Incidental Mutation 'R1994:Trip12'
| ID |
224049 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1994 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84726893 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 36
(F36I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140789
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000189670]
[ENSMUST00000189841]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: F1226I
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: F1226I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: F1226I
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: F1226I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: F1193I
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: F1193I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189670
AA Change: F36I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
AA Change: F36I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189841
|
| SMART Domains |
Protein: ENSMUSP00000140879
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
51 |
63 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190125
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
A |
T |
2: 69,113,014 (GRCm39) |
|
probably null |
Het |
| Abcc8 |
T |
G |
7: 45,806,543 (GRCm39) |
R388S |
probably benign |
Het |
| Abhd18 |
C |
T |
3: 40,889,361 (GRCm39) |
R414* |
probably null |
Het |
| Acap1 |
C |
T |
11: 69,780,324 (GRCm39) |
V40I |
probably benign |
Het |
| Actn1 |
C |
A |
12: 80,251,745 (GRCm39) |
G111* |
probably null |
Het |
| Adam26b |
T |
C |
8: 43,973,676 (GRCm39) |
Q442R |
probably benign |
Het |
| Adamts19 |
T |
C |
18: 59,105,903 (GRCm39) |
|
probably null |
Het |
| Agtpbp1 |
T |
G |
13: 59,678,872 (GRCm39) |
K145N |
probably damaging |
Het |
| AI661453 |
A |
G |
17: 47,777,959 (GRCm39) |
|
probably benign |
Het |
| Ap4e1 |
T |
C |
2: 126,903,467 (GRCm39) |
S790P |
probably benign |
Het |
| Asmt |
A |
G |
X: 169,109,524 (GRCm39) |
E168G |
possibly damaging |
Het |
| Atp2a3 |
T |
A |
11: 72,866,240 (GRCm39) |
S287T |
probably damaging |
Het |
| AY358078 |
T |
A |
14: 52,063,519 (GRCm39) |
D388E |
probably damaging |
Het |
| Bicd1 |
A |
T |
6: 149,415,050 (GRCm39) |
T588S |
probably benign |
Het |
| Birc6 |
T |
G |
17: 74,905,057 (GRCm39) |
N1283K |
probably benign |
Het |
| Cacna1e |
T |
A |
1: 154,353,563 (GRCm39) |
Q423L |
probably damaging |
Het |
| Capn3 |
T |
A |
2: 120,326,418 (GRCm39) |
Y537N |
probably damaging |
Het |
| Ccn3 |
T |
A |
15: 54,612,750 (GRCm39) |
V253E |
probably benign |
Het |
| Cep295 |
C |
T |
9: 15,252,179 (GRCm39) |
E397K |
probably damaging |
Het |
| Chgb |
T |
C |
2: 132,628,418 (GRCm39) |
S48P |
possibly damaging |
Het |
| Cidec |
T |
A |
6: 113,405,193 (GRCm39) |
Y159F |
probably damaging |
Het |
| Clec18a |
T |
C |
8: 111,808,234 (GRCm39) |
S66G |
possibly damaging |
Het |
| Cpsf1 |
G |
A |
15: 76,487,360 (GRCm39) |
T138M |
probably benign |
Het |
| Dclre1c |
C |
T |
2: 3,439,022 (GRCm39) |
R61W |
probably damaging |
Het |
| Eef1akmt1 |
A |
C |
14: 57,787,911 (GRCm39) |
V149G |
probably benign |
Het |
| Fam131b |
T |
C |
6: 42,297,818 (GRCm39) |
T112A |
possibly damaging |
Het |
| Fbln2 |
A |
G |
6: 91,211,283 (GRCm39) |
E409G |
probably damaging |
Het |
| Fkbp15 |
G |
A |
4: 62,222,618 (GRCm39) |
P1094S |
probably benign |
Het |
| Fpr1 |
A |
G |
17: 18,097,879 (GRCm39) |
S37P |
probably benign |
Het |
| Fryl |
G |
T |
5: 73,265,836 (GRCm39) |
T495K |
probably damaging |
Het |
| Gja6 |
A |
T |
X: 159,686,374 (GRCm39) |
I186N |
possibly damaging |
Het |
| Gm4922 |
T |
C |
10: 18,659,388 (GRCm39) |
T445A |
probably benign |
Het |
| Gria2 |
G |
A |
3: 80,709,664 (GRCm39) |
L10F |
probably benign |
Het |
| Gspt2 |
A |
G |
X: 93,681,025 (GRCm39) |
D388G |
possibly damaging |
Het |
| Hdc |
T |
A |
2: 126,458,107 (GRCm39) |
I72F |
probably damaging |
Het |
| Ift70b |
A |
G |
2: 75,768,402 (GRCm39) |
L117P |
probably damaging |
Het |
| Igf2r |
T |
C |
17: 12,911,625 (GRCm39) |
K1905E |
probably benign |
Het |
| Il33 |
A |
G |
19: 29,934,304 (GRCm39) |
D155G |
possibly damaging |
Het |
| Klk1b9 |
C |
T |
7: 43,628,979 (GRCm39) |
T161I |
probably benign |
Het |
| Mfsd12 |
C |
A |
10: 81,193,515 (GRCm39) |
H28Q |
probably damaging |
Het |
| Mgat5 |
A |
T |
1: 127,387,696 (GRCm39) |
I551F |
possibly damaging |
Het |
| Miga2 |
A |
T |
2: 30,272,000 (GRCm39) |
D25V |
probably damaging |
Het |
| Mlc1 |
T |
C |
15: 88,858,782 (GRCm39) |
N122S |
possibly damaging |
Het |
| Mmp20 |
T |
A |
9: 7,645,293 (GRCm39) |
M281K |
probably benign |
Het |
| Muc5ac |
C |
A |
7: 141,366,889 (GRCm39) |
P2232T |
possibly damaging |
Het |
| N4bp2l2 |
A |
G |
5: 150,584,748 (GRCm39) |
S411P |
possibly damaging |
Het |
| Ngef |
G |
A |
1: 87,415,626 (GRCm39) |
S346L |
probably damaging |
Het |
| Or10j27 |
C |
T |
1: 172,958,418 (GRCm39) |
R122H |
possibly damaging |
Het |
| Or2t6 |
A |
G |
14: 14,175,854 (GRCm38) |
I76T |
probably benign |
Het |
| Or4c112 |
T |
A |
2: 88,853,487 (GRCm39) |
T287S |
probably damaging |
Het |
| Or4f15 |
T |
A |
2: 111,814,429 (GRCm39) |
M5L |
probably benign |
Het |
| Or51aa2 |
T |
C |
7: 103,187,566 (GRCm39) |
I292V |
possibly damaging |
Het |
| Or52m2 |
C |
T |
7: 102,263,747 (GRCm39) |
V150M |
probably damaging |
Het |
| Or56b2 |
T |
C |
7: 104,337,690 (GRCm39) |
I156T |
probably benign |
Het |
| Or6c215 |
T |
C |
10: 129,637,530 (GRCm39) |
Y288C |
probably damaging |
Het |
| Or6c6 |
T |
A |
10: 129,186,561 (GRCm39) |
I43N |
probably damaging |
Het |
| Pecam1 |
G |
T |
11: 106,586,763 (GRCm39) |
H150N |
possibly damaging |
Het |
| Polr3c |
A |
T |
3: 96,621,689 (GRCm39) |
|
probably null |
Het |
| Pop1 |
A |
C |
15: 34,530,617 (GRCm39) |
Q1005P |
probably damaging |
Het |
| Prss22 |
G |
A |
17: 24,215,288 (GRCm39) |
P163S |
probably damaging |
Het |
| Prss33 |
G |
A |
17: 24,053,172 (GRCm39) |
A223V |
probably damaging |
Het |
| Prss53 |
C |
T |
7: 127,486,565 (GRCm39) |
V354I |
probably benign |
Het |
| Rab3gap2 |
C |
T |
1: 184,968,221 (GRCm39) |
T191I |
probably damaging |
Het |
| Rictor |
T |
C |
15: 6,805,637 (GRCm39) |
F608L |
probably benign |
Het |
| Ryr3 |
T |
A |
2: 112,484,837 (GRCm39) |
E3884V |
probably null |
Het |
| Scaf11 |
G |
A |
15: 96,316,721 (GRCm39) |
R948* |
probably null |
Het |
| Sec61g |
A |
T |
11: 16,456,444 (GRCm39) |
V40E |
probably damaging |
Het |
| Serpinb3d |
A |
T |
1: 107,008,518 (GRCm39) |
F116I |
possibly damaging |
Het |
| Sipa1l3 |
T |
C |
7: 29,099,036 (GRCm39) |
D411G |
probably benign |
Het |
| Slc13a3 |
T |
C |
2: 165,275,984 (GRCm39) |
N254S |
possibly damaging |
Het |
| Slc35a2 |
T |
A |
X: 7,759,064 (GRCm39) |
L110Q |
probably damaging |
Het |
| Spata31d1b |
G |
C |
13: 59,864,194 (GRCm39) |
L447F |
probably benign |
Het |
| Spsb2 |
T |
C |
6: 124,786,329 (GRCm39) |
|
probably null |
Het |
| Tent4b |
C |
T |
8: 88,973,112 (GRCm39) |
T277M |
probably damaging |
Het |
| Tmcc3 |
T |
C |
10: 94,414,468 (GRCm39) |
S57P |
possibly damaging |
Het |
| Traf7 |
A |
G |
17: 24,729,476 (GRCm39) |
V445A |
probably damaging |
Het |
| Trib1 |
A |
G |
15: 59,521,192 (GRCm39) |
S61G |
possibly damaging |
Het |
| Tshz3 |
T |
C |
7: 36,469,247 (GRCm39) |
I412T |
probably damaging |
Het |
| Tsku |
T |
C |
7: 98,001,353 (GRCm39) |
Y326C |
probably damaging |
Het |
| Ttn |
T |
G |
2: 76,712,038 (GRCm39) |
|
probably benign |
Het |
| Ugt1a6a |
G |
A |
1: 88,066,470 (GRCm39) |
R92H |
probably benign |
Het |
| Vmn1r63 |
A |
G |
7: 5,806,254 (GRCm39) |
V126A |
probably benign |
Het |
| Vmn2r84 |
T |
A |
10: 130,221,878 (GRCm39) |
S781C |
probably damaging |
Het |
| Wdr91 |
T |
A |
6: 34,869,297 (GRCm39) |
H409L |
probably damaging |
Het |
| Wnt7a |
T |
A |
6: 91,342,938 (GRCm39) |
T315S |
possibly damaging |
Het |
| Zdhhc25 |
A |
G |
15: 88,485,027 (GRCm39) |
T121A |
probably benign |
Het |
| Zfp109 |
T |
C |
7: 23,928,743 (GRCm39) |
H222R |
probably benign |
Het |
| Zfp286 |
A |
G |
11: 62,670,646 (GRCm39) |
S476P |
probably damaging |
Het |
| Zfp605 |
T |
C |
5: 110,275,418 (GRCm39) |
Y179H |
probably damaging |
Het |
| Zfp955a |
T |
C |
17: 33,460,620 (GRCm39) |
H504R |
probably damaging |
Het |
| Zswim2 |
T |
A |
2: 83,746,007 (GRCm39) |
N477I |
possibly damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGGGCTTCGTGTCTAGCTTC -3'
(R):5'- CTCCACTCTTTTAGGTGGATGG -3'
Sequencing Primer
(F):5'- CATCTCTGTGAATGAATTGCAACCC -3'
(R):5'- ATGGTGGAGCTGAGTGCC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation