Incidental Mutation 'R1989:Lrrk1'
| ID |
223020 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
040001-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1989 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 65931432 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Leucine
at position 43
(S43L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: S1128L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: S1128L
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145954
AA Change: S43L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
AA Change: S43L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034J05Rik |
T |
A |
6: 146,854,394 (GRCm39) |
D216V |
possibly damaging |
Het |
| Acaca |
T |
C |
11: 84,153,355 (GRCm39) |
M921T |
probably damaging |
Het |
| Actn2 |
A |
T |
13: 12,355,276 (GRCm39) |
W36R |
probably benign |
Het |
| Adcy9 |
A |
T |
16: 4,116,591 (GRCm39) |
V643D |
probably damaging |
Het |
| Agbl4 |
A |
T |
4: 111,423,879 (GRCm39) |
T302S |
possibly damaging |
Het |
| Akap13 |
A |
G |
7: 75,354,264 (GRCm39) |
N1795S |
probably benign |
Het |
| Ang |
T |
A |
14: 51,339,008 (GRCm39) |
C50S |
probably damaging |
Het |
| Anxa13 |
T |
A |
15: 58,205,344 (GRCm39) |
|
noncoding transcript |
Het |
| Asxl3 |
T |
C |
18: 22,585,420 (GRCm39) |
V115A |
probably damaging |
Het |
| B4galt5 |
A |
T |
2: 167,146,923 (GRCm39) |
W304R |
probably damaging |
Het |
| Bptf |
T |
C |
11: 106,965,652 (GRCm39) |
K1118E |
probably damaging |
Het |
| Cacna1b |
T |
C |
2: 24,611,386 (GRCm39) |
Y335C |
probably damaging |
Het |
| Catsperb |
A |
T |
12: 101,568,970 (GRCm39) |
I881F |
probably damaging |
Het |
| Ccn1 |
A |
T |
3: 145,353,498 (GRCm39) |
Y355N |
probably benign |
Het |
| Chrm5 |
A |
G |
2: 112,310,597 (GRCm39) |
V173A |
probably damaging |
Het |
| Cyfip2 |
A |
T |
11: 46,144,825 (GRCm39) |
Y676* |
probably null |
Het |
| Cyp2f2 |
A |
G |
7: 26,828,628 (GRCm39) |
D90G |
probably damaging |
Het |
| Dnah5 |
T |
C |
15: 28,343,737 (GRCm39) |
I2379T |
probably damaging |
Het |
| E2f8 |
T |
C |
7: 48,523,028 (GRCm39) |
E349G |
probably benign |
Het |
| Ebf1 |
T |
C |
11: 44,512,793 (GRCm39) |
M134T |
probably damaging |
Het |
| Fn1 |
T |
C |
1: 71,690,784 (GRCm39) |
H59R |
probably damaging |
Het |
| Focad |
T |
C |
4: 88,151,021 (GRCm39) |
|
probably null |
Het |
| Gabra1 |
A |
T |
11: 42,045,842 (GRCm39) |
D89E |
probably damaging |
Het |
| Hip1r |
G |
T |
5: 124,127,761 (GRCm39) |
V90F |
probably damaging |
Het |
| Ifi213 |
C |
A |
1: 173,396,374 (GRCm39) |
|
probably null |
Het |
| Kcnj9 |
A |
G |
1: 172,153,716 (GRCm39) |
I136T |
probably benign |
Het |
| Kmt2c |
A |
G |
5: 25,703,542 (GRCm39) |
S3P |
possibly damaging |
Het |
| Lrrc4b |
GAGAAG |
GAG |
7: 44,111,654 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,391,519 (GRCm39) |
|
probably null |
Het |
| Mad1l1 |
A |
G |
5: 140,289,425 (GRCm39) |
S167P |
probably benign |
Het |
| Maml3 |
G |
T |
3: 51,605,179 (GRCm39) |
A64D |
probably damaging |
Het |
| Mgat4c |
T |
C |
10: 102,214,020 (GRCm39) |
M1T |
probably null |
Het |
| Mkrn2os |
G |
T |
6: 115,566,311 (GRCm39) |
T88K |
probably damaging |
Het |
| Mob3c |
T |
C |
4: 115,688,754 (GRCm39) |
Y96H |
probably damaging |
Het |
| Mpo |
T |
A |
11: 87,694,298 (GRCm39) |
I96N |
probably damaging |
Het |
| Mup17 |
T |
A |
4: 61,511,860 (GRCm39) |
Y138F |
probably benign |
Het |
| Myh8 |
A |
G |
11: 67,183,550 (GRCm39) |
I754V |
probably benign |
Het |
| Naa30 |
T |
A |
14: 49,415,597 (GRCm39) |
L289* |
probably null |
Het |
| Nap1l4 |
A |
C |
7: 143,080,921 (GRCm39) |
F292V |
probably damaging |
Het |
| Nek5 |
T |
A |
8: 22,601,185 (GRCm39) |
N129Y |
probably damaging |
Het |
| Nlrp9a |
A |
G |
7: 26,273,338 (GRCm39) |
E880G |
probably benign |
Het |
| Nsun6 |
G |
T |
2: 15,042,995 (GRCm39) |
N155K |
probably benign |
Het |
| Or2aj5 |
A |
T |
16: 19,425,407 (GRCm39) |
Y4N |
probably benign |
Het |
| Or4c102 |
T |
A |
2: 88,422,943 (GRCm39) |
I265K |
probably damaging |
Het |
| Or4f62 |
T |
A |
2: 111,986,722 (GRCm39) |
I142N |
probably benign |
Het |
| Or52a33 |
A |
T |
7: 103,288,702 (GRCm39) |
I215K |
probably damaging |
Het |
| Or52ad1 |
T |
A |
7: 102,995,316 (GRCm39) |
Y273F |
possibly damaging |
Het |
| Or5p5 |
A |
T |
7: 107,413,907 (GRCm39) |
I39L |
probably benign |
Het |
| Or8d23 |
T |
C |
9: 38,842,171 (GRCm39) |
S235P |
possibly damaging |
Het |
| Palm3 |
G |
A |
8: 84,756,651 (GRCm39) |
S721N |
possibly damaging |
Het |
| Ppp2r5d |
C |
T |
17: 46,995,025 (GRCm39) |
V559M |
probably benign |
Het |
| Ptgfr |
A |
T |
3: 151,540,976 (GRCm39) |
Y177* |
probably null |
Het |
| Rnase10 |
A |
T |
14: 51,247,095 (GRCm39) |
I121L |
probably benign |
Het |
| Sall2 |
G |
A |
14: 52,551,896 (GRCm39) |
P431L |
probably damaging |
Het |
| Sbf2 |
A |
G |
7: 109,948,130 (GRCm39) |
V1194A |
possibly damaging |
Het |
| Scimp |
T |
C |
11: 70,682,402 (GRCm39) |
K105E |
possibly damaging |
Het |
| Scrt2 |
A |
T |
2: 151,924,007 (GRCm39) |
D13V |
probably damaging |
Het |
| Snx19 |
A |
G |
9: 30,339,404 (GRCm39) |
S181G |
possibly damaging |
Het |
| Spata2 |
G |
A |
2: 167,326,234 (GRCm39) |
T195M |
possibly damaging |
Het |
| Sptbn4 |
A |
G |
7: 27,067,127 (GRCm39) |
V614A |
probably damaging |
Het |
| Srpk2 |
G |
A |
5: 23,723,421 (GRCm39) |
A565V |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,531,887 (GRCm39) |
I2715V |
probably benign |
Het |
| Sval1 |
A |
G |
6: 41,932,425 (GRCm39) |
T92A |
possibly damaging |
Het |
| Synrg |
T |
C |
11: 83,910,781 (GRCm39) |
|
probably null |
Het |
| Tlr12 |
T |
C |
4: 128,510,862 (GRCm39) |
T463A |
probably benign |
Het |
| Tnxb |
A |
G |
17: 34,902,351 (GRCm39) |
H945R |
probably benign |
Het |
| Tnxb |
A |
T |
17: 34,912,859 (GRCm39) |
D1791V |
probably damaging |
Het |
| Topaz1 |
C |
T |
9: 122,579,190 (GRCm39) |
T700I |
possibly damaging |
Het |
| Trappc8 |
A |
G |
18: 20,978,708 (GRCm39) |
V796A |
probably benign |
Het |
| Trpm1 |
A |
T |
7: 63,858,780 (GRCm39) |
|
probably null |
Het |
| Ttll4 |
G |
T |
1: 74,724,527 (GRCm39) |
V566L |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,581,285 (GRCm39) |
N23203Y |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,601,131 (GRCm39) |
Y18781N |
probably damaging |
Het |
| Tuba3a |
T |
C |
6: 125,258,216 (GRCm39) |
N258S |
probably damaging |
Het |
| Upk1b |
A |
T |
16: 38,604,603 (GRCm39) |
W141R |
possibly damaging |
Het |
| Vars1 |
T |
C |
17: 35,230,814 (GRCm39) |
F567L |
possibly damaging |
Het |
| Vcpip1 |
G |
C |
1: 9,815,788 (GRCm39) |
A865G |
probably benign |
Het |
| Vmn2r22 |
A |
T |
6: 123,614,500 (GRCm39) |
F363L |
probably damaging |
Het |
| Vmn2r66 |
A |
T |
7: 84,661,201 (GRCm39) |
F10I |
probably benign |
Het |
| Wbp2 |
C |
T |
11: 115,971,047 (GRCm39) |
|
probably null |
Het |
| Yy1 |
T |
C |
12: 108,772,534 (GRCm39) |
L270P |
probably damaging |
Het |
| Zan |
A |
T |
5: 137,418,268 (GRCm39) |
C2943* |
probably null |
Het |
| Zfp51 |
T |
A |
17: 21,676,582 (GRCm39) |
Y18N |
possibly damaging |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAACTTCACTTTCTCAAAGAGGC -3'
(R):5'- TCCTACAGGGCACACAGATC -3'
Sequencing Primer
(F):5'- CTTCACTTTCTCAAAGAGGCAGTCAG -3'
(R):5'- ACACAGATCCTGGGGGTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation