Incidental Mutation 'R1993:Gria2'
| ID |
223831 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gria2
|
| Ensembl Gene |
ENSMUSG00000033981 |
| Gene Name |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
| Synonyms |
Glur-2, GluA2, GluR2, GluR-B, Glur2 |
| MMRRC Submission |
040004-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.274)
|
| Stock # |
R1993 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
80588757-80710142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 80709664 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 10
(L10F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075316]
[ENSMUST00000107745]
[ENSMUST00000192463]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075316
AA Change: L10F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000074787
Gene: ENSMUSG00000033981
AA Change: L10F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
49 |
379 |
2.7e-58 |
PFAM |
|
PBPe
|
415 |
790 |
3.75e-132 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107745
AA Change: L10F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000103374
Gene: ENSMUSG00000033981
AA Change: L10F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
47 |
379 |
4.8e-53 |
PFAM |
|
PBPe
|
415 |
790 |
8.16e-133 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192463
AA Change: L10F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000141447
Gene: ENSMUSG00000033981
AA Change: L10F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
47 |
379 |
1.7e-51 |
PFAM |
|
PBPe
|
415 |
770 |
1.2e-105 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.2e-35 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193645
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194164
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194383
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194523
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195062
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
T |
G |
5: 8,871,322 (GRCm39) |
I292S |
possibly damaging |
Het |
| Abcc4 |
T |
C |
14: 118,763,694 (GRCm39) |
N1047S |
probably benign |
Het |
| Abcc8 |
G |
T |
7: 45,766,847 (GRCm39) |
|
probably null |
Het |
| Akap9 |
T |
A |
5: 4,088,520 (GRCm39) |
|
probably null |
Het |
| Alox5 |
T |
A |
6: 116,392,424 (GRCm39) |
I366F |
probably damaging |
Het |
| Amn |
A |
G |
12: 111,242,526 (GRCm39) |
N447S |
probably damaging |
Het |
| Ankrd22 |
A |
T |
19: 34,143,174 (GRCm39) |
M1K |
probably null |
Het |
| Asic1 |
G |
T |
15: 99,569,765 (GRCm39) |
G29C |
probably damaging |
Het |
| Atxn7l1 |
A |
G |
12: 33,395,976 (GRCm39) |
N235S |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,063,519 (GRCm39) |
D388E |
probably damaging |
Het |
| Bod1l |
A |
G |
5: 41,974,679 (GRCm39) |
S2212P |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,353,563 (GRCm39) |
Q423L |
probably damaging |
Het |
| Calu |
T |
C |
6: 29,366,974 (GRCm39) |
I62T |
possibly damaging |
Het |
| Cars2 |
A |
G |
8: 11,564,515 (GRCm39) |
V75A |
probably benign |
Het |
| Catsperb |
T |
A |
12: 101,569,026 (GRCm39) |
N899K |
possibly damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,228,089 (GRCm39) |
C86* |
probably null |
Het |
| Cdh5 |
G |
T |
8: 104,864,447 (GRCm39) |
L469F |
probably damaging |
Het |
| Clrn3 |
A |
T |
7: 135,115,848 (GRCm39) |
D167E |
probably benign |
Het |
| Csmd1 |
A |
T |
8: 16,396,698 (GRCm39) |
C411S |
probably damaging |
Het |
| Dchs1 |
A |
T |
7: 105,411,755 (GRCm39) |
S1454T |
probably benign |
Het |
| Ddx20 |
G |
A |
3: 105,586,660 (GRCm39) |
Q562* |
probably null |
Het |
| Dgkg |
T |
G |
16: 22,419,344 (GRCm39) |
Y52S |
probably damaging |
Het |
| Dhx58 |
T |
C |
11: 100,594,316 (GRCm39) |
|
probably null |
Het |
| Dpp6 |
A |
T |
5: 27,604,004 (GRCm39) |
I145L |
probably benign |
Het |
| Efna2 |
A |
T |
10: 80,022,711 (GRCm39) |
Y85F |
possibly damaging |
Het |
| Eif3a |
C |
T |
19: 60,769,954 (GRCm39) |
V127I |
probably benign |
Het |
| Exph5 |
A |
T |
9: 53,284,935 (GRCm39) |
H672L |
possibly damaging |
Het |
| Fam131b |
T |
C |
6: 42,297,818 (GRCm39) |
T112A |
possibly damaging |
Het |
| Fcgr1 |
A |
T |
3: 96,193,184 (GRCm39) |
V271E |
probably damaging |
Het |
| Fgfr4 |
A |
G |
13: 55,313,715 (GRCm39) |
D508G |
probably damaging |
Het |
| Fndc3b |
A |
G |
3: 27,473,549 (GRCm39) |
M1172T |
probably benign |
Het |
| Fryl |
G |
T |
5: 73,265,836 (GRCm39) |
T495K |
probably damaging |
Het |
| Garin5b |
A |
T |
7: 4,761,017 (GRCm39) |
V565E |
probably damaging |
Het |
| Gm5134 |
A |
T |
10: 75,802,227 (GRCm39) |
I93F |
probably damaging |
Het |
| Gpbar1 |
G |
A |
1: 74,318,603 (GRCm39) |
G282D |
possibly damaging |
Het |
| Grm7 |
T |
C |
6: 111,184,769 (GRCm39) |
Y367H |
probably benign |
Het |
| H1f9 |
T |
A |
11: 94,858,858 (GRCm39) |
V51E |
probably damaging |
Het |
| Hivep1 |
G |
A |
13: 42,310,969 (GRCm39) |
A1070T |
probably benign |
Het |
| Il33 |
A |
G |
19: 29,934,304 (GRCm39) |
D155G |
possibly damaging |
Het |
| Kdm6b |
T |
C |
11: 69,297,129 (GRCm39) |
S408G |
probably null |
Het |
| Kntc1 |
A |
G |
5: 123,948,874 (GRCm39) |
|
probably null |
Het |
| Kntc1 |
G |
A |
5: 123,897,162 (GRCm39) |
|
probably null |
Het |
| Ltbp2 |
T |
G |
12: 84,855,220 (GRCm39) |
|
probably null |
Het |
| Mapk8ip3 |
G |
T |
17: 25,133,562 (GRCm39) |
L83I |
probably damaging |
Het |
| Meltf |
C |
A |
16: 31,711,440 (GRCm39) |
Y554* |
probably null |
Het |
| Mov10 |
A |
C |
3: 104,706,735 (GRCm39) |
F725C |
probably damaging |
Het |
| Ms4a6d |
A |
C |
19: 11,567,523 (GRCm39) |
L18R |
probably damaging |
Het |
| Naip2 |
T |
C |
13: 100,298,515 (GRCm39) |
N507S |
probably benign |
Het |
| Nodal |
A |
G |
10: 61,254,113 (GRCm39) |
Q12R |
probably benign |
Het |
| Npy6r |
T |
C |
18: 44,409,575 (GRCm39) |
L332P |
probably damaging |
Het |
| Nrxn3 |
A |
G |
12: 89,227,181 (GRCm39) |
K272R |
possibly damaging |
Het |
| Obox2 |
G |
T |
7: 15,131,174 (GRCm39) |
K93N |
probably benign |
Het |
| Or10j27 |
C |
T |
1: 172,958,418 (GRCm39) |
R122H |
possibly damaging |
Het |
| Or51a6 |
G |
T |
7: 102,603,953 (GRCm39) |
P285Q |
probably damaging |
Het |
| Or5b112 |
A |
G |
19: 13,319,178 (GRCm39) |
T19A |
possibly damaging |
Het |
| Or5w13 |
C |
T |
2: 87,523,777 (GRCm39) |
V150M |
probably benign |
Het |
| Pcdh12 |
T |
A |
18: 38,415,196 (GRCm39) |
D643V |
possibly damaging |
Het |
| Pcsk2 |
A |
G |
2: 143,529,539 (GRCm39) |
D112G |
probably benign |
Het |
| Pms1 |
A |
G |
1: 53,234,174 (GRCm39) |
S781P |
probably benign |
Het |
| Prtg |
A |
G |
9: 72,752,178 (GRCm39) |
D188G |
probably benign |
Het |
| Psg21 |
A |
T |
7: 18,388,695 (GRCm39) |
N132K |
probably benign |
Het |
| Psip1 |
A |
G |
4: 83,400,769 (GRCm39) |
V25A |
probably damaging |
Het |
| Psmd13 |
T |
A |
7: 140,478,107 (GRCm39) |
I319N |
probably damaging |
Het |
| Ptges2 |
A |
G |
2: 32,290,104 (GRCm39) |
T173A |
probably benign |
Het |
| Ptprm |
G |
A |
17: 67,054,155 (GRCm39) |
R975W |
probably damaging |
Het |
| Rdh1 |
A |
G |
10: 127,601,214 (GRCm39) |
D254G |
probably benign |
Het |
| Rnf138 |
T |
G |
18: 21,157,540 (GRCm39) |
N212K |
probably damaging |
Het |
| Serpine2 |
A |
G |
1: 79,799,159 (GRCm39) |
S32P |
probably damaging |
Het |
| Serpini1 |
G |
T |
3: 75,521,971 (GRCm39) |
W154L |
probably damaging |
Het |
| Sf3a1 |
C |
A |
11: 4,129,177 (GRCm39) |
Q713K |
possibly damaging |
Het |
| Sgo2b |
A |
T |
8: 64,379,867 (GRCm39) |
H988Q |
probably benign |
Het |
| Sin3a |
T |
C |
9: 57,008,483 (GRCm39) |
F468L |
probably damaging |
Het |
| Slamf6 |
A |
T |
1: 171,761,776 (GRCm39) |
I66F |
possibly damaging |
Het |
| Slc22a28 |
A |
T |
19: 8,094,488 (GRCm39) |
C178S |
possibly damaging |
Het |
| Slc35a1 |
A |
C |
4: 34,675,181 (GRCm39) |
V119G |
probably damaging |
Het |
| Slc39a12 |
A |
T |
2: 14,439,030 (GRCm39) |
H428L |
probably damaging |
Het |
| Speer2 |
A |
G |
16: 69,654,965 (GRCm39) |
S167P |
probably benign |
Het |
| Sphkap |
G |
A |
1: 83,255,236 (GRCm39) |
R838* |
probably null |
Het |
| Spsb2 |
T |
C |
6: 124,786,329 (GRCm39) |
|
probably null |
Het |
| Stam2 |
A |
T |
2: 52,593,168 (GRCm39) |
Y341* |
probably null |
Het |
| Sv2b |
G |
A |
7: 74,856,089 (GRCm39) |
A67V |
probably benign |
Het |
| Svep1 |
A |
G |
4: 58,064,170 (GRCm39) |
|
probably null |
Het |
| Syt15 |
A |
T |
14: 33,944,969 (GRCm39) |
Q172L |
probably benign |
Het |
| T |
G |
A |
17: 8,660,634 (GRCm39) |
S415N |
probably benign |
Het |
| Tep1 |
A |
G |
14: 51,061,641 (GRCm39) |
F2625S |
possibly damaging |
Het |
| Tex14 |
T |
C |
11: 87,427,581 (GRCm39) |
V11A |
possibly damaging |
Het |
| Tiam2 |
A |
T |
17: 3,465,401 (GRCm39) |
R377* |
probably null |
Het |
| Tirap |
A |
G |
9: 35,102,312 (GRCm39) |
|
probably null |
Het |
| Tm4sf20 |
T |
C |
1: 82,737,938 (GRCm39) |
T118A |
probably benign |
Het |
| Trank1 |
A |
T |
9: 111,207,900 (GRCm39) |
Q1715L |
probably benign |
Het |
| Trpm2 |
C |
T |
10: 77,783,823 (GRCm39) |
V217M |
probably damaging |
Het |
| Ubap1l |
G |
A |
9: 65,279,078 (GRCm39) |
E126K |
possibly damaging |
Het |
| Urgcp |
G |
T |
11: 5,666,526 (GRCm39) |
P604Q |
probably damaging |
Het |
| Vmn1r63 |
A |
G |
7: 5,806,254 (GRCm39) |
V126A |
probably benign |
Het |
| Vmn2r90 |
T |
C |
17: 17,933,525 (GRCm39) |
C362R |
probably damaging |
Het |
| Vmn2r96 |
A |
G |
17: 18,804,138 (GRCm39) |
I271V |
probably damaging |
Het |
| Vps13a |
A |
T |
19: 16,699,822 (GRCm39) |
I740K |
probably benign |
Het |
| Vps13c |
A |
G |
9: 67,883,138 (GRCm39) |
T3562A |
probably damaging |
Het |
| Wdr91 |
T |
A |
6: 34,869,297 (GRCm39) |
H409L |
probably damaging |
Het |
| Wnt7a |
T |
A |
6: 91,342,938 (GRCm39) |
T315S |
possibly damaging |
Het |
| Zfp616 |
A |
G |
11: 73,975,795 (GRCm39) |
H688R |
probably benign |
Het |
| Zfp763 |
A |
T |
17: 33,237,413 (GRCm39) |
H577Q |
probably damaging |
Het |
| Zfp808 |
G |
A |
13: 62,320,721 (GRCm39) |
S650N |
probably benign |
Het |
| Zfp977 |
A |
T |
7: 42,229,409 (GRCm39) |
M372K |
probably benign |
Het |
|
| Other mutations in Gria2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00796:Gria2
|
APN |
3 |
80,618,097 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL00832:Gria2
|
APN |
3 |
80,614,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Gria2
|
APN |
3 |
80,599,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Gria2
|
APN |
3 |
80,615,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01924:Gria2
|
APN |
3 |
80,617,638 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01999:Gria2
|
APN |
3 |
80,639,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02362:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02389:Gria2
|
APN |
3 |
80,616,729 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02444:Gria2
|
APN |
3 |
80,609,860 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02532:Gria2
|
APN |
3 |
80,614,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Gria2
|
UTSW |
3 |
80,615,116 (GRCm39) |
nonsense |
probably null |
|
|
R0015:Gria2
|
UTSW |
3 |
80,615,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Gria2
|
UTSW |
3 |
80,615,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Gria2
|
UTSW |
3 |
80,615,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Gria2
|
UTSW |
3 |
80,618,165 (GRCm39) |
splice site |
probably benign |
|
|
R0551:Gria2
|
UTSW |
3 |
80,639,333 (GRCm39) |
splice site |
probably benign |
|
|
R0655:Gria2
|
UTSW |
3 |
80,639,377 (GRCm39) |
nonsense |
probably null |
|
|
R0866:Gria2
|
UTSW |
3 |
80,629,331 (GRCm39) |
splice site |
probably benign |
|
|
R1393:Gria2
|
UTSW |
3 |
80,614,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Gria2
|
UTSW |
3 |
80,639,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1563:Gria2
|
UTSW |
3 |
80,598,704 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1771:Gria2
|
UTSW |
3 |
80,599,608 (GRCm39) |
nonsense |
probably null |
|
|
R1775:Gria2
|
UTSW |
3 |
80,598,645 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Gria2
|
UTSW |
3 |
80,629,415 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1994:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1995:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R2001:Gria2
|
UTSW |
3 |
80,618,112 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2389:Gria2
|
UTSW |
3 |
80,609,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Gria2
|
UTSW |
3 |
80,614,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Gria2
|
UTSW |
3 |
80,648,260 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3967:Gria2
|
UTSW |
3 |
80,618,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4285:Gria2
|
UTSW |
3 |
80,614,969 (GRCm39) |
intron |
probably benign |
|
|
R4611:Gria2
|
UTSW |
3 |
80,599,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4612:Gria2
|
UTSW |
3 |
80,639,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4616:Gria2
|
UTSW |
3 |
80,614,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4706:Gria2
|
UTSW |
3 |
80,648,297 (GRCm39) |
missense |
probably benign |
|
|
R4996:Gria2
|
UTSW |
3 |
80,614,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5502:Gria2
|
UTSW |
3 |
80,614,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5930:Gria2
|
UTSW |
3 |
80,614,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6142:Gria2
|
UTSW |
3 |
80,709,024 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6233:Gria2
|
UTSW |
3 |
80,614,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6317:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6453:Gria2
|
UTSW |
3 |
80,648,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6526:Gria2
|
UTSW |
3 |
80,599,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Gria2
|
UTSW |
3 |
80,648,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6574:Gria2
|
UTSW |
3 |
80,596,603 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6720:Gria2
|
UTSW |
3 |
80,709,611 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7009:Gria2
|
UTSW |
3 |
80,614,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Gria2
|
UTSW |
3 |
80,596,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7191:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7225:Gria2
|
UTSW |
3 |
80,709,938 (GRCm39) |
unclassified |
probably benign |
|
|
R7374:Gria2
|
UTSW |
3 |
80,648,383 (GRCm39) |
missense |
probably benign |
|
|
R7837:Gria2
|
UTSW |
3 |
80,618,095 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8034:Gria2
|
UTSW |
3 |
80,709,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8125:Gria2
|
UTSW |
3 |
80,614,550 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8189:Gria2
|
UTSW |
3 |
80,629,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8209:Gria2
|
UTSW |
3 |
80,616,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8362:Gria2
|
UTSW |
3 |
80,615,197 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8481:Gria2
|
UTSW |
3 |
80,708,998 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8500:Gria2
|
UTSW |
3 |
80,599,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Gria2
|
UTSW |
3 |
80,614,294 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8918:Gria2
|
UTSW |
3 |
80,599,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Gria2
|
UTSW |
3 |
80,618,170 (GRCm39) |
intron |
probably benign |
|
|
R8971:Gria2
|
UTSW |
3 |
80,615,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Gria2
|
UTSW |
3 |
80,709,689 (GRCm39) |
start codon destroyed |
probably null |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCCTCTATTGTGTCAAAAGGC -3'
(R):5'- CACTTCGTGGTTTTAGCAGCTC -3'
Sequencing Primer
(F):5'- GTTTCAATCTGGAATGCAGTCAAGG -3'
(R):5'- CCTTGCTAAATTTCGACCTCAAAATG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation