Incidental Mutation 'R0140:Slk'
ID 22291
Institutional Source Beutler Lab
Gene Symbol Slk
Ensembl Gene ENSMUSG00000025060
Gene Name STE20-like kinase
Synonyms Etk4, Stk2, 9A2, SLK, mSLK
MMRRC Submission 038425-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0140 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 19
Chromosomal Location 47568458-47633685 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 47610774 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 815 (D815N)
Ref Sequence ENSEMBL: ENSMUSP00000026043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026043] [ENSMUST00000051691]
AlphaFold O54988
Predicted Effect probably damaging
Transcript: ENSMUST00000026043
AA Change: D815N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026043
Gene: ENSMUSG00000025060
AA Change: D815N

DomainStartEndE-ValueType
S_TKc 34 292 3.18e-99 SMART
low complexity region 305 328 N/A INTRINSIC
low complexity region 442 452 N/A INTRINSIC
low complexity region 585 600 N/A INTRINSIC
low complexity region 690 703 N/A INTRINSIC
low complexity region 783 795 N/A INTRINSIC
Pfam:PKK 849 928 1.2e-19 PFAM
Pfam:PKK 986 1127 7.4e-49 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000051691
AA Change: D815N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000049977
Gene: ENSMUSG00000025060
AA Change: D815N

DomainStartEndE-ValueType
S_TKc 34 292 3.18e-99 SMART
low complexity region 305 328 N/A INTRINSIC
low complexity region 442 452 N/A INTRINSIC
low complexity region 585 600 N/A INTRINSIC
low complexity region 690 703 N/A INTRINSIC
low complexity region 783 795 N/A INTRINSIC
Pfam:PKK 850 988 1.6e-40 PFAM
Pfam:PKK 1018 1158 1.2e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123816
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130115
Meta Mutation Damage Score 0.1052 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency 98% (79/81)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,057,789 (GRCm39) probably benign Het
9330161L09Rik T C 12: 103,373,587 (GRCm39) probably benign Het
Abca2 T G 2: 25,328,097 (GRCm39) probably null Het
Adgrf3 T C 5: 30,401,379 (GRCm39) K13R probably benign Het
Arhgap15 C A 2: 44,212,779 (GRCm39) F416L probably damaging Het
Arhgef26 C G 3: 62,355,666 (GRCm39) T746R probably benign Het
Aspm C T 1: 139,408,379 (GRCm39) T2422I probably benign Het
Atp4a C G 7: 30,419,526 (GRCm39) R659G probably benign Het
AY358078 T A 14: 52,063,399 (GRCm39) D348E probably benign Het
Blnk A T 19: 40,928,668 (GRCm39) S285T probably damaging Het
Calr3 C T 8: 73,188,732 (GRCm39) probably benign Het
Camsap2 A T 1: 136,208,120 (GRCm39) V1124D probably benign Het
Ccdc40 G A 11: 119,155,125 (GRCm39) G1122S probably benign Het
Ccdc69 C A 11: 54,941,325 (GRCm39) C196F possibly damaging Het
Cdhr3 T G 12: 33,130,412 (GRCm39) N141T probably benign Het
Cdk4 T C 10: 126,900,214 (GRCm39) V37A probably damaging Het
Celsr2 C T 3: 108,305,249 (GRCm39) R2110K probably benign Het
Clcn7 A G 17: 25,372,728 (GRCm39) Y437C probably damaging Het
Col6a6 A G 9: 105,579,474 (GRCm39) F1917S probably damaging Het
Cps1 T G 1: 67,219,275 (GRCm39) S872A probably benign Het
Crebbp G T 16: 3,935,363 (GRCm39) T842N probably damaging Het
Dennd2d G A 3: 106,399,799 (GRCm39) V234I probably benign Het
Fam227b T C 2: 125,966,523 (GRCm39) M130V possibly damaging Het
Fbxw24 G T 9: 109,434,482 (GRCm39) L373I possibly damaging Het
Fubp3 T C 2: 31,498,196 (GRCm39) Y359H probably damaging Het
Gm19684 T C 17: 36,438,319 (GRCm39) probably benign Het
Hrnr C T 3: 93,238,800 (GRCm39) Q3013* probably null Het
Il12rb1 T C 8: 71,272,415 (GRCm39) probably benign Het
Lepr A T 4: 101,625,264 (GRCm39) D473V probably damaging Het
Myof A T 19: 37,940,004 (GRCm39) Y820* probably null Het
Nfil3 G A 13: 53,121,681 (GRCm39) Q408* probably null Het
Nolc1 G A 19: 46,069,817 (GRCm39) probably benign Het
Npbwr1 A C 1: 5,986,840 (GRCm39) Y225D probably damaging Het
Nrip3 T C 7: 109,361,022 (GRCm39) probably benign Het
Ntrk1 A C 3: 87,685,875 (GRCm39) L749R probably damaging Het
Or10ag53 A G 2: 87,082,969 (GRCm39) I229M probably damaging Het
Or2b11 A G 11: 59,461,804 (GRCm39) L254P probably damaging Het
Or4c126 T A 2: 89,824,463 (GRCm39) V242D probably damaging Het
Or52a24 A G 7: 103,381,349 (GRCm39) D72G probably damaging Het
Or6c211 G T 10: 129,505,557 (GRCm39) T277N probably damaging Het
Paox A T 7: 139,713,971 (GRCm39) T244S probably damaging Het
Pcdhb9 T A 18: 37,536,014 (GRCm39) D669E possibly damaging Het
Pggt1b A G 18: 46,391,150 (GRCm39) probably null Het
Phkg1 T A 5: 129,893,449 (GRCm39) I334F probably benign Het
Phtf1 A T 3: 103,894,876 (GRCm39) R208W probably null Het
Pnliprp2 A T 19: 58,754,795 (GRCm39) I280F probably benign Het
Pnma8a A G 7: 16,694,147 (GRCm39) M1V probably null Het
Prcp A G 7: 92,577,819 (GRCm39) T328A probably damaging Het
Pxdn A G 12: 30,032,753 (GRCm39) E179G probably benign Het
Racgap1 A T 15: 99,521,532 (GRCm39) N541K probably benign Het
Rnf103 T A 6: 71,486,315 (GRCm39) F315L possibly damaging Het
Septin2 A G 1: 93,429,361 (GRCm39) R237G probably damaging Het
Setd6 T A 8: 96,442,737 (GRCm39) L58Q probably damaging Het
Sipa1l1 G A 12: 82,442,974 (GRCm39) V755I probably damaging Het
Slc16a12 G T 19: 34,650,104 (GRCm39) probably benign Het
Stx1a T C 5: 135,074,439 (GRCm39) probably benign Het
Tbc1d15 T A 10: 115,056,124 (GRCm39) I283F probably damaging Het
Tenm4 T C 7: 96,545,259 (GRCm39) I2425T possibly damaging Het
Tle1 G A 4: 72,038,422 (GRCm39) H702Y probably damaging Het
Tmc6 A G 11: 117,657,077 (GRCm39) probably benign Het
Tmem268 G A 4: 63,496,096 (GRCm39) R179H possibly damaging Het
Tmem9 A G 1: 135,961,900 (GRCm39) K165R probably damaging Het
Trpm6 A G 19: 18,796,558 (GRCm39) probably null Het
Tufm C T 7: 126,089,003 (GRCm39) P88S probably damaging Het
Ubqln1 A G 13: 58,341,103 (GRCm39) I216T probably damaging Het
Urad T G 5: 147,259,141 (GRCm39) M1L probably benign Het
Utp6 A G 11: 79,847,551 (GRCm39) probably benign Het
Vav2 C T 2: 27,163,688 (GRCm39) probably benign Het
Vmn2r55 G T 7: 12,402,104 (GRCm39) Q395K possibly damaging Het
Wwox T G 8: 115,433,027 (GRCm39) V231G probably damaging Het
Zfp646 T A 7: 127,482,678 (GRCm39) N1618K probably benign Het
Zzef1 G A 11: 72,790,377 (GRCm39) M2110I possibly damaging Het
Other mutations in Slk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Slk APN 19 47,608,148 (GRCm39) missense probably benign 0.00
IGL00515:Slk APN 19 47,630,535 (GRCm39) unclassified probably benign
IGL00755:Slk APN 19 47,597,449 (GRCm39) missense probably damaging 0.99
IGL00990:Slk APN 19 47,568,691 (GRCm39) missense probably damaging 0.98
IGL02283:Slk APN 19 47,630,432 (GRCm39) missense probably damaging 1.00
R0364:Slk UTSW 19 47,608,628 (GRCm39) nonsense probably null
R0944:Slk UTSW 19 47,597,432 (GRCm39) missense probably damaging 1.00
R1756:Slk UTSW 19 47,611,116 (GRCm39) missense probably damaging 0.97
R1795:Slk UTSW 19 47,608,973 (GRCm39) missense possibly damaging 0.72
R1869:Slk UTSW 19 47,613,891 (GRCm39) missense probably damaging 1.00
R1980:Slk UTSW 19 47,600,428 (GRCm39) missense probably damaging 1.00
R2261:Slk UTSW 19 47,625,791 (GRCm39) missense probably damaging 0.99
R2278:Slk UTSW 19 47,608,188 (GRCm39) missense probably damaging 0.97
R3746:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3748:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3749:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R3750:Slk UTSW 19 47,608,248 (GRCm39) missense possibly damaging 0.88
R4024:Slk UTSW 19 47,610,809 (GRCm39) splice site probably null
R4471:Slk UTSW 19 47,603,862 (GRCm39) missense probably damaging 1.00
R4647:Slk UTSW 19 47,608,713 (GRCm39) missense possibly damaging 0.71
R4825:Slk UTSW 19 47,608,395 (GRCm39) missense probably benign
R5205:Slk UTSW 19 47,613,899 (GRCm39) missense possibly damaging 0.91
R5228:Slk UTSW 19 47,613,771 (GRCm39) missense probably damaging 1.00
R5372:Slk UTSW 19 47,613,832 (GRCm39) missense probably damaging 1.00
R5665:Slk UTSW 19 47,624,896 (GRCm39) missense probably damaging 1.00
R5688:Slk UTSW 19 47,608,451 (GRCm39) missense probably benign 0.00
R5859:Slk UTSW 19 47,597,481 (GRCm39) missense probably benign 0.37
R6279:Slk UTSW 19 47,630,443 (GRCm39) missense probably damaging 1.00
R6368:Slk UTSW 19 47,608,622 (GRCm39) missense possibly damaging 0.85
R6431:Slk UTSW 19 47,609,327 (GRCm39) missense probably damaging 1.00
R6563:Slk UTSW 19 47,624,908 (GRCm39) critical splice donor site probably null
R6705:Slk UTSW 19 47,597,498 (GRCm39) missense probably benign 0.01
R6790:Slk UTSW 19 47,624,007 (GRCm39) missense probably damaging 0.96
R7495:Slk UTSW 19 47,627,417 (GRCm39) missense probably damaging 1.00
R7598:Slk UTSW 19 47,624,901 (GRCm39) missense probably damaging 1.00
R7728:Slk UTSW 19 47,609,255 (GRCm39) missense probably damaging 1.00
R7850:Slk UTSW 19 47,610,796 (GRCm39) missense probably damaging 1.00
R7860:Slk UTSW 19 47,630,510 (GRCm39) missense possibly damaging 0.65
R7911:Slk UTSW 19 47,603,668 (GRCm39) missense
R8000:Slk UTSW 19 47,597,344 (GRCm39) missense
R8847:Slk UTSW 19 47,607,632 (GRCm39) missense
R8944:Slk UTSW 19 47,600,057 (GRCm39) missense probably damaging 0.99
R8962:Slk UTSW 19 47,610,748 (GRCm39) missense probably damaging 1.00
R8988:Slk UTSW 19 47,608,712 (GRCm39) missense probably benign 0.00
R9028:Slk UTSW 19 47,608,512 (GRCm39) missense probably benign
R9093:Slk UTSW 19 47,603,883 (GRCm39) missense
R9747:Slk UTSW 19 47,608,346 (GRCm39) missense possibly damaging 0.71
X0052:Slk UTSW 19 47,609,372 (GRCm39) missense probably benign 0.05
Z1176:Slk UTSW 19 47,610,715 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCTAACAGCCCTGCACTTGACC -3'
(R):5'- TCCTTCTGAAGAAGCCTCAGCTCC -3'

Sequencing Primer
(F):5'- TCATAGCTGGCAAGACATCTTC -3'
(R):5'- AAGTTCCTGACGCCTGACAG -3'
Posted On 2013-04-16