Incidental Mutation 'R1987:Sema6a'
| ID |
222757 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
039999-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1987 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 47433209 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 74
(D74G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121442
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000126684]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019791
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076043
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115449
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000126684
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000118655
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
56 |
216 |
2.5e-51 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135790
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141224
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144223
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156422
AA Change: D74G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151382
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahnak |
A |
T |
19: 8,992,615 (GRCm39) |
D4633V |
probably damaging |
Het |
| Akap6 |
T |
C |
12: 53,187,578 (GRCm39) |
F1664S |
possibly damaging |
Het |
| Arhgef28 |
T |
C |
13: 98,103,604 (GRCm39) |
M803V |
probably benign |
Het |
| Bltp1 |
T |
A |
3: 37,008,134 (GRCm39) |
|
probably null |
Het |
| Bltp2 |
A |
T |
11: 78,158,993 (GRCm39) |
Q433L |
probably damaging |
Het |
| Ccdc73 |
T |
A |
2: 104,761,390 (GRCm39) |
L130* |
probably null |
Het |
| Ccdc73 |
A |
G |
2: 104,829,504 (GRCm39) |
E1059G |
probably damaging |
Het |
| Ccer2 |
A |
C |
7: 28,456,708 (GRCm39) |
S151R |
possibly damaging |
Het |
| Cep128 |
T |
A |
12: 91,197,603 (GRCm39) |
H406L |
probably benign |
Het |
| Cep135 |
A |
G |
5: 76,745,275 (GRCm39) |
D229G |
probably benign |
Het |
| Cpvl |
T |
A |
6: 53,931,596 (GRCm39) |
D103V |
probably benign |
Het |
| Crppa |
T |
A |
12: 36,571,995 (GRCm39) |
L301Q |
probably damaging |
Het |
| Cstdc6 |
C |
A |
16: 36,142,194 (GRCm39) |
G61C |
probably damaging |
Het |
| Disp3 |
G |
A |
4: 148,343,210 (GRCm39) |
A567V |
probably damaging |
Het |
| Dnah5 |
T |
C |
15: 28,343,737 (GRCm39) |
I2379T |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,072,027 (GRCm39) |
Y2433C |
probably damaging |
Het |
| Dock3 |
A |
G |
9: 106,985,620 (GRCm39) |
I85T |
probably benign |
Het |
| Dock9 |
A |
C |
14: 121,829,242 (GRCm39) |
S1380A |
probably benign |
Het |
| Erbin |
T |
C |
13: 104,022,711 (GRCm39) |
T43A |
probably benign |
Het |
| Fastkd3 |
T |
C |
13: 68,733,360 (GRCm39) |
V502A |
possibly damaging |
Het |
| Fn1 |
T |
C |
1: 71,690,784 (GRCm39) |
H59R |
probably damaging |
Het |
| Fsd2 |
A |
G |
7: 81,209,407 (GRCm39) |
V145A |
possibly damaging |
Het |
| Fzr1 |
A |
G |
10: 81,206,153 (GRCm39) |
V178A |
probably damaging |
Het |
| Gnpnat1 |
T |
C |
14: 45,618,455 (GRCm39) |
R116G |
probably damaging |
Het |
| Grm7 |
T |
A |
6: 110,891,472 (GRCm39) |
V235E |
probably damaging |
Het |
| Hdac4 |
A |
C |
1: 91,862,367 (GRCm39) |
N1002K |
probably damaging |
Het |
| Hey1 |
C |
T |
3: 8,729,957 (GRCm39) |
A167T |
probably benign |
Het |
| Hrnr |
A |
G |
3: 93,239,911 (GRCm39) |
N3383S |
unknown |
Het |
| Ints2 |
A |
T |
11: 86,108,626 (GRCm39) |
V907D |
probably benign |
Het |
| Jchain |
T |
A |
5: 88,669,326 (GRCm39) |
Q109L |
probably damaging |
Het |
| Klhdc7a |
A |
T |
4: 139,693,335 (GRCm39) |
Y537* |
probably null |
Het |
| Klra1 |
C |
T |
6: 130,354,742 (GRCm39) |
S92N |
probably benign |
Het |
| Krt31 |
C |
T |
11: 99,940,406 (GRCm39) |
G150S |
probably benign |
Het |
| Lrrc71 |
G |
A |
3: 87,649,950 (GRCm39) |
T326M |
probably benign |
Het |
| Lrrn4 |
T |
C |
2: 132,712,363 (GRCm39) |
T487A |
probably benign |
Het |
| Map4k5 |
T |
G |
12: 69,889,686 (GRCm39) |
R198S |
probably damaging |
Het |
| Men1 |
G |
A |
19: 6,388,867 (GRCm39) |
C354Y |
probably damaging |
Het |
| Ms4a18 |
A |
T |
19: 10,991,019 (GRCm39) |
V25E |
probably damaging |
Het |
| Mutyh |
T |
A |
4: 116,676,565 (GRCm39) |
S512R |
possibly damaging |
Het |
| Myh10 |
G |
T |
11: 68,705,322 (GRCm39) |
A1947S |
possibly damaging |
Het |
| Nfasc |
T |
C |
1: 132,538,624 (GRCm39) |
D427G |
probably damaging |
Het |
| Nlrp9c |
A |
G |
7: 26,077,481 (GRCm39) |
M767T |
probably benign |
Het |
| Nrbp1 |
T |
C |
5: 31,402,735 (GRCm39) |
L185P |
probably damaging |
Het |
| Pcdh9 |
G |
A |
14: 94,125,741 (GRCm39) |
P143L |
probably damaging |
Het |
| Pcsk6 |
A |
T |
7: 65,577,035 (GRCm39) |
M158L |
possibly damaging |
Het |
| Pkd1 |
G |
T |
17: 24,795,566 (GRCm39) |
|
probably null |
Het |
| Plk4 |
A |
T |
3: 40,760,252 (GRCm39) |
S383C |
possibly damaging |
Het |
| Plxna2 |
T |
C |
1: 194,326,297 (GRCm39) |
L77P |
probably damaging |
Het |
| Pnpla6 |
A |
T |
8: 3,592,370 (GRCm39) |
T1209S |
probably benign |
Het |
| Prdm2 |
A |
G |
4: 142,859,079 (GRCm39) |
S1404P |
possibly damaging |
Het |
| Preb |
T |
C |
5: 31,116,157 (GRCm39) |
D150G |
probably damaging |
Het |
| Prrt2 |
A |
G |
7: 126,617,902 (GRCm39) |
V59A |
probably benign |
Het |
| Prss40 |
T |
C |
1: 34,597,095 (GRCm39) |
N151S |
possibly damaging |
Het |
| Ptprt |
G |
T |
2: 161,400,818 (GRCm39) |
A1053D |
probably damaging |
Het |
| Ptprt |
A |
G |
2: 161,608,241 (GRCm39) |
V685A |
possibly damaging |
Het |
| Rfx4 |
C |
T |
10: 84,731,952 (GRCm39) |
S549F |
possibly damaging |
Het |
| Rnaset2b |
T |
A |
17: 7,263,876 (GRCm39) |
V87E |
probably benign |
Het |
| Rnf213 |
G |
A |
11: 119,331,933 (GRCm39) |
E2381K |
probably damaging |
Het |
| Sectm1a |
A |
T |
11: 120,960,506 (GRCm39) |
I103N |
probably damaging |
Het |
| Selp |
T |
A |
1: 163,970,327 (GRCm39) |
L597Q |
probably damaging |
Het |
| Serpinb9b |
T |
C |
13: 33,213,542 (GRCm39) |
V33A |
probably benign |
Het |
| Setd1b |
A |
T |
5: 123,285,769 (GRCm39) |
T272S |
unknown |
Het |
| Sgf29 |
G |
C |
7: 126,248,649 (GRCm39) |
|
probably null |
Het |
| Slc4a10 |
C |
A |
2: 62,098,548 (GRCm39) |
Q561K |
probably damaging |
Het |
| Slc4a5 |
T |
C |
6: 83,250,214 (GRCm39) |
I649T |
possibly damaging |
Het |
| Slc5a7 |
A |
G |
17: 54,600,863 (GRCm39) |
Y91H |
probably damaging |
Het |
| Styxl1 |
T |
C |
5: 135,785,976 (GRCm39) |
Y23C |
probably damaging |
Het |
| Tbc1d24 |
A |
G |
17: 24,425,846 (GRCm39) |
V490A |
possibly damaging |
Het |
| Tbpl2 |
A |
T |
2: 23,984,744 (GRCm39) |
F133L |
probably benign |
Het |
| Tnfrsf22 |
T |
C |
7: 143,192,126 (GRCm39) |
|
probably benign |
Het |
| Top2b |
A |
G |
14: 16,398,916 (GRCm38) |
E512G |
probably damaging |
Het |
| Trgc3 |
C |
A |
13: 19,445,164 (GRCm39) |
F37L |
probably damaging |
Het |
| Ttc17 |
T |
A |
2: 94,194,690 (GRCm39) |
H561L |
probably benign |
Het |
| Ttll4 |
G |
T |
1: 74,724,527 (GRCm39) |
V566L |
possibly damaging |
Het |
| Ubqlnl |
A |
G |
7: 103,797,692 (GRCm39) |
Y602H |
probably benign |
Het |
| Vmn1r231 |
T |
A |
17: 21,110,212 (GRCm39) |
E234D |
probably damaging |
Het |
| Wbp11 |
A |
G |
6: 136,797,583 (GRCm39) |
S279P |
probably damaging |
Het |
| Wdr6 |
A |
G |
9: 108,453,733 (GRCm39) |
L50P |
probably damaging |
Het |
| Zfp715 |
A |
C |
7: 42,948,073 (GRCm39) |
I629S |
possibly damaging |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0114:Sema6a
|
UTSW |
18 |
47,423,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5133:Sema6a
|
UTSW |
18 |
47,433,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Sema6a
|
UTSW |
18 |
47,381,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7574:Sema6a
|
UTSW |
18 |
47,424,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Sema6a
|
UTSW |
18 |
47,415,009 (GRCm39) |
missense |
probably benign |
|
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGATGTGTAATAAACCCTCACTC -3'
(R):5'- AGCTGAGCTCTCTATGTATGGC -3'
Sequencing Primer
(F):5'- TCACTCACCCTAAATCAGACATC -3'
(R):5'- AGCTCTCTATGTATGGCTCAGTAG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation