Incidental Mutation 'R0141:Ugt2b37'
ID 22310
Institutional Source Beutler Lab
Gene Symbol Ugt2b37
Ensembl Gene ENSMUSG00000057425
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms 0610033E06Rik
MMRRC Submission 038426-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R0141 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 5
Chromosomal Location 87388351-87402647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 87388842 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 457 (P457L)
Ref Sequence ENSEMBL: ENSMUSP00000075255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075858]
AlphaFold Q8VCN3
Predicted Effect probably damaging
Transcript: ENSMUST00000075858
AA Change: P457L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: P457L

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 5.5e-256 PFAM
Pfam:Glyco_tran_28_C 328 449 2.5e-9 PFAM
Meta Mutation Damage Score 0.8616 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 89.9%
Validation Efficiency 88% (50/57)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 A C 13: 91,919,947 (GRCm39) D294A probably benign Het
Adamts9 T C 6: 92,920,066 (GRCm39) D24G probably benign Het
Ahnak G A 19: 8,984,044 (GRCm39) G1776D probably damaging Het
Arfgef3 C A 10: 18,473,155 (GRCm39) C1636F probably damaging Het
AW551984 A G 9: 39,501,940 (GRCm39) L722P probably damaging Het
Ccndbp1 T A 2: 120,842,903 (GRCm39) M188K probably damaging Het
Col27a1 A T 4: 63,183,870 (GRCm39) probably null Het
Cpt1c A G 7: 44,616,095 (GRCm39) Y306H probably damaging Het
Cyp3a57 A G 5: 145,298,912 (GRCm39) I71V probably benign Het
Def8 G A 8: 124,183,234 (GRCm39) A278T probably damaging Het
Dmrt2 A T 19: 25,655,655 (GRCm39) Q418L possibly damaging Het
Ebf1 T C 11: 44,798,827 (GRCm39) L284S probably damaging Het
Fam131a G A 16: 20,517,738 (GRCm39) A15T probably benign Het
Fbxo17 A G 7: 28,432,916 (GRCm39) T146A possibly damaging Het
Fer1l6 A G 15: 58,430,251 (GRCm39) E226G probably damaging Het
Galnt18 A T 7: 111,198,238 (GRCm39) I174N probably damaging Het
Gm44501 T C 17: 40,889,744 (GRCm39) I86T probably benign Het
Gtsf1l T C 2: 162,929,246 (GRCm39) Q79R probably benign Het
Hapln4 T C 8: 70,540,930 (GRCm39) L321P probably damaging Het
Herc2 A G 7: 55,771,309 (GRCm39) T1024A probably benign Het
Hps5 A G 7: 46,438,605 (GRCm39) S43P probably damaging Het
Igsf10 A G 3: 59,238,253 (GRCm39) Y643H probably damaging Het
Lama4 G A 10: 38,968,274 (GRCm39) R1472H probably benign Het
Lhx9 A G 1: 138,767,744 (GRCm39) Y73H possibly damaging Het
Loxl1 T A 9: 58,219,415 (GRCm39) Q252L probably damaging Het
Lrrc37 A C 11: 103,504,512 (GRCm39) I2485M probably damaging Het
Nfat5 C T 8: 108,065,707 (GRCm39) R156W probably damaging Het
Nr3c2 T A 8: 77,635,037 (GRCm39) V46D probably damaging Het
Or11h4 T C 14: 50,973,840 (GRCm39) S260G possibly damaging Het
Or4k77 T A 2: 111,199,835 (GRCm39) I286N probably damaging Het
Or5i1 C G 2: 87,613,049 (GRCm39) P55R possibly damaging Het
Or5p63 A C 7: 107,811,210 (GRCm39) N175K possibly damaging Het
Or5p70 A T 7: 107,994,575 (GRCm39) N83Y probably benign Het
Osbp T C 19: 11,951,223 (GRCm39) V256A possibly damaging Het
Pclo A T 5: 14,841,936 (GRCm39) D4737V unknown Het
Pkdrej A G 15: 85,699,831 (GRCm39) I2035T probably damaging Het
Plek2 A G 12: 78,941,278 (GRCm39) S185P probably damaging Het
Pnpla6 G T 8: 3,582,117 (GRCm39) probably null Het
Pou3f2 T C 4: 22,487,210 (GRCm39) T308A possibly damaging Het
Pramel22 T C 4: 143,381,138 (GRCm39) Y295C probably benign Het
Pxmp4 A G 2: 154,434,215 (GRCm39) V82A probably damaging Het
Rnf6 A T 5: 146,148,645 (GRCm39) N135K possibly damaging Het
Rtl1 A G 12: 109,559,382 (GRCm39) V819A probably damaging Het
Scn1a C A 2: 66,119,406 (GRCm39) V1355L probably damaging Het
Scn2a T A 2: 65,542,160 (GRCm39) N754K probably benign Het
Serpina3b A T 12: 104,097,030 (GRCm39) N104Y probably damaging Het
Sh3rf2 T C 18: 42,289,122 (GRCm39) S648P probably benign Het
Slc17a6 G A 7: 51,318,815 (GRCm39) V486I probably benign Het
Spata31e2 A T 1: 26,722,863 (GRCm39) N772K probably benign Het
Syne2 T G 12: 75,988,072 (GRCm39) D1743E probably damaging Het
Tex14 T G 11: 87,383,857 (GRCm39) probably null Het
Tfb1m T C 17: 3,605,232 (GRCm39) D87G probably damaging Het
Tll2 C T 19: 41,086,351 (GRCm39) G609S probably damaging Het
Tsc22d2 A T 3: 58,324,577 (GRCm39) probably benign Het
Tsen2 A G 6: 115,545,790 (GRCm39) D360G probably damaging Het
Vmn1r68 T C 7: 10,261,252 (GRCm39) N282S possibly damaging Het
Vmn2r58 G A 7: 41,511,309 (GRCm39) S498F probably benign Het
Zfp959 T C 17: 56,205,139 (GRCm39) I392T probably benign Het
Other mutations in Ugt2b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Ugt2b37 APN 5 87,390,340 (GRCm39) missense possibly damaging 0.90
IGL00567:Ugt2b37 APN 5 87,401,933 (GRCm39) missense probably damaging 1.00
IGL00787:Ugt2b37 APN 5 87,390,288 (GRCm39) missense probably benign 0.00
IGL01560:Ugt2b37 APN 5 87,399,698 (GRCm39) missense probably damaging 1.00
IGL01617:Ugt2b37 APN 5 87,399,738 (GRCm39) missense probably damaging 1.00
IGL01982:Ugt2b37 APN 5 87,390,291 (GRCm39) missense probably damaging 1.00
IGL02299:Ugt2b37 APN 5 87,390,174 (GRCm39) missense probably benign 0.00
IGL02323:Ugt2b37 APN 5 87,398,423 (GRCm39) splice site probably benign
IGL02326:Ugt2b37 APN 5 87,388,861 (GRCm39) missense probably benign 0.25
IGL02516:Ugt2b37 APN 5 87,388,741 (GRCm39) missense probably damaging 1.00
IGL03285:Ugt2b37 APN 5 87,388,734 (GRCm39) missense probably damaging 1.00
R0076:Ugt2b37 UTSW 5 87,402,080 (GRCm39) missense probably benign 0.31
R0312:Ugt2b37 UTSW 5 87,398,524 (GRCm39) missense probably damaging 1.00
R0359:Ugt2b37 UTSW 5 87,398,443 (GRCm39) missense probably benign 0.10
R0523:Ugt2b37 UTSW 5 87,399,691 (GRCm39) missense possibly damaging 0.91
R1938:Ugt2b37 UTSW 5 87,388,716 (GRCm39) missense probably damaging 1.00
R1962:Ugt2b37 UTSW 5 87,402,193 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b37 UTSW 5 87,402,569 (GRCm39) missense probably damaging 0.97
R3704:Ugt2b37 UTSW 5 87,390,846 (GRCm39) missense possibly damaging 0.55
R4430:Ugt2b37 UTSW 5 87,401,951 (GRCm39) missense probably benign 0.00
R4825:Ugt2b37 UTSW 5 87,398,498 (GRCm39) missense possibly damaging 0.91
R5043:Ugt2b37 UTSW 5 87,399,719 (GRCm39) nonsense probably null
R5098:Ugt2b37 UTSW 5 87,390,812 (GRCm39) missense probably damaging 1.00
R5174:Ugt2b37 UTSW 5 87,399,739 (GRCm39) missense probably benign 0.00
R5522:Ugt2b37 UTSW 5 87,388,759 (GRCm39) missense probably benign 0.14
R5879:Ugt2b37 UTSW 5 87,402,265 (GRCm39) missense probably benign
R5999:Ugt2b37 UTSW 5 87,402,036 (GRCm39) missense probably benign 0.25
R6374:Ugt2b37 UTSW 5 87,390,279 (GRCm39) missense probably damaging 1.00
R6454:Ugt2b37 UTSW 5 87,388,836 (GRCm39) missense probably damaging 1.00
R6857:Ugt2b37 UTSW 5 87,388,705 (GRCm39) missense probably damaging 0.98
R6875:Ugt2b37 UTSW 5 87,390,288 (GRCm39) missense probably benign 0.00
R6916:Ugt2b37 UTSW 5 87,402,459 (GRCm39) missense probably benign 0.07
R7099:Ugt2b37 UTSW 5 87,388,848 (GRCm39) missense probably benign 0.00
R7239:Ugt2b37 UTSW 5 87,402,590 (GRCm39) missense probably benign
R7470:Ugt2b37 UTSW 5 87,401,971 (GRCm39) missense probably benign 0.24
R7810:Ugt2b37 UTSW 5 87,402,118 (GRCm39) missense probably damaging 1.00
R7841:Ugt2b37 UTSW 5 87,398,489 (GRCm39) missense probably benign 0.05
R7860:Ugt2b37 UTSW 5 87,402,189 (GRCm39) missense probably damaging 1.00
R7861:Ugt2b37 UTSW 5 87,390,299 (GRCm39) nonsense probably null
R8200:Ugt2b37 UTSW 5 87,388,750 (GRCm39) nonsense probably null
R8211:Ugt2b37 UTSW 5 87,390,235 (GRCm39) missense probably benign 0.07
R8282:Ugt2b37 UTSW 5 87,402,440 (GRCm39) missense probably benign 0.01
R8312:Ugt2b37 UTSW 5 87,390,799 (GRCm39) missense probably benign 0.15
R8520:Ugt2b37 UTSW 5 87,388,714 (GRCm39) missense probably benign 0.04
R8688:Ugt2b37 UTSW 5 87,390,240 (GRCm39) missense possibly damaging 0.52
R8695:Ugt2b37 UTSW 5 87,390,243 (GRCm39) missense probably benign 0.00
R8772:Ugt2b37 UTSW 5 87,402,345 (GRCm39) missense probably benign 0.00
R8839:Ugt2b37 UTSW 5 87,402,415 (GRCm39) missense probably damaging 1.00
R9087:Ugt2b37 UTSW 5 87,401,996 (GRCm39) missense probably benign 0.01
R9139:Ugt2b37 UTSW 5 87,399,636 (GRCm39) missense probably benign 0.09
R9424:Ugt2b37 UTSW 5 87,402,217 (GRCm39) missense probably damaging 0.99
R9432:Ugt2b37 UTSW 5 87,402,046 (GRCm39) missense probably damaging 0.97
R9498:Ugt2b37 UTSW 5 87,402,244 (GRCm39) missense probably benign 0.07
R9711:Ugt2b37 UTSW 5 87,402,532 (GRCm39) missense possibly damaging 0.85
R9718:Ugt2b37 UTSW 5 87,390,802 (GRCm39) missense probably benign 0.11
R9783:Ugt2b37 UTSW 5 87,388,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTGAAAGTTCATTCATGTGGTGC -3'
(R):5'- TGGGCTGGTGACTTAGCTCTCTAAC -3'

Sequencing Primer
(F):5'- GGTGCATTGACAATGAACTCTACTC -3'
(R):5'- cttgaactcagaaatccgcc -3'
Posted On 2013-04-16