 UTSW 1 71,692,314 (GRCm39) splice site probably null
R3844:Fn1 UTSW 1 71,648,733 (GRCm39) missense possibly damaging 0.61
R3886:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3887:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3888:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3889:Fn1 UTSW 1 71,679,465 (GRCm39) missense probably damaging 1.00
R3905:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3906:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3907:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R3909:Fn1 UTSW 1 71,647,072 (GRCm39) missense probably damaging 1.00
R4611:Fn1 UTSW 1 71,663,337 (GRCm39) nonsense probably null
R4724:Fn1 UTSW 1 71,687,307 (GRCm39) critical splice acceptor site probably null
R4732:Fn1 UTSW 1 71,641,671 (GRCm39) splice site probably null
R4733:Fn1 UTSW 1 71,641,671 (GRCm39) splice site probably null
R4756:Fn1 UTSW 1 71,629,967 (GRCm39) missense probably damaging 1.00
R4809:Fn1 UTSW 1 71,691,959 (GRCm39) intron probably benign
R4839:Fn1 UTSW 1 71,681,242 (GRCm39) missense probably damaging 1.00
R4915:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R4917:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R4918:Fn1 UTSW 1 71,634,968 (GRCm39) splice site probably null
R5002:Fn1 UTSW 1 71,668,887 (GRCm39) missense possibly damaging 0.48
R5015:Fn1 UTSW 1 71,665,336 (GRCm39) missense probably damaging 0.98
R5022:Fn1 UTSW 1 71,663,338 (GRCm39) missense probably damaging 1.00
R5109:Fn1 UTSW 1 71,688,394 (GRCm39) missense probably damaging 1.00
R5267:Fn1 UTSW 1 71,668,863 (GRCm39) missense probably damaging 1.00
R5323:Fn1 UTSW 1 71,636,591 (GRCm39) missense probably benign 0.09
R5333:Fn1 UTSW 1 71,663,339 (GRCm39) missense probably damaging 1.00
R5631:Fn1 UTSW 1 71,629,355 (GRCm39) missense probably damaging 1.00
R5644:Fn1 UTSW 1 71,666,409 (GRCm39) missense probably damaging 1.00
R5754:Fn1 UTSW 1 71,639,481 (GRCm39) missense probably damaging 1.00
R5807:Fn1 UTSW 1 71,687,218 (GRCm39) missense probably damaging 1.00
R6053:Fn1 UTSW 1 71,638,449 (GRCm39) missense probably damaging 1.00
R6133:Fn1 UTSW 1 71,636,886 (GRCm39) missense probably damaging 1.00
R6186:Fn1 UTSW 1 71,676,449 (GRCm39) missense probably damaging 1.00
R6270:Fn1 UTSW 1 71,676,434 (GRCm39) missense probably damaging 1.00
R6332:Fn1 UTSW 1 71,667,230 (GRCm39) missense probably benign 0.01
R6431:Fn1 UTSW 1 71,687,003 (GRCm39) splice site probably null
R6571:Fn1 UTSW 1 71,665,349 (GRCm39) missense probably damaging 1.00
R6596:Fn1 UTSW 1 71,648,641 (GRCm39) missense probably damaging 1.00
R6862:Fn1 UTSW 1 71,653,066 (GRCm39) missense probably benign 0.43
R6898:Fn1 UTSW 1 71,639,572 (GRCm39) missense probably damaging 1.00
R6984:Fn1 UTSW 1 71,665,238 (GRCm39) missense probably damaging 1.00
R7107:Fn1 UTSW 1 71,666,408 (GRCm39) missense probably damaging 1.00
R7121:Fn1 UTSW 1 71,639,697 (GRCm39) intron probably benign
R7127:Fn1 UTSW 1 71,636,703 (GRCm39) missense probably benign 0.16
R7194:Fn1 UTSW 1 71,641,482 (GRCm39) missense probably damaging 1.00
R7274:Fn1 UTSW 1 71,667,272 (GRCm39) missense probably benign
R7285:Fn1 UTSW 1 71,676,498 (GRCm39) missense probably damaging 1.00
R7426:Fn1 UTSW 1 71,688,384 (GRCm39) missense probably damaging 1.00
R7453:Fn1 UTSW 1 71,630,039 (GRCm39) missense probably damaging 1.00
R7508:Fn1 UTSW 1 71,636,675 (GRCm39) missense probably benign 0.01
R7724:Fn1 UTSW 1 71,642,894 (GRCm39) missense probably benign 0.02
R7848:Fn1 UTSW 1 71,689,760 (GRCm39) missense probably damaging 1.00
R7992:Fn1 UTSW 1 71,638,825 (GRCm39) missense probably benign 0.34
R8036:Fn1 UTSW 1 71,629,310 (GRCm39) nonsense probably null
R8077:Fn1 UTSW 1 71,651,761 (GRCm39) missense probably damaging 1.00
R8175:Fn1 UTSW 1 71,638,824 (GRCm39) missense probably damaging 1.00
R8177:Fn1 UTSW 1 71,648,746 (GRCm39) missense probably benign
R8212:Fn1 UTSW 1 71,682,064 (GRCm39) missense probably benign 0.01
R8322:Fn1 UTSW 1 71,667,618 (GRCm39) missense probably benign 0.04
R8745:Fn1 UTSW 1 71,676,528 (GRCm39) missense probably benign 0.00
R8780:Fn1 UTSW 1 71,682,308 (GRCm39) missense probably benign 0.00
R8805:Fn1 UTSW 1 71,644,239 (GRCm39) missense probably benign 0.27
R8927:Fn1 UTSW 1 71,638,535 (GRCm39) missense probably benign 0.16
R8928:Fn1 UTSW 1 71,638,535 (GRCm39) missense probably benign 0.16
R8928:Fn1 UTSW 1 71,641,777 (GRCm39) intron probably benign
R8989:Fn1 UTSW 1 71,663,446 (GRCm39) missense possibly damaging 0.95
R8991:Fn1 UTSW 1 71,676,491 (GRCm39) missense probably benign 0.05
R9095:Fn1 UTSW 1 71,647,149 (GRCm39) missense probably null 0.02
R9455:Fn1 UTSW 1 71,647,112 (GRCm39) missense probably benign
R9589:Fn1 UTSW 1 71,668,941 (GRCm39) missense probably damaging 1.00
R9631:Fn1 UTSW 1 71,625,387 (GRCm39) missense probably benign 0.01
R9645:Fn1 UTSW 1 71,667,629 (GRCm39) missense probably benign 0.35
R9723:Fn1 UTSW 1 71,663,369 (GRCm39) missense possibly damaging 0.95
X0023:Fn1 UTSW 1 71,637,532 (GRCm39) critical splice donor site probably null
Z1088:Fn1 UTSW 1 71,688,451 (GRCm39) missense probably damaging 1.00
Z1176:Fn1 UTSW 1 71,636,570 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- AGCATGTGAAAAGCCAGTGC -3'
(R):5'- CTAGTTTCCACATCTGAACTTTAGTGG -3'

Sequencing Primer
(F):5'- TTACAAGCGACTGGAGCAG -3'
(R):5'- ACATCTGAACTTTAGTGGAATATTGC -3'
Posted On 2014-08-25