Incidental Mutation 'R2017:Adgrg7'
ID 223292
Institutional Source Beutler Lab
Gene Symbol Adgrg7
Ensembl Gene ENSMUSG00000022755
Gene Name adhesion G protein-coupled receptor G7
Synonyms 9130020O16Rik, Gpr128
MMRRC Submission 040026-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2017 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 56544972-56616218 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 56553169 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 643 (T643A)
Ref Sequence ENSEMBL: ENSMUSP00000023437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023437]
AlphaFold Q8BM96
Predicted Effect probably benign
Transcript: ENSMUST00000023437
AA Change: T643A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000023437
Gene: ENSMUSG00000022755
AA Change: T643A

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
SCOP:d1edmb_ 52 76 1e-3 SMART
GPS 376 424 6.16e-8 SMART
Pfam:7tm_2 428 712 4.5e-40 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025C18Rik T C 2: 164,920,946 (GRCm39) D29G unknown Het
Abca13 A T 11: 9,240,619 (GRCm39) L827F probably damaging Het
Abcc1 T A 16: 14,279,068 (GRCm39) V1126E probably damaging Het
Abcc12 A G 8: 87,290,617 (GRCm39) L41S probably damaging Het
Angpt2 T C 8: 18,755,747 (GRCm39) N240S probably damaging Het
Apc A G 18: 34,446,655 (GRCm39) T1150A probably benign Het
Apob G A 12: 8,057,751 (GRCm39) D2078N possibly damaging Het
Apool T A X: 111,274,258 (GRCm39) S234T probably benign Het
Ascc3 C T 10: 50,566,307 (GRCm39) P751S probably benign Het
Astn2 G A 4: 65,459,178 (GRCm39) T1079I probably damaging Het
Atp8b1 T C 18: 64,673,405 (GRCm39) N989S probably damaging Het
B3gnt2 T C 11: 22,786,621 (GRCm39) D189G probably damaging Het
Bcas1 A C 2: 170,190,081 (GRCm39) probably null Het
Btk T C X: 133,448,350 (GRCm39) D355G probably benign Het
C2cd4c A G 10: 79,448,823 (GRCm39) V108A possibly damaging Het
Cbfa2t2 T C 2: 154,359,727 (GRCm39) L264P probably damaging Het
Cd22 A T 7: 30,572,205 (GRCm39) L423Q probably damaging Het
Cep128 T C 12: 91,333,238 (GRCm39) D9G probably damaging Het
Cer1 A T 4: 82,801,120 (GRCm39) V181D probably damaging Het
Ciita T C 16: 10,329,540 (GRCm39) L584P probably damaging Het
Cmss1 T C 16: 57,136,641 (GRCm39) D77G probably damaging Het
Col4a2 T C 8: 11,495,086 (GRCm39) F1515L probably benign Het
Cyria T A 12: 12,412,362 (GRCm39) V208D probably damaging Het
Dcaf1 A G 9: 106,725,122 (GRCm39) E536G probably damaging Het
Dcaf1 T A 9: 106,716,287 (GRCm39) D360E probably benign Het
Dnah2 T A 11: 69,327,896 (GRCm39) I3370F probably damaging Het
Dsg1c T C 18: 20,399,253 (GRCm39) V119A possibly damaging Het
Edn3 A G 2: 174,620,455 (GRCm39) E103G probably benign Het
Efemp1 G T 11: 28,871,613 (GRCm39) R376L probably damaging Het
Eid1 A G 2: 125,515,121 (GRCm39) M4V probably benign Het
Emilin3 G A 2: 160,751,530 (GRCm39) R170C possibly damaging Het
Epx T C 11: 87,765,163 (GRCm39) D178G probably damaging Het
Fkbp10 G A 11: 100,312,499 (GRCm39) V252I possibly damaging Het
Flnc G A 6: 29,443,796 (GRCm39) probably null Het
Fsip2 A G 2: 82,813,076 (GRCm39) K3132E possibly damaging Het
Gla C T X: 133,497,071 (GRCm39) A39T probably damaging Het
Hivep2 C T 10: 14,006,501 (GRCm39) T1033M probably damaging Het
Hsd17b8 A T 17: 34,245,187 (GRCm39) M259K probably damaging Het
Ift70a1 A G 2: 75,811,801 (GRCm39) L94P probably benign Het
Ikzf4 C T 10: 128,470,026 (GRCm39) G498D probably damaging Het
Impg1 T C 9: 80,322,720 (GRCm39) Y95C probably damaging Het
Ino80c T A 18: 24,244,810 (GRCm39) K136* probably null Het
Iqsec1 A C 6: 90,666,912 (GRCm39) H508Q probably benign Het
Itgb3 A G 11: 104,528,788 (GRCm39) H305R possibly damaging Het
Jup T A 11: 100,277,167 (GRCm39) T14S probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Klf12 T C 14: 100,260,073 (GRCm39) R219G possibly damaging Het
Klhl42 G T 6: 147,009,291 (GRCm39) V377L probably benign Het
Large1 A G 8: 73,578,825 (GRCm39) F460S probably damaging Het
Loxl3 A T 6: 83,025,958 (GRCm39) D402V probably damaging Het
Lrrc37a T A 11: 103,391,951 (GRCm39) Y1158F probably benign Het
Map2 T A 1: 66,451,958 (GRCm39) S365T probably damaging Het
Mapk8ip1 A G 2: 92,221,379 (GRCm39) probably null Het
Med26 A G 8: 73,250,791 (GRCm39) S103P probably damaging Het
Muc4 T C 16: 32,570,121 (GRCm39) S394P possibly damaging Het
Nle1 G T 11: 82,796,373 (GRCm39) P166Q probably damaging Het
Obox5 T C 7: 15,492,807 (GRCm39) I254T probably benign Het
Or1p1c T A 11: 74,161,159 (GRCm39) W315R probably benign Het
Or4g7 G T 2: 111,309,532 (GRCm39) M134I probably benign Het
Or52j3 T C 7: 102,836,137 (GRCm39) F110L probably benign Het
Or7c19 T C 8: 85,957,373 (GRCm39) L83P possibly damaging Het
Pacs2 A T 12: 113,026,077 (GRCm39) N545Y probably damaging Het
Palld T C 8: 62,137,799 (GRCm39) E652G probably damaging Het
Pgm5 T C 19: 24,801,676 (GRCm39) N184S probably benign Het
Pitpnm1 T C 19: 4,161,873 (GRCm39) V955A probably benign Het
Plcb1 T A 2: 135,204,340 (GRCm39) I898N possibly damaging Het
Pramel13 A G 4: 144,121,244 (GRCm39) V260A possibly damaging Het
Prr36 T A 8: 4,265,205 (GRCm39) T182S probably benign Het
Prss35 A G 9: 86,637,565 (GRCm39) S112G probably benign Het
Ptprj C T 2: 90,294,958 (GRCm39) V417M probably damaging Het
Ptprm G T 17: 67,264,148 (GRCm39) probably null Het
Rasgrp2 T C 19: 6,463,195 (GRCm39) V498A probably benign Het
Rfx6 A G 10: 51,597,700 (GRCm39) N513S possibly damaging Het
Rhbdf1 A G 11: 32,160,471 (GRCm39) I693T probably damaging Het
Scn9a T C 2: 66,345,665 (GRCm39) T1143A probably damaging Het
Spata17 A G 1: 186,780,650 (GRCm39) S366P possibly damaging Het
Svep1 A G 4: 58,070,568 (GRCm39) L2406P probably benign Het
Tasor2 A T 13: 3,626,770 (GRCm39) I1060K probably benign Het
Tgfb2 A T 1: 186,362,962 (GRCm39) Y287* probably null Het
Trip11 A T 12: 101,851,619 (GRCm39) V815E probably benign Het
Trp53bp2 G T 1: 182,276,580 (GRCm39) V854L probably benign Het
Vmn1r78 T C 7: 11,887,270 (GRCm39) S294P possibly damaging Het
Vmn2r86 T C 10: 130,282,582 (GRCm39) K678R probably benign Het
Yeats2 T A 16: 19,977,931 (GRCm39) N138K probably benign Het
Zup1 A T 10: 33,803,460 (GRCm39) N541K possibly damaging Het
Other mutations in Adgrg7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Adgrg7 APN 16 56,568,282 (GRCm39) critical splice donor site probably null
IGL03122:Adgrg7 APN 16 56,590,725 (GRCm39) splice site probably benign
orchard UTSW 16 56,545,342 (GRCm39) missense probably damaging 1.00
sevin UTSW 16 56,562,769 (GRCm39) missense probably damaging 1.00
R0632:Adgrg7 UTSW 16 56,562,952 (GRCm39) missense possibly damaging 0.89
R0673:Adgrg7 UTSW 16 56,593,849 (GRCm39) missense possibly damaging 0.48
R1690:Adgrg7 UTSW 16 56,615,993 (GRCm39) missense probably damaging 0.99
R2009:Adgrg7 UTSW 16 56,582,236 (GRCm39) missense probably benign 0.08
R2132:Adgrg7 UTSW 16 56,588,281 (GRCm39) missense probably damaging 1.00
R2153:Adgrg7 UTSW 16 56,572,791 (GRCm39) missense possibly damaging 0.75
R2229:Adgrg7 UTSW 16 56,572,766 (GRCm39) missense probably benign
R2436:Adgrg7 UTSW 16 56,582,308 (GRCm39) missense possibly damaging 0.78
R2878:Adgrg7 UTSW 16 56,570,817 (GRCm39) missense probably benign 0.14
R2981:Adgrg7 UTSW 16 56,570,769 (GRCm39) critical splice donor site probably null
R4014:Adgrg7 UTSW 16 56,562,651 (GRCm39) missense probably damaging 1.00
R4023:Adgrg7 UTSW 16 56,550,661 (GRCm39) missense probably damaging 1.00
R4024:Adgrg7 UTSW 16 56,550,661 (GRCm39) missense probably damaging 1.00
R4026:Adgrg7 UTSW 16 56,550,661 (GRCm39) missense probably damaging 1.00
R4551:Adgrg7 UTSW 16 56,568,375 (GRCm39) missense probably damaging 1.00
R4834:Adgrg7 UTSW 16 56,553,232 (GRCm39) missense probably damaging 1.00
R5041:Adgrg7 UTSW 16 56,550,711 (GRCm39) missense probably benign 0.21
R5145:Adgrg7 UTSW 16 56,562,682 (GRCm39) missense probably benign 0.04
R5377:Adgrg7 UTSW 16 56,550,669 (GRCm39) missense possibly damaging 0.68
R5549:Adgrg7 UTSW 16 56,570,790 (GRCm39) missense probably damaging 1.00
R5915:Adgrg7 UTSW 16 56,550,748 (GRCm39) splice site probably null
R5957:Adgrg7 UTSW 16 56,593,790 (GRCm39) missense probably damaging 0.96
R6146:Adgrg7 UTSW 16 56,593,829 (GRCm39) missense probably benign 0.21
R6198:Adgrg7 UTSW 16 56,597,556 (GRCm39) missense possibly damaging 0.64
R6233:Adgrg7 UTSW 16 56,599,005 (GRCm39) missense possibly damaging 0.52
R6337:Adgrg7 UTSW 16 56,572,788 (GRCm39) missense probably damaging 0.96
R6633:Adgrg7 UTSW 16 56,550,649 (GRCm39) missense probably benign 0.05
R6693:Adgrg7 UTSW 16 56,590,587 (GRCm39) missense probably damaging 0.97
R6812:Adgrg7 UTSW 16 56,616,161 (GRCm39) start gained probably benign
R6841:Adgrg7 UTSW 16 56,570,787 (GRCm39) missense probably damaging 1.00
R6868:Adgrg7 UTSW 16 56,593,839 (GRCm39) missense probably benign
R7076:Adgrg7 UTSW 16 56,562,769 (GRCm39) missense probably damaging 1.00
R7146:Adgrg7 UTSW 16 56,550,605 (GRCm39) missense probably damaging 1.00
R7232:Adgrg7 UTSW 16 56,597,515 (GRCm39) splice site probably null
R7266:Adgrg7 UTSW 16 56,590,674 (GRCm39) missense probably benign 0.00
R7376:Adgrg7 UTSW 16 56,545,342 (GRCm39) missense probably damaging 1.00
R7390:Adgrg7 UTSW 16 56,553,207 (GRCm39) missense probably damaging 0.98
R7401:Adgrg7 UTSW 16 56,562,781 (GRCm39) missense probably benign 0.43
R7496:Adgrg7 UTSW 16 56,553,220 (GRCm39) missense probably benign
R7540:Adgrg7 UTSW 16 56,570,792 (GRCm39) missense probably damaging 1.00
R8147:Adgrg7 UTSW 16 56,562,876 (GRCm39) missense probably damaging 1.00
R8354:Adgrg7 UTSW 16 56,616,045 (GRCm39) start gained probably benign
R8372:Adgrg7 UTSW 16 56,616,114 (GRCm39) start gained probably benign
R8393:Adgrg7 UTSW 16 56,582,477 (GRCm39) missense probably damaging 1.00
R8454:Adgrg7 UTSW 16 56,616,045 (GRCm39) start gained probably benign
R8723:Adgrg7 UTSW 16 56,582,282 (GRCm39) missense probably benign 0.00
R8891:Adgrg7 UTSW 16 56,572,762 (GRCm39) missense probably benign 0.03
R9017:Adgrg7 UTSW 16 56,553,211 (GRCm39) missense probably benign 0.01
R9570:Adgrg7 UTSW 16 56,570,813 (GRCm39) missense probably damaging 1.00
R9604:Adgrg7 UTSW 16 56,597,570 (GRCm39) missense probably damaging 0.99
R9628:Adgrg7 UTSW 16 56,553,193 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAATACCCCATGCCCTTGG -3'
(R):5'- AAGCCAAGGGATATTCTTATCAAGGAC -3'

Sequencing Primer
(F):5'- CCATGCCCTTGGTTTGTGCAG -3'
(R):5'- CAAGGACTTCAGTTCCATGGATGC -3'
Posted On 2014-08-25